KEGG ENZYME: 2.1.1.161

ENZYME: 2.1.1.161

Entry

EC 2.1.1.161                Enzyme

Name

dimethylglycine N-methyltransferase;
BsmB;
DMT

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase (betaine-forming)

Reaction(IUBMB)

S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine [RN:R07244]

Reaction(KEGG)

R07244

Substrate

S-adenosyl-L-methionine [CPD:C00019];
N,N-dimethylglycine [CPD:C01026]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
betaine [CPD:C00719]

Comment

This enzyme, from the marine cyanobacterium Synechococcus sp. WH8102, differs from EC 2.1.1.157, sarcosine/dimethylglycine N-methyltransferase in that it cannot use sarcosine as an alternative substrate [1]. Betaine is a 'compatible solute' that enables cyanobacteria to cope with osmotic stress by maintaining a positive cellular turgor.

History

EC 2.1.1.161 created 2007

Pathway

ec00260

Glycine, serine and threonine metabolism

ec01100

Metabolic pathways

Orthology

K13042

dimethylglycine N-methyltransferase

Genes

SYX:	SynWH7803_0360

SYNR:

KR49_11735

SYNW:

SynWH8103_02186(gbmt2)

SYW:	SYNW1913(sdmt)

PMT:

PMT_0551

PMF:	P9303_17021

Reference

1 [PMID:17019606]

Authors

Lu WD, Chi ZM, Su CD

Title

Identification of glycine betaine as compatible solute in Synechococcus sp. WH8102 and characterization of its N-methyltransferase genes involved in betaine synthesis.

Journal

Arch Microbiol 186:495-506 (2006)
DOI:10.1007/s00203-006-0167-8

Sequence

[syw:SYNW1913]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.161

IUBMB Enzyme Nomenclature:

2.1.1.161

ExPASy - ENZYME nomenclature database:

2.1.1.161

BRENDA, the Enzyme Database:

2.1.1.161

DBGET integrated database retrieval system