KEGG   ENZYME: 2.1.1.234Help
Entry
EC 2.1.1.234                Enzyme                                 

Name
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase;
DesVI
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose 3-N,N-dimethyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose = 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose [RN:R06427]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose
Product
S-adenosyl-L-homocysteine [CPD:C00021];
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose [CPD:C11911]
Comment
The enzyme is involved in the biosynthesis of desosamine, a 3-(dimethylamino)-3,4,6-trideoxyhexose found in certain macrolide antibiotics such as erthyromycin, azithromycin, and clarithromycin.
History
EC 2.1.1.234 created 2011
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K13311  dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase
K13326  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase
Genes
AER: AERYTH_15940
SEN: SACE_0718(eryCVI)
ACTI: UA75_17810
ACAD: UA74_17275
AHG: AHOG_15450(desVI)
AMS: AMIS_50600
AEY: CDG81_13200
Taxonomy
Reference
1  [PMID:12119032]
  Authors
Chen H, Yamase H, Murakami K, Chang CW, Zhao L, Zhao Z, Liu HW
  Title
Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine.
  Journal
Biochemistry 41:9165-83 (2002)
DOI:10.1021/bi020245j
  Sequence
Reference
2  [PMID:18327916]
  Authors
Burgie ES, Holden HM
  Title
Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis.
  Journal
Biochemistry 47:3982-8 (2008)
DOI:10.1021/bi800063j
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.234
IUBMB Enzyme Nomenclature: 2.1.1.234
ExPASy - ENZYME nomenclature database: 2.1.1.234
BRENDA, the Enzyme Database: 2.1.1.234

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