KEGG   ENZYME: 2.1.1.305Help
Entry
EC 2.1.1.305                Enzyme                                 

Name
8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase;
ElmMI
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C = S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [RN:R10956]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
8-demethyl-8-alpha-L-rhamnosyltetracenomycin C [CPD:C20974]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [CPD:C20975]
Comment
The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin.
History
EC 2.1.1.305 created 2014
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K19567  8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
Reference
1  [PMID:11376004]
  Authors
Patallo EP, Blanco G, Fischer C, Brana AF, Rohr J, Mendez C, Salas JA.
  Title
Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes.
  Journal
J Biol Chem 276:18765-74 (2001)
DOI:10.1074/jbc.M101225200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.305
IUBMB Enzyme Nomenclature: 2.1.1.305
ExPASy - ENZYME nomenclature database: 2.1.1.305
BRENDA, the Enzyme Database: 2.1.1.305

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