KEGG ENZYME: 2.1.1.314

ENZYME: 2.1.1.314

Entry

EC 2.1.1.314                Enzyme

Name

diphthine methyl ester synthase;
S-adenosyl-L-methionine:elongation factor 2 methyltransferase (ambiguous);
diphthine methyltransferase (ambiguous);
Dph5 (ambiguous)

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] methyltransferase (diphthine methyl ester-[translation elongation factor 2]-forming)

Reaction(IUBMB)

4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] = 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] [RN:R11165]

Reaction(KEGG)

R11165

Substrate

S-adenosyl-L-methionine [CPD:C00019];
2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] [CPD:C04441]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
diphthine methyl ester-[translation elongation factor 2] [CPD:C21151]

Comment

This eukaryotic enzyme is part of the biosynthetic pathway of diphthamide. Different from the archaeal enzyme, which performs only 3 methylations, producing diphthine (cf. EC 2.1.1.98). The relevant histidine of elongation factor 2 is His715 in mammals and His699 in yeast. The order of the 4 methylations is not known.

History

EC 2.1.1.314 created 2015

Orthology

K00586

diphthine methyl ester synthase

Genes

HSA:	51611(DPH5)

PTR:	457062(DPH5)

PPS:	100976633(DPH5)

GGO:	101127053(DPH5)

PON:	100453387(DPH5)

PPYG:

129030326(DPH5)

NLE:	100586352(DPH5)

HMH:	116469702(DPH5)

SSYN:

134734143(DPH5)

MCC:	712253(DPH5)

MCF:	102128354(DPH5)

MTHB:

126929203

MNI:	105485475(DPH5)

CSAB:

103224358(DPH5)

CATY:

105590133(DPH5)

PANU:

101012769(DPH5)

TGE:	112624460(DPH5)

MLEU:

105548505(DPH5)

RRO:	104673263(DPH5)

RBB:	108519964(DPH5)

TFN:	117075442(DPH5)

PTEH:

111525764(DPH5)

CANG:

105506903(DPH5)

CJC:	100415127(DPH5)

SBQ:	101042608(DPH5)

CIMI:

108317290(DPH5)

ANAN:

105726887(DPH5)

CSYR:

103252396(DPH5)

MMUR:

105862239(DPH5)

LCAT:

123635345(DPH5)

PCOQ:

105818764(DPH5)

OGA:	100959084(DPH5)

MMU:	69740(Dph5)

MCAL:

110291208(Dph5)

MPAH:

110320467(Dph5)

RNO:	295394(Dph5)

MCOC:

116093671(Dph5)

ANU:	117707739(Dph5)

ASYL:

127682770(Dph5)

MUN:	110551869(Dph5)

CGE:

100755934

MAUA:

101841367(Dph5)

PROB:

127223115(Dph5)

PLEU:

114682444(Dph5)

MORG:

121448980(Dph5)

MFOT:

126507828

AAMP:

119800651(Dph5)

NGI:	103741876(Dph5)

HGL:	101696986(Dph5)

CPOC:

100732624(Dph5)

CCAN:

109698072(Dph5)

DORD:

105997100(Dph5)

DSP:	122108752(Dph5)

DMER:

138804443 138817344(Dph5)

PLOP:

125355608(Dph5)

NCAR:

124991537

MMMA:

107156555(Dph5)

ITI:	101970602(Dph5)

OCU:

100345003

OPI:	101536409(DPH5)

TUP:	102477552(DPH5)

GVR:	103599460(DPH5)

CFA:	612092(DPH5)

CLUD:

112640771(DPH5)

VVP:	112918478(DPH5)

VLG:	121486457(DPH5)

NPO:	129519650(DPH5)

AML:	100481131(DPH5)

UMR:	103669323(DPH5)

UAH:	113254339(DPH5)

UAR:	123795150(DPH5)

ELK:

111143015

LLV:	125098429 125104965

MPUF:

101682000(DPH5)

MNP:	132001198(DPH5)

MLK:	131809626(DPH5)

NVS:	122900250(DPH5)

ORO:	101369128(DPH5)

EJU:	114207936(DPH5)

ZCA:	113934849(DPH5)

MLX:	118019079(DPH5)

NSU:	110580383(DPH5)

LWW:	102740436(DPH5)

FCA:	101090957(DPH5)

PYU:	121027568(DPH5)

PCOO:

112871850(DPH5)

PBG:	122480843(DPH5)

PVIV:

125172399(DPH5)

LRUF:

124514964

LGF:	123598328(DPH5)

AJU:

106976419

PTG:	102958220(DPH5)

PPAD:

109271933(DPH5)

PUC:

125912340

PLEZ:

122228156(DPH5)

HHV:	120226815(DPH5)

BTA:	508904(DPH5)

BOM:	102267176(DPH5)

BIU:	109556005(DPH5)

BBUB:

102408149(DPH5)

BBIS:

104981720(DPH5)

CHX:	102173522(DPH5)

OAS:	101115329(DPH5)

BTAX:

128045260(DPH5)

CSUM:

138073696(DPH5)

ODA:	120856789(DPH5)

CCAD:

122436627(DPH5)

MREE:

136148379(DPH5) 136158912

OVR:	110145666(DPH5)

MBEZ:

129540555(DPH5)

SSC:	100157715(DPH5)

CFR:	102518705(DPH5)

CBAI:

105065363(DPH5)

CDK:	105084897(DPH5)

VPC:	102537923(DPH5)

BACU:

103000130(DPH5)

BMUS:

118885571(DPH5)

LVE:	103089744(DPH5)

OOR:	101285892(DPH5)

LALB:

132514579(DPH5)

GMF:	115859644(DPH5)

DLE:	111180109(DPH5)

PCAD:

102988442(DPH5)

PSIU:

116739752(DPH5)

PPHC:

136127907(DPH5)

NASI:

112403625(DPH5)

ECB:	100050115(DPH5)

EPZ:	103550054(DPH5)

EAI:	106837770(DPH5)

MYB:	102248566(DPH5)

MYD:	102755928(DPH5)

MMYO:

118673470(DPH5)

MLF:	102436513(DPH5)

MDT:	132221180(DPH5)

MYUM:

138996004(DPH5)

PKL:	118727455(DPH5)

EFUS:

103291315(DPH5)

MNA:	107530684(DPH5)

DRO:	112313814(DPH5)

SHON:

118990626(DPH5)

AJM:	119054959(DPH5)

PDIC:

114488982(DPH5)

PHAS:

123804702(DPH5)

MMF:	118637891(DPH5)

PPAM:

129063710(DPH5)

HAI:	109371355(DPH5)

RFQ:	117014701(DPH5)

PALE:

102884526(DPH5)

PGIG:

120607846(DPH5)

PVP:	105298160(DPH5)

RAY:	107504391(DPH5)

MJV:	108402213(DPH5)

TOD:	119236039(DPH5)

SARA:

101552034(DPH5)

SFUM:

130046208(DPH5)

SETR:

125997345(DPH5)

LAV:	100660768(DPH5)

TMU:

101346258

ETF:	101643570(DPH5)

DNM:	101417099(DPH5)

MDO:	100032968(DPH5)

GAS:	123235390 123243960(DPH5)

SHR:	100914997(DPH5)

AFZ:

127559447

PCW:	110217583(DPH5)

TVP:	118856572(DPH5)

PBRV:

138162942(DPH5)

MLAO:

141488307(DPH5)

OAA:	100074886(DPH5)

TACU:

119927307(DPH5)

GGA:	424463(DPH5)

PCOC:

116243533(DPH5)

MGP:	100549424(DPH5)

CJO:	107317334(DPH5)

TPAI:

128072124(DPH5)

LMUT:

125693468(DPH5)

NMEL:

110402399(DPH5)

APLA:

101793155(DPH5)

ACYG:

106039414(DPH5)

CATA:

118243307(DPH5)

AFUL:

116491820(DPH5)

TGU:	100219750(DPH5)

LSR:	110477492(DPH5)

SCAN:

103814859(DPH5)

PMOA:

120506388(DPH5)

OTC:	121345232(DPH5)

PRUF:

121362196(DPH5)

ATRC:

139594271(DPH5)

GFR:	102036363(DPH5)

FAB:	101821538(DPH5)

OMA:	130256327(DPH5)

PHI:	102114227(DPH5)

PMAJ:

107208069(DPH5)

CCAE:

111932728(DPH5)

CCW:	104695384(DPH5)

CBRC:

103612570(DPH5)

ACOE:

138113788(DPH5)

ETL:	114061651(DPH5)

ZAB:	102066581(DPH5)

ZLE:	135451284(DPH5)

ACHL:

103807553(DPH5)

SVG:	106858448(DPH5)

MMEA:

130572553(DPH5)

HRT:	120756498(DPH5)

SATI:

136365040(DPH5)

CCIC:

134046648(DPH5)

FPG:	101921285(DPH5)

FCH:	102056137(DPH5)

CCRI:

104160840(DPH5)

NNT:	104410423(DPH5)

SHAB:

115611940(DPH5)

ACUN:

113482993(DPH5)

TALA:

104360730(DPH5)

ACHC:

115348770(DPH5)

HALD:

104313330(DPH5)

HLE:	104829407(DPH5)

AGEN:

126041701

HHAR:

128148617(DPH5)

GCL:

127018883

CSTI:

104551505(DPH5)

LDI:	104354748(DPH5)

MNB:	103775571(DPH5)

DPUB:

104304617(DPH5)

PPUS:

135177295(DPH5)

AVIT:

104271898(DPH5)

BRHI:

104500004(DPH5)

EGZ:	104134012(DPH5)

NNI:	104015521(DPH5)

PCRI:

104037867(DPH5)

PCAO:

104042081(DPH5)

PADL:

103925092(DPH5)

AFOR:

103902185(DPH5)

FGA:	104069521(DPH5)

GSTE:

104250689(DPH5)

CBOY:

140654072(DPH5)

CLV:	102086197(DPH5)

CNIC:

136002285(DPH5)

MUI:	104544391(DPH5)

PGUU:

104458256(DPH5)

PLET:

104625115(DPH5)

EHS:	104502763(DPH5)

CMAC:

104476171(DPH5)

CUCA:

104063306(DPH5)

TEO:	104369895(DPH5)

BREG:

104629554(DPH5)

OHA:	104332582(DPH5)

ACAR:

104523004(DPH5)

CPEA:

104396770(DPH5)

CVF:	104286202(DPH5)

RTD:	128914259(DPH5)

CRID:

134519790(DPH5)

AAM:	106499746(DPH5)

AROW:

112966828(DPH5)

NPD:	112951118(DPH5)

TGT:	104565821(DPH5)

DNE:	112979777(DPH5)

SCAM:

104151237(DPH5)

ASN:	102388223(DPH5)

AMJ:	102573130(DPH5)

CPOO:

109307235(DPH5)

GGN:	109286888(DPH5)

PSS:	102462255(DPH5)

CMY:	102931019(DPH5)

CCAY:

125641799(DPH5)

DCC:	119860413(DPH5)

CPIC:

101944042(DPH5)

TST:	117881427(DPH5)

CABI:

116839201(DPH5)

MRV:	120370732(DPH5)

ACS:	100562876(dph5)

ASAO:

132774185(DPH5)

PVT:	110076528(DPH5)

SUND:

121929331(DPH5)

PBI:	103049292(DPH5)

PMUR:

107302499(DPH5)

CTIG:

120310256(DPH5)

PGUT:

117677271(DPH5)

PCAE:

139315139(DPH5)

APRI:

131196222(DPH5)

PTEX:

113436157(DPH5)

NSS:	113414764(DPH5)

VKO:	123024529(DPH5)

PMUA:

114598700(DPH5)

PRAF:

128415427(DPH5)

ZVI:	118089424(DPH5)

HCG:	128324091(DPH5)

GJA:	107107446(DPH5)

STOW:

125432445(DPH5)

EMC:	129329757(DPH5)

XLA:	380263(dph5.S)

XTR:	448611(dph5)

NPR:	108791464(DPH5)

RTEM:

120945617(DPH5)

ACAT:

141103432(DPH5)

BBUF:

120979469(DPH5)

BGAR:

122943107(DPH5)

DTC:	141085974(DPH5)

PWL:	138293143(DPH5)

MUO:	115472726(DPH5)

GSH:	117346795(DPH5)

DRE:	492514(dph5)

SRX:	107715097 107757489(dph5)

SANH:

107669825

SGH:	107588067(dph5) 107592713

CCAR:

109047508(dph5) 109047511

CAUA:

113040132(dph5)

CGIB:

127942451 127987902

PTET:

122327640(dph5)

LROH:

127153135(dph5)

GRF:	141338622(dph5)

OMC:	131531204(dph5)

PPRM:

120486777(dph5)

RKG:	130089303(dph5)

MAMB:

125251293(dph5)

CIDE:

127520605

CERY:

137027695(dph5)

MASI:

127438601 127438630

TROS:

130549024(dph5)

TDW:	130429754(dph5)

MANU:

129453115(dph5)

PDAB:

135727241(dph5)

IPU:

108271146

IFU:	128614111(dph5)

PHYP:

113536511(dph5)

SMEO:

124391159(dph5)

TFD:	113650737(dph5)

TVC:	132854496(dph5)

CGAR:

128542623(dph5)

NGRA:

132899396(dph5)

TRN:	134331379(dph5)

AMEX:

103037464(dph5)

CMAO:

118818831(dph5)

EEE:	113574556(dph5)

CHAR:

105912936(dph5)

SPIL:

134101993(dph5)

TRU:	101065858(dph5)

TFS:	130528442(dph5)

TNG:	GSTEN00008282G001

LCO:	104936355(dph5)

NCC:	104954007(dph5)

TBEN:

117497831(dph5)

PGEO:

117444223(dph5)

GACU:

117560349(dph5)

EMAC:

134869944(dph5)

ELY:	117253951(dph5)

EFO:	125895560(dph5)

PLEP:

121940894(dph5)

SLUC:

116059029(dph5)

PFLV:

114561013(dph5)

GAT:	120824138(dph5)

PPUG:

119216181(dph5)

AFB:	129094525(dph5)

CLUM:

117729654(dph5)

PSWI:

130194193(dph5)

CANA:

137795466(dph5)

CVE:	137883757(dph5)

MSAM:

119888720 119889122

SCHU:

122877743(dph5)

CUD:	121511893(dph5)

SPUL:

138606766(dph5)

LMIX:

132971926(dph5)

ALAT:

119028917(dph5)

ASTR:

137598638(dph5)

MZE:	101480932(dph5)

ONL:	100691910(dph5)

OAU:	116320806(dph5)

OLA:	101171985(dph5)

OML:	112136738(dph5)

CSAI:

133458697(dph5)

XMA:	102236269(dph5)

XCO:	114141461(dph5)

XHE:	116726233(dph5)

PRET:

103463161(dph5)

PFOR:

103150015(dph5)

PLAI:

106954343(dph5)

PMEI:

106922598(dph5)

GAF:	122838560(dph5)

PPRL:

129368819(dph5)

CVG:	107094698(dph5)

CTUL:

119784589(dph5)

GMU:	124874003(dph5)

NFU:	107393084(dph5)

KMR:	108248681(dph5)

ALIM:

106525066(dph5)

NWH:	119430474(dph5)

AOCE:

111583774(dph5)

EJA:	138193749(dph5)

BFRE:

138634721(dph5)

MCEP:

125009538(dph5)

CSEM:

103398551(dph5)

POV:	109644652(dph5)

SSEN:

122780969(dph5)

SSOE:

131465961(dph5)

HHIP:

117759848(dph5)

HSP:	118121071(dph5)

PPLT:

128447962(dph5)

SMAU:

118317780(dph5)

LCF:

108874223

SDU:	111236192(dph5)

SLAL:

111668215(dph5)

XGL:	120790601(dph5)

HCQ:	109506828(dph5)

SSCV:

125975648(dph5)

SBIA:

133503737(dph5)

PEE:	133406290(dph5)

PTAO:

133480843(dph5)

ENY:	140353616(dph5)

MALB:

109965234(dph5)

BSPL:

114853148(dph5)

SJO:	128361644(dph5)

GMH:	115555818(dph5)

SASA:

106573967(dph5) 106613590

STRU:

115158062

OTW:

112250700

OMY:	110524102(dph5)

OGO:	123995730(dph5) 123997364

ONE:	115108141(dph5)

OKI:	109902343(dph5)

OKE:	118387753(dph5)

OMM:	135512617(dph5)

OCLA:

139410099

SALP:

111952694(dph5) 111975882

SNH:	120054002(dph5) 120054659

CCLU:

121533698(dph5)

ELS:	105011378(dph5)

OEP:	134012681(dph5)

SFM:	108919061(dph5)

PKI:	111844640(dph5)

AANG:

118225790(dph5)

AROT:

135253674(dph5)

CCOG:

133127011(dph5)

LOC:	102698591(dph5)

PSPA:

121326539(dph5)

ARUT:

117417302(dph5)

PSEX:

120537983(dph5)

LCM:	102345453(DPH5)

CMK:	103188848(dph5)

RTP:	109915341(dph5)

CPLA:

122554521(dph5)

HOC:	132819003(dph5)

LERI:

129701233(dph5)

HAKA:

140737163(dph5)

PMRN:

116948810(DPH5)

LRJ:	133351914(DPH5)

BFO:

118432428

BBEL:

109475271

CIN:

100181968

SCLV:

120348207

SPU:

577892

LPIC:

129271637 129271640

AJJ:

139982717

APLC:

110977432

ARUN:

117297647

AAMU:

139945901

AFIL:

140166317

AJC:

117110670

SKO:

100366716

PFLL:

139138757

DME:	Dmel_CG31289(Dph5)

DER:

6555113

DSE:

6607456

DSI:	Dsimw501_GD18446(Dsim_GD18446)

DYA:	Dyak_GE24024(Dyak_Dph5)

DAN:

6498942

DSR:

110188269

DPO:

4800610

DPE:

6594873

DMN:

108156735

DWI:

6647360

DGR:

6567370

DMO:	Dmoj_GI10523

DAZ:

108616603

DNV:

108653623

DHE:

111595896

DVI:	6629689(Dph5)

CCAT:

101453064

BOD:

106616144

BDR:

105232551

RZE:	108376442 108377611

AOQ:

129253193

ALUD:

128854826

TDA:	119680011 119685040

MDE:

101896586

SCAC:

106083398

LCQ:

111684683

LSQ:

119611404

CVJ:	135963783(Dph5)

GFS:	119633751 119634663

ECOE:

129942248

CLON:

129607170

HIS:

119651702

AGA:

1274556

ACOZ:

120950438

AARA:

120895999

AMER:

121590689

ASTE:

118503179

AMAP:

126558729

AFUN:

125763185

AMOU:

128310710

AMRS:

128707759

AALI:

118458903

ACOS:

131272818

AAG:

5576116

AALB:

109403854 115264229

ASUA:

134208037

CQU:	CpipJ_CPIJ008675

CBRI:

134834120

CNS:

116346963

BCOO:

119070515

LLL:

129788020

PPAP:

129798397

AME:

412557

ACER:

107998482

ALAB:

122715034

ADR:

102673698

AFLR:

100871950

BIM:

100747247

BBIF:

117213118

BVK:

117232627

BVAN:

117156320

BHUN:

126871953

BTER:

100646946

BAFF:

126922279

BPYO:

122567498

BPAS:

132912991

FVI:

122531406

CCAL:

108624624

OBB:

114880580

OLG:

117602993

MGEN:

117221319

NMEA:

116423853

CGIG:

122398977

SOC:

105197794

MPHA:

105837618

AEC:

105152429

ACEP:

105626466

ACOC:

108686730

MZT:	108721852(Dph5)

PBAR:

105427617

VEM:

105559747

COBS:

139106444(Dph5)

TLN:	139820980(Dph5)

HST:

105184193

DQU:

106750767

CFO:

105254164

FEX:

115237380

PMEC:

138944817(Dph5)

LHU:	105668887(Dph5)

PGC:

109857302

OBO:

105277059

PCF:

106790251

PFUC:

122517591

VPS:

122638173

VCRB:

124432813

VVE:

124947278

NVI:

100120480

CSOL:

105367362

TPRE:

106651955

LHT:

122498388

LBD:

127285005

MDL:

103572391

CGLO:

123275103

CTYP:

141530397(Dph5)

FAS:

105268572

DAM:

107036001

AGIF:

122854429

CINS:

118069961

VCAN:

122408890

CCIN:

107264162

DSM:

124414099

NPT:	124223804(Dph5)

NFB:

124186756

NLO:

107223513

NVG:

124309151

AROA:

125500240

TMOL:

138125028(Dph5)

DPA:

109537206

ESIM:

136410726(Dph5)

EFOR:

136345315(Dph5)

SOY:

115887322

AGRG:

126735654

ATD:

109598953

CSET:

123308655

HAXR:

123671498

AGB:

108914858

LDC:

111506996

DVV:

114328906

NVL:

108567934

DCOR:

135799047(Dph5)

APLN:

108739515

PPYR:

116160474

OTU:

111423904

BMOR:

101746700

BMAN:

114240393

MSEX:

115443394

DPL:	KGM_202307

BANY:

112044307

MJU:

123874896

NIQ:

126775866

VCD:

124538622

MCIX:

123662386

PMAC:

106721558

PPOT:

106101098

PXU:

106120183

BPHI:

137919870(Dph5)

PRAP:

110997434

PBX:

123716390

PNAP:

125053909

ZCE:

119828645

CCRC:

123699964

LSIN:

126972567 126972569

AAGE:

121725918

HAW:

110373393

HZE:

124639965

TNL:

113504715

SLIU:

111350253

OFU:

114352254

ONU:

135080604

ATRA:

106130316

GMW:

113519908

PXY:

105382354

PGW:

126374928

LGLY:

125232505

CSTB:

134748156

CFUM:

141432628(Dph5)

CFEL:

113384629 113384725

API:

100160206

DNX:

107166759

AGS:

114126319

RMD:

113556934

ACOO:

126844946

DVT:

126898437

BTAB:

109032879

DCI:	103506226 103506253

CLEC:

106669101

HHAL:

106690655(Dph5)

NLU:

111061408

HVI:

124373798

MQU:

128983954

PHU:	Phum_PHUM004200

FOC:

113206276

ZNE:

110831424

CSEC:

111863378

PAME:

138699613(Dph5)

SGRE:

126266812

BROR:

134538316

IEL:

124159501

HAMR:

139691934(Dph5)

FCD:

110859232

DPX:	DAPPUDRAFT_331033

DMK:

116934882

DPZ:

124316079

AFRA:

136028808

PJA:

122260754

PCHN:

125042568

CQD:	128694513(Dph5)

PTRU:

123503472

EAF:

111713117

LSM:	121132464(Dph5)

TCF:

131879971

PPOI:

119092681 119092693

DSV:

119453817

RSAN:

119399618

RMP:	119175568 119179931

VDE:

111244279

VJA:

111269643

GOE:

100906989

TUT:

107360805

DPTE:

113788857

DFR:

124498003

CSCU:

111634931

CVS:	136984467(Dph5)

PTEP:

107451453

ABRU:

129970596

UDV:

129220312

SDM:

118192405

LPOL:

106469413

PMEO:

129592512

CEL:	CELE_B0491.7(dph-5)

CBR:

CBG_02918

NAI:	NECAME_15246

BMY:	BM_BM11348(Bm11348)

LOA:	LOAG_02159

TSP:

Tsp_10674

HRO:	HELRODRAFT_169662

LGI:	LOTGIDRAFT_213693

PCAN:

112574548

LSAX:

138967353

BGT:

106068956

GAE:

121375442

HRF:

124116728

HRJ:

124255685

HASI:

137290693

HCRA:

139478672

CRG:

117684754

CANU:

128167019

CVN:

111120988

OED:

125670738

MYI:

110440663

PMAX:

117325476

AIRR:

138324719

MCAF:

127726444

MMER:

123525490

RPHI:

132730900

DPOL:

127876828 127878047

MAEA:

128213939

OBI:

106876766

OSN:	115217989 115227937

LJP:

135470464

LAK:

106177069

SMM:	Smp_025570.1

SHX:	MS3_00003741(DPH5)

OVI:	T265_03076

EGL:

EGR_02199

LLON:

135486581

NVE:

5517180

EPA:

110255079

ATEN:

116293077

ADF:	107327155 107330171 107330804 107358146

AMIL:

114974404

MCAZ:

138024004 138024265

MFOO:

137973777

PDAM:

113683056

SPIS:

111331566

DGT:

114515703

XEN:

124440175

HMG:

105845166

HSY:

130612386

AQU:

100639400

ATH:

AT4G31790

ALY:

9305383

CRB:

17879784

CSAT:

104717011 104721658 104730135

EUS:	EUTSA_v10025950mg

BRP:

103851539

BNA:	106372680 106375398

BOE:	106309997 106324828

RSZ:

108822679

THJ:

104825772

CPAP:

110813746

CIT:

102624591

CIC:	CICLE_v10002090mg

PVY:

116141785

MINC:

123203256 123228828

TCC:

18589955

GRA:

105790074

GHI:	107938393 121220142

GAB:

108467847

HSYR:

120209112

DZI:	111301173 111303931

EGR:

104448830

RARG:

115738782

GMX:	100784092 100787586

GSJ:	114401518 114419736

PVU:

137816298

VRA:

106767046

VAR:

108341879

VUN:

114176477

VUM:

124841464

CCAJ:

109805078

APRC:

113860093

MTR:

11437114

TPRA:

123897559

CAM:

101492091

PSAT:

127083950

VVO:	131654877 131660266 131660268

LJA:	130720834 130727816

ADU:	107460175 107465594

AIP:	107609938 107635861

AHF:	112705640 112706912 112722746 112765890

LANG:

109338598

PCIN:

129318647

QSA:	O6P43_030020

FVE:

101310189

AANS:

126783360

RCN:

112171856

PPER:

18792326

PMUM:

103321264

PAVI:

110771090

PDUL:

117616530

MDM:	103428613 103450379

MSYL:

126604444 126631191 126632624

PXB:

103927928

PCOX:

137718066 137749016

ZJU:

107408931

MNT:

21399109

CSAV:

115695856

CSV:

101207207

CMO:	103488034 103497544

BHJ:

120075855

MCHA:

111013896

CMAX:

111492052

CMOS:

111462364

CPEP:

111806080

RCU:

8274645

MEAN:

126656692 126678414

JCU:

105639907

HBR:

110673830

MESC:

110616237 110625574

POP:

7490655

PEU:

105128853

PALZ:

118052715

PNZ:

133691347

JRE:

109021810

CILL:

122316669

CAVE:

132173066

AGLU:

133852231

QSU:

111990871

QLO:

115974524

TWL:

120009391

VVI:

100242000

VRI:

117906452

SLY:

101259434

SPEN:

107015939

SOT:

102593085

SSTN:

125854209

SDUL:

129904320

CANN:

107866886

LBB:

132628107

NTA:	107819004 107821395

NSY:

104231683

NTO:

104104526

NAU:

109241656

INI:

109152797

ITR:

116026784

SIND:

105159337

OEU:

111378944

EGT:

105958950

SSPL:

121754213 121755951

SMIL:

130986634 131000292 131000293

SHIS:

125185524

APAN:

127246499

HPUM:

140863224

PHUA:

140982221

PEBU:

140808128

HAN:

110865884

ECAD:

122605183

LSV:	111920725 111920726 111920734

CCAV:

112502490

DCR:

108215109

CSIN:

114291072

RVL:

131330238

AEW:

130759003

DLT:

127807800

BVG:

104897101

SOE:

110791440

CQI:

110737681

ATRI:

130813883

MOF:

131164388

NNU:

104588007

MING:

122066589 122073320

TSS:

122661827

PSOM:

113330376 113361575

OSA:

4332866

DOSA:

Os03g0355800

OBR:

102714357

OGL:

127767546

BDI:

100846135

ATS:

109767419

TDC:	119301100 119308623

TAES:

123103313 123111503 123120725

TUA:	125508957 125508964

LPER:

127332148

LRD:	124657170 124698354 124698374

SBI:

8082642

ZMA:

100191377

MFLO:

136465958 136539850 136539940 136539941 136543343 136544861

SITA:

101779467

SVS:

117837863

PVIR:

120652326 120652327 120688614

PHAI:

112874462 112874463

PAUA:

133910556 133916089

TANG:

140775321

PDA:

103719882

EGU:	105044158 140857093

MUS:

135605518

ZOF:	122051425 122055670

DCT:

110104280

PEQ:

110033313

AOF:

109838810

MSIN:

131237309

ACAK:

137934793

NCOL:

116246740 116248953

ATR:	18436337 18440152

CJF:

131064637

SMO:	SELMODRAFT_232025 SELMODRAFT_232835

PPP:

112277156

CRE:	CHLRE_05g233300v5

VCN:	VOLCADRAFT_109194

MNG:	MNEG_14986

CSL:	COCSUDRAFT_18056

CVR:	CHLNCDRAFT_54649

APRO:

F751_4143

OLU:	OSTLU_40543

OTA:	OT_ostta16g01480

BPG:	Bathy16g01060

MIS:	MICPUN_88722

MPP:	MICPUCDRAFT_22456

CME:	CYME_CMJ181C

GSL:	Gasu_02030

CCP:	CHC_T00008650001

SCE:	YLR172C(DPH5)

SEUB:

DI49_3689

SPAO:

SPAR_L02070

AGO:	AGOS_AFR123W

ERC:

Ecym_2725

KLA:	KLLA0_F22836g

KMX:	KLMA_40290(DPH5)

LTH:	KLTH0H11748g

VPO:	Kpol_1061p22

ZRO:	ZYRO0E05258g

CGR:	2886596(GVI51_B04873)

NCS:	NCAS_0A08800(NCAS0A08800)

NDI:	NDAI_0G05220(NDAI0G05220)

TPF:	TPHA_0B03580(TPHA0B03580)

TBL:	TBLA_0C01150(TBLA0C01150)

TGB:	HG536_0C02610

TDL:	TDEL_0B06200(TDEL0B06200)

KAF:	KAFR_0I02070(KAFR0I02070)

KNG:	KNAG_0I01400(KNAG0I01400)

ZMK:	HG535_0B04490

SLUD:

SCDLUD_003463

DHA:	DEHA2E23914g

PIC:	PICST_78373(DPH5)

PGU:	PGUG_04761

SPAA:

SPAPADRAFT_61281

LEL:	PVL30_004708(DPH5)

LBG:	92210756(LODBEIA_P55600)

CAL:	CAALFM_C503640WA(CaO19.6676) CAALFM_C503700CA(CaO19.6682)

CTP:	CTRG_05527 CTRG_05542

COT:	CORT_0E05000

CDU:	CD36_53390 CD36_53440

CTEN:

18250680(DPH5)

CLU:	CLUG_05937

CLUS:

A9F13_05g00110

CAUR:

CJI96_0000012

ASAU:

88171165(PUMCH_000096)

PPA:	PAS_chr2-1_0577

PKZ:	C5L36_0C02340

BNN:	FOA43_004172(DPH5)

BBRX:

BRETT_001946(DPH5)

OPA:	HPODL_01338

YLI:	2907831(YALI2_F00633g)

SLB:	AWJ20_4140(DPH5)

NCR:

NCU07266

NTE:	NEUTE1DRAFT61330(NEUTE1DRAFT_61330)

SMP:	10807425(SMAC4_00801)

PAN:	PODANS72p127

PBEL:

QC761_609290(DPH5)

PPSD:

QC762_609290(DPH5)

PPSP:

QC763_609290(DPH5)

PPSA:

QC764_609290(DPH5)

TTT:	THITE_2114762

MTM:	MYCTH_2298356

CTHR:

CTHT_0035270

RTHE:

98125530(VTJ83DRAFT_4400)

MGR:

MGG_10496

PPEI:

PpBr36_00109

PGRI:

PgNI_05025

TMN:	UCRPA7_3374

SSCK:

SPSK_09544

FGR:	FGSG_09628

FPU:	FPSE_05908

FPOA:

FPOAC1_012021(DPH5)

FVN:	FVRRES_13091

FVR:	FVEG_04193

FOX:	FOXG_06341

NHE:	NECHADRAFT_58379

FFC:	NCS54_00280100

FKR:	NCS57_00275900

FMU:	J7337_004191(DPH5)

TRE:	TRIREDRAFT_74943

TRR:	M419DRAFT_5624

TATV:

25775985(TrAtP1_001339)

TASP:

36615874(DPH5)

MAW:	19250682(DPH5_1)

MAJ:

MAA_05103

MBRN:

26237547(DPH5)

PCHM:

VFPPC_09008

CMT:

CCM_04207

AMUS:

LMH87_006389

PLJ:	28882968(PLICBS_001015)

PTKZ:

JDV02_007825(DPH5)

VAL:	VDBG_01098

VDA:	VDAG_00707

CFJ:	CFIO01_03647

CLUP:

CLUP02_17752

CHIG:

CH63R_13946

CDET:

87947514(CDEST_11014)

SAPO:

SAPIO_CDS8449

ELA:	UCREL1_9292

PFY:	PFICI_04920

SSL:	SS1G_09828

BFU:	BCIN_11g05290(Bcdph5)

MBE:

MBM_01613

PSCO:

LY89DRAFT_707325

GLZ:	GLAREA_12726

ANI:	ANIA_00720

AFM:	AFUA_1G14020

ACT:	ACLA_021450

NFI:	NFIA_011450

AOR:	AO090012000475

ANG:	An08g07220

AFV:	AFLA_002196

ALUC:

AKAW2_30367S(DPH5)

ACHE:

ACHE_30546A(DPH5)

APUU:

APUU_11269S(DPH5)

PCS:	N7525_010508

PDP:	PDIP_67100

POU:	POX_c03726

TMF:	EYB26_006140

TRG:	TRUGW13939_08930

CIM:	CIMG_03364

CPW:	9694300(DPH5)

URE:	UREG_07192

ABE:

ARB_00078

TVE:

TRV_00926

PBL:	PAAG_02178

PBN:	PADG_00839

AJE:	HCAG_06727

BGH:	BDBG_03028

PNO:	SNOG_03141

PTE:

PTT_18731

BZE:	COCCADRAFT_9650

BSC:	COCSADRAFT_138369

BOR:	COCMIDRAFT_31430

AALT:

CC77DRAFT_996074

ADAC:

96087726(ACET3X_007404)

ARAB:

EKO05_0000191

ZTR:	MYCGRDRAFT_93945

PFJ:	MYCFIDRAFT_38626

FFU:	CLAFUR5_09631

CBET:

CB0940_10117

BCOM:

BAUCODRAFT_109835

NPA:	UCRNP2_4698

TML:	GSTUM_00008315001

SPO:	2539471(dph5)

SOM:	SOMG_04867(dph5)

CNE:

CNF03650

CNB:

CNBF1170

CNG:	CNAG_06656

CGI:	CGB_F1570W

CDEU:

CNBG_1914

CDEC:

89990861(IAS62_004089)

CTEG:

91990503(I308_103647)

CBAS:

91984085(I312_104040)

CDEP:

91090571(L203_106363)

KMG:	30160840(I203_105208)

KNE:	92184314(IAR55_007056)

KDJ:	28972326(I303_106730)

KBI:	30208983(I302_101211)

KPIN:

30173684(I206_107141)

KSH:	87958071(IL334_005941)

KER:	91103544(V865_004743)

TMS:	TREMEDRAFT_34182

TASA:

A1Q1_05769

CCAC:

CcaHIS019_0600360(DPH5)

PPL:	POSPLDRAFT_88734

TVS:	TRAVEDRAFT_60574

DSQ:	DICSQDRAFT_107082

PCO:	PHACADRAFT_125502

SHS:	STEHIDRAFT_142522

HIR:	HETIRDRAFT_127120

PSQ:	PUNSTDRAFT_121848

ADL:	AURDEDRAFT_113528

FME:	FOMMEDRAFT_131067

GTR:	GLOTRDRAFT_42497 GLOTRDRAFT_8414

LBC:	LACBIDRAFT_334053

CCI:	CC1G_04639

ABP:	AGABI1DRAFT56726(AGABI1DRAFT_56726)

ABV:	AGABI2DRAFT222176(AGABI2DRAFT_222176)

PCUB:

JR316_0002643

MRR:	Moror_1008

E1B28_010254

SCM:	SCHCO_02630999(SCHCODRAFT_02630999)

CPUT:

CONPUDRAFT_125363

SLA:	SERLADRAFT_456781

WSE:	WALSEDRAFT_60529

WIC:	J056_003731

UMA:	UMAG_04406

PFP:	PFL1_05725

SGRA:

EX895_002360

MGL:

MGL_2369

MRT:

MRET_3286

MSYM:

MSY001_1711

PGR:	PGTG_12290

PTRC:

PtA15_4A270

PSTR:

Pst134EA_011375

MLR:	MELLADRAFT_37443

ECU:	ECU11_1430

EIN:	Eint_111320

EHE:	EHEL_111320

ERO:	EROM_111320

NCE:	NCER_101909

VNX:	VNE69_11172

RIE:	OCT59_018595

MBR:	MONBRDRAFT_33663

DDI:	DDB_G0276115(dph5)

DPP:	DICPUDRAFT_37635

DFA:	DFA_02534(dph5)

EHI:	EHI_127240(129.t00009)

EDI:	EDI_190670

EIV:	EIN_379350 EIN_379610

PFA:	PF3D7_1009000

PFH:	PFHG_02658

PREI:

PRSY57_1008400

PGAB:

PGSY75_1009000

PLAG:

39741953(PADL01_1007400)

PYO:	PY17X_1210500

PCB:	PCHAS_1208000

PBE:	PBANKA_1207300

PVV:	PVVCY_1200810

PKN:	PKNH_0808700

PVX:	PVX_094665

PCY:	PCYB_081860

PMAL:

PMUG01_08024900(DPH5)

PREL:

PRELSG_0806800

PCOT:

PCOAH_00022590

TAN:

TA03050

TPV:

TP01_0634

TOT:	TOT_010000583

BEQ:	BEWA_045850

BBO:	BBOV_IV002920

BMIC:

BMR1_03g01210

BBIG:

BBBOND_0111270

CPV:

cgd6_1200

CHO:	Chro.60154

TGO:	TGME49_249920

BBES:

BESB_003710

TET:	TTHERM_00833850

PTM:	GSPATT00026998001 GSPATT00028621001

PTI:	PHATRDRAFT_5236

FCY:	FRACYDRAFT_186536

TPS:	THAPSDRAFT_20788

AAF:	AURANDRAFT_29030

PIF:	PITG_11907

BLAC:

94348549(CCR75_004792)

SPAR:

SPRG_18083

TBR:	Tb927.4.4650

TBG:	TbgDal_IV4830

TCR:	407477.30 511389.130

LMA:	LMJF_31_1610

LIF:	LINJ_31_1640

LDO:	LDBPK_311640

LMI:	LMXM_30_1610

LMAT:

92511591(LSCM1_01468)

LBZ:	LBRM_31_1820

LPAN:

LPMP_311540

LOI:	92359200(LSCM4_03253)

LEIS:

94177095(GH5_01504)

LENR:

94169985(CUR178_02723)

LEIN:

94186457(JIQ42_02754) 94186468(JIQ42_02766)

PHET:

94289961(JKF63_03887)

GLA:	GL50803_0028666

SSAO:

94300948(SS50377_26925)

EHX:	EMIHUDRAFT_236620 EMIHUDRAFT_246613

GTT:	GUITHDRAFT_158589 GUITHDRAFT_49003

» show all

Reference

1 [PMID:3042777]

Authors

Chen JY, Bodley JW.

Title

Biosynthesis of diphthamide in Saccharomyces cerevisiae. Partial purification and characterization of a specific S-adenosylmethionine:elongation factor 2 methyltransferase.

Journal

J Biol Chem 263:11692-6 (1988)

Reference

2 [PMID:3346227]

Authors

Moehring JM, Moehring TJ.

Title

The post-translational trimethylation of diphthamide studied in vitro.

Journal

J Biol Chem 263:3840-4 (1988)

Reference

3 [PMID:24739148]

Authors

Lin Z, Su X, Chen W, Ci B, Zhang S, Lin H

Title

Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis.

Journal

J Am Chem Soc 136:6179-82 (2014)
DOI:10.1021/ja5009272

Sequence

[sce:YLR172C]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.314

IUBMB Enzyme Nomenclature:

2.1.1.314

ExPASy - ENZYME nomenclature database:

2.1.1.314

BRENDA, the Enzyme Database:

2.1.1.314

All links

Gene (3912)   
   MGENES (1200)   
   RefGene (2712)   
Protein sequence (4120)   
   UniProt (4072)   
   SWISS-PROT (18)   
   RefSeq(pep) (30)   
DNA sequence (143)   
   RefSeq(nuc) (55)   
   GenBank (45)   
   EMBL (43)   
Protein domain (5)   
   InterPro (5)   
All databases (8180)   

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