KEGG   ENZYME: 2.1.1.320
Entry
EC 2.1.1.320                Enzyme                                 
Name
type II protein arginine methyltransferase;
PRMT5 (gene name);
PRMT9 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega'-dimethyl-L-arginine-forming)
Reaction(IUBMB)
2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-Nomega,Nomega'-dimethyl-L-arginine (overall reaction) [RN:R11220];
(1a) S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine [RN:R11216];
(1b) S-adenosyl-L-methionine + [protein]-Nomega-methyl-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega,Nomega'-dimethyl-L-arginine [RN:R11218]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[protein]-L-arginine [CPD:C00613];
[protein]-Nomega-methyl-L-arginine [CPD:C04143]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[protein]-Nomega,Nomega'-dimethyl-L-arginine [CPD:C21189];
[protein]-Nomega-methyl-L-arginine [CPD:C04143]
Comment
The enzyme catalyses the methylation of one of the terminal guanidino nitrogen atoms in arginine residues within proteins, forming monomethylarginine, followed by the methylation of the second terminal nitrogen atom to form a symmetrical dimethylarginine. The mammalian enzyme is active in both the nucleus and the cytoplasm, and plays a role in the assembly of snRNP core particles by methylating certain small nuclear ribonucleoproteins. cf. EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.321, type III protein arginine methyltransferase, and EC 2.1.1.322, type IV protein arginine methyltransferase.
History
EC 2.1.1.320 created 2015
Orthology
K02516  type II protein arginine methyltransferase
K19737  type II protein arginine methyltransferase
Genes
HSA10419(PRMT5) 90826(PRMT9)
PTR452789(PRMT5) 461532(PRMT9)
PPS100969512(PRMT9) 100984604(PRMT5)
GGO101135513(PRMT9) 101153684(PRMT5)
PON100173581(PRMT5) 100441291(PRMT9)
NLE100583805(PRMT5) 100583992(PRMT9)
MCC708267(PRMT9) 712718(PRMT5)
MCF101866818(PRMT5) 102116652(PRMT9)
MTHB126955377 126958267
CSAB103231449(PRMT5) 103236353(PRMT9)
CATY105580734(PRMT9) 105598789(PRMT5)
PANU101022221(PRMT5) 101024788(PRMT9)
TGE112624969(PRMT9) 112629053(PRMT5)
RRO104660206(PRMT9) 104674138(PRMT5)
RBB108514052(PRMT9) 108523581(PRMT5)
TFN117069989(PRMT5) 117085999(PRMT9)
PTEH111552874(PRMT9) 111554784(PRMT5)
CJC100390650(PRMT5) 100408126(PRMT9)
SBQ101035264(PRMT9) 101038820(PRMT5)
CSYR103267456(PRMT9) 103267682(PRMT5)
MMUR105864709(PRMT5) 105881836(PRMT9)
LCAT123620536(PRMT5) 123638473(PRMT9)
OGA100955969(PRMT9) 100958457(PRMT5)
MMU102182(Prmt9) 27374(Prmt5)
MCAL110291194 110299990(Prmt9) 110309285(Prmt5)
MPAH110326015(Prmt5)
RNO291947(Prmt9) 364382(Prmt5)
MCOC116069601(Prmt9) 116084769(Prmt5)
MUN110550042(Prmt5) 110551093(Prmt9)
CGE100768836(Prmt5) 100773595(Prmt9)
MAUA101826948(Prmt5) 101832646(Prmt9)
PLEU114688095(Prmt9) 114708710(Prmt5)
MORG121434960(Prmt5) 121455765(Prmt9)
MFOT126487799 126490917
AAMP119800014(Prmt5) 119801630 119801839(Prmt9)
NGI103739477(Prmt5) 103748462(Prmt9)
HGL101722396(Prmt5) 101724582(Prmt9)
CPOC100722293(Prmt9) 100731218(Prmt5)
CCAN109685803(Prmt5) 109697645(Prmt9)
DORD105992550(Prmt5) 105995671(Prmt9)
DSP122113481(Prmt5) 122127096(Prmt9)
NCAR124976733 124994373
OCU100357415(PRMT5) 100358967(PRMT9)
OPI101517727(PRMT5) 101519780(PRMT9)
TUP102471509(PRMT5) 102499397(PRMT9)
CFA475460(PRMT9) 480242(PRMT5)
CLUD112654353(PRMT9) 112656977(PRMT5)
VVP112926498(PRMT5) 112934680(PRMT9)
VLG121481341(PRMT9) 121493068(PRMT5)
AML100473723(PRMT5) 100474793(PRMT9)
UMR103658007(PRMT9) 103681032(PRMT5)
UAH113246049(PRMT5) 113255735(PRMT9)
UAR123793230(PRMT9) 123795794(PRMT5)
ELK111156940 111161708
LLV125093024 125104964
MPUF101687523(PRMT9) 101687899(PRMT5)
ORO101362645(PRMT9) 101367846(PRMT5) 101384882
EJU114217952(PRMT5) 114225559(PRMT9)
ZCA113910291(PRMT5) 113924355(PRMT9)
MLX118003725(PRMT5) 118007452 118022262(PRMT9)
NSU110585132(PRMT5) 110588448(PRMT9) 110588807
FCA101082901(PRMT9) 101091118(PRMT5)
PYU121028754(PRMT9) 121031494(PRMT5)
PBG122468876(PRMT5) 122475745(PRMT9)
LRUF124508814 124520492
PTG102951801(PRMT9) 102965178(PRMT5)
PPAD109250102(PRMT9) 109255038(PRMT5)
AJU106983326(PRMT9) 106988224(PRMT5)
HHV120240489(PRMT5) 120246304(PRMT9)
BTA515594(PRMT5) 532021(PRMT9)
BOM102265210(PRMT9) 102279561(PRMT5)
BIU109564815(PRMT5) 109571187(PRMT9)
BBUB102395876(PRMT9) 102409425(PRMT5)
CHX102173593(PRMT9) 102176421(PRMT5)
OAS101102816(PRMT5) 101108080(PRMT9)
ODA120853421(PRMT5) 120871457(PRMT9)
CCAD122443211(PRMT5) 122451867(PRMT9)
SSC100294711(PRMT5) 100521981(PRMT9)
CFR102518881(PRMT5) 102519361(PRMT9)
CBAI105068662(PRMT9) 105068767(PRMT5)
CDK105091220(PRMT9) 105096972(PRMT5)
VPC102529821(PRMT5) 102533199(PRMT9)
BACU103004982(PRMT5) 103008208(PRMT9)
LVE103069919(PRMT9) 103082461(PRMT5)
OOR101270835(PRMT9) 101283289(PRMT5)
DLE111164191(PRMT5) 111178406 111187701(PRMT9)
PCAD102980796(PRMT9) 102985567(PRMT5)
PSIU116749826(PRMT5) 116754111(PRMT9)
ECB100052729(PRMT5) 100070676(PRMT9)
EPZ103555690(PRMT9) 103556731(PRMT5)
EAI106829177(PRMT9) 106840656(PRMT5)
MYB102247375(PRMT9) 102259179(PRMT5)
MYD102751352(PRMT9) 102774930(PRMT5)
MMYO118658042(PRMT9) 118679281(PRMT5)
MLF102424649(PRMT5) 102438455(PRMT9)
MNA107531694(PRMT5) 107532508(PRMT9)
PKL118710740(PRMT9) 118724906(PRMT5)
HAI109392732(PRMT9) 109393677(PRMT5)
DRO112301472(PRMT5) 112312544(PRMT9)
SHON118980959(PRMT5) 118995413(PRMT9)
AJM119037303(PRMT5) 119061732(PRMT9)
PDIC114491697(PRMT5) 114504209(PRMT9)
PHAS123814202(PRMT9) 123820505(PRMT5)
MMF118616192(PRMT9) 118630475(PRMT5)
RFQ117023246(PRMT5) 117037742(PRMT9)
PALE102885673(PRMT5) 102897642(PRMT9)
PGIG120593832(PRMT5) 120613311(PRMT9)
PVP105291550(PRMT9) 105300523(PRMT5)
RAY107498002(PRMT5) 107517768(PRMT9)
MJV108384723(PRMT9) 108400035(PRMT5)
TOD119233712(PRMT9) 119238910(PRMT5)
SARA101546190(PRMT9) 101549900(PRMT5)
LAV100662130(PRMT9) 100672667(PRMT5)
TMU101344593 101350139
DNM101416816(PRMT5) 101447810(PRMT9)
MDO100024287(PRMT5) 100025895(PRMT9)
GAS123236024(PRMT5) 123251590(PRMT9)
SHR100918751(PRMT9) 100923294(PRMT5)
PCW110213657(PRMT9) 110223717(PRMT5)
OAA100079858(PRMT9) 100090626(PRMT5)
GGA422470(PRMT9)
PCOC116226127(PRMT9) 116239779(PRMT5)
MGP100546295(PRMT9) 104915775(PRMT5)
CJO107307212(PRMT5) 107313138(PRMT9)
NMEL110398593(PRMT9)
APLA101797154(PRMT9)
ACYG106032235(PRMT9)
AFUL116488777(PRMT9) 116501633(PRMT5)
TGU100221621(PRMT9)
LSR110473778(PRMT9) 110482783(PRMT5)
SCAN103826078(PRMT9)
PMOA120497231(PRMT9)
OTC121339868(PRMT9)
PRUF121365219(PRMT9)
GFR102038881(PRMT9)
FAB101819740(PRMT9)
PHI102102600(PRMT5) 102112252(PRMT9)
PMAJ107203471(PRMT9)
CCAE111922090(PRMT5) 111928844(PRMT9)
CCW104697242(PRMT9)
CBRC103622348(PRMT9)
ETL114070210(PRMT9)
ZAB102068138(PRMT9)
ACHL103803833(PRMT9)
FPG101918237(PRMT9)
FCH102058436(PRMT9)
CLV102096595(PRMT9)
EGZ104130586(PRMT9)
NNI104015966(PRMT9)
PLET104626309(PRMT9)
PCRI104024736(PRMT9)
ACUN113479775(PRMT9)
TALA104363670(PRMT9)
PADL103919905(PRMT9)
AFOR103899735(PRMT9)
ACHC115338601(PRMT9)
HALD104318797(PRMT9)
CCRI104157973(PRMT9)
CSTI104556390(PRMT9)
EHS104512336(PRMT9)
CMAC104483395(PRMT9)
MUI104544319(PRMT9)
FGA104070150(PRMT9)
GSTE104259668(PRMT9)
LDI104340320(PRMT9)
MNB103780088(PRMT9)
OHA104337009(PRMT9)
NNT104410545(PRMT9)
DPUB104296909(PRMT9)
PGUU104466535(PRMT9)
ACAR104526172(PRMT9)
AVIT104269978(PRMT9)
CVF104291497(PRMT9)
AAM106492009(PRMT9)
AROW112976358(PRMT9)
NPD112950117(PRMT9)
TGT104578583(PRMT9)
DNE112986847(PRMT9)
SCAM104153364(PRMT9)
ASN102369472(PRMT9) 102376326(PRMT5)
AMJ102567905(PRMT9) 102573715(PRMT5)
CPOO109309656(PRMT9)
GGN109301203(PRMT9)
PSS102456502(PRMT9)
CMY102931547(PRMT5) 102933173(PRMT9)
CPIC101937959(PRMT9) 101945173(PRMT5)
TST117878080(PRMT9)
CABI116818420(PRMT5) 116832478(PRMT9)
MRV120380919(PRMT5) 120406615(PRMT9)
ACS100555438(prmt5) 100566556(prmt9)
PVT110073621(PRMT9) 110087819(PRMT5)
SUND121931957(PRMT9) 121935069(PRMT5)
PBI103053165(PRMT5) 103065716(PRMT9)
PMUR107287892(PRMT9) 107294118(PRMT5)
CTIG120313587(PRMT9) 120317983(PRMT5)
TSR106542538 106546369(PRMT9) 106549143(PRMT5)
PGUT117657309(PRMT5) 117680284(PRMT9)
VKO123018640(PRMT5) 123023769(PRMT9)
PMUA114581890(PRMT5) 114604752(PRMT9)
ZVI118084504(PRMT9) 118095163(PRMT5)
GJA107106184(PRMT5) 107116534(PRMT9)
STOW125440128(PRMT9) 125444809(PRMT5)
XLA407754(prmt5.S) 495515(prmt5.L) 779342(prmt9.L)
XTR100145788(prmt5) 100216218(prmt9)
NPR108785213(PRMT9) 108786750(PRMT5)
RTEM120919599(PRMT9) 120941031(PRMT5)
BBUF120989029(PRMT5) 120990023 120990024
BGAR122933106(PRMT5) 122943026(PRMT9)
DRE368664(prmt5) 553290(prmt9)
SRX107706342(prmt5) 107734542(prmt9) 107738202 107742543
SANH107668985 107670713(prmt9) 107694666
SGH107550666(prmt9) 107558089 107591393
CCAR109067790(prmt5) 109077115(prmt9)
CAUA113044973 113095006(prmt9) 113119990
PPRM120465134(prmt5) 120477360(prmt9)
MAMB125250760(prmt5) 125272087(prmt9)
IPU100862741(prmt5) 108263142(prmt9)
PHYP113539781(prmt5) 113542450(prmt9)
SMEO124388139(prmt5) 124400182(prmt9)
TFD113644123(prmt5) 113662648(prmt9)
AMEX103022172(prmt9) 103045296(prmt5)
EEE113589193(prmt5) 113590198(prmt9)
TRU101076778(prmt5) 101079919(prmt9)
TNGGSTEN00015158G001 GSTEN00032887G001
LCO104917887(prmt9) 104931179(prmt5)
NCC104955606(prmt5)
CGOB115009624(prmt9) 115023150(prmt5)
ELY117255416(prmt9) 117271481(prmt5)
EFO125885820(prmt9) 125902558(prmt5)
PLEP121941900(prmt9) 121951330(prmt5)
SLUC116034372(prmt9) 116057961(prmt5)
ECRA117954465(prmt5) 117957365(prmt9)
ESP116698900(prmt5) 116705694(prmt9)
PFLV114546840(prmt9) 114565132(prmt5)
GAT120816086(prmt5) 120825200(prmt9)
PPUG119209709(prmt5) 119217468(prmt9)
MSAM119898851(prmt9) 119902509(prmt5)
CUD121508264(prmt9) 121519591(prmt5)
ALAT119011220(prmt5) 119021319(prmt9)
MZE101478579(prmt9) 101486164(prmt5)
ONL100711244(prmt5) 100711939(prmt9)
OAU116330124(prmt9) 116333762(prmt5)
OLA100144380(prmt5) 101156711(prmt9)
OML112137407(prmt9) 112147675(prmt5)
XMA102235844(prmt5) 102238012(prmt9)
XCO114144574(prmt9) 114147165(prmt5)
XHE116719635(prmt9) 116722301(prmt5)
PRET103471363(prmt9) 103478892(prmt5)
PFOR103138414(prmt5) 103144843(prmt9)
PLAI106934772(prmt5) 106955481(prmt9)
PMEI106903835(prmt5) 106925469(prmt9)
GAF122829818(prmt9) 122840708(prmt5)
CVG107087708(prmt5) 107102822(prmt9)
CTUL119773876(prmt9) 119793383(prmt5)
GMU124868518(prmt9) 124870643(prmt5)
NFU107384235(prmt5) 107388313(prmt9)
KMR108231448(prmt9) 108238589(prmt5)
ALIM106514955(prmt5) 106527548(prmt9)
NWH119414444(prmt5) 119423116(prmt9)
AOCE111563252(prmt9) 111584912(prmt5)
MCEP125003954(prmt9) 125010859(prmt5)
CSEM103383354(prmt9) 103396603(prmt5)
POV109638324(prmt9) 109646024(prmt5)
SSEN122771604(prmt9) 122773940(prmt5)
HHIP117763076(prmt9) 117778917(prmt5)
HSP118118104(prmt5) 118120222(prmt9)
LCF108883946 108893098
SDU111216597(prmt9) 111223811(prmt5)
SLAL111652933(prmt9) 111666520(prmt5)
XGL120799500(prmt5) 120800062(prmt9)
HCQ109512807(prmt5)
BPEC110165484(prmt9) 110170406(prmt5)
MALB109955535(prmt9) 109962655(prmt5)
BSPL114844963(prmt5) 114855074(prmt9)
SASA100380736(anm5) 106569427 106610222(YD010) 106610226(prmt9)
STRU115157327 115169480 115191795 115202229
OTW112226699 112235700 112261285 112261295
OMY110497372 110508474 110530616 110534523 118944823
OGO124001867 124009364 124012363 124041584(prmt5)
ONE115102773 115114685 115137499 115145591
SALP111956635 111979295 112069588(prmt9)
SNH120019969(prmt5) 120034691 120053051
CCLU121535645 121536013 121581123(prmt5) 123490859
ELS105020932(prmt9) 105021437(prmt5)
SFM108924575(prmt9) 108937898(prmt5)
PKI111837323(prmt9) 111854545(prmt5)
AANG118226347(prmt9) 118233967(prmt5)
LOC102684451(prmt9)
PSPA121296896 121305266(prmt5) 121323056(prmt9)
ARUT117398342(prmt5) 117408525(prmt9)
LCM102356690(PRMT9) 102358052(PRMT5)
CMK103182233(prmt9)
RTP109936519(prmt9)
BFO118417461 118419403
BBEL109470545 109473835
CIN100180206 100186564 101242933
SCLV120330335 120332796 120347154
SPU754460
APLC110974704 110976990
SKO100375736 102801052
DMEDmel_CG3730(csul)
DER6548647
DSE6609412
DSIDsimw501_GD11176(Dsim_GD11176)
DYADyak_GE11771
DAN6496421
DSR110182389
DPO4803820
DPE6590738
DMN108159271 117188489 117189453 117189454 117189455 117189456 117191548
DWI6638460
DGR6559311
DMODmoj_GI19242
DAZ108616764
DNV108653696
DHE111600717
DVI6627219
CCAT101455408
BOD106619120
RZE108382555
MDE101892351
SCAC106089590
LCQ111680705
LSQ119612110
HIS119647953
AGAAgaP_AGAP009048 AgaP_AGAP010203
ACOZ120958787 120959329
AARA120901034 120903942
ASTE118511053 118514539
AAG110676669 110680820 5569383
AALB109409622 109410215 109413765 115258888
CQUCpipJ_CPIJ001916 CpipJ_CPIJ005601
CPII120416303 120430020
CNS116341589 116345712 116345866 116347306
BCOO119068709 119068711 119078567
AME100577481 410664
ACER107992724 107994702
ALAB122712472 122716479
BIM100742212 100747841
BBIF117204503 117207572
BVK117233016 117233167
BVAN117153600 117156849
BTER100650563 100651844
BPYO122569568 122572980
CCAL108625161 108629796
OBB114872620 114878652
MGEN117224576 117228657
NMEA116425247 116433129
CGIG122395081 122399669
SOC105201826 105204607
MPHA105828876 105839136
AEC105145803 105154070
ACEP105617959 105624186
PBAR105428490 105428724
VEM105555698 105567317
HST105187543 105190569
DQU106746759 106750763
CFO105252174 105256771
FEX115232782 115234311
LHU105672176 105675835
PGC109853176 109855746
OBO105283422 105285797 113561771
PCF106790596
PFUC122525568
VPS122630889 122633486
NVI100115766 100117949
CSOL105364721 105366849
TPRE106654631
MDL103572761
CGLO123267144
FAS105271425 105273376
DAM107044338 107048198
AGIF122856623 122856645
LHT122498985
CCIN107269179
TCA100141922 657559
DPA109533205 109534684
SOY115879921 115888144
ATD109597746 109603391 109605435
CSET123309647 123315006
AGB108907969 108912839
LDC111503238 111510166
NVL108565983 108566929
APLN108732725
PPYR116169593 116172951
OTU111413425 111417095 111422991
BMOR101742218 101744972
BMAN114247171 114251753
MSEX115441884 115447852
DPLKGM_204390
BANY112046612 112058205
NIQ126779110
PMAC106707819 106710388
PPOT106108025 106111209
PXU106114739 106117473
PRAP110993490 110993724
ZCE119830095 119830255 119830325
HAW110376597 110383841
HZE124639013 124640649
TNL113492573 113492954
SLIU111354203 111354560
OFU114351797 114359442 114360068
PXY105386740
CFEL113372589
API100159228 100163950
DNX107168703 107173481
AGS114126002 114127680 114127989 114130304
RMD113551000 113559804
BTAB109031411 109033240
DCI103507092 103509794 103509797
CLEC106666548 106673810
HHAL106682090 106687501
NLU111043959 111051610 111052729 120354707
PHUPhum_PHUM336830 Phum_PHUM351000
FOC113202964 113204246
TPAL117640531 117653776
ZNE110828466 110828507
CSEC111866851 111867498
FCD110858236 110863539
DPXDAPPUDRAFT_308857
DMK116926041
PVM113800113 113820721 113825410
PJA122243062 122247295
PCHN125038953 125042373
HAME121860584 121867170
PCLA123747014 123759643
PTRU123499596 123503444
HAZT108665615 108666473
EAF111706796 111712583
LSM121121229
PPOI119098646 119107653
ISCIscW_ISCW012935 IscW_ISCW023698
DSV119434241 119449462
RSAN119382627 119405323
RMP119171718 119179226
VDE111252872
VJA111266429
TUT107360578
DPTE113797881
DFR124493709
CSCU111613486 111625596
PTEP107437363 107444462
SDM118202056 118203147
CELCELE_C34E10.5(prmt-5)
CBRCBG_21172(Cbr-prmt-5)
BMYBM_BM2581(Bma-prmt-5) BM_BM9023(Bma-prmt-9)
LOALOAG_08049 LOAG_17545
NAINECAME_10236 NECAME_10574
TSPTsp_06312 Tsp_08085
HROHELRODRAFT_187900 HELRODRAFT_68344
LGILOTGIDRAFT_194048 LOTGIDRAFT_71709
PCAN112559436 112576494
BGT106069343 106069677
GAE121375019 121388903
HRF124112845 124134391
HRJ124252668 124259965 124266338
CRG105319241 105323137
MYI110443758 110457238
PMAX117329084 117337151
MMER123544374 123549629 123557667
OBI106882157
OSN115210539
LAK106152235 106160933 106166924
SMMSmp_171150
SHXMS3_00006290(PRMT5_1)
OVIT265_08688
EGLEGR_00178
NVE5503639 5510314 5513411
EPA110235880 110241550 110248417
ATEN116300376 116303597 116305266
ADF107350982 107353005
AMIL114959722 114977780
PDAM113671820 113673947
SPIS111325879 111329551
DGT114516490 114536906
XEN124437431 124442595
HMG100206587
TADTRIADDRAFT_56661 TRIADDRAFT_59862
AQU100633293 100639403
ATHAT4G31120(SKB1)
ALY9303386
CRB17878662
CSAT104717081 104721724 104730184
EUSEUTSA_v10000136mg EUTSA_v10000691mg EUTSA_v10024653mg
BRP103834634 103862031
BNA106372843 106390035 106411055 106424099 106452791
BOE106301318 106328602 106329370
RSZ108819403 108831826 108855733
THJ104803893
CIT102629964
CICCICLE_v10007631mg
PVY116127692
MINC123208150
TCC18587570
GRA105789848
GHI107930849 107932997
GAB108450507
DZI111302818
EGR104442376
GMX100782245 100815240
GSJ114409031 114415053
PVUPHAVU_009G099900g
VRA106762815
VAR108329933
VUN114163791
CCAJ109809478
APRC113847793 113847801 113866204
MTR11431985
CAM101494476 101494797 101495989 101500972
LJALj1g3v1955070.1(Lj1g3v1955070.1) Lj1g3v1965080.1(Lj1g3v1965080.1)
ADU107463077
AIP107613516
AHF112707790 112771657
LANG109327133 109328609
FVE101293505
RCN112170552
PPER18793346
PMUM103319997
PAVI110774549
PDUL117624497
MDM103400227 103428827
PXB103931156 103953552 103966016
ZJU107420807
MNT21398021
CSV101221977
CMO103503776
BHJ120087351
MCHA111023018
CMAX111481292
CMOS111445899
CPEP111788127
RCU8282110
JCU105646318
HBR110640900
MESC110628124
POP7490510
PEU105109858
PALZ118059448
JRE108985498 109009600
QSU111995511 112019252
QLO115971268
TWL120004835
VVI100242249
VRI117912840
SLY101255013
SPEN107028915
SOT102597573
SSTN125877883
CANN107853969
NTA107817563 107828310
NSY104235380
NTO104114534
NAU109243424
INI109191495
ITR116006596
SIND105159937
OEU111373032
EGT105967215
SSPL121766336 121769996
HAN110930143
ECAD122599741
LSV111903484
CCAV112529217
DCR108205097
CSIN114281953
BVG104886755
SOE110783941
CQI110683813 110710133
NNU104590273
MING122081344
TSS122659794
PSOM113341070 113355712
NCOL116266943
OSA4328251
DOSAOs02t0139200-01(Os02g0139200)
OBR102701698
BDI100833717
ATS109761313
TDC119315149 119320382
TAES123132175 123136208 123143713
TUA125513479
SBI8069950
ZMA100273548 100383756
SITA101755713
SVS117846360
PVIR120645102 120654616
PHAI112886540
PDA103712231
EGU105049252
MUS103999845
DCT110104632
PEQ110029550
AOF109823243 109838030
ATR18440815
SMOSELMODRAFT_131598 SELMODRAFT_183431
PPP112290561 112294900
VCNVOLCADRAFT_56541
MNGMNEG_0265 MNEG_10514
CSLCOCSUDRAFT_52768
CVRCHLNCDRAFT_142244
APROF751_6950
OLUOSTLU_34972
OTAOT_ostta09g03510
BPGBathy10g01050
MISMICPUN_86035
MPPMICPUCDRAFT_45363
GSLGasu_33490
CCPCHC_T00000212001
SCEYBR133C(HSL7)
SEUBDI49_1163
SPAOSPAR_B02330
AGOAGOS_ABR110W
ERCEcym_5439
KLAKLLA0_C15829g
KMXKLMA_70212(HSL7)
LTHKLTH0F11242g
VPOKpol_526p11
ZROZYRO0C17226g
CGRCAGL0C00517g
NCSNCAS_0I02020(NCAS0I02020)
NDINDAI_0A06610(NDAI0A06610)
TPFTPHA_0A02440(TPHA0A02440)
TBLTBLA_0C02500(TBLA0C02500)
TDLTDEL_0C05360(TDEL0C05360)
TGBHG536_0B01850
KAFKAFR_0K01370(KAFR0K01370)
KNGKNAG_0B01260(KNAG0B01260)
ZMKHG535_0A01820
PPAPAS_chr2-2_0491
DHADEHA2E22528g
PICPICST_46913(SKB1)
PGUPGUG_02814
CTENCANTEDRAFT_112835
YLIYALI0E18524g
CLUCLUG_02620
CLUSA9F13_07g02475
CAURCJI97_003188
SLBAWJ20_4017(HSL7)
PKZC5L36_0A03080
BNNFOA43_000290
BBRXBRETT_000338
OPAHPODL_03102
NCRNCU01613(pp-2)
NTENEUTE1DRAFT83626(NEUTE1DRAFT_83626)
SMPSMAC_02353
PANPODANSg7039
TTTTHITE_2124178
MTMMYCTH_2071301
CTHRCTHT_0005770
MGRMGG_03894
PPEIPpBr36_04362
TMNUCRPA7_854
SSCKSPSK_01025
FGRFGSG_10756
FPUFPSE_01329
FVRFVEG_11418
FOXFOXG_12683
NHENECHADRAFT_40291(PRMT2102)
TRETRIREDRAFT_107383
TRRM419DRAFT_81062
MAWMAC_03615
MAJMAA_02573
CMTCCM_00198
PLJVFPFJ_06805
VALVDBG_01549
VDAVDAG_02006
CFJCFIO01_12720
CLUPCLUP02_01419
CHIGCH63R_10319
SAPOSAPIO_CDS6645
ELAUCREL1_529
PFYPFICI_11347
SSLSS1G_02372
BFUBCIN_13g02360(Bchsl7)
MBEMBM_07410
PSCOLY89DRAFT_679945
GLZGLAREA_01531
ANIAN0134.2
AFMAFUA_5G11610
ACTACLA_014680
NFINFIA_075660
AORAO090026000665
ANGANI_1_394164(An18g03130)
AFVAFLA_005626
ALUCAKAW2_31272A(SKB1)
ACHEACHE_41170A(SKB1)
APUUAPUU_12017A(SKB1)
PCSPc21g06690
PDPPDIP_60180
TMFPMAA_030820
TRGTRUGW13939_05631
CIMCIMG_09164
CPWCPC735_015820
UREUREG_05212
PBLPAAG_02402
PBNPADG_05543
ABEARB_03101
TVETRV_05821
AJEHCAG_00842
BGHBDBG_01016
PNOSNOG_07246
PTEPTT_06560
BZECOCCADRAFT_96167
BSCCOCSADRAFT_232017
BORCOCMIDRAFT_28541
AALTCC77DRAFT_1030172
ZTRMYCGRDRAFT_75506(PRMT2402)
PFJMYCFIDRAFT_58569
FFUCLAFUR5_11030
BCOMBAUCODRAFT_78806
NPAUCRNP2_866
TMLGSTUM_00005832001
SPOSPBC16H5.11c(skb1)
CNECNC04460
CNBCNBC2710
CNGCNAG_02829
CGICGB_C6570C
TMSTREMEDRAFT_41913
TASAA1Q1_07079
TVSTRAVEDRAFT_168974
DSQDICSQDRAFT_80230
PCOPHACADRAFT_193338
SHSSTEHIDRAFT_137064
HIRHETIRDRAFT_417080
PSQPUNSTDRAFT_146143
ADLAURDEDRAFT_84835
FMEFOMMEDRAFT_131412
GTRGLOTRDRAFT_116729
CCICC1G_14413
ABPAGABI1DRAFT59773(AGABI1DRAFT_59773)
ABVAGABI2DRAFT218502(AGABI2DRAFT_218502)
MRRMoror_13136
MOREE1B28_011434
SCMSCHCO_01094928(SCHCODRAFT_01094928)
CPUTCONPUDRAFT_163226
SLASERLADRAFT_356020
WSEWALSEDRAFT_41813(Skb1)
WICJ056_001320
UMAUMAG_15057
PFPPFL1_00903
MGLMGL_4031
MRTMRET_4121
MSYMMSY001_2173
PGRPGTG_08883
MLRMELLADRAFT_116545
MBRMONBRDRAFT_12628 MONBRDRAFT_31396
SREPTSG_04292 PTSG_05845
DDIDDB_G0287327(prmt5)
DPPDICPUDRAFT_28207
DFADFA_08931(prmt5)
EHIEHI_158560(277.t00010)
EDIEDI_036640
EIVEIN_223690
ACANACA1_061190 ACA1_263190
PFAPF3D7_1361000
PFHPFHG_03275
PREIPRSY57_1359900
PGABPGSY75_1361000
PYOPY17X_1138500
PCBPCHAS_1136600
PBEPBANKA_1137100
PVVPVVCY_1103820
PKNPKNH_1110400
PVXPVX_115010
PCYPCYB_111960
TANTA20055
TPVTP01_0100
TOTTOT_010000092
BEQBEWA_033740
BBOBBOV_IV000750(21.m03003)
BMICBMR1_03g00025
BBIGBBBOND_0403230
CPVcgd7_3600
CHOChro.70401
TGOTGME49_215560(PRMT5)
PTMGSPATT00032324001
SMINv1.2.004362.t1(symbB.v1.2.004362.t1) v1.2.004363.t1(symbB.v1.2.004363.t1)
PTIPHATRDRAFT_16141
FCYFRACYDRAFT_187478
TPSTHAPSDRAFT_24429
NGDNGA_2015400(PRMT5)
AAFAURANDRAFT_1146(PRMT1)
PIFPITG_12489
PSOJPHYSODRAFT_516025
SPARSPRG_02020
EHXEMIHUDRAFT_67341 EMIHUDRAFT_72646
GTTGUITHDRAFT_107339 GUITHDRAFT_159368
TBRTb10.70.7570
TBGTbgDal_X650
TCR506853.30
LMALMJF_21_1450(PRMT5)
LIFLINJ_21_1690(PRMT5)
LDOLDBPK_211690
LMILMXM_21_1450
LBZLBRM_21_1830(PRMT5)
LPANLPMP_211660(PRMT5)
NGRNAEGRDRAFT_39225
TVATVAG_2v0058600 TVAG_2v0655230
 » show all
Reference
1  [PMID:11413150]
  Authors
Branscombe TL, Frankel A, Lee JH, Cook JR, Yang Z, Pestka S, Clarke S
  Title
PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins.
  Journal
J Biol Chem 276:32971-6 (2001)
DOI:10.1074/jbc.M105412200
Reference
2  [PMID:17363895]
  Authors
Wang X, Zhang Y, Ma Q, Zhang Z, Xue Y, Bao S, Chong K
  Title
SKB1-mediated symmetric dimethylation of histone H4R3 controls flowering time in  Arabidopsis.
  Journal
EMBO J 26:1934-41 (2007)
DOI:10.1038/sj.emboj.7601647
  Sequence
[ath:AT4G31120]
Reference
3  [PMID:18404153]
  Authors
Lacroix M, El Messaoudi S, Rodier G, Le Cam A, Sardet C, Fabbrizio E
  Title
The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5.
  Journal
EMBO Rep 9:452-8 (2008)
DOI:10.1038/embor.2008.45
  Sequence
[hsa:10419]
Reference
4  [PMID:18984161]
  Authors
Chari A, Golas MM, Klingenhager M, Neuenkirchen N, Sander B, Englbrecht C, Sickmann A, Stark H, Fischer U
  Title
An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.
  Journal
Cell 135:497-509 (2008)
DOI:10.1016/j.cell.2008.09.020
  Sequence
[hsa:10419]
Reference
5  [PMID:23071334]
  Authors
Antonysamy S, Bonday Z, Campbell RM, Doyle B, Druzina Z, Gheyi T, Han B, Jungheim LN, Qian Y, Rauch C, Russell M, Sauder JM, Wasserman SR, Weichert K, Willard FS, Zhang A, Emtage S
  Title
Crystal structure of the human PRMT5:MEP50 complex.
  Journal
Proc Natl Acad Sci U S A 109:17960-5 (2012)
DOI:10.1073/pnas.1209814109
  Sequence
[hsa:10419]
Reference
6  [PMID:25979344]
  Authors
Hadjikyriacou A, Yang Y, Espejo A, Bedford MT, Clarke SG
  Title
Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2.
  Journal
J Biol Chem 290:16723-43 (2015)
DOI:10.1074/jbc.M115.659433
  Sequence
[hsa:90826]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.320
IUBMB Enzyme Nomenclature: 2.1.1.320
ExPASy - ENZYME nomenclature database: 2.1.1.320
BRENDA, the Enzyme Database: 2.1.1.320

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