KEGG   ENZYME: 2.1.1.321
Entry
EC 2.1.1.321                Enzyme                                 
Name
type III protein arginine methyltransferase;
PRMT7 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega-methyl-L-arginine-forming)
Reaction(IUBMB)
S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine [RN:R11216]
Reaction(KEGG)
R11216
Substrate
S-adenosyl-L-methionine [CPD:C00019];
protein-L-arginine [CPD:C00613]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[protein]-Nomega-methyl-L-arginine
Comment
Type III protein arginine methyltransferases catalyse the single methylation of one of the terminal nitrogen atoms of the guanidino group in an L-arginine residue within a protein. Unlike type I and type II protein arginine methyltransferases, which also catalyse this reaction, type III enzymes do not methylate the substrate any further. cf. EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.320, type II protein arginine methyltransferase, and EC 2.1.1.322, type IV protein arginine methyltransferase.
History
EC 2.1.1.321 created 2015
Orthology
K11438  type III protein arginine methyltransferase
Genes
HSA54496(PRMT7)
PTR454190(PRMT7)
PPS100984194(PRMT7)
GGO101143219(PRMT7)
PON100458610(PRMT7)
NLE100594100(PRMT7)
MCC702853(PRMT7)
MCF102139106(PRMT7)
CSAB103233235(PRMT7)
CATY105583389(PRMT7)
PANU101004554(PRMT7)
TGE112614072(PRMT7)
RRO104655594(PRMT7)
RBB108515353(PRMT7)
TFN117088485(PRMT7)
PTEH111541384(PRMT7)
CJC100407526(PRMT7)
SBQ101038150(PRMT7)
CSYR103269768(PRMT7)
MMUR105858927(PRMT7)
LCAT123625170(PRMT7)
OGA100958640(PRMT7)
MMU214572(Prmt7)
MCAL110300561(Prmt7)
MPAH110337323(Prmt7)
RNO361402(Prmt7)
MCOC116070095(Prmt7)
MUN110545908(Prmt7)
CGE100759617(Prmt7)
MAUA101835079(Prmt7)
PLEU114683434(Prmt7)
MORG121446822(Prmt7)
AAMP119801922(Prmt7)
NGI103734924(Prmt7)
HGL101723197(Prmt7)
CPOC100726568(Prmt7)
CCAN109697457(Prmt7)
DORD105983187(Prmt7)
DSP122126234(Prmt7)
NCAR124966547
OCU100349655(PRMT7)
OPI101536742(PRMT7)
TUP102485073(PRMT7)
CFA479677(PRMT7)
CLUD112646535(PRMT7)
VVP112929452(PRMT7)
VLG121499931(PRMT7)
AML100476575(PRMT7)
UMR103673630(PRMT7)
UAH113252405(PRMT7)
UAR123803519(PRMT7)
ELK111152894
LLV125089307
MPUF101679230(PRMT7)
ORO101377061(PRMT7)
EJU114200098(PRMT7)
ZCA113936027(PRMT7)
MLX118023637(PRMT7)
FCA101093979(PRMT7)
PYU121009696(PRMT7)
PBG122495137(PRMT7)
PTG102951008(PRMT7)
PPAD109270726(PRMT7)
AJU106972034(PRMT7)
HHV120224502(PRMT7)
BTA514202(PRMT7)
BOM102286106(PRMT7)
BIU109572087(PRMT7)
BBUB102405217(PRMT7)
CHX102169616(PRMT7)
OAS101119070(PRMT7)
ODA120872708(PRMT7)
CCAD122420366(PRMT7)
SSC100517946(PRMT7)
CFR102519549(PRMT7)
CBAI105074859(PRMT7)
CDK105088413(PRMT7)
VPC102538328(PRMT7)
BACU102997779(PRMT7)
LVE103075888(PRMT7)
OOR101286708(PRMT7)
DLE111179598(PRMT7)
PCAD102987422(PRMT7)
PSIU116744288(PRMT7)
ECB100066681(PRMT7)
EPZ103549716(PRMT7)
EAI106822433(PRMT7)
MYB102241473(PRMT7)
MYD102766841(PRMT7)
MMYO118674585(PRMT7)
MLF102429126(PRMT7)
MNA107527891(PRMT7)
PKL118720944(PRMT7)
HAI109389445(PRMT7)
DRO112300800(PRMT7)
SHON118983817(PRMT7)
AJM119061855(PRMT7)
PDIC114488257(PRMT7)
PHAS123805741(PRMT7)
MMF118638535(PRMT7)
RFQ117034837(PRMT7)
PALE102884573(PRMT7)
PGIG120593907(PRMT7)
PVP105305751(PRMT7)
RAY107520539(PRMT7)
MJV108391625
TOD119248981(PRMT7)
SARA101544745(PRMT7)
LAV100665998(PRMT7)
TMU101353373
DNM101420939(PRMT7)
MDO100022634(PRMT7)
GAS123234624(PRMT7)
SHR100917733(PRMT7)
PCW110210373(PRMT7)
OAA100074014(PRMT7)
GGA415620(PRMT7)
PCOC116243766(PRMT7)
MGP100550199(PRMT7)
CJO107319042(PRMT7)
NMEL110404567(PRMT7)
APLA101796707(PRMT7)
ACYG106043104(PRMT7)
AFUL116494187(PRMT7)
TGU100227591(PRMT7)
LSR110473019(PRMT7)
SCAN103816642(PRMT7)
PMOA120508094(PRMT7)
OTC121334075(PRMT7)
PRUF121349002(PRMT7)
GFR102041628(PRMT7)
FAB101812114(PRMT7)
PHI102104291(PRMT7)
PMAJ107209751(PRMT7)
CCAE111934562(PRMT7)
CCW104687487(PRMT7)
CBRC103620179(PRMT7)
ETL114069470(PRMT7)
ZAB102062075(PRMT7)
FPG101922872(PRMT7)
FCH102054526(PRMT7)
CLV102086847(PRMT7)
EGZ104130218(PRMT7)
NNI104016363(PRMT7)
PLET104617973(PRMT7)
ACUN113484450(PRMT7)
TALA104366920(PRMT7)
PADL103914193(PRMT7)
ACHC115346269(PRMT7)
HALD104324249(PRMT7)
CCRI104162906(PRMT7)
CSTI104561495(PRMT7)
EHS104508413(PRMT7)
FGA104073117(PRMT7)
GSTE104251356(PRMT7)
LDI104346145(PRMT7)
MNB103770205(PRMT7)
AAM106483183(PRMT7)
AROW112967539(PRMT7)
NPD112950551(PRMT7)
DNE112984311(PRMT7)
ASN102367847(PRMT7)
AMJ102576580(PRMT7)
CPOO109310386(PRMT7)
GGN109289315(PRMT7)
PSS102452055(PRMT7)
CMY102929874(PRMT7)
CPIC101947537(PRMT7)
TST117886791(PRMT7)
CABI116817532(PRMT7)
MRV120384760(PRMT7)
ACS100564730(prmt7)
PVT110085499
SUND121914599(PRMT7)
PBI103050931(PRMT7)
PMUR107295259(PRMT7)
TSR106539755(PRMT7)
PGUT117670321(PRMT7)
VKO123025427(PRMT7)
PMUA114601918(PRMT7)
ZVI118087090(PRMT7)
GJA107126188(PRMT7)
STOW125443756(PRMT7)
XLA379700(prmt7.L)
XTR550075(prmt7)
NPR108795167(PRMT7)
RTEM120917658(PRMT7)
BBUF120980626(PRMT7)
BGAR122920218(PRMT7)
DRE393475(prmt7)
SRX107707497(prmt7) 107739801
SANH107674976(prmt7)
SGH107573013 107589198(prmt7)
CCAR109050591 109079422
CAUA113043703 113066814 113078202 113096605
PPRM120460274(prmt7)
MAMB125247185(prmt7)
IPU108268999(prmt7)
PHYP113546488(prmt7)
SMEO124386627(prmt7)
TFD113636118(prmt7)
AMEX111195751(prmt7)
EEE113581780(prmt7)
TRU101074790(prmt7)
TNGGSTEN00016832G001
LCO104933573(prmt7)
NCC104942619(prmt7)
CGOB115009709(prmt7)
ELY117262108(prmt7)
EFO125887811(prmt7)
PLEP121949907(prmt7)
SLUC116040182(prmt7)
ECRA117948750(prmt7)
PFLV114559972(prmt7)
GAT120809264(prmt7)
PPUG119195681(prmt7)
MSAM119893602(prmt7)
CUD121514936(prmt7)
ALAT119024142(prmt7)
MZE101474070(prmt7)
ONL100705029(prmt7)
OAU116322472(prmt7)
OLA101166868(prmt7)
OML112152763(prmt7)
XMA102221539(prmt7)
XCO114151091(prmt7)
XHE116736285(prmt7)
PRET103466292(prmt7)
PFOR103142440(prmt7) 103142516
PLAI106936539(prmt7) 106946767
PMEI106904998(prmt7) 106933755
GAF122835637(prmt7)
CVG107099370(prmt7)
CTUL119784724(prmt7)
GMU124878552(prmt7)
NFU107389267(prmt7)
KMR108246602(prmt7)
ALIM106536322(prmt7)
NWH119416183(prmt7)
AOCE111562933(prmt7)
MCEP125014316(prmt7)
CSEM103379897(prmt7)
POV109624470(prmt7)
SSEN122776399(prmt7)
HHIP117762788(prmt7)
HSP118109782(prmt7)
LCF108901970(prmt7)
SDU111238832(prmt7)
SLAL111647687(prmt7)
XGL120793787(prmt7)
HCQ109513066(prmt7)
BPEC110159987(prmt7)
MALB109951271(prmt7)
BSPL114857826(prmt7)
SASA106573657(prmt7)
OTW112252280(prmt7)
OMY110515549(prmt7)
OGO123992134(prmt7)
ONE115109309(prmt7)
SALP111952879(prmt7)
SNH120053845(prmt7)
CCLU121576717(prmt7)
ELS105018548(prmt7)
SFM108933988(prmt7)
PKI111848070(prmt7)
AANG118226754(prmt7)
LOC102683560(prmt7)
PSPA121325643(prmt7)
ARUT117424600 117425627
LCM102349070(PRMT7)
CMK103185924(prmt7)
RTP109933111(prmt7)
BFO118419322
BBEL109487647
CIN100184941
SCLV120331180
SPU574858
APLC110980044
SKO100372372
DMEDmel_CG9882(Art7)
DER6547319
DSE6615651
DSIDsimw501_GD25084(Dsim_GD25084)
DYADyak_GE11609
DAN6494167
DSR110184063
DPO6898207
DPE6590260
DMN108159379
DWI6639894
DGR6569154
DMODmoj_GI21139
DAZ108616420
DNV108654769
DHE111593911
DVI6626596
CCAT101461952
BOD106624197
MDE101899960
SCAC106087726
LCQ111683491
LSQ119602098
HIS119649955
AGAAgaP_AGAP006938(ANM7_ANOGA)
ACOZ120951881
AARA120896879
ASTE118514227
AAG5571748 5575498
AALB109412526 115254000
CQUCpipJ_CPIJ014415
CPII120412637
CNS116352324
BCOO119079844
AME408925
ACER107999454
ALAB122716579
BIM100742196
BBIF117209746
BVK117235116
BVAN117158726
BTER100642606
BPYO122568994
CCAL108629655
OBB114877936
MGEN117221776
NMEA116424167
CGIG122400336
SOC105207719
MPHA105834152
AEC105144369
ACEP105622968
PBAR105434072
VEM105570461
HST105189145
DQU106745085
CFO105253330
FEX115236238
LHU105673226
PGC109864204
OBO105287501
PCF106784852
PFUC122520657
VPS122637601
NVI100120936
CSOL105367418
TPRE106651907
MDL103573988
CGLO123266204
FAS105267217
DAM107036397
AGIF122849197
CCIN107274399
TCA655557
DPA109538057
SOY115879883
ATD109605142
CSET123322794
AGB108914423
LDC111515373
NVL108559883
APLN108732758
PPYR116174777 116174885
OTU111414736
BMOR101742905
BMAN114242262
MSEX115441188
DPLKGM_212929
BANY112055059
PMAC106718323
PPOT106109809
PXU106121473
PRAP110992555
ZCE119840912
HAW110377965
HZE124635311
TNL113498157
SLIU111358999
OFU114351131
PXY105392654
API100169215
DNX107173352
AGS114123223
RMD113553892
BTAB109041113
DCI103510910
CLEC106665975
HHAL106681391
NLU111053872
FOC113212369
TPAL117651316
ZNE110833257
CSEC111866404
FCD110846324 110850563
DPXDAPPUDRAFT_188007
DMK116934526
PVM113808874
PJA122249240
PCHN125035769
HAME121874320
PCLA123771952
PTRU123505159
HAZT108682250
EAF111710650
LSM121121419
PPOI119098919
ISCIscW_ISCW022274
DSV119435907
RSAN119406698
RMP119177260
VDE111252900
VJA111270624
TUT107368005 107368112
DPTE113796564
DFR124494049
CSCU111633420
PTEP107444093
SDM118183422
CELCELE_W06D4.4(prmt-7)
CBRCBG_12433(Cbr-prmt-7)
BMYBM_BM11397(Bma-prmt-7)
LOALOAG_17373
TSPTsp_07955
HROHELRODRAFT_100002
LGILOTGIDRAFT_213858
PCAN112577130
GAE121388439
HRF124119432 124119651
HRJ124290150
CRG105345044
MYI110453648
PMAX117338472
MMER123548495
OBI106869174
OSN115212858
LAK106170363
SMMSmp_025550
SHXMS3_0020542
OVIT265_10877
NVE116608304
ATEN116292768
ADF107345714
AMIL114965121
PDAM113667512
SPIS111342064
DGT114517093
XEN124436730
HMG101237887
TADTRIADDRAFT_55586
AQU100635923 100640084
ATHAT4G16570(PRMT7)
ALY9304187
CRB111829529
CSAT104718710 104723449 104731948
EUSEUTSA_v10024535mg
BRP103869383
BNA106392002 106446226
BOE106324178
RSZ108842933
THJ104815493
CPAP110817584
CIT102609967
CICCICLE_v10023597mg
PVY116106279
MINC123211999
TCC18606266
GRA105789248
GHI107942538 121215615
GAB108480956
DZI111290368
EGR104441909
GMX100785846
GSJ114412163
PVUPHAVU_006G006200g
VRA106776133
VAR108343351
VUN114187927
CCAJ109807721
APRC113849966
MTRMTR_4g100980
CAM101491869
LJALj4g3v1260350.3(Lj4g3v1260350.3)
LANG109341433
FVE101305264
RCN112175442
PPER18777556
PMUM103337146
PAVI110757179
PDUL117628846
MDM103433012
PXB103927321
ZJU107430291
MNT21395049
CSV101204902
CMO103482612
BHJ120068078
MCHA111021993
CMAX111468834
CMOS111430252
CPEP111809419
RCU8265552
JCU105632263
HBR110637626
MESC110603204
POP7471624
PEU105130867
PALZ118062933
JRE109011641
QSU111983087 112007321
QLO115971591
TWL119986553
VVI100243649
VRI117927872
SLY101253908
SPEN107021154
SOT102595431
SSTN125851677
CANN107872975
NTA107819964 107823530
NSY104246422
NTO104113300
NAU109205640
INI109152072
ITR116001994
SIND105164329
OEU111393900
EGT105962275 105963234 105963237
SSPL121795681
HAN110921526
ECAD122587404
LSV111917632
CCAV112527958
DCR108206226
CSIN114293321
BVG104907847
SOE110788317
CQI110712866
NNU104602340
MING122086984
TSS122664267
PSOM113284293
NCOL116253051
OSA4339860
DOSAOs06t0105500-01(Os06g0105500)
OBR102713829
BDI100841698
ATS109766148
TDC119288334 119330742
TAES123088560 123150848 123166842
TUA125523021 125529484
SBI8066868
ZMA100273522
SITA101768659
SVS117853808
PVIR120697247 120702336
PHAI112889501 112892764 112893952
PDA103710710
EGU105059515
MUS103973496
DCT110093492
PEQ110027779
AOF109823019
ATR18428796
SMOSELMODRAFT_185054 SELMODRAFT_425255 SELMODRAFT_425258 SELMODRAFT_425264 SELMODRAFT_427394 SELMODRAFT_427398 SELMODRAFT_430728 SELMODRAFT_447442
PPP112283608
VCNVOLCADRAFT_104892
CVRCHLNCDRAFT_144981
OLUOSTLU_88314
BPGBathy10g00470
MPPMICPUCDRAFT_51540
MBRMONBRDRAFT_18255
SREPTSG_03146 PTSG_05080 PTSG_09839 PTSG_11677
SMINv1.2.018977.t1(symbB.v1.2.018977.t1) v1.2.026170.t3(symbB.v1.2.026170.t3)
PTIPHATRDRAFT_49245
FCYFRACYDRAFT_245017
TPSTHAPSDRAFT_25810
AAFAURANDRAFT_11485(PRMT2) AURANDRAFT_61429
PIFPITG_04448
PSOJPHYSODRAFT_527383
SPARSPRG_09147
EHXEMIHUDRAFT_210815 EMIHUDRAFT_211926 EMIHUDRAFT_42351 EMIHUDRAFT_76098
GTTGUITHDRAFT_101153
TBRTb927.7.5490
TBGTbgDal_VII6370
TCR509153.100
LMALMJF_06_0870(PRMT7)
LIFLINJ_06_0900(PRMT7)
LDOLDBPK_060900
LMILMXM_06_0870
LBZLBRM_06_0840(PRMT7)
LPANLPMP_060830(PRMT7)
 » show all
Reference
1  [PMID:15044439]
  Authors
Miranda TB, Miranda M, Frankel A, Clarke S
  Title
PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity.
  Journal
J Biol Chem 279:22902-7 (2004)
DOI:10.1074/jbc.M312904200
  Sequence
[hsa:54496]
Reference
2  [PMID:17709427]
  Authors
Gonsalvez GB, Tian L, Ospina JK, Boisvert FM, Lamond AI, Matera AG
  Title
Two distinct arginine methyltransferases are required for biogenesis of Sm-class  ribonucleoproteins.
  Journal
J Cell Biol 178:733-40 (2007)
DOI:10.1083/jcb.200702147
  Sequence
[hsa:54496]
Reference
3  [PMID:25294873]
  Authors
Feng Y, Hadjikyriacou A, Clarke SG
  Title
Substrate specificity of human protein arginine methyltransferase 7 (PRMT7): the  importance of acidic residues in the double E loop.
  Journal
J Biol Chem 289:32604-16 (2014)
DOI:10.1074/jbc.M114.609271
  Sequence
[hsa:54496]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.321
IUBMB Enzyme Nomenclature: 2.1.1.321
ExPASy - ENZYME nomenclature database: 2.1.1.321
BRENDA, the Enzyme Database: 2.1.1.321

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