KEGG   ENZYME: 2.1.1.327
Entry
EC 2.1.1.327                Enzyme                                 
Name
phenazine-1-carboxylate N-methyltransferase;
phzM (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:phenazine-1-carboxylate 5-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + phenazine-1-carboxylate = S-adenosyl-L-homocysteine + 5-methylphenazine-1-carboxylate [RN:R11533]
Reaction(KEGG)
R11533
Substrate
S-adenosyl-L-methionine [CPD:C00019];
phenazine-1-carboxylate [CPD:C21442]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
5-methylphenazine-1-carboxylate [CPD:C21295]
Comment
The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is involved in the biosynthesis of pyocyanin, a toxin produced and secreted by the organism. The enzyme is active in vitro only in the presence of EC 1.14.13.218, 5-methylphenazine-1-carboxylate 1-monooxygenase.
History
EC 2.1.1.327 created 2016
Pathway
ec00405  Phenazine biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K21103  phenazine-1-carboxylate N-methyltransferase
Genes
PAEPA4209(phzM)
PAEVN297_4341
PAEIN296_4341
PAUPA14_09490(phzM)
PAPPSPA7_0889
PAGPLES_07181(phzM)
PAFPAM18_0728(phzM)
PNCNCGM2_5454(phzM)
PAEBNCGM1900_0750(phzM)
PDKPADK2_03625
PSGG655_03660
PRPM062_22175
PAEPPA1S_03775
PAERPA1R_gp2100
PAEMU769_03805
PAELT223_03710
PAESSCV20265_0753
PAEUBN889_04683(phzM)
PAEGAI22_00135
PAECM802_4339
PAEOM801_4207
SECHB18_04190
SHAWCEB94_18915
SCINCP977_15890
SMAOCAG99_00495
PRYPrubr_64750
 » show all
Reference
1  [PMID:17253782]
  Authors
Parsons JF, Greenhagen BT, Shi K, Calabrese K, Robinson H, Ladner JE
  Title
Structural and functional analysis of the pyocyanin biosynthetic protein PhzM from Pseudomonas aeruginosa.
  Journal
Biochemistry 46:1821-8 (2007)
DOI:10.1021/bi6024403
  Sequence
[pae:PA4209]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.327
IUBMB Enzyme Nomenclature: 2.1.1.327
ExPASy - ENZYME nomenclature database: 2.1.1.327
BRENDA, the Enzyme Database: 2.1.1.327

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