KEGG   ENZYME: 2.1.1.339Help
Entry
EC 2.1.1.339                Enzyme                                 

Name
xanthohumol 4'-O-methyltransferase;
OMT2 (ambiguous)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:xanthohumol 4'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + xanthohumol = S-adenosyl-L-homocysteine + 4'-O-methylxanthohumol [RN:R11596]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
xanthohumol [CPD:C16417]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
4'-O-methylxanthohumol [CPD:C21492]
Comment
The enzyme from hops (Humulus lupulus) has a broad substrate specificity. The best substrates in vitro are resveratrol, desmethylxanthohumol, naringenin chalcone and isoliquiritigenin.
History
EC 2.1.1.339 created 2017
Pathway
ec00941  Flavonoid biosynthesis
Orthology
K21582  xanthohumol 4'-O-methyltransferase
Reference
1  [PMID:18223037]
  Authors
Nagel J, Culley LK, Lu Y, Liu E, Matthews PD, Stevens JF, Page JE
  Title
EST analysis of hop glandular trichomes identifies an O-methyltransferase that catalyzes the biosynthesis of xanthohumol.
  Journal
Plant Cell 20:186-200 (2008)
DOI:10.1105/tpc.107.055178
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.339
IUBMB Enzyme Nomenclature: 2.1.1.339
ExPASy - ENZYME nomenclature database: 2.1.1.339
BRENDA, the Enzyme Database: 2.1.1.339

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