KEGG   ENZYME: 2.1.1.356Help
Entry
EC 2.1.1.356                Enzyme                                 

Name
[histone H3]-lysine27 N-trimethyltransferase;
KMT6A (gene name);
KMT6B (gene name);
EZH1 (gene name);
EZH2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine27 N6-methyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine27;
[histone H3]-N6-methyl-L-lysine27;
[histone H3]-N6,N6-dimethyl-L-lysine27
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine27;
[histone H3]-N6-methyl-L-lysine27;
[histone H3]-N6,N6-dimethyl-L-lysine27
Comment
This entry describes enzymes that successively methylate the L-lysine27 residue of histone H3 (H3K27), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. The methylation of lysine27 leads to transcriptional repression of the affected target genes. The enzyme associates with other proteins to form a complex that is essential for activity. The enzyme can also methylate some non-histone proteins.
History
EC 2.1.1.356 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.356
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11430  [histone H3]-lysine27 N-trimethyltransferase EZH2
K17451  [histone H3]-lysine27 N-trimethyltransferase EZH1
Genes
HSA: 2145(EZH1) 2146(EZH2)
PTR: 454697(EZH1) 745437(EZH2)
PPS: 100967877(EZH1) 100971244(EZH2)
GGO: 101126515(EZH1) 101147968(EZH2)
PON: 100171872(EZH1) 100447447(EZH2)
NLE: 100580962(EZH2) 100604860(EZH1)
MCC: 709075(EZH2) 711173(EZH1)
MCF: 102130547(EZH1) 102146280(EZH2)
CSAB: 103227182(EZH2) 103243395(EZH1)
RRO: 104667012(EZH2) 104680126(EZH1)
RBB: 108522307(EZH2) 108526767(EZH1)
CJC: 100394758(EZH2) 100411881(EZH1)
SBQ: 101038203(EZH1) 101051611(EZH2)
MMU: 14055(Ezh1) 14056(Ezh2)
MCAL: 110295592(Ezh2) 110304611(Ezh1)
MPAH: 110315211(Ezh2) 110331872(Ezh1)
RNO: 303547(Ezh1) 312299(Ezh2)
MUN: 110547503(Ezh2) 110550881(Ezh1)
CGE: 100758055(Ezh2) 100760595(Ezh1)
NGI: 103731383(Ezh2) 103735912(Ezh1)
HGL: 101702710(Ezh2) 101723063(Ezh1)
CCAN: 109687337(Ezh1) 109695508(Ezh2)
OCU: 100345157(EZH2) 100351852(EZH1)
TUP: 102485788(EZH1) 102495627(EZH2)
CFA: 475511(EZH2) 480516(EZH1)
VVP: 112910738(EZH1) 112934818(EZH2)
AML: 100466177(EZH2) 100472619(EZH1)
UMR: 103668955(EZH2) 103672584(EZH1)
UAH: 113241452(EZH2) 113265406(EZH1)
ORO: 101369941(EZH2) 101379551(EZH1)
FCA: 101087309(EZH2) 101099602(EZH1)
PTG: 102956220(EZH2) 102961028(EZH1)
PPAD: 109258535(EZH1) 109269218(EZH2)
AJU: 106972615(EZH1) 106981407(EZH2)
BTA: 509106(EZH2) 533087(EZH1)
BOM: 102276653(EZH1) 102287858(EZH2)
BIU: 109557756(EZH2) 109573994(EZH1)
BBUB: 102405899(EZH2) 102407322(EZH1)
CHX: 102189343(EZH1) 102190101(EZH2)
OAS: 101104765(EZH1) 101120745(EZH2)
SSC: 100518394(EZH1) 100625497(EZH2)
CFR: 102515793(EZH2) 102516907(EZH1)
CDK: 105085196(EZH2) 105090473(EZH1) 116154104
LVE: 103069623(EZH2) 103073364(EZH1)
OOR: 101280796(EZH2) 101285746(EZH1)
DLE: 111166246(EZH1) 111177205(EZH2)
PCAD: 102994010(EZH2) 102994197(EZH1) 112061879
ECB: 100051290(EZH2) 100052411(EZH1)
EPZ: 103545927 103550351(EZH1) 103553703(EZH2)
EAI: 106826432(EZH1) 106842131(EZH2)
MYB: 102246299(EZH2) 102259730(EZH1)
MYD: 102755313(EZH1) 102768989(EZH2)
MNA: 107523768(EZH2) 107528927(EZH1)
HAI: 109395452(EZH2) 109395755(EZH1)
DRO: 112298572(EZH1) 112308348(EZH2)
PALE: 102879627(EZH1) 102886689(EZH2)
RAY: 107500533(EZH2) 107513838(EZH1)
MJV: 108386069(EZH1) 108386657(EZH2)
LAV: 100664312(EZH2) 100673691(EZH1)
MDO: 100010738(EZH1) 100013390(EZH2)
SHR: 100926678(EZH2) 100932535(EZH1)
PCW: 110198374(EZH1) 110201666(EZH2)
OAA: 100073485(EZH2) 100082851(EZH1)
GGA: 420023(EZH1) 420784(EZH2)
MGP: 100540374(EZH2) 100547448(EZH1)
CJO: 107309835(EZH2) 107325326(EZH1)
NMEL: 110388515(EZH1) 110390789(EZH2)
APLA: 101791765(EZH1) 101793453(EZH2)
ACYG: 106048025(EZH1) 106048735(EZH2)
TGU: 100226728(EZH2) 100227472(EZH1)
LSR: 110471820(EZH1) 110479186(EZH2)
SCAN: 103819367(EZH2) 103821570(EZH1)
GFR: 102035477(EZH1) 102038673(EZH2)
FAB: 101809240(EZH2) 101811414(EZH1)
PHI: 102099930(EZH2) 102103576(EZH1)
PMAJ: 107200653(EZH2) 107215126(EZH1)
CCAE: 111923642(EZH2) 111940096(EZH1)
CCW: 104688925(EZH2) 104697765(EZH1)
ETL: 114063607(EZH1) 114063865(EZH2)
FPG: 101911332(EZH2) 101915579(EZH1)
FCH: 102052374(EZH1) 102055584(EZH2)
CLV: 102093761(EZH2) 102097006(EZH1)
EGZ: 104125781(EZH2) 104134781(EZH1)
NNI: 104009878(EZH1) 104015388(EZH2)
ACUN: 113477549(EZH2) 113489070
PADL: 103916088(EZH2) 103919098(EZH1)
AAM: 106491114(EZH1) 106495267(EZH2)
ASN: 102372569(EZH2) 102383438(EZH1)
AMJ: 102562122(EZH2) 102566481(EZH1)
PSS: 102453330(EZH2) 102463087(EZH1)
CMY: 102932650(EZH2) 102934538(EZH1)
CPIC: 101934118(EZH1) 101937752(EZH2)
ACS: 100559669(ezh1) 100564989(ezh2)
PVT: 110080273(EZH1) 110088673(EZH2)
PBI: 103051581(EZH2) 103052924(EZH1)
PMUR: 107288847(EZH2) 107290401 107302416(EZH1)
TSR: 106547020(EZH2) 106554239(EZH1)
PMUA: 114581626(EZH1) 114607413(EZH2)
GJA: 107119624(EZH2) 107123351(EZH1)
XLA: 100381148(ezh2.S) 108701022(ezh1.L) 108702719(ezh1.S) 399174(ezh2.L)
XTR: 100493532(ezh1) 550047(ezh2)
NPR: 108794364(EZH2) 108796324(EZH1)
DRE: 664754(ezh1) 768133(ezh2)
IPU: 108256455(ezh2) 108279279(ezh1)
PHYP: 113528051(ezh1) 113541351(ezh2)
AMEX: 103027230(ezh2) 103044086(ezh1)
EEE: 113589064(ezh2) 113590056
TRU: 101068728(ezh2) 101070195(ezh1)
LCO: 104923910(ezh1) 104933871(ezh2)
NCC: 104940789(ezh2) 104944052
MZE: 101464777 101474304(ezh1) 112429845(ezh2)
ONL: 100695015(ezh1) 100702594(ezh2)
OLA: 100125823(ezh2) 101166385(ezh1)
XMA: 102218572(ezh2) 102228014(ezh1)
XCO: 114136427(ezh2) 114160264(ezh1)
PRET: 103457011(ezh2) 103468644(ezh1) 103469387
CVG: 107091776(ezh1) 107097879(ezh2)
NFU: 107378461(ezh1) 107383138(ezh2)
KMR: 108243802(ezh1) 108249555(ezh2)
ALIM: 106511331 106528219(ezh1) 106531656(ezh2)
AOCE: 111564547(ezh1) 111570645(ezh2)
CSEM: 103377188(ezh2) 103393149(ezh1) 103399469
LCF: 108884998(ezh2) 108900993(ezh1)
SDU: 111217595(ezh1) 111238320(ezh2)
SLAL: 111647273(ezh2) 111660565(ezh1)
HCQ: 109508596 109521815(ezh2)
BPEC: 110158320(ezh2) 110166859(ezh1)
MALB: 109951056(ezh2) 109964204(ezh1)
ELS: 105013194(ezh1) 105022040(ezh2)
LCM: 102364190(EZH1)
CMK: 103187005(ezh2)
CIN: 100177449
SPU: 585842
APLC: 110990448
DME: Dmel_CG6502(E(z))
DER: 6546346
DSI: Dsimw501_GD12857(Dsim_GD12857)
DSR: 110185151
DPE: 6601386
DMN: 108151423
DWI: 6646360
DAZ: 108614083
DNV: 108652219
MDE: 101887292
LCQ: 111677283
AAG: 5577466
AALB: 109401157
AME: 552235
BIM: 100747000
BTER: 100647736
CCAL: 108631087
OBB: 114880742
SOC: 105197183
MPHA: 105835069
AEC: 105143480
ACEP: 105617407
PBAR: 105425935
VEM: 105559070
DQU: 106746421
CFO: 105250747
LHU: 105670949
PGC: 109855910
OBO: 105285382
PCF: 106792137
NVI: 100113526(E(z))
CSOL: 105367879
TCA: 659759
DPA: 109536169
NVL: 108560889
BMOR: 101739540 101745450(E(Z))
BMAN: 114243273
PMAC: 106718913
PRAP: 110995414
HAW: 110375985
TNL: 113498098
API: 100168406
DNX: 107161946
AGS: 114123060
RMD: 113551950
BTAB: 109035984
CLEC: 106666006
ZNE: 110841374
DPTE: 113792645
PTEP: 107455687
CEL: CELE_R06A4.7(mes-2)
CBR: CBG11099(Cbr-mes-2)
BMY: Bm1_55060
TSP: Tsp_01566
PCAN: 112556350
CRG: 105330640
MYI: 110442389
OBI: 106874217
LAK: 106181368
EGL: EGR_02209
EPA: 110249650
AMIL: 114967312
PDAM: 113673889
SPIS: 111323365
DGT: 114531596
HMG: 100201207
AQU: 109587656
ATH: AT1G02580(MEA) AT2G23380(CLF) AT4G02020(SWN)
LJA: Lj0g3v0213049.1(Lj0g3v0213049.1) Lj2g3v1890940.1(Lj2g3v1890940.1) Lj2g3v1890940.2(Lj2g3v1890940.2) Lj5g3v1598420.1(Lj5g3v1598420.1) Lj5g3v1598420.2(Lj5g3v1598420.2) Lj5g3v1598420.3(Lj5g3v1598420.3) Lj5g3v1598420.4(Lj5g3v1598420.4)
SLY: 100134891(EZ1) 100134892(EZ2) 101267964
DOSA: Os03t0307800-01(Os03g0307800) Os06t0275500-01(Os06g0275500)
ATS: 109742834(LOC109742834) 109781663(LOC109781663) 109781665(LOC109781665)
ZMA: 541954(mez1) 541955(mez3) 542659(mez2)
PPP: 112274954
MNG: MNEG_1960
MBE: MBM_04736
PTE: PTT_08614
ZTR: MYCGRDRAFT_71291(SDG2401)
LBC: LACBIDRAFT_312288(SDG16204)
 » show all
Taxonomy
Reference
1  [PMID:12351676]
  Authors
Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y
  Title
Role of histone H3 lysine 27 methylation in Polycomb-group silencing.
  Journal
Science 298:1039-43 (2002)
  Sequence
[hsa:2146]
Reference
2  [PMID:12435631]
  Authors
Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D
  Title
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.
  Journal
Genes Dev 16:2893-905 (2002)
  Sequence
[hsa:2146]
Reference
3  [PMID:15231737]
  Authors
Kirmizis A, Bartley SM, Kuzmichev A, Margueron R, Reinberg D, Green R, Farnham PJ
  Title
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.
  Journal
Genes Dev 18:1592-605 (2004)
  Sequence
[hsa:2146]
Reference
4  [PMID:17200670]
  Authors
Schlesinger Y, Straussman R, Keshet I, Farkash S, Hecht M, Zimmerman J, Eden E, Yakhini Z, Ben-Shushan E, Reubinoff BE, Bergman Y, Simon I, Cedar H
  Title
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo  methylation in cancer.
  Journal
Nat Genet 39:232-6 (2007)
  Sequence
[hsa:2146]
Reference
5  [PMID:19026780]
  Authors
Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH
  Title
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.
  Journal
Mol Cell 32:491-502 (2008)
  Sequence
[mmu:14055 14056]
Reference
6  [PMID:21317239]
  Authors
Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E
  Title
EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.
  Journal
Genes Dev 25:485-98 (2011)
  Sequence
[mmu:14055 14056]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.356
IUBMB Enzyme Nomenclature: 2.1.1.356
ExPASy - ENZYME nomenclature database: 2.1.1.356
BRENDA, the Enzyme Database: 2.1.1.356

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