Entry
Name
[histone H4]-lysine20 N-methyltransferase;
KMT5A (gene name);
SET8 (gene name);
PR-SET7 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H4]-L-lysine20 N6-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
[histone H4]-L-lysine20
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
[histone H4]-N6-methyl-L-lysine20
Comment
The enzyme catalyses the monomethylation of the L-lysine20 residue of histone H4 (H4K20). This event is usually followed by further methylation by EC
2.1.1.362 , [histone H4]-N-methyl-L-lysine20 N-methyltransferase. This enzyme plays a pivotal role in DNA replication. Activity is high during the G2 and M phases, but declines significantly during G1 and S phases. Mutations in the enzyme have severe consequences, including DNA double-strand breaks, activation of DNA damage checkpoints, defective cell cycle progression, and reduced cell proliferation.
History
EC 2.1.1.361 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.361
Pathway
Orthology
K11428 [histone H4]-lysine20 N-methyltransferase SETD8
K20795 [histone H4]-lysine20 N-methyltransferase PRDM6
Genes
HSA : 387893(KMT5A) 93166(PRDM6)
PTR : 452343(KMT5A) 742318(PRDM6)
PPS : 100978154 100982491(PRDM6) 100986737(KMT5A)
GGO : 101134637 101143097(PRDM6) 101145513(KMT5A) 129526378 129528161 129529284 129529286 129529426 129530289 129530468 129530502 134756700
PON : 100451760(KMT5A) 100460132(PRDM6)
PPYG : 129010500(KMT5A) 129036743(PRDM6)
NLE : 100579681(PRDM6) 100580339(KMT5A)
HMH : 116470339(PRDM6) 116477743(KMT5A)
SSYN : 129460330(KMT5A) 129492994(PRDM6)
MCC : 703499(PRDM6) 709345(KMT5A)
MCF : 102128021(KMT5A) 102142246(PRDM6)
MTHB : 126930652 126957524
MNI : 105463145(PRDM6) 105494001(KMT5A)
CSAB : 103239328(KMT5A) 103244427(PRDM6)
CATY : 105591004(SETD8) 105599677(PRDM6)
PANU : 101010043(KMT5A) 101014277(PRDM6)
TGE : 112625690(PRDM6) 112635259(KMT5A)
MLEU : 105528012(SETD8) 105545038(PRDM6)
RRO : 104660930(PRDM6) 104666320(KMT5A)
RBB : 108520391(PRDM6) 108540752(KMT5A)
TFN : 117065954(PRDM6) 117080344 117089217(KMT5A)
PTEH : 111527675(PRDM6) 111538508 111539563
CANG : 105516385(SETD8) 105526098 105527423(PRDM6)
CJC : 100411011(PRDM6) 100414548(KMT5A)
SBQ : 101040690(SETD8) 101047827(PRDM6)
CIMI : 108294847 108306767(PRDM6) 108315116(KMT5A)
ANAN : 105704644 105713398(KMT5A) 105714374(PRDM6)
CSYR : 103271959(KMT5A) 103275779(PRDM6)
MMUR : 105880868(KMT5A) 105884549(PRDM6)
LCAT : 123626118(KMT5A) 123648463(PRDM6)
PCOQ : 105825686(SETD8) 105826327(PRDM6)
OGA : 100940536(KMT5A) 100963252(PRDM6)
MMU : 225518(Prdm6) 67956(Kmt5a)
MCAL : 110284774(Prdm6) 110295130(Kmt5a)
MPAH : 110312821(Kmt5a) 110333293(Prdm6)
RNO : 100361623(Kmt5al2) 100909949(Kmt5al1) 288346(Kmt5al3) 307305(Prdm6) 689820(Kmt5a)
MCOC : 116068429(Kmt5a) 116087169(Prdm6)
ANU : 117698248(Kmt5a) 117719895(Prdm6)
MUN : 110552670(Kmt5a) 110559610(Prdm6)
CGE : 100773424(Prdm6) 100774411(Kmt5a)
MAUA : 101824166 101824988(Kmt5a) 101825910(Prdm6)
PROB : 127234198(Prdm6) 127237018(Kmt5a)
PLEU : 114686055 114694780(Prdm6) 114704516(Kmt5a)
MORG : 121437304 121441958 121446283(Kmt5a) 121453606
MFOT : 126504306 126506031
AAMP : 119815859(Prdm6) 119825159(Kmt5a)
NGI : 103738642(Prdm6) 103739033(Kmt5a)
HGL : 101720211(Prdm6) 101726359(Kmt5a)
CCAN : 109683525(Kmt5a) 109694403(Prdm6)
DORD : 105985212(Prdm6) 105990613(Setd8)
DSP : 122098573(Kmt5a) 122103832(Prdm6)
PLOP : 125349195(Kmt5a) 125351358(Prdm6)
NCAR : 124987672 124990908
MMMA : 107155481(Prdm6) 107156385(Kmt5a)
OCU : 100347868 100354345 100354805
OPI : 101516912(PRDM6) 101521103(KMT5A)
TUP : 102471250(KMT5A) 102489496(PRDM6)
GVR : 103585529(PRDM6) 103606858(SETD8)
CFA : 100687856(PRDM6) 610615(KMT5A)
CLUD : 112649926(PRDM6) 112676464
NPO : 129494975(PRDM6) 129507931(KMT5A)
AML : 100481447(PRDM6) 100482312(KMT5A)
UMR : 103661256(KMT5A) 103670579(PRDM6)
UAH : 113261649(PRDM6) 113266900(KMT5A)
UAR : 123779868(KMT5A) 123790588(PRDM6)
MPUF : 101672174(PRDM6) 101688179(SETD8)
MNP : 132023093(KMT5A) 132028028(PRDM6)
MLK : 131811166(KMT5A) 131832558(PRDM6)
NVS : 122903070(KMT5A) 122916431(PRDM6)
ORO : 101370999(PRDM6) 101380066(SETD8)
EJU : 114200359(KMT5A) 114209391(PRDM6)
ZCA : 113912844(KMT5A) 113929417(PRDM6)
MLX : 118016573(PRDM6) 118018398(KMT5A)
NSU : 110588347(KMT5A) 110591103(PRDM6)
FCA : 101084511(PRDM6) 101086008(KMT5A)
PYU : 121010394(KMT5A) 121010609(PRDM6)
PCOO : 112860693(PRDM6) 112870284(KMT5A)
PBG : 122470153(KMT5A) 122486759(PRDM6)
PVIV : 125149201(KMT5A) 125174873(PRDM6)
LRUF : 124518212 124522439
PTG : 102956571(PRDM6) 102962714(KMT5A)
PPAD : 109277736(KMT5A) 109278870(PRDM6)
HHV : 120236767(KMT5A) 120246097(PRDM6)
BTA : 519857(PRDM6) 532622(KMT5A)
BOM : 102264795(KMT5A) 102279737(PRDM6)
BIU : 109560980 109561855 109571313(KMT5A)
BBUB : 102392447(KMT5A) 102401941(PRDM6)
BBIS : 104989668(SETD8) 104993167(PRDM6)
CHX : 102176319(PRDM6) 102183718(KMT5A)
OAS : 101103235(PRDM6) 101122308(KMT5A)
BTAX : 128051594(PRDM6) 128062161(KMT5A)
ODA : 120864690(PRDM6) 120871058(KMT5A)
CCAD : 122424360(KMT5A) 122440092(PRDM6)
MREE : 136145416(KMT5A) 136167132(PRDM6)
MBEZ : 129542239(KMT5A) 129559287(PRDM6)
SSC : 100524509(PRDM6) 100626555(KMT5A)
CFR : 102513845(PRDM6) 102521782(KMT5A)
CBAI : 105080660(SETD8) 105082233(PRDM6)
CDK : 105102547(KMT5A) 105105065(PRDM6)
VPC : 102527939(KMT5A) 116278202(PRDM6)
BACU : 103012927(KMT5A) 103016372(PRDM6)
BMUS : 118879863(KMT5A) 118892895(PRDM6)
LVE : 103079356(SETD8) 103088820(PRDM6)
OOR : 101270549(KMT5A) 101289146(PRDM6)
DLE : 111182365(PRDM6) 111186967(KMT5A)
PCAD : 102973557(PRDM6) 102996167(KMT5A)
PSIU : 116739152(KMT5A) 116751578(PRDM6)
NASI : 112407769(PRDM6) 112408791(KMT5A)
ECB : 100060853(KMT5A) 100073092(PRDM6)
EPZ : 103549882(KMT5A) 103557946(PRDM6)
EAI : 106842331(KMT5A) 106842785(PRDM6)
MYB : 102240957 102242179 102255214(PRDM6)
MYD : 102763890(PRDM6) 102770785(KMT5A)
MMYO : 118656525 118657022 118678140(KMT5A)
MDT : 132221734(KMT5A) 132233317(PRDM6)
PKL : 118703399(PRDM6) 118725421(KMT5A)
EFUS : 103286199(PRDM6) 103287217(KMT5A)
MNA : 107529655(KMT5A) 107540856(PRDM6)
DRO : 112310724(KMT5A) 112314700(PRDM6)
SHON : 118974854 118975099(PRDM6) 118991026(KMT5A)
AJM : 119060733(KMT5A) 119063966(PRDM6)
PDIC : 114503519(PRDM6) 114509389(KMT5A)
PHAS : 123818107(PRDM6) 123821187(KMT5A)
MMF : 118639841(KMT5A) 118642786(PRDM6)
PPAM : 129083481(PRDM6) 129087254(KMT5A)
HAI : 109379016(PRDM6) 109386114(KMT5A)
RFQ : 117017602(KMT5A) 117024498(PRDM6)
PALE : 102889990(PRDM6) 102897510(KMT5A)
PGIG : 120590885(PRDM6) 120616022(KMT5A)
PVP : 105289367(KMT5A) 105290874(PRDM6)
RAY : 107511140(PRDM6) 107515249(KMT5A)
MJV : 108400443(PRDM6) 108408425(KMT5A)
TOD : 119243542(PRDM6) 119245049(KMT5A)
SARA : 101540129(SETD8) 101557162(PRDM6)
SETR : 126002027(KMT5A) 126006064(PRDM6)
LAV : 100657495(PRDM6) 100673523(KMT5A)
ETF : 101641327(KMT5A) 101644936(PRDM6)
DNM : 101414380(KMT5A) 101439546(PRDM6)
MDO : 100014170(PRDM6) 100023739(KMT5A)
GAS : 123231332(PRDM6) 123244631(KMT5A)
SHR : 100919577(PRDM6) 100933547(KMT5A)
AFZ : 127542111 127542390 127545404 127562337
PCW : 110196792(KMT5A) 110223799(PRDM6)
TVP : 118828010(PRDM6) 118833026 118851423(KMT5A)
OAA : 100075898(KMT5A) 114808134(PRDM6)
GGA : 416825(KMT5A) 426800(PRDM6)
CJO : 107306730(PRDM6) 107321176(KMT5A)
TPAI : 128084807(KMT5A) 128089575(PRDM6)
LMUT : 125687132(PRDM6) 125701678(KMT5A)
NMEL : 110390181(PRDM6) 110406291(KMT5A)
APLA : 101791393(PRDM6) 101791981(KMT5A)
ACYG : 106031170(KMT5A) 106046221(PRDM6)
CATA : 118257207(KMT5A) 118258319(PRDM6)
AFUL : 116495994(KMT5A) 116501112(PRDM6)
TGU : 100225643(KMT5A) 100229699(PRDM6)
LSR : 110471779(KMT5A) 110479151(PRDM6)
SCAN : 103818327(KMT5A) 103821458 115485138
PMOA : 120509636(KMT5A) 120513557(PRDM6)
OTC : 121331505(PRDM6) 121338931(KMT5A)
PRUF : 121362572(PRDM6) 121365047(KMT5A)
GFR : 102037830(KMT5A) 102042417(PRDM6)
FAB : 101815311(PRDM6) 101821143(KMT5A)
OMA : 130259825(KMT5A) 130265532(PRDM6)
PHI : 102107973(PRDM6) 102109183(SETD8)
PMAJ : 107211636(KMT5A) 107216286(PRDM6)
CCAE : 111936365(KMT5A) 111941215(PRDM6)
CCW : 104688723(KMT5A) 104690502(PRDM6)
CBRC : 103611636(PRDM6) 103616016(KMT5A)
ETL : 114054956(KMT5A) 114055348(PRDM6)
ZAB : 102060759(KMT5A) 102075464(PRDM6)
ZLE : 135454649(KMT5A) 135459778(PRDM6)
ACHL : 103797331(PRDM6) 103806489(SETD8)
SVG : 106852006(PRDM6) 106852390(KMT5A)
MMEA : 130574514(PRDM6) 130581001(KMT5A)
HRT : 120760454(KMT5A) 120765604(PRDM6)
SATI : 136369104(KMT5A) 136374478(PRDM6)
FPG : 101914736(KMT5A) 101915352(PRDM6)
FCH : 102050773(PRDM6) 102053153(KMT5A)
CCRI : 104160072(PRDM6) 104165021(SETD8)
NNT : 104399055(SETD8) 104408128(PRDM6)
SHAB : 115614939(KMT5A) 115619843(PRDM6)
ACUN : 113485973(KMT5A) 113489673(PRDM6)
TALA : 104355475(KMT5A) 104362362(PRDM6)
ACHC : 115337406(PRDM6) 115345824(KMT5A)
HALD : 104310615(SETD8) 104318949
HLE : 104828186(PRDM6) 104840920(SETD8)
AGEN : 126035838 126040879
CSTI : 104549246(SETD8) 104552905(PRDM6)
LDI : 104339768(SETD8) 104348450(PRDM6)
MNB : 103776190 103776967(SETD8)
DPUB : 104300379(PRDM6) 104308378(SETD8)
AVIT : 104273219(SETD8) 104275291(PRDM6)
BRHI : 104492388 104492471(SETD8)
EGZ : 104124245(PRDM6) 104130151(SETD8)
NNI : 104012509(PRDM6) 104020902(SETD8)
PCRI : 104023788(SETD8) 104038182
PCAO : 104039362(SETD8) 104048902(PRDM6)
PADL : 103914479(PRDM6) 103914547(SETD8)
AFOR : 103902872(KMT5A) 103903028(PRDM6)
FGA : 104069168(SETD8) 104078388(PRDM6)
GSTE : 104250299(SETD8) 104256291(PRDM6)
CLV : 102089973(KMT5A) 102097159(PRDM6)
MUI : 104545868(SETD8) 104548511
PGUU : 104457692(SETD8) 104465797
PLET : 104620595(SETD8) 104624542
EHS : 104502556(SETD8) 104513170
CMAC : 104473009(SETD8) 104485198
CUCA : 104061037(PRDM6) 104068460(KMT5A)
TEO : 104369654(SETD8) 104379022(PRDM6)
BREG : 104635738(SETD8) 104638597
OHA : 104327609(SETD8) 104327991(PRDM6)
ACAR : 104517510(KMT5A) 104525072(PRDM6)
CPEA : 104388755(SETD8) 104391240(PRDM6)
CVF : 104282255(SETD8) 104294239(PRDM6)
RTD : 128902631(PRDM6) 128916957(KMT5A)
AAM : 106484130 106497676(KMT5A)
AROW : 112962511(KMT5A) 112965157(PRDM6)
NPD : 112945813(KMT5A) 112953531(PRDM6)
TGT : 104574851(SETD8) 104580314(PRDM6)
DNE : 112991842(KMT5A) 112992354(PRDM6)
SCAM : 104138814(SETD8) 104150296(PRDM6)
ASN : 102380913(PRDM6) 102382842(KMT5A)
AMJ : 102569777(PRDM6) 102571182(KMT5A)
CPOO : 109312708(KMT5A) 109323639(PRDM6)
GGN : 109290516(KMT5A) 109297186(PRDM6)
PSS : 102458837(PRDM6) 102463287(KMT5A)
CMY : 102929316(KMT5A) 102942167(PRDM6)
CCAY : 125623204(KMT5A) 125636408(PRDM6)
DCC : 119843904(KMT5A) 119856237(PRDM6)
CPIC : 101932163(KMT5A) 101947533(PRDM6)
TST : 117879252(PRDM6) 117888053(KMT5A)
CABI : 116831030(PRDM6) 116836714(KMT5A)
MRV : 120386460(KMT5A) 120407456(PRDM6)
ACS : 100552008(prdm6) 100559474(kmt5a)
ASAO : 132767240(PRDM6) 132781355(KMT5A)
PVT : 110077521(PRDM6) 110083872(KMT5A)
SUND : 121916628(KMT5A) 121923239(PRDM6)
PBI : 103053204(KMT5A) 103057070(PRDM6)
PMUR : 107285441(KMT5A) 107292729(PRDM6)
CTIG : 120301984(PRDM6) 120316702(KMT5A)
TSR : 106540545(SETD8) 106540743(PRDM6)
PGUT : 117661309(PRDM6) 117672147(KMT5A)
APRI : 131185573(KMT5A) 131193382(PRDM6)
PTEX : 113445479(PRDM6) 113448664(KMT5A)
NSS : 113414534(PRDM6) 113425036(KMT5A)
VKO : 123028707(KMT5A) 123031474(PRDM6)
PMUA : 114586282(KMT5A) 114606447(PRDM6)
PRAF : 128403602(KMT5A) 128423233(PRDM6)
ZVI : 118075547(KMT5A) 118076680(PRDM6)
HCG : 128337839(KMT5A) 128346614(PRDM6)
GJA : 107114655(PRDM6) 107117211(KMT5A)
STOW : 125437159(PRDM6) 125442912(KMT5A)
EMC : 129335019(PRDM6) 129341573(KMT5A)
XLA : 100158384(kmt5a.S) 108707198(prdm6.S) 108717331(prdm6.L) 398318(kmt5a.L)
XTR : 100494529(prdm6) 780276(kmt5a)
NPR : 108787307(KMT5A) 108799254(PRDM6)
RTEM : 120932151(PRDM6) 120934096(KMT5A)
BBUF : 120988467(PRDM6) 120988620(KMT5A)
BGAR : 122934655(KMT5A) 122935336(PRDM6)
MUO : 115463228(PRDM6) 115480711(KMT5A)
GSH : 117352297 117352539(PRDM6) 117365706(KMT5A)
DRE : 100004770(kmt5ab) 101886516(prdm6) 751629(kmt5aa)
SRX : 107706747 107713557 107722327 107726219 107728092 107740028
SANH : 107655184 107657332 107693405(kmt5a) 107702926 107703628 107704173 107704572(prdm6)
SGH : 107548535(kmt5a) 107554512 107556037 107573249(prdm6) 107578348 107588935
CCAR : 109059003 109067610 109074173 109074406 109080144 109084763 109088593 109095529(prdm6)
CAUA : 113052697 113052839 113054712 113085032 113094229(kmt5a) 113106897 113110209
CGIB : 127958296 127963374 127966870 127990317 128018085 128020806
PTET : 122333772(kmt5aa) 122346190(kmt5ab) 122350132(prdm6)
LROH : 127164824(kmt5ab) 127169980(prdm6) 127172239(kmt5aa)
OMC : 131540749(kmt5ab) 131545628(prdm6) 131547944(kmt5aa)
PPRM : 120461932(prdm6) 120472105(kmt5ab) 120483070(kmt5aa)
RKG : 130069118(kmt5ab) 130076729(prdm6) 130094948(kmt5aa)
MAMB : 125262448(kmt5aa) 125267634(kmt5ab) 125280692(prdm6)
CIDE : 127513635 127517329 127521439
CERY : 137026179(prdm6) 137029395(kmt5aa) 137034079(kmt5ab)
MASI : 127414562 127423857 127432609 127433711 127436002
TROS : 130546290(kmt5aa) 130566440(kmt5ab) 130567577(prdm6)
TDW : 130411644(kmt5aa) 130420150(kmt5ab) 130440366(prdm6)
MANU : 129414431(prdm6) 129441120(kmt5ab) 129446503(kmt5aa)
IPU : 108256031(kmt5ab) 108265069 108276718(kmt5aa)
IFU : 128599066(kmt5ab) 128607806(prdm6) 128620161(kmt5aa)
PHYP : 113542401 113544710(kmt5a) 113547211(prdm6)
SMEO : 124393992(kmt5aa) 124399512(prdm6)
TFD : 113638387(kmt5aa) 113655973(prdm6)
TVC : 132854032(prdm6) 132863456(kmt5aa)
TRN : 134317598(prdm6) 134332356(kmt5aa) 134335451(kmt5ab)
AMEX : 103024833 103046457(kmt5aa) 103046528(prdm6) 111197404(kmt5ab) 125781346 125782436 125785953 125787564 125806109
CMAO : 118812882(prdm6) 118824954(kmt5aa) 118827214(kmt5ab)
EEE : 113571045(prdm6) 113581614 113584033(kmt5a)
CHAR : 105889376(kmt5aa) 105905089(kmt5ab) 105907553(prdm6)
TRU : 101062904(kmt5a) 101063309(prdm6) 101068946
TFS : 130517062(kmt5aa) 130525629(kmt5ab) 130526149(prdm6)
TNG : GSTEN00007631G001 GSTEN00025268G001 GSTEN00029438G001 GSTEN00031036G001
LCO : 104920299(kmt5a) 104935163(prdm6) 104940038
NCC : 104947636 104962306(setd8)
TBEN : 117473218(prdm6) 117476384(kmt5aa) 117496893(kmt5ab)
CGOB : 115013499 115014170(prdm6) 115016800(kmt5a)
PGEO : 117453157(prdm6) 117453176(kmt5ab) 117456051(kmt5aa)
GACU : 117555403(prdm6) 117561043(kmt5ab) 117561434(kmt5aa)
EMAC : 134868523(kmt5aa) 134873978(prdm6) 134874034(kmt5ab)
ELY : 117252541(prdm6) 117253040(kmt5ab) 117269340(kmt5aa)
EFO : 125890454(kmt5ab) 125890825(prdm6) 125906085(kmt5aa)
PLEP : 121944730(prdm6) 121944809(kmt5ab) 121959919
SLUC : 116051045(kmt5aa) 116054117(prdm6) 116056808(kmt5ab)
ECRA : 117944403(prdm6) 117944747(kmt5ab) 117959177(kmt5aa)
ESP : 116689426(prdm6) 116690287 116704008
PFLV : 114556014 114556289(prdm6) 114571152(kmt5a)
GAT : 120831092(kmt5ab) 120831743(kmt5aa)
PPUG : 119224952(kmt5ab) 119225651(prdm6) 119226398(kmt5aa)
AFB : 129101029(kmt5ab) 129101216(prdm6) 129102900(kmt5aa)
CLUM : 117735828(prdm6) 117736716(kmt5ab) 117740929(kmt5aa)
PSWI : 130196067(prdm6) 130196295(kmt5ab) 130205142(kmt5aa)
CANA : 137779249(kmt5ab) 137784248(kmt5aa) 137799426(prdm6)
CVE : 137867098(prdm6) 137867389(kmt5ab) 137869207(kmt5aa)
MSAM : 119891381(kmt5ab) 119891864(prdm6) 119914618(kmt5aa) 119917840
SCHU : 122865281(kmt5aa) 122875973(kmt5ab) 122876825(prdm6)
CUD : 121510055(kmt5ab) 121510064(prdm6) 121524944(kmt5aa)
ALAT : 119019228(prdm6) 119019846(kmt5ab) 119029806(kmt5aa)
ASTR : 137592154(prdm6) 137592904(kmt5ab) 137608272(kmt5aa)
MZE : 101468308(prdm6) 101470368(kmt5a) 101485410 112433498 112434147 112436186 112436306
ONL : 100702115 100709871(prdm6) 109194214(kmt5a) 109195113 109202029
OAU : 116313178(kmt5aa) 116313574(prdm6) 116332401(kmt5ab) 120440039 120442224
OLA : 101169793(kmt5a) 101172663 105354834(prdm6)
OML : 112137690(prdm6) 112148771(kmt5ab) 112163317(kmt5aa) 118599191
CSAI : 133450524(kmt5ab) 133450828 133450839(prdm6) 133455038(kmt5aa)
XMA : 102219947(kmt5a) 102220630(prdm6) 102233201
XCO : 114149247(kmt5a) 114154537 114154779(prdm6)
XHE : 116725040(kmt5a) 116729855 116729983(prdm6)
PRET : 103461350 103470267 103470825(prdm6) 103473254(kmt5a)
PFOR : 103151021(kmt5a) 103151865 103151868 103151873 103152623(prdm6)
PLAI : 106942166 106942497 106943016 106945940(prdm6) 106954785(kmt5a)
PMEI : 106909822 106918989(prdm6) 106925250(kmt5a) 106928543 106929479
GAF : 122819727(kmt5aa) 122828541(prdm6) 122828794(kmt5ab)
PPRL : 129365904(prdm6) 129372146(kmt5ab) 129374296(kmt5aa)
CVG : 107084661(prdm6) 107086058 107087301
CTUL : 119784767(kmt5aa) 119784854(prdm6) 119790158(kmt5ab)
GMU : 124872904(kmt5aa) 124877283(prdm6) 124878265(kmt5ab)
NFU : 107375146 107386117(prdm6) 107394219(kmt5a)
KMR : 108234482(kmt5ab) 108245860(prdm6) 108248169(kmt5aa)
ALIM : 106511939 106523808(setd8) 106527566 106533133
NWH : 119413069(kmt5ab) 119425123(kmt5aa)
AOCE : 111565810 111566914(prdm6) 111576642
MCEP : 124996558(kmt5aa) 125012176(kmt5ab) 125012780(prdm6)
CSEM : 103389958 103397505 103397995(prdm6)
POV : 109626470(kmt5a) 109638204
SSEN : 122758422(kmt5aa) 122769022(kmt5ab) 122769149(prdm6)
HHIP : 117767484(kmt5ab) 117768446(prdm6) 117771531(kmt5aa)
HSP : 118098042(kmt5aa) 118114691(prdm6) 118115071(kmt5ab)
PPLT : 128424596(kmt5aa) 128437660(kmt5ab) 128437745(prdm6)
SMAU : 118310057(kmt5aa) 118313817(prdm6) 118314035
LCF : 108874937 108878140(kmt5ab) 108897302(kmt5aa)
SDU : 111217857(kmt5a) 111230938 111239241(prdm6)
SLAL : 111649965 111658242 111667134(prdm6)
XGL : 120805543(kmt5ab) 120805697(prdm6) 120806784(kmt5aa)
HCQ : 109513448(prdm6) 109525154 109529122
SSCV : 125979925(kmt5aa) 125994035(prdm6) 125994152(kmt5ab)
SBIA : 133490551(kmt5aa) 133498922(prdm6) 133499651(kmt5ab)
PEE : 133400124(kmt5ab) 133400162(prdm6) 133413732(kmt5aa)
PTAO : 133474871(kmt5ab) 133475748(prdm6) 133489815(kmt5aa)
BPEC : 110168947 110171341 110172486(kmt5a)
MALB : 109953053 109957446(prdm6) 109961594(kmt5a)
BSPL : 114861706(prdm6) 114862890(kmt5ab) 114866997(kmt5aa)
SJO : 128365016(kmt5ab) 128380747(kmt5aa)
SASA : 106562505 106568287 106568308 106585273(kmt5a) 106587041(prdm6)
STRU : 115149301(kmt5a) 115159250 115164478 115167640(prdm6)
OTW : 112219631(kmt5aa) 112233539(kmt5ab) 112248945(prdm6) 112257473
OMY : 110523849 110525699(kmt5ab) 110526138(prdm6) 110537078
OGO : 123999640(kmt5aa) 124033969(prdm6) 124034294 124048656
ONE : 115105910(kmt5a) 115111631 115112017(prdm6) 115127850
OKI : 109868488 109874149(prdm6) 109880068 109892437
OKE : 118387821 118391486 118393236 118393619(prdm6)
SALP : 111958152 111961353 111973725(prdm6) 111974204 111981803(kmt5a)
SNH : 120023165(kmt5ab) 120026139 120044218 120051923(prdm6)
CCLU : 121530937 121574138 121582766 121584618(prdm6)
ELS : 105014800(kmt5a) 105025387(prdm6) 105026110
SFM : 108934749(kmt5a) 108938054(prdm6)
PKI : 111856522(prdm6) 111860044(kmt5a)
AANG : 118206487(kmt5ab) 118206970(prdm6) 118213194(kmt5aa)
LOC : 102686646(kmt5a) 102697014(prdm6)
PSPA : 121296780 121299694 121302484 121315476
ARUT : 117408833 117426360 117962465 117962511
PSEX : 120532709(prdm6) 120540871(kmt5aa)
LCM : 102355801(KMT5A) 102357740(PRDM6)
CMK : 103182382(prdm6) 103188010
CPLA : 122551012 122565544
HOC : 132827003 132827953(prdm6)
LERI : 129695800(prdm6) 129709245
PMRN : 116942008(PRDM6) 116944662(KMT5A)
LRJ : 133340495(KMT5A) 133343740(PRDM6)
BBEL : 109463004 109476176 109484669
SPU : 100892850 105440265 105442287 115917928 115918102 115921211 115921240 115923119 115926391 592467
DSI : Dsimw501_GD18956(Dsim_GD18956)
ASUA : 134219321 134219322
NVI : 100123008 100123020 100677939
CSOL : 105359046 105368743
TPRE : 106658250 111693283
AGRG : 126733460 126749230
SLIU : 111360462 111360948
TPAL : 117642704 117651861
PPOI : 119099287 119099433
CBR : CBG_16281 CBG_16282 CBG_19678(Cbr-set-1)
CRQ : GCK72_010704 GCK72_023057
BMY : BM_BM12185(Bma-set-1)
MMER : 123533535 123547644
MAEA : 128205549 128232909 128235719 128245101
NVE : 116601963 116619195 116619196 116619198 5509219 5510380 5510391 5514175 5518226 5518227 5520359
EPA : 110232839 110242476 110252276 110252283 110253323 110253439 110253440 110253496 110253497 110253500
ATEN : 116288855 116290567 116290576 116290935 116303623 116303624 116303633 116305629
ADF : 107333633 107333634 107333696 107333697 107333699 107333700 107333701 107343202 107347668
AMIL : 114953657 114956003 114961844 114961845 114961846 114961847 114961848 114961850 114961851 114972890
PDAM : 113670441 113672624 113672625 113672651 113672652 113672653 113672654 113672655 113679436 113684845
SPIS : 111322434 111322526 111322790 111322987 111333025 111335406 111335791 111336163 111336247 111339595
DGT : 114522454 114522456 114522520 114522531 114522584 114522647 114522697 114537567 114538303
XEN : 124434221 124450553 124454775 124454793 124454879
HMG : 100201879 100204152 100208645
PLAG : 39740122(PADL01_0403500)
PREL : PRELSG_0301100(SET8)
» show all
Taxonomy
Reference
Authors
Fang J, Feng Q, Ketel CS, Wang H, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Simon JA, Zhang Y
Title
Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase.
Journal
Sequence
Reference
Authors
Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, Reinberg D
Title
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin.
Journal
Sequence
Reference
Authors
Jorgensen S, Elvers I, Trelle MB, Menzel T, Eskildsen M, Jensen ON, Helleday T, Helin K, Sorensen CS
Title
The histone methyltransferase SET8 is required for S-phase progression.
Journal
Sequence
Reference
Authors
Oda H, Okamoto I, Murphy N, Chu J, Price SM, Shen MM, Torres-Padilla ME, Heard E, Reinberg D
Title
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development.
Journal
Sequence
Reference
Authors
Jorgensen S, Schotta G, Sorensen CS
Title
Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.361