KEGG   ENZYME: 2.1.1.368
Entry
EC 2.1.1.368                Enzyme                                 

Name
[histone H3]-lysine9 N-dimethyltransferase;
SUVH1 (gene name);
SUVR1 (gene name);
SET32 (gene name);
SDG32 (gene name);
SET13 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine9 N6-dimethyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
Reaction(KEGG)
(other) R03875 R04866
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine9;
[histone H3]-N6-methyl-L-lysine9
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6-dimethyl-L-lysine9;
[histone H3]-N6-methyl-L-lysine9
Comment
This entry describes several enzymes, characterized from plants, that successively methylate the L-lysine-9 residue of histone H3 (H3K9) twice, ultimately generating a dimethylated form. These modifications influence the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.367, [histone H3]-lysine9 N-methyltransferase, EC 2.1.1.366, [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase, and EC 2.1.1.355, [histone H3]-lysine9 N-trimethyltransferase.
History
EC 2.1.1.368 created 2020
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K24405  [histone H3]-lysine9 N-dimethyltransferase
Genes
ATH: AT5G04940(SUVH1)
ALY: 9307195
CRB: 17881599
CSAT: 104708619 104734501 104768691
EUS: EUTSA_v10012854mg EUTSA_v10015751mg
BRP: 103847241 103855596
BNA: 106382993 106419316 106428185 106440647 106445541
BOE: 106317806 106334517
RSZ: 108815877 108846741
THJ: 104816485
CPAP: 110817121
TCC: 18586976
EGR: 104454490
LJA: Lj0g3v0128679.1(Lj0g3v0128679.1) Lj0g3v0266169.1(Lj0g3v0266169.1) Lj1g3v4059050.1(Lj1g3v4059050.1)
MNT: 21410587
CSV: 101218938
CMO: 103502895
BHJ: 120072888
MCHA: 111021743
RCU: 8276339
JCU: 105631294
BVG: 104907436
SOE: 110778852
NNU: 104593573
MING: 122084106
DOSA: Os01t0811300-01(Os01g0811300) Os05t0490700-01(Os05g0490700) Os11t0602200-01(Os11g0602200)
EGU: 105045520
ATR: 18426216
 » show all
Reference
1  [PMID:15546353]
  Authors
Yu Y, Dong A, Shen WH
  Title
Molecular characterization of the tobacco SET domain protein NtSET1 unravels its role in histone methylation, chromatin binding, and segregation.
  Journal
Plant J 40:699-711 (2004)
DOI:10.1111/j.1365-313X.2004.02240.x
  Sequence
[nta:107761901]
Reference
2  [PMID:15574848]
  Authors
Shen WH, Meyer D
  Title
Ectopic expression of the NtSET1 histone methyltransferase inhibits cell expansion, and affects cell division and differentiation in tobacco plants.
  Journal
Plant Cell Physiol 45:1715-9 (2004)
DOI:10.1093/pcp/pch184
Reference
3  [PMID:15775980]
  Authors
Naumann K, Fischer A, Hofmann I, Krauss V, Phalke S, Irmler K, Hause G, Aurich AC, Dorn R, Jenuwein T, Reuter G
  Title
Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis.
  Journal
EMBO J 24:1418-29 (2005)
DOI:10.1038/sj.emboj.7600604
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.368
IUBMB Enzyme Nomenclature: 2.1.1.368
ExPASy - ENZYME nomenclature database: 2.1.1.368
BRENDA, the Enzyme Database: 2.1.1.368

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