KEGG   ENZYME: 2.1.1.372
Entry
EC 2.1.1.372                Enzyme                                 

Name
[histone H4]-lysine20 N-trimethyltransferase;
SET9 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[histone H4]-L-lysine20 N6-trimethyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H4]-L-lysine20 = 3 S-adenosyl-L-homocysteine + a [histone H4]-N6,N6,N6-trimethyl-L-lysine20 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H4]-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20;
(1b) S-adenosyl-L-methionine + a [histone H4]-N6-methyl-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6,N6-dimethyl-L-lysine20;
(1c) S-adenosyl-L-methionine + a [histone H4]-N6,N6-dimethyl-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6,N6,N6-trimethyl-L-lysine20
Reaction(KEGG)
(other) R03875 R04866 R04867
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H4]-L-lysine20;
[histone H4]-N6-methyl-L-lysine20;
[histone H4]-N6,N6-dimethyl-L-lysine20
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H4]-N6,N6,N6-trimethyl-L-lysine20;
[histone H4]-N6-methyl-L-lysine20;
[histone H4]-N6,N6-dimethyl-L-lysine20
Comment
The enzyme, characterized from the fission yeast Schizosaccharomyces pombe, catalyses three successive methylations of the L-lysine-20 residue of histone H4 (H4K20), forming the trimethylated form. The methylation of this site is apparently not involved in the regulation of gene expression or heterochromatin function but participates in DNA damage response. cf. EC 2.1.1.361, [histone H4]-lysine20 N-methyltransferase, and EC 2.1.1.362, [histone H4]-N-methyl-L-lysine20 N-methyltransferase.
History
EC 2.1.1.372 created 2020
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K24407  [histone H4]-lysine20 N-trimethyltransferase
Genes
SPO: SPCC4B3.12(set9)
Reference
1  [PMID:15550243]
  Authors
Sanders SL, Portoso M, Mata J, Bahler J, Allshire RC, Kouzarides T
  Title
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.
  Journal
Cell 119:603-14 (2004)
DOI:10.1016/j.cell.2004.11.009
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.372
IUBMB Enzyme Nomenclature: 2.1.1.372
ExPASy - ENZYME nomenclature database: 2.1.1.372
BRENDA, the Enzyme Database: 2.1.1.372

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