EC                Enzyme                                 

propanoyl-CoA C-acyltransferase;
SCP2 (gene name);
peroxisomal thiolase 2;
sterol carrier protein-chi;
PTE-2 (ambiguous);
propionyl-CoA C2-trimethyltridecanoyltransferase;
3-oxopristanoyl-CoA hydrolase;
3-oxopristanoyl-CoA thiolase;
peroxisome sterol carrier protein thiolase;
sterol carrier protein;
oxopristanoyl-CoA thiolase;
peroxisomal 3-oxoacyl coenzyme A thiolase;
4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase
Transferring groups other than aminoacyl groups
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA [RN:R03719]
R03719 > R04811;
(other) R05330 R07937 R07953
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA [CPD:C01794];
propanoyl-CoA [CPD:C00100]
CoA [CPD:C00010];
3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA [CPD:C05467]
Also acts on dihydroxy-5beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives. The enzyme catalyses the penultimate step in the formation of bile acids. The bile acid moiety is transferred from the acyl-CoA thioester (RCO-SCoA) to either glycine or taurine (NH2R') by EC, bile acid-CoA:amino acid N-acyltransferase [3].
EC created 2005 (EC created 2000, incorporated 2015)
ec00120  Primary bile acid biosynthesis
ec01040  Biosynthesis of unsaturated fatty acids
ec01100  Metabolic pathways
K08764  sterol carrier protein 2
HSA: 6342(SCP2)
PTR: 456862(SCP2)
PPS: 100986541(SCP2)
GGO: 101143883(SCP2)
PON: 100173072(SCP2)
NLE: 100597097(SCP2)
MCC: 715765(SCP2)
MCF: 102140312(SCP2)
CSAB: 103224800(SCP2)
RRO: 104669256(SCP2)
RBB: 108531191(SCP2)
CJC: 100388218(SCP2)
SBQ: 101036680(SCP2)
MMU: 20280(Scp2)
MCAL: 110292209(Scp2)
MPAH: 110323135(Scp2)
RNO: 25541(Scp2)
MUN: 110563883(Scp2)
CGE: 100757558(Scp2)
NGI: 103730241(Scp2)
HGL: 101705283(Scp2)
CCAN: 109693360(Scp2)
OCU: 100008683(SCP2)
TUP: 102487249(SCP2)
CFA: 479564(SCP2)
VVP: 112926124(SCP2)
AML: 100469567(SCP2)
UMR: 103670702(SCP2)
UAH: 113254655(SCP2)
ORO: 101367151(SCP2)
ELK: 111143445
FCA: 101093036(SCP2)
PTG: 102951550(SCP2)
PPAD: 109266864(SCP2)
AJU: 106987886(SCP2)
BTA: 508918(SCP2)
BOM: 102281973
BIU: 109556283(SCP2)
BBUB: 102409865(SCP2)
CHX: 102182369(SCP2)
OAS: 101117285(SCP2)
SSC: 397439(SCP2)
CFR: 102516689(SCP2)
CDK: 105090773(SCP2)
BACU: 103008562(SCP2)
LVE: 103081853
OOR: 101279314(SCP2)
DLE: 111175824(SCP2)
PCAD: 102988699(SCP2)
ECB: 100061338(SCP2)
EPZ: 103558615(SCP2)
EAI: 106833182(SCP2)
MYB: 102242920(SCP2)
MYD: 102765227(SCP2)
MNA: 107535398(SCP2)
DRO: 112314454(SCP2)
PALE: 102884769(SCP2)
RAY: 107497927(SCP2)
MJV: 108403979(SCP2)
LAV: 100666078
TMU: 101347488
MDO: 100017946(SCP2)
SHR: 100922562(SCP2)
PCW: 110209359(SCP2)
OAA: 100084202(SCP2)
GGA: 396550(SCP2)
MGP: 100541979(SCP2)
CJO: 107317654(SCP2)
NMEL: 110402526(SCP2)
APLA: 101803933(SCP2)
ACYG: 106032940(SCP2)
TGU: 100218387(SCP2)
LSR: 110470146(SCP2)
SCAN: 103815029(SCP2)
GFR: 102042799(SCP2)
FAB: 101820874(SCP2)
PHI: 102105546(SCP2)
PMAJ: 107208151(SCP2)
CCAE: 111933041(SCP2)
CCW: 104695523(SCP2)
ETL: 114062766(SCP2)
FPG: 101913645(SCP2)
FCH: 102053527(SCP2)
CLV: 102087499(SCP2)
EGZ: 104131500(SCP2)
ACUN: 113483071(SCP2)
PADL: 103913664(SCP2)
AAM: 106491062(SCP2)
AMJ: 102570791(SCP2)
PSS: 102461487(SCP2)
CMY: 102931842
CPIC: 101937963(SCP2)
ACS: 100559527(scp2)
PVT: 110082239(SCP2)
PBI: 103053379(SCP2)
PMUR: 107283044(SCP2)
TSR: 106546053(SCP2)
PMUA: 114598987(SCP2)
GJA: 107120559(SCP2)
XLA: 108715604 494715(scp2.L)
XTR: 548512(scp2)
NPR: 108783818(SCP2)
DRE: 393839(scp2a)
SRX: 107719264(scp2) 107722381
SANH: 107681719(scp2)
SGH: 107593851(scp2)
CCAR: 109091477
IPU: 108267621(scp2)
PHYP: 113540595
AMEX: 103022159(scp2)
EEE: 113570128(scp2)
TRU: 101069006(scp2)
LCO: 104936979(scp2)
NCC: 104949681(scp2)
MZE: 101481799(scp2)
ONL: 100711328
OLA: 101175107(scp2)
XMA: 102226285
XCO: 114145905(scp2)
PRET: 103479011(scp2)
CVG: 107083609(scp2)
NFU: 107384403
KMR: 108238206(scp2)
ALIM: 106527182(scp2)
AOCE: 111587618(scp2)
CSEM: 103395834(scp2)
POV: 109646608(scp2)
LCF: 108883814(scp2)
SDU: 111228861(scp2)
SLAL: 111670554(scp2)
HCQ: 109521343(scp2)
BPEC: 110173449(scp2) 110173461
MALB: 109970643(scp2)
SASA: 106569705(scp2)
OTW: 112260891(scp2)
SALP: 112069550
ELS: 105022798(scp2)
SFM: 108935159(scp2)
PKI: 111847545(scp2)
LCM: 102354489
CMK: 103185291(scp2)
RTP: 109913670(scp2)
APLC: 110986063
SKO: 100368127(SCP2) 100368276
DME: Dmel_CG17320(ScpX) Dmel_CG17597(CG17597)
DSI: Dsimw501_GD21807(Dsim_GD21807)
MDE: 101899830
LCQ: 111680181
AAG: 5575668
AME: 408904
BIM: 100748275
BTER: 100647066
CCAL: 108628439
OBB: 114870987
SOC: 105201416
MPHA: 105840706
AEC: 105153563
ACEP: 105618569
PBAR: 105432859
VEM: 105559618
HST: 105189995
DQU: 106742407
CFO: 105251216
LHU: 105675589
PGC: 109861339
OBO: 105274767
PCF: 106788866
NVI: 100123951
CSOL: 105363609
MDL: 103571215
TCA: 657233(Scpx)
DPA: 109539789
ATD: 109602926
NVL: 108556749
BMOR: 692782(Scpx)
BMAN: 114242327
PRAP: 110993930
HAW: 110373174
TNL: 113497353
PXY: 105382506
API: 100161454
DNX: 107161308
AGS: 114122268
RMD: 113555937
BTAB: 109035142
CLEC: 106670708
ZNE: 110831910
FCD: 110850871
PVM: 113823286
TUT: 107367461
CSCU: 111639045
CEL: CELE_Y57A10C.6(daf-22)
CBR: CBG20965
BMY: Bm1_53275
MYI: 110461537
OBI: 106877352
AMIL: 114970597
DGT: 114526215
AQU: 100638133
NCR: NCU03372
MGR: MGG_02409
SSCK: SPSK_02507
MAW: MAC_03561
MAJ: MAA_02626
MBE: MBM_04974
ANG: ANI_1_216184(An04g00740)
PBL: PAAG_11860(PAAG_04374)
ABE: ARB_01676
TVE: TRV_00032
PTE: PTT_11137
TASA: A1Q1_03740
SFR: Sfri_0743
CPS: CPS_0669
PSEO: OM33_12585
PSPO: PSPO_a2037
ADI: B5T_02065
APAC: S7S_16300
AXE: P40_09880
GPB: HDN1F_17110(tioL)
AAA: Acav_2987
HPSE: HPF_13290(paaJ2)
EBA: ebA306(tioL) ebA5797
TCL: Tchl_1577
PLA: Plav_0155
BRS: S23_06920
RPB: RPB_4078
RPD: RPD_3814
XAU: Xaut_4071
CAK: Caul_0450
SPSE: SULPSESMR1_04594(fadA)
SWI: Swit_4119
SMIC: SmB9_09260
AZL: AZL_a11110(fadA)
TMO: TMO_0975
MJL: Mjls_1512
MVQ: MYVA_4960
MCHT: MCHIJ_01810(ltp1_1)
ASD: AS9A_0934
NSR: NS506_04193(scp2)
GOR: KTR9_3195
 » show all
1  [PMID:7461136]
Pedersen JI, Gustafsson J.
Conversion of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid into cholic acid by rat liver peroxisomes.
FEBS Lett 121:345-8 (1980)
2  [PMID:6668450]
Kase F, Bjorkhem I, Pedersen JI.
Formation of cholic acid from 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes.
J Lipid Res 24:1560-7 (1983)
3  [PMID:8034703]
Falany CN, Johnson MR, Barnes S, Diasio RB.
Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.
J Biol Chem 269:19375-9 (1994)
4  [PMID:8063752]
Seedorf U, Brysch P, Engel T, Schrage K, Assmann G.
Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity.
J Biol Chem 269:21277-83 (1994)
5  [PMID:9245689]
Wanders RJ, Denis S, Wouters F, Wirtz KW, Seedorf U.
Sterol carrier protein X (SCPx) is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: a new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes.
Biochem Biophys Res Commun 236:565-9 (1997)
6  [PMID:12543708]
Russell DW.
The enzymes, regulation, and genetics of bile acid synthesis.
Annu Rev Biochem 72:137-74 (2003)
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