KEGG   ENZYME: 2.3.1.65
Entry
EC 2.3.1.65                 Enzyme                                 
Name
bile acid-CoA:amino acid N-acyltransferase;
glycine---taurine N-acyltransferase;
amino acid N-choloyltransferase;
BAT;
glycine N-choloyltransferase;
BACAT;
cholyl-CoA glycine-taurine N-acyltransferase;
cholyl-CoA:taurine N-acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
choloyl-CoA:glycine N-choloyltransferase
Reaction(IUBMB)
choloyl-CoA + glycine = CoA + glycocholate [RN:R03718]
Reaction(KEGG)
R03718;
(other) R03720 R08744 R08745
Substrate
choloyl-CoA [CPD:C01794];
glycine [CPD:C00037]
Product
CoA [CPD:C00010];
glycocholate [CPD:C01921]
Comment
Also acts on CoA derivatives of other bile acids. Taurine and 2-fluoro-beta-alanine can act as substrates, but more slowly [4]. The enzyme can also conjugate fatty acids to glycine and can act as a very-long-chain acyl-CoA thioesterase [7]. Bile-acid---amino-acid conjugates serve as detergents in the gastrointestinal tract, solubilizing long chain fatty acids, mono- and diglycerides, fat-soluble vitamins and cholesterol [4]. This is the second enzyme in a two-step process leading to the conjugation of bile acids with amino acids; the first step is the conversion of bile acids into their acyl-CoA thioesters, which is catalysed by EC 6.2.1.7, cholate---CoA ligase.
History
EC 2.3.1.65 created 1983, modified 2005
Pathway
ec00120  Primary bile acid biosynthesis
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Orthology
K00659  bile acid-CoA:amino acid N-acyltransferase
Genes
HSA570(BAAT)
PTR472997
PPS100992429(BAAT)
GGO101140183(BAAT)
PON100431907(BAAT) 100461881
NLE100598200(BAAT)
HMH116475340(BAAT)
MCC100429419(BAAT)
MCF102132073(BAAT)
MTHB126937773
MNI105480981(BAAT)
CSAB103219118(BAAT)
CATY105593023(BAAT)
PANU101007875(BAAT)
TGE112608227(BAAT)
MLEU105546769(BAAT) 105546778
RRO104670797(BAAT)
RBB108537176(BAAT)
TFN117098906(BAAT)
PTEH111536312(BAAT)
CANG105518150(BAAT)
CJC100394190 100396712(BAAT)
SBQ101036806
CIMI108303855(BAAT)
CSYR103256776 103256777
MMUR105873759(BAAT) 105873760
LCAT123645821(BAAT)
PCOQ105805378(BAAT) 105805407
OGA100957082 100957390
MMU12012(Baat) 209186(Acnat2) 230161(Acnat1)
MCAL110292343 110293184
MPAH110323775(Baat) 110323900
RNO29725(Baat) 313220(Acnat2) 681043(Acnat1)
MCOC116095310(Baat) 116096003
ANU117708778 117709136 117709479 117709552
MUN110557337 110557338
CGE100756252(Baat) 100756541
MAUA101835789 101836051
PROB127224676 127224678
PLEU114702315(Baat) 114702326
MORG121451765 121452021
MFOT126509815 126509848
AAMP119826151 119826854
NGI103749095 103749096 103749097
HGL101716142(Baat) 101717293
CPOC100719696(Baat) 100719973
CCAN109696243(Baat)
DORD105990724
DSP122122419(Baat) 122123761
PLOP125346048 125356113
NCAR124964800 124964957
MMMA107147751(Baat) 107147755
OCU100348617 100350133 100350872
OPI101519913(BAAT)
TUP102472797 102473647(BAAT)
GVR103607004
CFA481634 481635(BAAT)
CLUD112649971(BAAT) 112649972
VVP112930766(BAAT) 112930863
VLG121494953 121494954
NPO129494523 129494875
AML100476252 100476755
UMR103678524 103678630(BAAT)
UAH113260385 113260386(BAAT)
UAR123781224 123781225
ELK111145724 111145726
LLV125082990 125083316
MPUF101671389 101671902(BAAT)
MNP132024553 132024555
MLK131812402 131812403
NVS122917401 122917402
ORO101365672 101365978
EJU114213433 114213445
ZCA113934001
MLX118018214(BAAT) 118018215
NSU110581717(BAAT) 110581808
LWW102729180 102729479
FCA101095691(BAAT) 101096116
PYU121034756(BAAT) 121034758
PCOO112850975 112860692(BAAT)
PBG122474312 122474485(BAAT)
LRUF124526231 124526233
PTG102969591(BAAT) 102969870
PPAD109270057 109270058
PUC125926097 125926223
AJU106972069 106972070
HHV120224623(BAAT) 120224624
BTA530653 786798
BOM102268462
BIU109563300(BAAT)
BBUB102403928 102405119
BBIS104992074
CHX102174570(BAAT)
OAS101106149 101106409(BAAT)
BTAX128052871
ODA120863959
CCAD122431993
SSC100515185 102158534 110255172
CFR102523415(BAAT)
CBAI105067405(BAAT)
CDK105086911(BAAT)
VPC102529299(BAAT)
BACU103006095 103017253(BAAT)
LVE103081315 103082496(BAAT)
OOR101284164 101284403
DLE111188015(BAAT)
PCAD102984994(BAAT)
PSIU116754977 116755602
NASI112392644(BAAT) 112392655
ECB100054567 100063137(BAAT)
EPZ103552469(BAAT) 103568036
EAI106831794 106831795
MYB102262596 102263115
MYD102764048 102764710
MMYO118667244 118667245
MLF102433860 102434162(BAAT)
MNA107546604(BAAT)
PKL118716241 118716242
EFUS103286385(BAAT)
HAI109395040(BAAT)
DRO112304453(BAAT)
SHON118979701(BAAT)
AJM119045945(BAAT)
PDIC114503289(BAAT)
PHAS123819950(BAAT)
MMF118629687(BAAT)
RFQ117032410(BAAT)
PPAM129079385(BAAT)
PALE102892341(BAAT) 102897591
PGIG120597018
PVP105296259(BAAT) 105296291
RAY107499578 107499579
MJV108397381(BAAT)
TOD119232402(BAAT)
SARA101540428(BAAT)
LAV100654296 100670223
TMU101357199
ETF101654639 101654956
DNM101418518 101419268 101447075
MDO100017693 100023136(BAAT)
GAS123230833(BAAT) 123230834 123254112
SHR100924464 100925244
AFZ127554786
PCW110219134(BAAT)
OAA100084056(BAAT)
GGA769879(BAAT)
PCOC116242919
MGP100539658
CJO107314177
TPAI128085669
LMUT125694885(BAAT)
NMEL110400838
APLA101797844
ACYG106048282
CATA118244478
AFUL116490259
TGU115495423
LSR110485078
SCAN103822142
PMOA120499625
OTC121339708
PRUF121355202
GFR102037789
FAB101815920
OMA130254435
PHI102101793
PMAJ107206148
CCAE111930612
CCW120410054
CBRC103611827
ETL114063343
ZAB102062391
ACHL103805502(BAAT)
SVG106854675
MMEA130580050
HRT120753731
FPG101924136
FCH102059453
CLV102094683
EGZ104134405(BAAT)
NNI104008979(BAAT)
PCRI104030139
ACUN113481099
TALA116961616
AFOR103895438
ACHC115352108
HLE104829793(BAAT)
AGEN126046987
GCL127017185
MNB103778534(BAAT)
OHA104328517
NNT104406607
SHAB115606966
DPUB104296264(BAAT)
ACAR104522067
CPEA104393367
CVF104283272(BAAT)
RTD128908803
CUCA104063337(BAAT)
TEO104377729
AAM106494986
AROW112960829(BAAT)
NPD112952722
TGT104578818
DNE112988642
SCAM104151146(BAAT)
ASN102368085(BAAT) 102376159 102383708
AMJ102559248 102564970(BAAT) 102575228
CPOO109323479 109323497
GGN109297368 109297370
PSS102447700(BAAT) 102461463 102461871
CMY102939533(BAAT) 102947935
CCAY125636624(BAAT) 125638328
DCC119856403(BAAT) 119857880
CPIC101932563 101938826(BAAT)
TST117876003 117879669(BAAT)
CABI116825950(BAAT)
MRV120403019 120407254(BAAT) 120407813
ACS100566890(baat)
ASAO132772260(BAAT)
PVT110078385(BAAT)
SUND121930998
PBI103065567(BAAT)
PMUR107292645 107292672
CTIG120308320 120308321 120308323
TSR106538123(BAAT)
PGUT117667061(BAAT)
APRI131184117(BAAT)
PTEX113449132(BAAT)
NSS113421915(BAAT)
VKO123021162 123021248
PMUA114600844(BAAT)
PRAF128418018(BAAT)
ZVI118089420(BAAT)
HCG128341173 128341626(BAAT)
GJA107106123 107106126(BAAT)
STOW125427301 125436721(BAAT)
EMC129324679 129334736(BAAT)
XLA100137716(XB5872576.L) 108707337(baat.S)
XTR100125079(baat) 100488333 100496940 100497260 100497423 100497580 100497738 116408197
NPR108790690 108790705 108790706 108795509
RTEM120926637 120926656 120926672 120943647
BBUF120992241(BAAT) 121008572
BGAR122924848 122924849 122924850 122945314
MUO115482004(BAAT)
SRX107726829
SANH107689220 107689257
CCAR109068937
CAUA113061125 113068447
IPU108280978
IFU128625280
PHYP113532413
TFD113656460
TVC132838449
CMAO118799894
EEE113584003
CHAR105912192
TFS130523915
TNGGSTEN00014025G001 GSTEN00019694G001
TBEN117489722
CGOB115008157
PGEO117447318
GACU117534190
ELY117256189 117256459 117256968
EFO125888830 125897968 125897977 125897983 125897996
PLEP121953471 121953523
SLUC116066678
ECRA117944007
ESP116688512
PFLV114553794
GAT120835251
PPUG119193948
AFB129105536
CLUM117730964
SCHU122867513
CUD121506802
ALAT119021228
ONL109198392
OAU116329896
OLA101166298
OML112145720
XMA102226402
XCO114135870
XHE116711136
PRET103465285
PFOR103144302
PLAI106934498
PMEI106906822
GAF122834742
PPRL129353154
CVG107083302
CTUL119791826
GMU124856113
NFU107385610
KMR108235667
NWH119411976
MCEP125006140
POV109628957 109644008
SSEN122767935 122768787
HHIP117761208
HSP118105133
SDU111221490
SLAL111667779
HCQ109522368
SSCV125976910
SBIA133507447 133507554
PEE133409198
PTAO133483319
BPEC110161506 110171280 110171322
MALB109956248
BSPL114856054
SJO128356051
SASA106584567 106609489
STRU115208005
OGO124003938
ONE115143032
OKI109894173
OKE118388720
SNH120062369 120065229
CCLU121577792
ELS105010081
SFM108933858
AANG118211819
LCM102356569(BAAT) 102363365 102363627
CIN100175018 100182847 100184394
SCLV120325725 120329571 120329639 120337556 120343818 120343819 120344834 120347055 120348310
SPU100892177 115926355
APLC110981446 110989383 110991145
AJC117105456 117105473
HAME121871783
PCLA123754342
PTRU123506716
HAZT108682704
LGILOTGIDRAFT_125734
PVUL126821684
PCAN112570277 112570289 112570596
HRF124137037 124146464
HRJ124268350 124270995 124270996 124270998 124276134 124277115 124277116
CRG105328098
CVN111131209 111131381
CANU128163038 128175585
OED125649731 125652746 125652747
MYI110465077
PMAX117323580 117335375 117335376 117336519
MMER123550893 123552208
RPHI132733646 132733647 132737676
DPOL127853306 127853745 127870784 127873764
OBI106881808
OSN115226141 115226175 115232312 115232313
LAK106169569
NVE5519541
EPA110233238 110233246 110242348
ADF107346883
AMIL114966874
PDAM113665012 113665467 113666427
SPIS111328316 111331670 111339322 111339330 111339338 111341936
HSY130624222 130648508 130662424
 » show all
Reference
1  [PMID:7372637]
  Authors
Czuba B, Vessey DA.
  Title
Kinetic characterization of cholyl-CoA glycine-taurine N-acyltransferase from bovine liver.
  Journal
J Biol Chem 255:5296-9 (1980)
Reference
2
  Authors
Jordan, T.W., Lee, R. and Lim, W.C.
  Title
Isoelectric focussing of soluble and particulate benzoyl-CoA and cholyl-CoA:amino acid N-acyltransferases from rat liver.
  Journal
Biochem Int 1:325-330 (1980)
Reference
3  [PMID:422567]
  Authors
Vessey DA.
  Title
The co-purification and common identity of cholyl CoA:glycine- and cholyl CoA:taurine-N-acyltransferase activities from bovine liver.
  Journal
J Biol Chem 254:2059-63 (1979)
Reference
4  [PMID:2037576]
  Authors
Johnson MR, Barnes S, Kwakye JB, Diasio RB.
  Title
Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver.
  Journal
J Biol Chem 266:10227-33 (1991)
  Sequence
[hsa:570]
Reference
5  [PMID:12454267]
  Authors
Falany CN, Xie X, Wheeler JB, Wang J, Smith M, He D, Barnes S.
  Title
Molecular cloning and expression of rat liver bile acid CoA ligase.
  Journal
J Lipid Res 43:2062-71 (2002)
DOI:10.1194/jlr.m200260-jlr200
Reference
6  [PMID:12951368]
  Authors
He D, Barnes S, Falany CN.
  Title
Rat liver bile acid CoA:amino acid N-acyltransferase: expression, characterization, and peroxisomal localization.
  Journal
J Lipid Res 44:2242-9 (2003)
DOI:10.1194/jlr.M300128-JLR200
  Sequence
[rno:29725]
Reference
7  [PMID:12810727]
  Authors
O'Byrne J, Hunt MC, Rai DK, Saeki M, Alexson SE.
  Title
The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine.
  Journal
J Biol Chem 278:34237-44 (2003)
DOI:10.1074/jbc.M300987200
  Sequence
[hsa:570]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.65
IUBMB Enzyme Nomenclature: 2.3.1.65
ExPASy - ENZYME nomenclature database: 2.3.1.65
BRENDA, the Enzyme Database: 2.3.1.65
CAS: 65979-40-0

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