KEGG   ENZYME: 2.4.1.148
Entry
EC 2.4.1.148                Enzyme                                 
Name
acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV;
uridine diphosphoacetylglucosamine-mucin beta(1->6)-acetylglucosaminyltransferase B;
core 4 beta6-GalNAc-transferase;
core 6beta-GalNAc-transferase B;
UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-D-galactosaminyl-R 6-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->6)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-N-acetyl-D-galactosaminyl-R [RN:R03514 R05915]
Reaction(KEGG)
R03514 R05915(G);
(other) R05910(G)
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-D-galactosaminyl-R [CPD:C01306]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->6)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-N-acetyl-D-galactosaminyl-R [CPD:C04917]
Comment
cf. EC 2.4.1.102 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase), EC 2.4.1.146 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) and EC 2.4.1.147 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase).
History
EC 2.4.1.148 created 1984
Pathway
ec00512  Mucin type O-glycan biosynthesis
ec01100  Metabolic pathways
Reference
1  [PMID:6226356]
  Authors
Brockhausen I, Rachaman ES, Matta KL, Schachter H.
  Title
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
  Journal
Carbohydr Res 120:3-16 (1983)
DOI:10.1016/0008-6215(83)88002-1
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.148
IUBMB Enzyme Nomenclature: 2.4.1.148
ExPASy - ENZYME nomenclature database: 2.4.1.148
BRENDA, the Enzyme Database: 2.4.1.148
CAS: 95978-15-7

  All links  
Protein sequence (881)   
   UniProt (860)   
   SWISS-PROT (13)   
   RefSeq(pep) (8)   
DNA sequence (8)   
   RefSeq(nuc) (8)   
Protein domain (1)   
   InterPro (1)   
All databases (890)   

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