KEGG ENZYME: 2.4.1.325

ENZYME: 2.4.1.325

Entry

EC 2.4.1.325                Enzyme

Name

TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase;
TDP-Fuc4NAc:lipid II Fuc4NAc-transferase;
TDP-Fuc4NAc:lipid II Fuc4NAc transferase;
wecF (gene name)

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

dTDP-N-acetyl-alpha-D-fucose:N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol N-acetylfucosaminyltransferase

Reaction(IUBMB)

dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = dTDP + 4-acetamido-4,6-dideoxy-alpha-D-galactosyl-(1->4)-N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R10303]

Reaction(KEGG)

R10303

Substrate

dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose [CPD:C20415];
N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol

Product

dTDP [CPD:C00363];
4-acetamido-4,6-dideoxy-alpha-D-galactosyl-(1->4)-N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol

Comment

Involved in the enterobacterial common antigen (ECA) biosynthesis in the bacterium Escherichia coli. The trisaccharide of the product (lipid III) is the repeat unit of ECA.

History

EC 2.4.1.325 created 2014

Orthology

K12582

dTDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase

Genes

ECO:	b4481(wecF)

ECJ:	JW5596(rffT)

ECD:	ECDH10B_3982(rffT)

EBW:	BWG_3475(rffT)

ECOK:

ECMDS42_3231(rffT)

ECE:

Z5304

ECS:	ECs_4726(wecF)

ECF:	ECH74115_5226(wecF)

ETW:	ECSP_4841(rffT)

ELX:	CDCO157_4463

EOI:	ECO111_4619(rffT)

EOJ:	ECO26_4793(rffT)

EOH:	ECO103_4371(rffT)

ECOO:

ECRM13514_4853

ECOH:

ECRM13516_4638

ESL:

O3K_24900

ESO:

O3O_00440

ESM:

O3M_24820

ECK:	EC55989_4265(rffT)

ECG:	E2348C_4094(rffT)

EOK:	G2583_4587(rffT)

ELR:	ECO55CA74_22010

ELH:

ETEC_4075

ECW:	EcE24377A_4305(wecF)

EUN:	UMNK88_4602

ECP:

ECP_3984

ENA:	ECNA114_3931(rffT)

ECOS:

EC958_4255

ECV:	APECO1_2682(rffT)

ECOA:

APECO78_22810

ECX:	EcHS_A4010(wecF)

ECM:	EcSMS35_4157(wecF)

ECY:

ECSE_4076

ECR:	ECIAI1_3980(rffT)

ECQ:	ECED1_4478(rffT)

EUM:	ECUMN_4318(rffT)

ECT:	ECIAI39_2994(rffT)

EOC:	CE10_4436(rffT)

EBR:	ECB_03671(rffT)

EBL:	ECD_03671(wecF)

EBE:	B21_03620(rffT)

EBD:

ECBD_4246

ECI:	UTI89_C4350

EIH:	ECOK1_4239(wecF)

ECZ:	ECS88_4215(rffT)

ECC:

c4714

ELO:	EC042_4170(rffT)

ELN:	NRG857_18840

ESE:

ECSF_3633

ECL:	EcolC_4210

EKO:	EKO11_4563

EKF:	KO11_03975(rffT)

EAB:	ECABU_c42720(rffT)

EDH:	EcDH1_4183

EDJ:	ECDH1ME8569_3675(rffT)

ELU:	UM146_19105

ELW:	ECW_m4091(rffT)

ELL:	WFL_19975(rffT)

ELC:

i14_4307

ELD:

i02_4307

ELP:	P12B_c3923(wecF)

ELF:	LF82_1863(rffT)

ECOL:

LY180_19640

ECOI:

ECOPMV1_04126(wecF)

ECOJ:

P423_20990

EFE:	EFER_3711(rffT)

EAL:	EAKF1_ch2144c(wecF)

EMA:	C1192_16600

ESZ:	FEM44_09720(rffT)

STY:

STY3628

STT:

t3370

SEX:	STBHUCCB_35540

SENT:

TY21A_17055

STM:

STM3927

SEO:	STM14_4725

SEV:	STMMW_39021

SEY:	SL1344_3886

SEM:	STMDT12_C40810

SEJ:	STMUK_3913

SEB:	STM474_4105

SEF:	UMN798_4264

SETU:

STU288_19820

SETC:

CFSAN001921_20795

SENR:

STMDT2_37981

SEND:

DT104_39451

SENI:

CY43_20560

SEEN:

SE451236_01265

SPT:

SPA3767

SEK:

SSPA3511

SPQ:	SPAB_04872

SEI:

SPC_4041

SEC:

SCH_3832

SEH:	SeHA_C4256(wecF)

SHB:

SU5_043

SENH:

CFSAN002069_12405

SEEH:

SEEH1578_05750

SEE:	SNSL254_A4207(wecF)

SENN:

SN31241_47950

SEW:	SeSA_A4138(wecF)

SEA:	SeAg_B4153(wecF)

SENS:

Q786_19245

SED:	SeD_A4315(wecF)

SEG:

SG3516

SEL:

SPUL_3499

SEGA:

SPUCDC_3485

SET:

SEN3732

SENA:

AU38_19260

SENO:

AU37_19255

SENV:

AU39_19275

SENQ:

AU40_21480

SENL:

IY59_19730

SENJ:

CFSAN001992_14025

SEEC:

CFSAN002050_02520

SEEB:

SEEB0189_022700

SEEP:

I137_16775

SENB:

BN855_40050(wecF)

SENE:

IA1_19090

SENC:

SEET0819_03490

SES:	SARI_03726

SBG:

SBG_3470

SBZ:

A464_3987

SBV:	N643_17345

SALZ:

EOS98_22700

SFL:	SF3867(yifM)

SFX:	S3893(yifM)

SFV:	SFV_3711(yifM)

SFE:	SFxv_4213(rffT)

SFN:

SFy_5521

SFS:

SFyv_5586

SFT:	NCTC1_04179(wecF)

SSN:	SSON_3965(yifM)

SBO:	SBO_3804(yifM)

SBC:	SbBS512_E4128(wecF)

SDY:	SDY_3955(yifM)

SDZ:	Asd1617_05184

SHQ:	A0259_00420

ENC:

ECL_04994

ENL:	A3UG_22185

ECLG:

EC036_43000

ECLE:

ECNIH2_01480

ECLN:

ECNIH4_21945

ECLI:

ECNIH5_01020

ECLX:

LI66_00860

ECLY:

LI62_01275

ECLZ:

LI64_00935

ECLO:

ENC_02110

EHM:	AB284_01240

EXF:	BFV63_00845

ECLA:

ECNIH3_01025

ECLC:

ECR091_01025

EAU:	DI57_19320

EKB:	BFV64_22685

ENO:	ECENHK_21390

EEC:	EcWSU1_04380(wecF)

ELG:	BH714_23065

ECAN:

CWI88_21935

ERN:	BFV67_21325

ECLS:

LI67_023525

ECHG:

FY206_23645

ESH:	C1N69_22200

ENT:	Ent638_3995

EAS:	Entas_4278

ENR:	H650_16110

ENX:	NI40_021420

ENF:	AKI40_4798

LNI:	CWR52_13440

EBG:	FAI37_07595

END:	A4308_06320

ENZ:	G0034_22300

ENS:	HWQ15_09185

ENK:	LOC22_11690

EHU:	D5067_0000835

EMOR:

L6Y89_00680

ENB:	ELK40_21820

ESA:

ESA_03767

CSK:	ES15_3692(wecF)

CSZ:	CSSP291_17435

CSJ:	CSK29544_00725

CCON:

AFK62_01315

CDM:	AFK67_01285

CSI:	P262_05488

CMJ:	AFK66_018815

CUI:	AFK65_00955

CMW:	AFK63_17335

CTU:	CTU_02290(wecF)

KPN:	KPN_04293(wecF)

KPU:	KP1_0155(wecF)

KPM:	KPHS_01400

KPP:

A79E_4895

KPH:	KPNIH24_00750

KPZ:	KPNIH27_00765

KPV:	KPNIH29_00720

KPW:	KPNIH30_00755

KPY:	KPNIH31_00755

KPG:	KPNIH32_00760

KPC:	KPNIH10_00745

KPQ:	KPR0928_00750

KPT:	VK055_3182(wecF)

KPO:	KPN2242_24480

KPR:	KPR_0247(wecF)

KPJ:

N559_4992

KPI:	D364_21870

KPA:	KPNJ1_05300

KPS:	KPNJ2_05256

KPX:	PMK1_01780(wecF)

KPB:	FH42_17825

KPNE:

KU54_025915

KPNU:

LI86_25815

KPNK:

BN49_4566(wecF)

KVA:

Kvar_4935

KPE:	KPK_5386(wecF)

KPK:	A593_11570

KVD:	KR75_08995

KVQ:	SP68_15590

KOX:

KOX_07590

KOE:

A225_0161

KOY:	J415_02160

KOM:	HR38_06175

KMI:	VW41_17930

KOK:	KONIH1_01040

KOC:	AB185_06180

KQU:	AVR78_05305

EAE:

EAE_07830

EAR:

CCG32433

KQV:	B8P98_26820

KLL:	BJF97_00890

KLW:	DA718_28385

KAR:	LGL98_24200

KGR:	JJJ10_26705

KPAS:

LUW96_07560

KLC:	K7H21_26945

ROR:	RORB6_17905

RON:	TE10_03065

RPLN:

B1209_26080

RAO:	DSD31_24915

RTG:	NCTC13098_07031(wecF)

REE:	electrica_04896(wecF)

CRO:	ROD_39541(rffT)

CKO:

CKO_00134

CFD:	CFNIH1_03880

CBRA:

A6J81_16820

CWE:	CO701_21775

CYO:	CD187_23765

CPOT:

FOB25_11025

CFQ:	C2U38_25605

CSED:

JY391_22085

CAMA:

F384_20595

CAF:	AL524_03450

CIF:	AL515_01635

CFAR:

CI104_24880

CIR:	C2U53_10175

CIE:	AN232_04045

CPAR:

CUC49_19570

CTEL:

GBC03_04815

CITZ:

E4Z61_16725

CARS:

E1B03_01350

EBT:	EBL_c37920(rffT)

CNT:	JT31_11665

CEM:	LH23_06045

CEN:	LH86_05980

CLAP:

NCTC11466_04435(wecF)

PGE:	LG71_04950

ESC:	Entcl_4238

KLE:	AO703_00680

KSA:	C813_14560

KOR:	AWR26_24220

KRD:	A3780_25555

KCO:	BWI95_22855

KOT:	EH164_21520

KPSE:

IP581_00770

KOB:	HF650_23420

KOO:	O9K67_23700

KGO:	CEW81_23930

KIE:	NCTC12125_03604(wecF)

KAS:	KATP_43480(wecF)

KLU:	K7B04_04050

LAX:	APT61_00885

LEI:	C2U54_03825

LEH:	C3F35_12670

LEE:	DVA44_22810

LER:	GNG29_22145

LEA:	GNG26_21350

LPNU:

KQ929_00185

LAZ:	A8A57_20800

LEF:	LJPFL01_4113

LEW:	DAI21_05255

BUF:	D8682_14675

BAGE:

BADSM9389_40040

BFT:	MNO13_23490

SYM:	K6K13_22220

METY:

MRY16398_54500(wecF)

AHN:	NCTC12129_04761(rffT)

ASUB:

NLZ15_21300

YRE:	HEC60_18715

SGOE:

A8O29_021760

KIN:	AB182_24220

PDZ:	HHA33_01225

IZH:	FEM41_06605

PSHI:

SAMEA2665130_3006(wecF)

PSGC:

G163CM_34180(wecF)

SCOL:

KFZ77_19030

PVJ:	LMA04_13175

EBF:

D782_4360

EBC:	C2U52_07180

EBU:	CUC76_14645

PSTS:

E05_20680

YPE:

YPO3857

YPK:	y0371(wecF)

YPH:

YPC_0365

YPA:

YPA_0161

YPN:

YPN_0106

YPM:	YP_3188(wecF1)

YPP:	YPDSF_3475

YPG:	YpAngola_A0521(wecF)

YPZ:

YPZ3_3411

YPT:	A1122_06525

YPD:

YPD4_3403

YPX:

YPD8_3403

YPW:

CH59_1800

YPJ:

CH55_3153

YPV:

BZ15_3851

YPL:

CH46_1204

YPS:

YPTB0177

YPO:

BZ17_2412

YPI:	YpsIP31758_0191(wecF)

YPY:

YPK_4024

YPB:

YPTS_0189

YPQ:	DJ40_2247(wecF)

YPU:

BZ21_3528

YPR:

BZ20_1948

YPC:

BZ23_3800

YPF:

BZ19_3635

YEN:

YE0178

YEP:	YE105_C0181

YEY:

Y11_33761

YEL:	LC20_05064

YEW:	CH47_3307(wecF)

YET:

CH48_1871

YEF:	FORC2_3920

YEE:	YE5303_41221

YSI:	BF17_08880

YAL:

AT01_2293

YFR:	AW19_3029(wecF)

YIN:

CH53_1981

YKR:

CH54_2759

YRO:

CH64_2767

YRU:

BD65_1769

YRB:	UGYR_09370

YAK:	ACZ76_10105

YMA:	DA391_21960

YHI:	D5F51_00945

YCA:	F0T03_00915

YMO:	HRD69_04295

YAS:	N0H69_21035

YKI:	HRD70_05440

SMAR:

SM39_4330(rffT)

SMAC:

SMDB11_4274(rffT) SMDB11_4639

SMW:	SMWW4_v1c01800(rffT)

SPE:

Spro_0170

SRR:	SerAS9_0132

SRL:	SOD_c01260(wecF)

SRY:	M621_00630

SPLY:

Q5A_000725(wecF)

SRS:	SerAS12_0132

SRA:	SerAS13_0131

SMAF:

D781_0138

SLQ:	M495_00670

SERF:

L085_05270

SERS:

SERRSCBI_00750

SFW:	WN53_09250

SFG:	AV650_01735

SRZ:	AXX16_0389

SERA:

Ser39006_003845

SERQ:

CWC46_03845

SERM:

CLM71_00755

SQU:	E4343_15440

SFJ:	SAMEA4384070_0133(wecF)

SOF:	NCTC11214_01916(wecF)

SSUR:

ATE40_021575 ATE40_023260

SURI:

J0X03_23185

SRHZ:

FO014_09260

SENP:

KHA73_22490

SNEM:

NLX84_00595

SFO:	Z042_12845

RAH:	Rahaq_4255

RACE:

JHW33_15660

RAQ:	Rahaq2_4368

RAA:

Q7S_21630

ROX:	BV494_17770

RVC:	J9880_06785

GQU:	AWC35_10745

FSM:	CCS41_11845

EAME:

GXP68_20350

RBAD:

H2866_08935

RCB:	O1V66_16365

ECA:	ECA4202(wecF)

PATR:

EV46_20960

PATO:

GZ59_42660(wecF)

PCT:

PC1_4002

PCC:	PCC21_039810

PCV:	BCS7_20015

PWA:	Pecwa_4194

PPAR:

A8F97_20510

PEC:

W5S_4357

PWS:	A7983_06115

PPOA:

BJK05_15000

PBRA:

B5S52_01195

PPUJ:

E2566_20355

PARI:

I2D83_01255

PAQU:

DMB82_0019210

PVZ:	OA04_42710(wecF)

PPAV:

LOZ86_02290

PQU:	IG609_018940

PPOO:

LW347_20455

PCAC:

OI450_01915

PACB:

M9782_00735

DDD:	Dda3937_00275(rffT)

DZE:	Dd1591_0165

DDC:	Dd586_3892

DZC:	W909_18965

DSO:	A4U42_07600

CED:	LH89_13885

DFN:	CVE23_20985

DDQ:

DDI_3999

DAQ:	DAQ1742_04238(rffT)

DIC:	Dpoa569_000262

DDA:	Dd703_0210

BGJ:	AWC36_20060

BRB:	EH207_16135

BNG:	EH206_01330

BIZ:	HC231_01315

LBQ:	CKQ53_04160

LPOP:

I6N93_00945

SGL:

SG2376

SOD:

Sant_0298

SLIG:

GTU79_01545

EAM:	EAMY_0180(wecF)

EAY:	EAM_0173(rffT)

ETA:	ETA_02060(wecF)

EPY:	EpC_01940(wecF)

EPR:	EPYR_00203(wecF)

EBI:	EbC_02030(wecF)

ERJ:	EJP617_13920(wecF)

EPE:	CI789_17715

ERWI:

GN242_20160

ETP:	LU633_24945

ERP:	LJN55_22135

EGE:	EM595_3327(wecF)

PAM:	PANA_0156(wecF)

PLF:	PANA5342_4271(wecF)

PAJ:	PAJ_3316(wecF)

PAQ:	PAGR_g4122

PVA:	Pvag_3391(wecF)

PAGG:

AL522_05090

PAO:	Pat9b_0149

KLN:	LH22_01515

PANT:

PSNIH1_06315

PANP:

PSNIH2_16580

PAGC:

BEE12_07475

PSTW:

DSJ_22165

PALH:

B1H58_08560

PANS:

FCN45_00770

PEY:	EE896_18355

PDIS:

D8B20_00625

PER:	LAC65_00420

PJI:	KTJ90_18330

PANO:

OJ965_20160

PGZ:	C2E15_20325

PCD:	C2E16_19745

MINT:

C7M51_03209(wecF)

MTHI:

C7M52_03790(wecF)

TCI:	A7K98_18790

TPTY:

NCTC11468_03533(wecF)

KPIE:

N5580_17440

PLU:	plu4653(wecF)

PLUM:

A4R40_23080

PAY:	PAU_04133(wecF)

PTT:	VY86_06555

PAKH:

B0X70_23520

PLUI:

CE143_23560

PMR:	PMI3325(rffT)

PMIB:

BB2000_3357(rffT)

PVL:	AOB99_01045

PVG:	CRN77_03030

PHAU:

PH4a_08075

PROT:

BTA34_17850

PCOL:

F1325_01005

PCIB:

F9282_01005

PPEE:

I6G31_08370

XBO:	XBJ1_4169(rffT)

XBV:	XBW1_4524(wecF)

XNE:	XNC1_0393(rffT)

XNM:	XNC2_0385(rffT)

XDO:	XDD1_0355(wecF)

XPO:	XPG1_3475(wecF)

XHO:	A9255_14185

XBU:	HGO23_18230

PSI:

S70_11685

PSX:	DR96_843(wecF)

PSTA:

BGK56_14615

PRG:	RB151_042110(wecF)

PALA:

CO695_05760

PHEI:

NCTC12003_03730(wecF)

PRQ:	CYG50_17680

PRJ:	NCTC6933_03744(wecF)

PVC:	G3341_18320

PMAG:

JI723_18685

MMK:

MU9_246

ANS:	ArsFIN_02220(wecF)

AED:	E3U36_04190

AET:	LDL57_00985

MWI:	MNY66_14790

EIC:	NT01EI_0099

ETR:	ETAE_0110(wecF)

ETD:

ETAF_0083

ETE:

ETEE_1871

ETC:	ETAC_00410

EDW:	QY76_02305

EDL:	AAZ33_00420

EHO:	A9798_16280

HAV:	AT03_01740

HPAR:

AL518_03865

OPO:	DSM2777_02260

LPV:	HYN51_09705

PFQ:	QQ39_17690

PRAG:

EKN56_00965

LRI:	NCTC12151_03584(wecF)

HDU:	HD_1836(wecF)

HAP:	HAPS_1061(wecF)

HPAZ:

K756_01465

HPAK:

JT17_09625

GLE:	CJD39_10775

MHT:	D648_23630

MHQ:

D650_2550

MHAT:

B824_3610

MHX:	MHH_c03440

MHAE:

F382_09235

MHAO:

J451_07000

MHAL:

N220_12980

MHAQ:

WC39_01280

MHAY:

VK67_01285

MVR:

X781_2190

MVI:	X808_19380

MVG:	X874_18160

MVE:

X875_1810

MGRA:

A4G16_10690

MBOS:

ICJ55_03500

APL:	APL_1545(wecF)

APJ:	APJL_1573(wecF)

APA:	APP7_1607(wecF)

ASI:	ASU2_09905

ASS:	ASU1_09950

AEU:	ACEE_09190

AIO:	EXH44_07105

ALIG:

NCTC10568_01899(wecF_1)

BTO:

WQG_3530

BTRE:

F542_18430

BTRH:

F543_20310

BTRA:

F544_3940

OOI:	A6A10_01425

FCL:	A4G17_03550

TBV:	H9L17_00515

VSH:	BSZ05_05040

MARA:

D0851_05405

IDI:	CWC33_02970

IDT:	C5610_02505

COM:	CMT41_10680

PPIS:

B1L02_14680

PEA:	PESP_a0467

PDJ:	D0907_14785

PSHO:

KQ246_12320

APEL:

CA267_014315

PMES:

FX988_03854

FPZ:

LA55_1370

FPJ:

LA02_1154

TUN:	J9260_17555

THIM:

KFB96_06595

HBE:	BEI_1674(wecF)

ALN:	AS19_09760

MGEO:

CFI10_15815

AEA:	C2U39_14455

BCIB:

IM45_423

NBA:	CUN60_12215

HWI:	A0Z60_07555 A0Z60_07580

ACRE:

ACRYA_0144

ALAN:

ALANTH_2109

AVP:	AVENP_2919

NAP:	C3L23_08595

DAX:	FDQ92_00595

CEU:	A7L45_18675

TMED:

DWB79_01375

FHW:	RN87_00930

PJE:	CRM71_04845

PNI:	J5A59_08545

BLQ:	L21SP5_01967

COY:	HF329_17530

OLI:	FKG96_06990

CAMU:

CA2015_3030

CHK:	D4L85_22095 D4L85_31200

GRL:	LPB144_02075

MARE:

EJ994_13080

LVN:	BWR22_10565

AQB:	D1818_14355

MESQ:

C7H62_1946

MARX:

INR76_00310

CTAK:

4412677_01816(wecF)

CCAS:

EIB73_09145

EBV:	F0358_02375

PRS:	B9H02_08730

FIA:	NA23_00710 NA23_09220

DTN:

DTL3_1010

MEF:	MSWH1_3005

MSZ:	MSSIH_2387

» show all

Reference

1 [PMID:11673418]

Authors

Rahman A, Barr K, Rick PD

Title

Identification of the structural gene for the TDP-Fuc4NAc:lipid II Fuc4NAc transferase involved in synthesis of enterobacterial common antigen in Escherichia coli K-12.

Journal

J Bacteriol 183:6509-16 (2001)
DOI:10.1128/JB.183.22.6509-6516.2001

Sequence

[eco:b4481]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.325

IUBMB Enzyme Nomenclature:

2.4.1.325

ExPASy - ENZYME nomenclature database:

2.4.1.325

BRENDA, the Enzyme Database:

2.4.1.325

DBGET integrated database retrieval system