KEGG   ENZYME: 2.4.1.364Help
Entry
EC 2.4.1.364                Enzyme                                 

Name
protopanaxadiol-type ginsenoside 3-O-glucosyltransferase;
UGT74AE2 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucose:protopanaxadiol-type ginsenoside 3-O-glucosyltransferase (configuration-retaining)
Reaction(IUBMB)
(1) UDP-alpha-D-glucose + (20S)-protopanaxadiol = UDP + (20S)-ginsenoside Rh2 [RN:R12383];
(2) UDP-alpha-D-glucose + ginsenoside C-K = UDP + ginsenoside F2 [RN:R12384]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucose [CPD:C00029];
(20S)-protopanaxadiol [CPD:C20715];
ginsenoside C-K [CPD:C22127]
Product
UDP [CPD:C00015];
(20S)-ginsenoside Rh2 [CPD:C22128];
ginsenoside F2 [CPD:C20779]
Comment
The enzyme, characterized from the plant Panax ginseng, transfers a glucosyl moiety to the free C-3-OH group of (20S)-protopanaxadiol and ginsenoside C-K.
History
EC 2.4.1.364 created 2019
Orthology
K23521  protopanaxadiol-type ginsenoside 3-O-glucosyltransferase
Reference
1  [PMID:25320211]
  Authors
Jung SC, Kim W, Park SC, Jeong J, Park MK, Lim S, Lee Y, Im WT, Lee JH, Choi G, Kim SC
  Title
Two ginseng UDP-glycosyltransferases synthesize ginsenoside Rg3 and Rd.
  Journal
Plant Cell Physiol 55:2177-88 (2014)
DOI:10.1093/pcp/pcu147
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.364
IUBMB Enzyme Nomenclature: 2.4.1.364
ExPASy - ENZYME nomenclature database: 2.4.1.364
BRENDA, the Enzyme Database: 2.4.1.364

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