KEGG   ENZYME: 2.4.99.1
Entry
EC 2.4.99.1                 Enzyme                                 

Name
beta-galactoside alpha-(2,6)-sialyltransferase;
ST6Gal-I;
CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase;
lactosylceramide alpha-2,6-N-sialyltransferase;
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine alpha-(2->6)-N-acetylneuraminyltransferase;
beta-galactoside alpha-2,6-sialyltransferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
Sysname
CMP-N-acetyl-beta-neuraminate:beta-D-galactoside alpha-(2->6)-N-acetylneuraminyltransferase (configuration-inverting)
Reaction(IUBMB)
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R [RN:R04532 R06188]
Reaction(KEGG)
R04532 R06188(G);
(other) R03489 R05580 R05905(G) R05906(G) R05990(G) R06121(G) R09298(G)
Substrate
CMP-N-acetyl-beta-neuraminate [CPD:C00128];
beta-D-galactosyl-R [CPD:C02900]
Product
CMP [CPD:C00055];
N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
Comment
The enzyme acts on the terminal non-reducing beta-D-galactosyl residue of the oligosaccharide moiety of glycoproteins and glycolipids.
History
EC 2.4.99.1 created 1972, modified 1976, modified 1986, modified 2016 (EC 2.4.99.11 created 1992, incorporated 2016), modified 2017
Pathway
ec00510  N-Glycan biosynthesis
ec00514  Other types of O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K00778  beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1)
K00779  beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 2)
K12248  beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 0160)
Genes
HSA: 6480(ST6GAL1) 84620(ST6GAL2)
PTR: 450198(ST6GAL2) 460922(ST6GAL1)
PPS: 100969795(ST6GAL1) 100981465(ST6GAL2)
GGO: 101129847(ST6GAL2) 101142727(ST6GAL1)
PON: 100174088(ST6GAL1) 100456090(ST6GAL2)
NLE: 100580010(ST6GAL2) 100599869(ST6GAL1)
MCC: 708113(ST6GAL1) 713552(ST6GAL2)
MCF: 102121444(ST6GAL1) 102142751(ST6GAL2)
CSAB: 103241198(ST6GAL2) 103241877(ST6GAL1)
CATY: 105575215(ST6GAL1) 105583608(ST6GAL2)
PANU: 101015073(ST6GAL1) 101020393(ST6GAL2)
RRO: 104660586(ST6GAL2) 104682948(ST6GAL1)
RBB: 108512469(ST6GAL2) 108530462(ST6GAL1)
TFN: 117062254(ST6GAL2) 117084352(ST6GAL1)
PTEH: 111542246(ST6GAL2) 111544264(ST6GAL1)
CJC: 100408699(ST6GAL1) 100411939(ST6GAL2)
SBQ: 101032294(ST6GAL1) 101047107(ST6GAL2)
MMUR: 105856143(ST6GAL2) 105885054(ST6GAL1)
MMU: 20440(St6gal1) 240119(St6gal2)
MCAL: 110284258(St6gal2) 110311654(St6gal1)
MPAH: 110329758(St6gal1) 110335627(St6gal2)
RNO: 25197(St6gal1) 301155(St6gal2)
MCOC: 116074404(St6gal2) 116086257(St6gal1)
MUN: 110548122(St6gal1) 110560861(St6gal2)
CGE: 100689389(St6gal1) 100763756(St6gal2)
PLEU: 114690834(St6gal2) 114697104(St6gal1)
NGI: 103726632(St6gal2) 103750114(St6gal1)
HGL: 101718025(St6gal1) 101722644(St6gal2)
CPOC: 100728814(St6gal2) 100730025(St6gal1)
CCAN: 109691378(St6gal1) 109701499(St6gal2)
OCU: 100353188(ST6GAL1) 100358153(ST6GAL2)
OPI: 101531549(ST6GAL1) 101536363(ST6GAL2)
TUP: 102499508(ST6GAL1) 102500330(ST6GAL2)
CFA: 478668(ST6GAL1) 481315(ST6GAL2)
VVP: 112915370(ST6GAL2) 112926300(ST6GAL1)
VLG: 121477448(ST6GAL1) 121492182(ST6GAL2)
AML: 100478457(ST6GAL2) 100481066(ST6GAL1)
UMR: 103670658(ST6GAL2) 103676045(ST6GAL1)
UAH: 113253796(ST6GAL1) 113267699(ST6GAL2)
ORO: 101374165(ST6GAL2) 101377549(ST6GAL1)
MPUF: 101672771(ST6GAL1) 101684375(ST6GAL2)
EJU: 114206991(ST6GAL1) 114209673(ST6GAL2)
MLX: 117999602 118006926(ST6GAL1) 118008290(ST6GAL2)
FCA: 101097832(ST6GAL1) 101098620(ST6GAL2)
PYU: 121016472(ST6GAL2) 121034129(ST6GAL1)
PBG: 122491626(ST6GAL1) 122496660(ST6GAL2)
PTG: 102956769(ST6GAL1) 102962032(ST6GAL2)
PPAD: 109254527(ST6GAL2) 109275279(ST6GAL1)
AJU: 106968006(ST6GAL1) 106977960(ST6GAL2)
HHV: 120224465(ST6GAL2) 120233104(ST6GAL1)
BTA: 282073(ST6GAL1) 493992(ST6GAL2)
BOM: 102273022(ST6GAL1) 102285977(ST6GAL2)
BIU: 109556984(ST6GAL1) 109566122(ST6GAL2)
BBUB: 102400138(ST6GAL1) 102408407(ST6GAL2)
CHX: 100861310(ST6GAL1) 102179776(ST6GAL2)
OAS: 100913159(ST6GAL1) 101108300(ST6GAL2) 114113140
ODA: 120851443(ST6GAL2) 120872484(ST6GAL1)
CCAD: 122441795(ST6GAL2) 122444810(ST6GAL1)
SSC: 100302026(ST6GAL1) 100512775(ST6GAL2)
CFR: 102508797(ST6GAL2) 102512873(ST6GAL1)
CBAI: 105072236(ST6GAL2) 105072335(ST6GAL1)
CDK: 105085840(ST6GAL1) 105099139(ST6GAL2)
BACU: 103009068(ST6GAL2) 103012200(ST6GAL1)
LVE: 103073782(ST6GAL2) 103086030(ST6GAL1)
OOR: 101273721(ST6GAL2) 101285111(ST6GAL1)
DLE: 111172829(ST6GAL1) 111187445(ST6GAL2)
PCAD: 102984003(ST6GAL2) 102992136(ST6GAL1)
PSIU: 116753628(ST6GAL1) 116764529(ST6GAL2)
ECB: 100059539(ST6GAL1) 100062033(ST6GAL2)
EPZ: 103555423(ST6GAL2) 103567256(ST6GAL1)
EAI: 106829390(ST6GAL2) 106832544(ST6GAL1)
MYB: 102241174(ST6GAL2) 102244256(ST6GAL1)
MYD: 102753980(ST6GAL1) 102768324(ST6GAL2)
MMYO: 118675025(ST6GAL2) 118675850(ST6GAL1)
MNA: 107527306(ST6GAL1) 107528699(ST6GAL2)
PKL: 118722907(ST6GAL1) 118724274(ST6GAL2)
HAI: 109375943(ST6GAL2) 109396927(ST6GAL1)
DRO: 112297515(ST6GAL2) 112308352(ST6GAL1)
SHON: 118979900(ST6GAL1) 119003878(ST6GAL2)
AJM: 119039092(ST6GAL1) 119049381(ST6GAL2)
PDIC: 114490820(ST6GAL1) 114498034(ST6GAL2)
MMF: 118617058(ST6GAL1) 118626624(ST6GAL2)
RFQ: 117020133(ST6GAL2) 117034495(ST6GAL1)
PALE: 102886717(ST6GAL1) 102890603(ST6GAL2)
PGIG: 120584474(ST6GAL2) 120593008(ST6GAL1)
RAY: 107497054(ST6GAL2) 107505891(ST6GAL1)
MJV: 108388564 108401260(ST6GAL1)
TOD: 119257382(ST6GAL1) 119259294(ST6GAL2)
LAV: 100660981(ST6GAL2) 100664378(ST6GAL1)
MDO: 100019249(ST6GAL2) 100617174(ST6GAL1)
GAS: 123242597(ST6GAL2) 123244652(ST6GAL1)
SHR: 100922140(ST6GAL1) 100932183(ST6GAL2)
PCW: 110209426(ST6GAL2) 110221205(ST6GAL1)
OAA: 100077134(ST6GAL2) 100093341(ST6GAL1)
GGA: 396169(ST6GAL1) 403122(ST6GAL2)
PCOC: 116230961(ST6GAL1) 116236510(ST6GAL2)
MGP: 100545097(ST6GAL2) 100548556 104909223(ST6GAL1)
CJO: 107306533(ST6GAL2) 107317947(ST6GAL1)
NMEL: 110397396(ST6GAL1) 110406996(ST6GAL2)
APLA: 101796015(ST6GAL2) 101803267(ST6GAL1)
ACYG: 106040277(ST6GAL1) 106041658(ST6GAL2)
TGU: 100226346(ST6GAL1) 100230425(ST6GAL2)
LSR: 110478726(ST6GAL2) 110484834(ST6GAL1)
SCAN: 103812379(ST6GAL2) 103815542(ST6GAL1)
PMOA: 120504713(ST6GAL2) 120511219(ST6GAL1)
OTC: 121342181(ST6GAL1) 121343184(ST6GAL2)
PRUF: 121354112(ST6GAL2) 121364093(ST6GAL1)
GFR: 102038321(ST6GAL2) 102042024(ST6GAL1)
FAB: 101810086(ST6GAL2) 101820079(ST6GAL1)
PHI: 102107561(ST6GAL1) 102109099(ST6GAL2)
PMAJ: 107208898(ST6GAL1) 107211419(ST6GAL2)
CCAE: 111922685(ST6GAL2) 111933760(ST6GAL1)
CCW: 104686087(ST6GAL2) 104693051(ST6GAL1)
ETL: 114057719(ST6GAL1) 114066979(ST6GAL2)
FPG: 101914140(ST6GAL2) 101924763(ST6GAL1)
FCH: 102056735(ST6GAL2) 102058385(ST6GAL1)
CLV: 102087342(ST6GAL2) 102097093(ST6GAL1)
EGZ: 104126364(ST6GAL2) 104135489(ST6GAL1)
NNI: 104019355(ST6GAL2) 104023676(ST6GAL1)
ACUN: 113481283(ST6GAL2) 113483390(ST6GAL1)
PADL: 103912776(ST6GAL1) 103918841(ST6GAL2)
AAM: 106494052(ST6GAL2) 106496189(ST6GAL1)
AROW: 112972895(ST6GAL1) 112974825(ST6GAL2)
NPD: 112943323(ST6GAL2) 112946787(ST6GAL1)
DNE: 112984983(ST6GAL2) 112988867(ST6GAL1)
ASN: 102372316(ST6GAL2) 102373489(ST6GAL1)
AMJ: 102569903(ST6GAL2) 102575767(ST6GAL1)
CPOO: 109306264(ST6GAL2)
GGN: 109288223 109303134(ST6GAL2)
PSS: 102446128(ST6GAL1) 102453477(ST6GAL2)
CMY: 102941507(ST6GAL1) 102943395(ST6GAL2)
CPIC: 101939719 101943605(ST6GAL1) 101950728(ST6GAL2)
TST: 117870744(ST6GAL2) 117882544(ST6GAL1)
CABI: 116829117(ST6GAL2) 116835529(ST6GAL1)
ACS: 100529108(st6gal2) 100529109(st6gal1)
PVT: 110074124(ST6GAL2) 110088940(ST6GAL1)
SUND: 121925605(ST6GAL2) 121926333(ST6GAL1)
PBI: 103050106 103061620(ST6GAL1) 103062404(ST6GAL2)
PMUR: 107286474 107288840(ST6GAL2)
TSR: 106540309(ST6GAL2) 106545885 106550706(ST6GAL1)
PGUT: 117666699(ST6GAL2) 117667611 117678419(ST6GAL1)
VKO: 123022793(ST6GAL2) 123024715(ST6GAL1)
PMUA: 114595050 114596422(ST6GAL2) 114597762(ST6GAL1)
ZVI: 118082642 118085557(ST6GAL2) 118093379(ST6GAL1)
GJA: 107110554(ST6GAL1) 107115211 107125130(ST6GAL2)
XLA: 108708393(st6gal2.L) 108709694(st6gal2.S) 108717116(st6gal1.L) 108718183(st6gal1.S)
XTR: 100491268(st6gal1) 407846(st6gal2)
NPR: 108785132(ST6GAL2) 108785675(ST6GAL1)
DRE: 403116(st6gal2a) 445376(st6gal1) 797439(st6gal2b)
PHYP: 113525857(st6gal2) 113538434 113541806
EEE: 113574044 113575118 113576168(st6gal1) 113584885(st6gal2)
TRU: 445982(st6gal1) 777969(st6gal2)
NCC: 104957421(st6gal2)
CGOB: 115004959 115018853 115026027(st6gal2)
SLUC: 116044405 116046205(st6gal2a) 116065100(st6gal1)
ECRA: 117953358(st6gal2a)
PFLV: 114550857 114563738(st6gal2) 114567309
GAT: 100653424(st6gal2) 100653425(st6gal1)
PPUG: 119215869(st6gal1) 119229337(st6gal2a)
MSAM: 119894937(st6gal1) 119904276 119907989
CUD: 121519008(st6gal1) 121522671(st6gal2a)
MZE: 101464130(st6gal2) 101466910
ONL: 100694560 100704184(st6gal2)
OAU: 116316053(st6gal2a) 116333190(st6gal1)
OLA: 100049380(st6gal1) 100049381(st6gal2)
OML: 112138424 112141097(st6gal1) 112154825(st6gal2a)
XMA: 102229475(st6gal2) 102231535
XCO: 114148521(st6gal2) 114152599
XHE: 116722651(st6gal2) 116727860
PRET: 103476390 103480039(st6gal2)
GAF: 122840278(st6gal2a) 122845362(st6gal1)
CVG: 107090303 107096899(st6gal2)
CTUL: 119786340(st6gal2a) 119796480(st6gal1)
NFU: 107384328 107389803(st6gal2)
KMR: 108232466(st6gal2a) 108243592 108243597
ALIM: 106514661 106519824(st6gal2)
AOCE: 111563401(st6gal1) 111570337 111582969(st6gal2)
CSEM: 103391691(st6gal2)
POV: 109631344(st6gal2) 109646428
SSEN: 122762074(st6gal2a) 122779139(st6gal1)
HHIP: 117754658(st6gal2a) 117774386 117774387
SDU: 111218195(st6gal2) 111221384(st6gal1)
SLAL: 111646873 111650885 111662108(st6gal2)
HCQ: 109513608 109530661(st6gal2)
BPEC: 110165642 110173121(st6gal2)
MALB: 109965389(st6gal2) 109975054
AANG: 118213679(st6gal2a) 118234825(st6gal1)
LOC: 102691434(st6gal1) 102695769 102698912(st6gal2)
CMK: 103172241(st6gal2) 103174913
BFO: 118418499
BBEL: 109473601
HDU: HD_0053
PMU: PM0188
PMP: Pmu_11250
PMUL: DR93_1878
SWP: swp_5060
 » show all
Reference
1  [PMID:5726897]
  Authors
Spiro MJ, Spiro RG.
  Title
Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid sialyltransferase.
  Journal
J Biol Chem 243:6520-8 (1968)
Reference
2  [PMID:4313609]
  Authors
Hickman J, Ashwell G, Morell AG, van den Hamer CJ, Scheinberg IH.
  Title
Physical and chemical studies on ceruloplasmin. 8. Preparation of N-acetylneuraminic acid-1-14C-labeled ceruloplasmin.
  Journal
J Biol Chem 245:759-66 (1970)
Reference
3  [PMID:4723915]
  Authors
Bartholomew BA, Jourdian GW, Roseman S.
  Title
The sialic acids. XV. Transfer of sialic acid to glycoproteins by a sialyltransferase from colostrum.
  Journal
J Biol Chem 248:5751-62 (1973)
Reference
4  [PMID:849932]
  Authors
Paulson JC, Beranek WE, Hill RL.
  Title
Purification of a sialyltransferase from bovine colostrum by affinity chromatography on CDP-agarose.
  Journal
J Biol Chem 252:2356-62 (1977)
Reference
5  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods Enzymol 98:98-134 (1983)
DOI:10.1016/0076-6879(83)98143-0
Reference
6  [PMID:2460092]
  Authors
Albarracin I, Lassaga FE, Caputto R.
  Title
Purification and characterization of an endogenous inhibitor of the sialyltransferase CMP-N-acetylneuraminate: lactosylceramide alpha 2,6-N-acetylneuraminyltransferase (EC 2.4.99.-).
  Journal
Biochem J 254:559-65 (1988)
DOI:10.1042/bj2540559
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.1
IUBMB Enzyme Nomenclature: 2.4.99.1
ExPASy - ENZYME nomenclature database: 2.4.99.1
BRENDA, the Enzyme Database: 2.4.99.1
CAS: 9075-81-4

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