KEGG   ENZYME: 2.4.99.7
Entry
EC 2.4.99.7                 Enzyme                                 

Name
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase;
sialyltransferase;
cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase;
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase;
SIAT7;
ST6GALNAC;
(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase;
CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
Sysname
CMP-N-acetylneuraminate:N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)- N-acetyl-D-galactosaminide galactosamine-6-alpha-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [RN:R04635]
Reaction(KEGG)
R04635 > R05914(G) R05959(G)
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R [CPD:C04885]
Product
CMP [CPD:C00055];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [CPD:C04926]
Comment
Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl-galactosamine only when present in the structure of alpha-N-acetyl-neuraminyl-(2->3)-beta-galactosyl-(1->3)-N-acetylgalactosaminyl-R, where R may be protein or p-nitrophenol. Not identical with EC 2.4.99.3 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase.
History
EC 2.4.99.7 created 1984, modified 1986, modified 2004
Pathway
ec00512  Mucin type O-glycan biosynthesis
ec00604  Glycosphingolipid biosynthesis - ganglio series
ec01100  Metabolic pathways
Orthology
K03373  N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7C)
K03374  N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7D)
Genes
HSA: 256435(ST6GALNAC3) 27090(ST6GALNAC4)
PTR: 450108(ST6GALNAC4) 450115(ST6GALNAC3)
PPS: 100985483(ST6GALNAC3) 100995780(ST6GALNAC4)
GGO: 101143514(ST6GALNAC3) 101151595(ST6GALNAC4)
PON: 100174350(ST6GALNAC3) 100439613(ST6GALNAC4)
NLE: 100598104(ST6GALNAC4) 100603395(ST6GALNAC3)
MCC: 705879(ST6GALNAC4) 709779(ST6GALNAC3)
MCF: 102122701(ST6GALNAC3) 102142909(ST6GALNAC4)
CSAB: 103224585(ST6GALNAC3) 103239817(ST6GALNAC4)
CATY: 105576245(ST6GALNAC4) 105595840(ST6GALNAC3)
RRO: 104665870(ST6GALNAC4) 104666528(ST6GALNAC3)
RBB: 108533045(ST6GALNAC3) 108542735(ST6GALNAC4)
TFN: 117072089(ST6GALNAC4) 117092117(ST6GALNAC3)
CJC: 100398966(ST6GALNAC3) 100401438(ST6GALNAC4)
SBQ: 101032564(ST6GALNAC3) 101037868(ST6GALNAC4)
MMUR: 105875232(ST6GALNAC4) 105884196(ST6GALNAC3)
MMU: 20447(St6galnac3) 20448(St6galnac4)
MCAL: 110288812(St6galnac4) 110290963(St6galnac3)
MPAH: 110318527(St6galnac4) 110320284(St6galnac3)
RNO: 29758(St6galnac3) 407764(St6galnac4)
MCOC: 116090006(St6galnac4) 116093960(St6galnac3)
MUN: 110562585(St6galnac4) 110563850
CGE: 100759065(St6galnac4) 100762285(St6galnac3)
PLEU: 114699850(St6galnac3) 114703806(St6galnac4)
NGI: 103727384(St6galnac4) 103746466(St6galnac3)
HGL: 101708035(St6galnac3) 101717187(St6galnac4)
CCAN: 109674707(St6galnac3) 109686789(St6galnac4)
OCU: 100345091(ST6GALNAC3) 100356933(ST6GALNAC4)
TUP: 102476286(ST6GALNAC3) 102487439(ST6GALNAC4)
CFA: 490205(ST6GALNAC3) 609133(ST6GALNAC4)
VVP: 112924453(ST6GALNAC3) 112927918(ST6GALNAC4)
AML: 100480565(ST6GALNAC4) 100481578(ST6GALNAC3)
UMR: 103662994(ST6GALNAC3) 103670294(ST6GALNAC4)
UAH: 113254511(ST6GALNAC3) 113266445(ST6GALNAC4)
ORO: 101368864(ST6GALNAC4) 101382354(ST6GALNAC3)
MPUF: 101672038(ST6GALNAC4) 101685214(ST6GALNAC3)
EJU: 114208382(ST6GALNAC3) 114212880(ST6GALNAC4)
FCA: 101091035(ST6GALNAC3) 101094459(ST6GALNAC4)
PTG: 102966320(ST6GALNAC4) 107178974(ST6GALNAC3)
PPAD: 109250108(ST6GALNAC4) 109266652(ST6GALNAC3)
AJU: 106966292(ST6GALNAC4) 113599298(ST6GALNAC3)
BTA: 404124(ST6GALNAC4) 782689(ST6GALNAC3)
BOM: 102287870(ST6GALNAC4)
BIU: 109556154(ST6GALNAC3)
BBUB: 102396911(ST6GALNAC4) 102415799(ST6GALNAC3)
CHX: 102170329(ST6GALNAC4) 102190655(ST6GALNAC3)
OAS: 101121471(ST6GALNAC3) 101123019(ST6GALNAC4)
SSC: 100512173(ST6GALNAC3) 396676(ST6GALNAC4)
CFR: 102505545(ST6GALNAC3) 116663270(ST6GALNAC4)
CDK: 105096656(ST6GALNAC3) 116152744(ST6GALNAC4)
BACU: 103005340(ST6GALNAC4) 103020698(ST6GALNAC3)
LVE: 103085714(ST6GALNAC3) 103086160(ST6GALNAC4)
OOR: 101278803(ST6GALNAC4) 101285214(ST6GALNAC3)
DLE: 111177188(ST6GALNAC4) 111178407(ST6GALNAC3)
PCAD: 102980952(ST6GALNAC3) 102990591(ST6GALNAC4) 102993381
ECB: 100066966(ST6GALNAC3) 100067121(ST6GALNAC4)
EPZ: 103544980(ST6GALNAC4) 103549422(ST6GALNAC3)
EAI: 106836550(ST6GALNAC3) 106845456(ST6GALNAC4)
MYB: 102248336 102253595(ST6GALNAC3) 102261251(ST6GALNAC4)
MYD: 102754268(ST6GALNAC4) 102760172(ST6GALNAC3)
MMYO: 118667025(ST6GALNAC4) 118676600(ST6GALNAC3)
MNA: 107535596(ST6GALNAC4) 107540092(ST6GALNAC3)
HAI: 109379933(ST6GALNAC4) 109383481(ST6GALNAC3)
DRO: 112306353(ST6GALNAC4) 112309356(ST6GALNAC3)
SHON: 118980054(ST6GALNAC4)
AJM: 119040023(ST6GALNAC3) 119056496(ST6GALNAC4)
MMF: 118626740(ST6GALNAC3) 118629692(ST6GALNAC4)
PALE: 102881827(ST6GALNAC4) 102894086(ST6GALNAC3)
RAY: 107503437(ST6GALNAC3) 107520248(ST6GALNAC4)
MJV: 108397264 108397977(ST6GALNAC4)
LAV: 100672433(ST6GALNAC3) 104845634(ST6GALNAC4)
MDO: 100010461(ST6GALNAC3) 100012077(ST6GALNAC4)
SHR: 100919945(ST6GALNAC3) 100921479(ST6GALNAC4)
PCW: 110193695(ST6GALNAC4) 110195706(ST6GALNAC3)
OAA: 100078837(ST6GALNAC4) 100087849(ST6GALNAC3)
GGA: 395182(ST6GALNAC4) 404746(ST6GALNAC3)
MGP: 100540755(ST6GALNAC3) 100543224(ST6GALNAC4)
CJO: 107317527(ST6GALNAC3) 107321783(ST6GALNAC4)
NMEL: 110390579(ST6GALNAC4) 110402576(ST6GALNAC3)
APLA: 101791163(ST6GALNAC4) 101793136(ST6GALNAC3)
ACYG: 106034022(ST6GALNAC3) 106047277(ST6GALNAC4)
TGU: 100221194(ST6GALNAC3) 100232134(ST6GALNAC4)
LSR: 110469217(ST6GALNAC3) 110482257(ST6GALNAC4)
SCAN: 103814945(ST6GALNAC3) 103819159(ST6GALNAC4)
GFR: 102032720(ST6GALNAC3) 102036471(ST6GALNAC4)
FAB: 101813361(ST6GALNAC3) 101817162(ST6GALNAC4)
PHI: 102101449(ST6GALNAC3) 102109129(ST6GALNAC4)
PMAJ: 107208224(ST6GALNAC3) 107211894(ST6GALNAC4)
CCAE: 111933158(ST6GALNAC3) 111936951(ST6GALNAC4)
CCW: 104688260(ST6GALNAC4) 104695278(ST6GALNAC3)
ETL: 114054554(ST6GALNAC4) 114066175(ST6GALNAC3)
FPG: 101917057(ST6GALNAC3) 101923804(ST6GALNAC4)
FCH: 102047399(ST6GALNAC3) 102056501(ST6GALNAC4)
CLV: 102084668(ST6GALNAC3) 102090323(ST6GALNAC4)
EGZ: 104122368(ST6GALNAC4) 104125535(ST6GALNAC3)
NNI: 104015564(ST6GALNAC3) 104022455(ST6GALNAC4)
ACUN: 113483151(ST6GALNAC3) 113486613(ST6GALNAC4)
PADL: 103912977(ST6GALNAC4) 103925221(ST6GALNAC3)
AAM: 106495296(ST6GALNAC4) 106499457(ST6GALNAC3)
ASN: 102383697(ST6GALNAC3) 102385694(ST6GALNAC4)
AMJ: 102575154(ST6GALNAC4) 102576099(MSH4)
PSS: 102443948(ST6GALNAC4) 102457102(ST6GALNAC3)
CMY: 102932867(ST6GALNAC4) 102940238(ST6GALNAC3)
CPIC: 101940645(ST6GALNAC4) 101944048(ST6GALNAC3)
ACS: 100552238(st6galnac4) 100567272(st6galnac3)
PVT: 110078837(ST6GALNAC4) 110079526(ST6GALNAC3)
PBI: 103052750(ST6GALNAC3) 103063354(ST6GALNAC4)
PMUR: 107287801(ST6GALNAC3) 107298943(ST6GALNAC4)
TSR: 106545572(ST6GALNAC3) 106551570
PMUA: 114589237(ST6GALNAC4) 114598841(ST6GALNAC3)
GJA: 107105744(ST6GALNAC4) 107113018(ST6GALNAC3)
XLA: 108714200(st6galnac3.L)
XTR: 100495364(st6galnac3) 779760(st6galnac4)
NPR: 108794466(ST6GALNAC4) 108799035(ST6GALNAC3)
DRE: 322609(st6galnac3) 751653(st6galnac4)
SRX: 107705960 107708685(st6galnac3) 107737196
IPU: 108268339(st6galnac3) 108279162(st6galnac4)
PHYP: 113535400 113540196(st6galnac3)
AMEX: 103027742(st6galnac4) 103028147(st6galnac3)
EEE: 113570133(st6galnac3) 113590039
TRU: 101064537 446080(st6galnac3)
LCO: 104924497 109140213(st6galnac3) 109142950
NCC: 104946126(st6galnac4) 104965762
MZE: 101465741 101474314(st6galnac3)
ONL: 100701389 100708358(st6galnac3)
OLA: 100049534(st6galnac3) 101164661(st6galnac4)
XMA: 102226898 102236276(st6galnac3)
XCO: 114145824(st6galnac3) 114149160
PRET: 103473419(st6galnac4) 103479928(st6galnac3)
CVG: 107089777(st6galnac4) 107094225(st6galnac3) 107104669
NFU: 107374797(st6galnac4) 107383508(st6galnac3)
KMR: 108230860(st6galnac4) 108232955(st6galnac3)
ALIM: 106520778(st6galnac3)
CSEM: 103396703(st6galnac3)
POV: 109625944 109637616(st6galnac3)
LCF: 108874088 108884275(st6galnac3) 108891392
SDU: 111231135(st6galnac3) 111237383
HCQ: 109516873(st6galnac3)
BPEC: 110155713(st6galnac3) 110157454
MALB: 109955309(st6galnac3) 109972319
SASA: 100196729(st6galnac4) 106569362 106591001
OTW: 112220107 112237760(st6galnac3)
SALP: 111961873
ELS: 105009744(st6galnac3) 105015283
SFM: 108923702(st6galnac3) 108935911(st6galnac4)
PKI: 111846074(st6galnac3)
LCM: 102356696(ST6GALNAC3) 102363654(ST6GALNAC4)
CMK: 103174732(st6galnac3)
RTP: 109923725
EPA: 110232907
ADF: 107334450
AMIL: 114960371
PDAM: 113681541
 » show all
Reference
1  [PMID:6190802]
  Authors
Bergh ML, Hooghwinkel GJ, van den Eijnden DH.
  Title
Biosynthesis of the O-glycosidically linked oligosaccharide chains of fetuin. Indications for an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase with a narrow acceptor specificity in fetal calf liver.
  Journal
J Biol Chem 258:7430-6 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.7
IUBMB Enzyme Nomenclature: 2.4.99.7
ExPASy - ENZYME nomenclature database: 2.4.99.7
BRENDA, the Enzyme Database: 2.4.99.7
CAS: 129924-24-9

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