KEGG   ENZYME: 2.4.99.7
Entry
EC 2.4.99.7                 Enzyme                                 

Name
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase;
sialyltransferase;
cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase;
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase;
SIAT7;
ST6GALNAC;
(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase;
CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
Sysname
CMP-N-acetylneuraminate:N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)- N-acetyl-D-galactosaminide galactosamine-6-alpha-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [RN:R04635]
Reaction(KEGG)
R04635 > R05914(G) R05959(G)
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R [CPD:C04885]
Product
CMP [CPD:C00055];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [CPD:C04926]
Comment
Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl-galactosamine only when present in the structure of alpha-N-acetyl-neuraminyl-(2->3)-beta-galactosyl-(1->3)-N-acetylgalactosaminyl-R, where R may be protein or p-nitrophenol. Not identical with EC 2.4.99.3 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase.
History
EC 2.4.99.7 created 1984, modified 1986, modified 2004
Pathway
ec00512  Mucin type O-glycan biosynthesis
ec00604  Glycosphingolipid biosynthesis - ganglio series
ec01100  Metabolic pathways
Orthology
K03373  N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7C)
K03374  N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7D)
Genes
HSA: 256435(ST6GALNAC3) 27090(ST6GALNAC4)
PTR: 450108(ST6GALNAC4) 450115(ST6GALNAC3)
PPS: 100985483(ST6GALNAC3) 100995780(ST6GALNAC4)
GGO: 101143514(ST6GALNAC3) 101151595(ST6GALNAC4)
PON: 100174350(ST6GALNAC3) 100439613(ST6GALNAC4)
NLE: 100598104(ST6GALNAC4) 100603395(ST6GALNAC3)
MCC: 705879(ST6GALNAC4) 709779(ST6GALNAC3)
MCF: 102122701(ST6GALNAC3) 102142909(ST6GALNAC4)
CSAB: 103224585(ST6GALNAC3) 103239817(ST6GALNAC4)
CATY: 105576245(ST6GALNAC4) 105595840(ST6GALNAC3)
RRO: 104665870(ST6GALNAC4) 104666528(ST6GALNAC3)
RBB: 108533045(ST6GALNAC3) 108542735(ST6GALNAC4)
TFN: 117072089(ST6GALNAC4) 117092117(ST6GALNAC3)
CJC: 100398966(ST6GALNAC3) 100401438(ST6GALNAC4)
SBQ: 101032564(ST6GALNAC3) 101037868(ST6GALNAC4)
MMUR: 105875232(ST6GALNAC4) 105884196(ST6GALNAC3)
MMU: 20447(St6galnac3) 20448(St6galnac4)
MCAL: 110288812(St6galnac4) 110290963(St6galnac3)
MPAH: 110318527(St6galnac4) 110320284(St6galnac3)
RNO: 29758(St6galnac3) 407764(St6galnac4)
MCOC: 116090006(St6galnac4) 116093960(St6galnac3)
MUN: 110562585(St6galnac4) 110563850
CGE: 100759065(St6galnac4) 100762285(St6galnac3)
PLEU: 114699850(St6galnac3) 114703806(St6galnac4)
NGI: 103727384(St6galnac4) 103746466(St6galnac3)
HGL: 101708035(St6galnac3) 101717187(St6galnac4)
CCAN: 109674707(St6galnac3) 109686789(St6galnac4)
OCU: 100345091(ST6GALNAC3) 100356933(ST6GALNAC4)
TUP: 102476286(ST6GALNAC3) 102487439(ST6GALNAC4)
CFA: 490205(ST6GALNAC3) 609133(ST6GALNAC4)
VVP: 112924453(ST6GALNAC3) 112927918(ST6GALNAC4)
AML: 100480565(ST6GALNAC4) 100481578(ST6GALNAC3)
UMR: 103662994(ST6GALNAC3) 103670294(ST6GALNAC4)
UAH: 113254511(ST6GALNAC3) 113266445(ST6GALNAC4)
ORO: 101368864(ST6GALNAC4) 101382354(ST6GALNAC3)
ELK: 111143388 111146222
MPUF: 101672038(ST6GALNAC4) 101685214(ST6GALNAC3)
EJU: 114208382(ST6GALNAC3) 114212880(ST6GALNAC4)
FCA: 101091035(ST6GALNAC3) 101094459(ST6GALNAC4)
PTG: 102966320(ST6GALNAC4) 107178974(ST6GALNAC3)
PPAD: 109250108(ST6GALNAC4) 109266652(ST6GALNAC3)
AJU: 106966292(ST6GALNAC4) 113599298(ST6GALNAC3)
BTA: 404124(ST6GALNAC4) 782689(ST6GALNAC3)
BOM: 102287870(ST6GALNAC4)
BIU: 109556154(ST6GALNAC3)
BBUB: 102396911(ST6GALNAC4) 102415799(ST6GALNAC3)
CHX: 102170329(ST6GALNAC4) 102190655(ST6GALNAC3)
OAS: 101121471(ST6GALNAC3) 101123019(ST6GALNAC4)
SSC: 100512173(ST6GALNAC3) 396676(ST6GALNAC4)
CFR: 102505545(ST6GALNAC3) 116663270(ST6GALNAC4)
CDK: 105096656(ST6GALNAC3) 116152744(ST6GALNAC4)
BACU: 103005340(ST6GALNAC4) 103020698(ST6GALNAC3)
LVE: 103085714(ST6GALNAC3) 103086160(ST6GALNAC4)
OOR: 101278803(ST6GALNAC4) 101285214(ST6GALNAC3)
DLE: 111177188(ST6GALNAC4) 111178407(ST6GALNAC3)
PCAD: 102980952(ST6GALNAC3) 102990591(ST6GALNAC4) 102993381
ECB: 100066966(ST6GALNAC3) 100067121(ST6GALNAC4)
EPZ: 103544980(ST6GALNAC4) 103549422(ST6GALNAC3)
EAI: 106836550(ST6GALNAC3) 106845456(ST6GALNAC4)
MYB: 102248336 102253595(ST6GALNAC3) 102261251(ST6GALNAC4)
MYD: 102754268(ST6GALNAC4) 102760172(ST6GALNAC3)
MMYO: 118667025(ST6GALNAC4) 118676600(ST6GALNAC3)
MNA: 107535596(ST6GALNAC4) 107540092(ST6GALNAC3)
HAI: 109379933(ST6GALNAC4) 109383481(ST6GALNAC3)
DRO: 112306353(ST6GALNAC4) 112309356(ST6GALNAC3)
SHON: 118980054(ST6GALNAC4)
AJM: 119040023(ST6GALNAC3) 119056496(ST6GALNAC4)
MMF: 118626740(ST6GALNAC3) 118629692(ST6GALNAC4)
PALE: 102881827(ST6GALNAC4) 102894086(ST6GALNAC3)
RAY: 107503437(ST6GALNAC3) 107520248(ST6GALNAC4)
MJV: 108397264 108397977(ST6GALNAC4)
LAV: 100672433(ST6GALNAC3) 104845634(ST6GALNAC4)
TMU: 101349108 101358972
MDO: 100010461(ST6GALNAC3) 100012077(ST6GALNAC4)
SHR: 100919945(ST6GALNAC3) 100921479(ST6GALNAC4)
PCW: 110193695(ST6GALNAC4) 110195706(ST6GALNAC3)
OAA: 100078837(ST6GALNAC4) 100087849(ST6GALNAC3)
GGA: 395182(ST6GALNAC4) 404746(ST6GALNAC3)
MGP: 100540755(ST6GALNAC3) 100543224(ST6GALNAC4)
CJO: 107317527(ST6GALNAC3) 107321783(ST6GALNAC4)
NMEL: 110390579(ST6GALNAC4) 110402576(ST6GALNAC3)
APLA: 101791163(ST6GALNAC4) 101793136(ST6GALNAC3)
ACYG: 106034022(ST6GALNAC3) 106047277(ST6GALNAC4)
TGU: 100221194(ST6GALNAC3) 100232134(ST6GALNAC4)
LSR: 110469217(ST6GALNAC3) 110482257(ST6GALNAC4)
SCAN: 103814945(ST6GALNAC3) 103819159(ST6GALNAC4)
GFR: 102032720(ST6GALNAC3) 102036471(ST6GALNAC4)
FAB: 101813361(ST6GALNAC3) 101817162(ST6GALNAC4)
PHI: 102101449(ST6GALNAC3) 102109129(ST6GALNAC4)
PMAJ: 107208224(ST6GALNAC3) 107211894(ST6GALNAC4)
CCAE: 111933158(ST6GALNAC3) 111936951(ST6GALNAC4)
CCW: 104688260(ST6GALNAC4) 104695278(ST6GALNAC3)
ETL: 114054554(ST6GALNAC4) 114066175(ST6GALNAC3)
FPG: 101917057(ST6GALNAC3) 101923804(ST6GALNAC4)
FCH: 102047399(ST6GALNAC3) 102056501(ST6GALNAC4)
CLV: 102084668(ST6GALNAC3) 102090323(ST6GALNAC4)
EGZ: 104122368(ST6GALNAC4) 104125535(ST6GALNAC3)
NNI: 104015564(ST6GALNAC3) 104022455(ST6GALNAC4)
ACUN: 113483151(ST6GALNAC3) 113486613(ST6GALNAC4)
PADL: 103912977(ST6GALNAC4) 103925221(ST6GALNAC3)
AAM: 106495296(ST6GALNAC4) 106499457(ST6GALNAC3)
ASN: 102383697(ST6GALNAC3) 102385694(ST6GALNAC4)
AMJ: 102575154(ST6GALNAC4) 102576099(MSH4)
PSS: 102443948(ST6GALNAC4) 102457102(ST6GALNAC3)
CMY: 102932867(ST6GALNAC4) 102940238(ST6GALNAC3)
CPIC: 101940645(ST6GALNAC4) 101944048(ST6GALNAC3)
ACS: 100552238(st6galnac4) 100567272(st6galnac3)
PVT: 110078837(ST6GALNAC4) 110079526(ST6GALNAC3)
PBI: 103052750(ST6GALNAC3) 103063354(ST6GALNAC4)
PMUR: 107287801(ST6GALNAC3) 107298943(ST6GALNAC4)
TSR: 106545572(ST6GALNAC3) 106551570
PMUA: 114589237(ST6GALNAC4) 114598841(ST6GALNAC3)
GJA: 107105744(ST6GALNAC4) 107113018(ST6GALNAC3)
XLA: 108714200(st6galnac3.L)
XTR: 100495364(st6galnac3) 779760(st6galnac4)
NPR: 108794466(ST6GALNAC4) 108799035(ST6GALNAC3)
DRE: 322609(st6galnac3) 751653(st6galnac4)
SRX: 107705960 107708685(st6galnac3) 107737196
SANH: 107661558 107675764 107681790 107703200
SGH: 107558185 107585701 107599397 107599406 107599847
CCAR: 109062816 109072017 109103371
IPU: 108268339(st6galnac3) 108279162(st6galnac4)
PHYP: 113535400 113540196(st6galnac3)
AMEX: 103027742(st6galnac4) 103028147(st6galnac3)
EEE: 113570133(st6galnac3) 113590039
TRU: 101064537 446080(st6galnac3)
LCO: 104924497 109140213(st6galnac3) 109142950
NCC: 104946126(st6galnac4) 104965762
MZE: 101465741 101474314(st6galnac3)
ONL: 100701389 100708358(st6galnac3)
OLA: 100049534(st6galnac3) 101164661(st6galnac4)
XMA: 102226898 102236276(st6galnac3)
XCO: 114145824(st6galnac3) 114149160
PRET: 103473419(st6galnac4) 103479928(st6galnac3)
CVG: 107089777(st6galnac4) 107094225(st6galnac3) 107104669
NFU: 107374797(st6galnac4) 107383508(st6galnac3)
KMR: 108230860(st6galnac4) 108232955(st6galnac3)
ALIM: 106520778(st6galnac3)
AOCE: 111564085 111586859
CSEM: 103396703(st6galnac3)
POV: 109625944 109637616(st6galnac3)
LCF: 108874088 108884275(st6galnac3) 108891392
SDU: 111231135(st6galnac3) 111237383
SLAL: 111668031 111668378
HCQ: 109516873(st6galnac3)
BPEC: 110155713(st6galnac3) 110157454
MALB: 109955309(st6galnac3) 109972319
SASA: 100196729(st6galnac4) 106569362 106591001
OTW: 112220107 112237760(st6galnac3)
SALP: 111961873
ELS: 105009744(st6galnac3) 105015283
SFM: 108923702(st6galnac3) 108935911(st6galnac4)
PKI: 111846074(st6galnac3)
LCM: 102356696(ST6GALNAC3) 102363654(ST6GALNAC4)
CMK: 103174732(st6galnac3)
RTP: 109923725
BFO: 118412964 118414638 118414665
SPU: 100891500 105443856 115923706 574822 581547 586641 588013 757189
APLC: 110976973 110977684 110983454 110984822 110986129
SKO: 100371080 100374020 100375887 100376183 102810239
EPA: 110232907
ADF: 107334450
AMIL: 114960371
PDAM: 113681541
 » show all
Reference
1  [PMID:6190802]
  Authors
Bergh ML, Hooghwinkel GJ, van den Eijnden DH.
  Title
Biosynthesis of the O-glycosidically linked oligosaccharide chains of fetuin. Indications for an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase with a narrow acceptor specificity in fetal calf liver.
  Journal
J Biol Chem 258:7430-6 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.7
IUBMB Enzyme Nomenclature: 2.4.99.7
ExPASy - ENZYME nomenclature database: 2.4.99.7
BRENDA, the Enzyme Database: 2.4.99.7
CAS: 129924-24-9

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Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (10)   
   KEGG COMPOUND (4)   
   KEGG GLYCAN (6)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (441)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (339)   
   KEGG MGENES (31)   
   RefGene (69)   
Protein sequence (53)   
   UniProt (12)   
   SWISS-PROT (5)   
   RefSeq(pep) (35)   
   PMD (1)   
DNA sequence (53)   
   RefSeq(nuc) (35)   
   GenBank (10)   
   EMBL (8)   
Protein domain (2)   
   InterPro (2)   
All databases (568)   

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