KEGG   ENZYME: 2.5.1.103
Entry
EC 2.5.1.103                Enzyme                                 
Name
presqualene diphosphate synthase;
SSL-1 (gene name);
hpnD (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
(2E,6E)-farnesyl-diphosphate:(2E,6E)-farnesyl-diphosphate farnesyltransferase (presqualene diphosphate-forming)
Reaction(IUBMB)
2 (2E,6E)-farnesyl diphosphate = presqualene diphosphate + diphosphate [RN:R00702]
Reaction(KEGG)
R00702
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
presqualene diphosphate [CPD:C03428];
diphosphate [CPD:C00013]
Comment
Isolated from the green alga Botryococcus braunii BOT22. Unlike EC 2.5.1.21, squalene synthase, where squalene is formed in one step from farnesyl diphosphate, in this alga the intermediate presqualene diphosphate is generated and released by this enzyme. This compound is then converted into either squalene (by EC 1.3.1.96, Botryococcus squalene synthase) or botryococcene (EC 1.3.1.97, botryococcene synthase).
History
EC 2.5.1.103 created 2012
Orthology
K21151  presqualene diphosphate synthase
K21678  presqualene diphosphate synthase
Genes
ACAVVI35_08830
AEAC2U39_09245
ARVC7N77_15940
AESC2U30_04565
RPJN234_32515
REHH16_B2206(h16_B2206)
CNCCNE_2c21840
CUHBJN34_33520
REUReut_B4953
RMERmet_4149(crtB)
CTIRALTA_B1982(crtB)
CBWRR42_s2400
CCUPBKK81_26335
CUPBKK80_29980
CUUBKK79_20630
CPAUEHF44_19250(hpnD)
COXE0W60_04540(hpnD)
CCAMM5D45_21260(hpnD)
BMABMAA2102
BMVBMASAVP1_1131
BMLBMA10229_1410
BMALDM55_3713(hpnD)
BMAEDM78_4587(hpnD)
BMAQDM76_4408(hpnD)
BMAIDM57_14645
BMAFDM51_3765(hpnD)
BMAZBM44_3672(hpnD)
BMABBM45_4449(hpnD)
BPSBPSS2340
BPMBURPS1710b_A1491
BPLBURPS1106A_A3163
BPDBURPS668_A3277
BPSEBDL_5819(hpnD)
BPSMBBQ_3759(hpnD)
BPSUBBN_5841(hpnD)
BPSDBBX_4988(hpnD)
BPZBP1026B_II2521
BPQBPC006_II3109
BPKBBK_5126(hpnD)
BPSHDR55_5385(hpnD)
BPSABBU_3645(hpnD)
BPSOX996_5155(hpnD)
BUTX994_4704(hpnD)
BTEBTH_II2361
BTQBTQ_3276(hpnD)
BTJBTJ_4308(hpnD)
BTZBTL_5109(hpnD)
BTDBTI_4771(hpnD)
BTVBTHA_5107(hpnD)
BTHEBTN_4770(hpnD)
BTHMBTRA_5038(hpnD)
BTHADR62_4874
BTHLBG87_5105(hpnD)
BOKDM82_3977(hpnD)
BOCBG90_4050(hpnD)
BUUWS70_28735
BSAVWS86_18640
BHGI6G56_29180(hpnD)
BVIBcep1808_3806
BVEAK36_4903(hpnD)
BURBcep18194_B0017
BCMBcenmc03_4554
BCHBcen2424_5681
BCJBCAM2833
BCENDM39_5011(hpnD)
BCEWDM40_3398(hpnD)
BCEOI35_6713
BAMBamb_4953
BACBamMC406_5506
BMUBmul_3173
BMKDM80_4551(hpnD)
BMULNP80_3381(hpnD)
BCTGEM_5579
BCEDDM42_5155(hpnD)
BCEPAPZ15_24785
BDLAK34_4972(hpnD)
BPYRABD05_21475
BCONNL30_18015
BUBBW23_4003(hpnD)
BDFWI26_26725
BLATWK25_29570
BTEIWS51_10755
BSEMWJ12_34030
BPSLWS57_00075
BMECWJ16_32505
BSTGWT74_32870
BSTLBBJ41_27940
BANNJFN94_18185(hpnD)
BGLbglu_2g22730
BGUKS03_3645(hpnD)
BUGBC1001_4761
BGFBC1003_4525
BGDbgla_2g29880
BGOBM43_6722(hpnD)
BYIBYI23_B013700(hpnD)
BUKMYA_3463
BUEBRPE67_BCDS00660(hpnD)
BULBW21_4300(hpnD)
BUQAC233_26240
BGPBGL_2c29500
BPLAbpln_2g29540
BUDAQ610_31640
BUMAXG89_19300
BUIAX768_29065
BURKDM992_25930(hpnD)
BXEBxe_B0010
BXBDR64_5374(hpnD)
BPHBphy_4139
BGEBC1002_5088
BPXBUPH_01326
BPYBphyt_7027
BUZAYM40_35485
BFNOI25_5472(hpnD)
BCAIK788_0000711
PSPWBJG93_21545(hpnD)
PARABTO02_22405
PARBCJU94_28545(hpnD)
PHSC2L64_18365(hpnD)
PTERC2L65_16200(hpnD)
PGPCUJ91_30000(hpnD)
PCJCUJ87_28070(hpnD)
PTSCUJ90_23655(hpnD)
PMEGFNZ07_04860(hpnD)
PTROG5S35_20790(hpnD)
PGISI6I06_28040(hpnD)
PACPFAZ97_23535(hpnD)
PACSFAZ98_18970(hpnD)
PEWKZJ38_24050(hpnD)
PDIOPDMSB3_3367.1(hpnD)
PPKU875_17030
PPNODA70_09100
PPNMLV28_21705
PRBX636_17390
PPULRO07_16095
PSPUNA29_21055
PAPISG18_00205
PVEUC34_07350
POXMB84_11685
PTXABW99_02785
PFGAB870_18045
PNRAT302_26710
PANDDRB87_06615(hpnD)
PFIBPI93_020490(hpnD)
PCOMNTU39_08360(hpnD)
CABASBC2_70720(hpnD)
BUOBRPE64_BCDS00790
VCVGJV44_p00025
PMOBHG718_04895(hpnD)
KMNHW532_17965(hpnD)
RHINGR_a00440(hpnD)
SINOSS05631_a45170
ESJSJ05684_a40270
BJAblr3002(blr3002)
BJUBJ6T_67650
BJPRN69_32810
BRABRADO2628
BBTBBta_2967
BRSS23_49950(hpnD)
AOLS58_49910
BRCBCCGELA001_13465
BRADBF49_1690
BICLMTR13_28340
BROBRAD285_4713
BRKCWS35_18215(hpnD)
BOTCIT37_38585(hpnD)
BRQCIT40_09510(hpnD)
BGQX265_25990(hpnD)
BGZXH91_24130(hpnD)
BSYMCIT39_08630(hpnD)
BBETF8237_05035(hpnD)
BARHWN72_16440(hpnD)
BVZBRAD3257_5708
BELBE61_70460
BDGLPJ38_18010(hpnD)
BSEPHAP48_0030890(hpnD)
BQBJ4P68_0032150(hpnD)
RPARPA3742
RPBRPB_1724
RPCRPC_1718
RPDRPD_3575
RPERPE_1812
RPTRpal_4263
RPXRpdx1_1603
RBKE0H22_09830(hpnD)
NWINwi_2271
NHANham_2684
OCAOCAR_6673(hpnD)
OCGOCA5_c13950
OCOOCA4_c13950
VGOGJW-30_1_02140(crtB_2)
TRBHB776_13765(hpnD)
STARG3545_15490(hpnD)
MEAMex_1p1816
MDIMETDI2703
MEXMext_1942
MCHMchl_2218
MPOMpop_1833
MZAB2G69_17170
MRDMrad2831_5424
METM446_6349
MNOMnod_7144
MORMOC_5999(hpnD)
METAY590_09030
MAQUMaq22A_c25245(erg9)
MPHYMCBMB27_04725
MEEDA075_06155(hpnD)
METDC0214_10785(hpnD)
METXA3862_03555
METSDK389_19265(hpnD)
METIDK427_24625(hpnD)
MMESMMSR116_24435(hpnD)
MTEADK419_24990(hpnD)
MINDmvi_55630
MOGMMB17_13740(hpnD)
MTADM6G65_20535(hpnD)
BIDBind_3154
MSLMsil_3241
MTUNMTUNDRAET4_2107(hpnD)
MLGCWB41_01835(hpnD)
BBARRHAL1_00132(hpnD)
HDNHden_0475
HDTHYPDE_24878
HMCHYPMC_3773
RVARvan_3019
RHZRHPLAN_23290
MSCBN69_1680
MBRYB1812_03900
MROSEHO51_00870(hpnD)
MHEYH2LOC_015885(hpnD)
MPARF7D14_11075(hpnD)
MTWCQW49_11735(hpnD)
PSINCAK95_04475
TSOIZ6_27210
RBMTEF_04820
LIZLGH83_10465(hpnD)
CAULKCG34_23155(hpnD)
PALWPSAL_001910(hpnD)
ZMOZMO0870
ZMNZa10_0422
ZMMZmob_0427
ZMBZZ6_0425
ZMIZCP4_0441
ZMCA265_00436(crtM)
ZMRA254_00436(crtM)
ZMPZymop_0395
NORFA702_05045(hpnD)
SPHMG432_09190
SPANAWL63_21310
SPHAD3Y57_13885(hpnD)
SARIH5J25_10650(hpnD)
HGNE6W36_05955
POQKZX46_17585(hpnD)
GOXGOX2258
GOHB932_2744
GOYGLS_c24010(hpnD)
GALA0U94_06160
GTIFXF46_13815(hpnD)
GSPIGS75_12755(hpnD)
GFAMKW11_14245(hpnD)
GBEGbCGDNIH1_1981
GBHGbCGDNIH2_1981
GBCGbCGDNIH3_1981
GBSGbCGDNIH4_1981
ACRAcry_0118
AMVACMV_01430
GDIGDI1622
GDJGdia_1827
GXYGLX_17350
GXLH845_3227
KNAB0W47_08880
KEUS101446_02251(crtB)
KSCCD178_01161(crtB_1)
KREGWK63_14325(hpnD)
APTAPA01_01970
APWAPA42C_01970
APFAPA03_01970
APUAPA07_01970
APGAPA12_01970
APQAPA22_01970
APXAPA26_01970
APZAPA32_01970
APKAPA386B_1685
ASZASN_2210
ASVWG31_01025
AACEA0U92_11680
APERA0U91_06965
APOMCPF11_06315(hpnD)
ATOCIW82_01580(hpnD)
AASCA4S02_11555
ACETDS739_01125(hpnD)
AOTAcetOri_orf02400
AOYEOV40_001050(hpnD)
ACEKFLP30_07010(hpnD)
ABGAsbog_02596(hpnD)
KBAA0U89_01830
RGIRGI145_09720
ROSCTJ15_07700(hpnD)
RMUCFOB66_09725(hpnD)
RMTIAI58_18585(hpnD)
NCHA0U93_11935
COQD9V35_08230(hpnD)
COMMGN303_08030(hpnD)
NTND5366_10590(hpnD)
NEHE3E11_07655(hpnD)
SSAME3D00_09655(hpnD)
SWFE3E12_06920(hpnD)
BOBGN304_03810(hpnD)
BOMBGT348_03335(hpnD)
EBLAJGUZn3_04110(hpnD)
LCKHN018_00150(hpnD)
KHAIFJ82_01375(hpnD)
PARZDTQ13_08065(hpnD)
RAPRHOA_2341(hpnD)
SHUMSTHU_15370 STHU_32400
SVCSTVA_19140 STVA_37720
STELSTAQ_34010
AZLAZL_014580(crtB)
ALIAZOLI_1388
ABSAZOBR_p120091
ABQABAZ39_16790
ABFAMK58_16905
ATIAL072_11960
AHUA6A40_05000
AZTTSH58p_22395
AZMDM194_04395(hpnD)
AZZDEW08_02165(hpnD)
AOZHUE56_17245(hpnD)
NAOY958_22680(hpnD)
SKTIGS68_10425(hpnD)
SMUCJL100_016810(hpnD)
SROEJL101_015660(hpnD)
MAGamb1366
MGYMGMSRv2__1219
MGRYMSR1_10400(crtB_1)
MAGXXM1_1989
MAGNWV31_17680
HTQFRZ44_04150
HADHFRZ61_04420
DEXHWD60_12245(hpnD)
DVNHQ394_07740(hpnD)
TXITH3_01790
THACCSC3H3_02195
MAGQMGMAQ_1492
PBFCFX0092_B0150
 » show all
Reference
1  [PMID:21746901]
  Authors
Niehaus TD, Okada S, Devarenne TP, Watt DS, Sviripa V, Chappell J
  Title
Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii.
  Journal
Proc Natl Acad Sci U S A 108:12260-5 (2011)
DOI:10.1073/pnas.1106222108
  Sequence
Reference
2  [PMID:26258173]
  Authors
Pan JJ, Solbiati JO, Ramamoorthy G, Hillerich BS, Seidel RD, Cronan JE, Almo SC, Poulter CD
  Title
Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes.
  Journal
ACS Cent Sci 1:77-82 (2015)
DOI:10.1021/acscentsci.5b00115
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.103
IUBMB Enzyme Nomenclature: 2.5.1.103
ExPASy - ENZYME nomenclature database: 2.5.1.103
BRENDA, the Enzyme Database: 2.5.1.103

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