KEGG   ENZYME: 2.5.1.138
Entry
EC 2.5.1.138                Enzyme                                 

Name
coumarin 8-geranyltransferase;
ClPT1
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
geranyl-diphosphate:umbelliferone 8-geranyltransferase
Reaction(IUBMB)
(1) geranyl diphosphate + umbelliferone = diphosphate + 8-geranylumbelliferone [RN:R11602];
(2) geranyl diphosphate + esculetin = diphosphate + 8-geranylesculetin [RN:R11603]
Reaction(KEGG)
R11602 R11603
Substrate
geranyl diphosphate [CPD:C00341];
umbelliferone [CPD:C09315];
esculetin [CPD:C09263]
Product
diphosphate [CPD:C00013];
8-geranylumbelliferone [CPD:C21495];
8-geranylesculetin [CPD:C21496]
Comment
The enzyme, characterized from the plant Citrus limon, is specific for geranyl diphosphate as a prenyl donor. It also has low activity with the coumarins 5,7-dihydroxycoumarin and 5-methoxy-7-hydroxycoumarin.
History
EC 2.5.1.138 created 2017
Orthology
K21587  coumarin 8-geranyltransferase
Genes
CIT: 102618825
CIC: CICLE_v10008336mg
MING: 122061896 122062797 122064065 122066900 122070394 122073653 122075438 122094399
Reference
1  [PMID:25077796]
  Authors
Munakata R, Inoue T, Koeduka T, Karamat F, Olry A, Sugiyama A, Takanashi K, Dugrand A, Froelicher Y, Tanaka R, Uto Y, Hori H, Azuma J, Hehn A, Bourgaud F, Yazaki K
  Title
Molecular cloning and characterization of a geranyl diphosphate-specific aromatic prenyltransferase from lemon.
  Journal
Plant Physiol 166:80-90 (2014)
DOI:10.1104/pp.114.246892
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.138
IUBMB Enzyme Nomenclature: 2.5.1.138
ExPASy - ENZYME nomenclature database: 2.5.1.138
BRENDA, the Enzyme Database: 2.5.1.138

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