KEGG   ENZYME: 2.5.1.56Help
Entry
EC 2.5.1.56                 Enzyme                                 

Name
N-acetylneuraminate synthase;
(NANA)condensing enzyme;
N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating);
NeuAc synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
Reaction(IUBMB)
phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate [RN:R01804]
Reaction(KEGG)
R01804;
(other) R04435
Show
Substrate
phosphoenolpyruvate [CPD:C00074];
N-acetyl-D-mannosamine [CPD:C00645];
H2O [CPD:C00001]
Product
phosphate [CPD:C00009];
N-acetylneuraminate [CPD:C00270]
History
EC 2.5.1.56 created 1972 as EC 4.1.3.19, transferred 2002 to EC 2.5.1.56
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K01654  N-acetylneuraminate synthase
K05304  sialic acid synthase
Genes
HSA: 54187(NANS)
PTR: 743934(NANS)
PPS: 100982112(NANS)
GGO: 101124502(NANS)
PON: 100446862(NANS)
NLE: 100596073 100603154(NANS)
MCC: 715459(NANS)
MCF: 102120030(NANS)
CSAB: 103219150(NANS)
RRO: 104657773(NANS)
RBB: 108539113(NANS)
CJC: 100411585(NANS)
SBQ: 101027621(NANS)
MMU: 94181(Nans)
RNO: 298071(Nans)
CGE: 100767837(Nans)
NGI: 103749137(Nans)
HGL: 101721582(Nans)
CCAN: 109697287(Nans)
OCU: 100356934(NANS)
TUP: 102496776(NANS)
CFA: 481624(NANS)
AML: 100471912(NANS)
UMR: 103678504(NANS)
ORO: 101377441(NANS)
FCA: 101092303(NANS)
PTG: 102952743(NANS)
AJU: 106981299(NANS)
BTA: 540602(NANS)
BOM: 102266035(NANS)
BIU: 109563072(NANS)
PHD: 102326794(NANS)
CHX: 102171423(NANS)
OAS: 101104048(NANS)
SSC: 100155883(NANS)
CFR: 102511644(NANS)
CDK: 105086903(NANS)
BACU: 103016138(NANS)
LVE: 103074242(NANS)
OOR: 101286113(NANS)
ECB: 100064126(NANS)
EPZ: 103550229(NANS)
EAI: 106842931(NANS)
MYB: 102254698(NANS)
MYD: 102770256(NANS)
HAI: 109386412(NANS)
RSS: 109446100(NANS)
PALE: 102882391(NANS)
LAV: 100659127(NANS)
TMU: 101361417
MDO: 100014569(NANS)
SHR: 100915225(NANS)
OAA: 100074951(NANS)
GGA: 427283(NANS)
MGP: 100540972(NANS)
CJO: 107306381(NANS)
APLA: 101793548(NANS)
ACYG: 106046483(NANS)
TGU: 100227675(NANS)
GFR: 102036907(NANS)
FAB: 101817049(NANS)
PHI: 102108606(NANS)
PMAJ: 107198262(NANS)
CCW: 104689769(NANS)
FPG: 101910977(NANS)
FCH: 102058691(NANS)
CLV: 102088004(NANS)
EGZ: 104135026(NANS)
AAM: 106487451(NANS)
ASN: 102371122(NANS)
AMJ: 102562418(NANS)
PSS: 102457496(NANS)
CMY: 102930222(NANS)
CPIC: 101940249(NANS)
ACS: 100558551(nans)
PVT: 110077827(NANS)
PBI: 103051012(NANS)
GJA: 107122992(NANS)
XLA: 432051 447417(nans.L)
XTR: 100492893(nans)
NPR: 108783786(NANS)
DRE: 322780(nansa)
IPU: 100528493(nans) 108260162
AMEX: 111195185(nans)
TRU: 778024(nans)
LCO: 104922341(nans)
NCC: 104951104(nans)
OLA: 101166198(nans)
XMA: 102234709(nans)
PRET: 103467988(nans) 103472627
ELS: 105022900(nans)
SFM: 108920829
CMK: 103177631(nans) 103177633
SPU: 577884(nans)
DME: Dmel_CG5232(NANS)
DSI: Dsimw501_GD18832(Dsim_GD18832)
MDE: 101899077
AAG: 5563645
TCA: 103312199
DPA: 109539228
NVL: 108567369
BMOR: 101744099
PRAP: 110994857
PXY: 105391284
DNX: 107161705
ZNE: 110829049
FCD: 110842189
TUT: 107368038
CRG: 105324122
ECI: UTI89_C3372(neuB)
ECV: APECO1_3471(neuB)
ECM: EcSMS35_3232(neuB)
ECT: ECIAI39_3443(neuB)
EOC: CE10_3481(neuB)
ECZ: ECS88_3330(neuB)
ESO: O3O_16390
ESM: O3M_09195
ESL: O3K_09230
EIH: ECOK1_3369(neuB)
ECOI: ECOPMV1_03252(spsE)
ECOO: ECRM13514_2762(nnaB)
ECOH: ECRM13516_2630(nnaB)
SBZ: A464_2222
ENC: ECL_03360
EBF: D782_1589
PEC: W5S_3015
ETR: ETAE_1207(neuB)
ETD: ETAF_1122
ETE: ETEE_3151(neuB)
HPR: PARA_02850(nnaB)
MHT: D648_18140(neuB)
MHQ: D650_8020(neuB)
MHAT: B824_18220(neuB)
MHX: MHH_c26670(nnaB)
MHAE: F382_04090
MHAM: J450_03120
MHAO: J451_04330
MHAL: N220_10190
MHAQ: WC39_04015
MHAY: VK67_04015
MVR: X781_5990
MVE: X875_5510
VVU: VV1_0808
VVY: VV0312
VPA: VP0200
VFI: VF_0143(neuB)
VFM: VFMJ11_0175(pseI)
PPR: PBPRA2707(CJ1317)
PMK: MDS_1970
PPF: Pput_1483
PFL: PFL_1625(pseI)
PSA: PST_3835
PPUU: PputUW4_03891(pseI)
ABM: ABSDF0070
ABX: ABK1_0091
SON: SO_3261
SAZ: Sama_2331
SBL: Sbal_2958
SLO: Shew_1329
SSE: Ssed_3100
SPL: Spea_0049
SHL: Shal_1403
SWD: Swoo_1582
ILO: IL0519(siaC) IL0551
CPS: CPS_2097
PAT: Patl_3076
MHC: MARHY2541(rkpQ)
MAD: HP15_2393
TCX: Tcr_1458
NHL: Nhal_0399
HCH: HCH_04835 HCH_05266(neuB)
AHA: AHA_4180(nueB)
ASA: ASA_0148(neuB)
ASR: WL1483_1781(pseI)
NME: NMB0068(siaC)
NMP: NMBB_0073(siaC)
NMQ: NMBM04240196_0082(siaC)
NMZ: NMBNZ0533_0074(siaC)
NMC: NMC0052(siaC)
NMN: NMCC_0076(siaC)
NMT: NMV_0069(siaC)
CVI: CV_4031(neuB)
BPH: Bphy_3008
PNE: Pnec_0333
BPT: Bpet2307(neuB)
BPSI: IX83_06875
VEI: Veis_4853
CTES: O987_16645
HAR: HEAR1126
JAG: GJA_936
TIN: Tint_2652
NEU: NE1570
NET: Neut_1549
DSU: Dsui_0079
DAR: Daro_1248
HAC: Hac_1271(neuB)
CJE: Cj1141(neuB1)
CJB: BN148_1141(neuB1)
CJU: C8J_1339
CJI: CJSA_1083(neuB1)
CJEJ: N564_01107
CJEU: N565_01150
CJEN: N755_01145
CJEI: N135_01178
CCY: YSS_07645
CIS: CINS_1205(neuB)
CSM: CSUB8521_1427(neuB)
GSU: GSU1970(neuB)
GME: Gmet_0455
GUR: Gura_4086
GLO: Glov_3405
GBM: Gbem_3726
PCA: Pcar_1140 Pcar_1277(neuB)
DVU: DVU0349
DDS: Ddes_1890
DGG: DGI_4066
DBA: Dbac_0367
DRT: Dret_0614
DAT: HRM2_36740(neuB)
HOH: Hoch_0346
DBR: Deba_1027
BBA: Bd1683(neuB)
PACA: ID47_09690
SMI: BN406_06051(rkpQ)
RHI: NGR_b09490(rkpQ)
SFH: SFHH103_06314(rkpQ)
RLG: Rleg_0440
RPB: RPB_1534
RPE: RPE_4236
NHA: Nham_1196
BVR: BVIR_1970
CCR: CC_2868
CSE: Cseg_0922
PZU: PHZ_c2601
RCP: RCAP_rcc02960(neuB)
RDE: RD1_4205
PDE: Pden_3556
HBA: Hbal_0198
RCE: RC1_3771(nans)
MGM: Mmc1_0562
BAY: RBAM_035120(spsE)
BCG: BCG9842_B1724(pseI)
BPU: BPUM_3432
GKA: GK3123
LSP: Bsph_1163
BBE: BBR47_53260(neuB)
SAG: SAG1161(neuB)
SAN: neuB
SAK: SAK_1250(neuB)
SGC: A964_1134(neuB)
SAGS: SaSA20_0983(neuB)
SAGL: GBS222_0993(neuB)
SAGM: BSA_12390
SAGI: MSA_12810
SAGR: SAIL_12810
SAGP: V193_05425
SAGC: DN94_05425
SAGE: EN72_06455
SAGG: EN73_05990
SAGN: W903_1244(neuB)
SSB: SSUBM407_1280(neuB)
SSI: SSU0535(neuB)
SSS: SSUSC84_0517(neuB)
SUP: YYK_02535
SSUT: TL13_1188(neuB)
SSUI: T15_1401(neuB)
CTC: CTC_01711
CBO: CBO2680
CBA: CLB_2621
CBH: CLC_2553
CBY: CLM_3044
CBL: CLK_2067
CBB: CLD_1885
CBI: CLJ_B2910
CBT: CLH_1466
CKL: CKL_2472
CKR: CKR_2186
BPB: bpr_I2559(neuB2)
SWO: Swol_0210
HMO: HM1_1244
MTA: Moth_0756
SCO: SCO4881(2SCK8.07)
SMA: SAVERM_3373(neuB)
SGR: SGR_2659
SLAU: SLA_6887
JDE: Jden_0843
MPH: MLP_28480
KFL: Kfla_0513
TFU: Tfu_0010
SRO: Sros_1204
GOB: Gobs_4334
SYW: SYNW0394
SYG: sync_0174
SYNR: KR49_06605
SYND: KR52_04985
PMB: A9601_14241(spsE)
PMF: P9303_01101(spsE)
PMG: P9301_14081(spsE)
PMH: P9215_14811(spsE)
PMJ: P9211_12451(spsE)
PME: NATL1_08721(spsE)
CYT: cce_4481
RCA: Rcas_0774
PUV: PUV_16450(spsE)
WCH: wcw_0976(neuB)
LIL: LA_1613(spsE)
LIE: LIF_A1300(spsE)
LIC: LIC_12169(sas)
LBJ: LBJ_1114(neuB-2)
LBL: LBL_1168(neuB-2)
LBF: LBF_1974(neuB-3)
BHY: BHWA1_01436(spsE)
BRM: Bmur_1664
BPO: BP951000_1153(spsE)
SUS: Acid_2246
FNU: FN1684
TAI: Taci_0643
BVU: BVU_4040
SRU: SRU_0605(spsE)
SRM: SRM_00699(spsE)
PHE: Phep_3942
CHU: CHU_2758(neuB)
DFE: Dfer_3363
SLI: Slin_4269
GFO: GFO_0569
FJO: Fjoh_0305
FPS: FP1256(neuB)
ZPR: ZPR_1117
CTE: CT0825
CPC: Cpar_0852
CCH: Cag_1072
CLI: Clim_0797
PVI: Cvib_1025
PLT: Plut_1274
PPH: Ppha_1574
PAA: Paes_0910
CTS: Ctha_2574
TNP: Tnap_0417
KOL: Kole_1281
NDE: NIDE2999
MJA: MJ_1065
MAE: Maeo_0420
MBU: Mbur_1586
MHU: Mhun_3098
MRU: mru_1878(neuB)
HMU: Hmuk_1456
NMG: Nmag_0151(neuB)
 » show all
Taxonomy
Reference
1  [PMID:13971393]
  Authors
BLACKLOW RS, WARREN L.
  Title
Biosynthesis of sialic acids by Neisseria meningitidis.
  Journal
J Biol Chem 237:3520-6 (1962)
Reference
2  [PMID:9438985]
  Authors
Komaki E, Ohta Y, Tsukada Y.
  Title
Purification and characterization of N-acetylneuraminate synthase from Escherichia coli K1-M12.
  Journal
Biosci Biotechnol Biochem 61:2046-50 (1997)
DOI:10.1271/bbb.61.2046
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.56
IUBMB Enzyme Nomenclature: 2.5.1.56
ExPASy - ENZYME nomenclature database: 2.5.1.56
BRENDA, the Enzyme Database: 2.5.1.56
CAS: 37290-66-7

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