Entry
Name
N-acetylneuraminate synthase;
(NANA)condensing enzyme;
N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating);
NeuAc synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
Reaction(IUBMB)
phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate [RN:
R01804 ]
Reaction(KEGG)
Substrate
Product
History
EC 2.5.1.56 created 1972 as EC 4.1.3.19, transferred 2002 to EC 2.5.1.56
Pathway
ec00520 Amino sugar and nucleotide sugar metabolism
ec00541 O-Antigen nucleotide sugar biosynthesis
Orthology
K01654 N-acetylneuraminate synthase
Genes
XLA : 432051(nans.S) 447417(nans.L)
DRE : 322780(nansa) 492779(nansb)
SRX : 107723182 107754352 107754390 107758866
SANH : 107665955 107686966 107686967 107692601
SGH : 107557947 107566238 107566239
CCAR : 109076464 109090623 109090659
CAUA : 113044320 113066551 113066555 113066556 113066635 113085422 113105679
CGIB : 127946856 127946857 127948763 127975766
PPRM : 120475377(nansb) 120475384 120475385 120475386 120478311(nansa)
MAMB : 125247499 125247713 125247908 125247921 125248041 125251616 125251645 125272478(nansa)
CIDE : 127507296 127519832
MASI : 127443667 127445253
IPU : 100528493(nansa) 108260162
SMEO : 124378730 124381237(nansa)
EEE : 113568448(nans) 113589926
CGOB : 115010173 115010214
MSAM : 119884880 119899378 119899379
CUD : 121507902 121508708 121508709
ONL : 100695579 100695847 100696106
OAU : 116310552 116310553 116310587
PRET : 103467988(nans) 103472627
CVG : 107083396(nans) 107083415 107083416
CTUL : 119787144 119787154 119787177
MCEP : 125003896 125004087 125004788
CSEM : 103384124 103384125
SSEN : 122770577 122771631
HHIP : 117769790 117769798
SLAL : 111656109 111659703
SSCV : 125969199 125969200
BPEC : 110166192 110166235
BSPL : 114858266 114858277 114858282
SASA : 100195066(sias) 106594767 106609889
STRU : 115191851 115202178 115202179 115202180 115202181
OMY : 110497423 110497424 110534455
OGO : 124001941 124001943 124012735
ONE : 115137363 115137722 115145762 115146546
SALP : 111971593 112068285 112080022
SNH : 120034903 120051990 120052901
CCLU : 121534521 121535761 121535762
PSEX : 120532357 120532358 120532359
CMK : 103177631(nansa) 103177633
CPLA : 122539555(nansa) 122547124
BBEL : 109471483 109471485
DSI : Dsimw501_GD18832(Dsim_GD18832)
APLN : 108741788 112904754
PMAC : 106708951 106709065
PPOT : 106100777 106100789
PPOI : 119112814 119113236
EHX : EMIHUDRAFT_437804(NEUB)
ECOO : ECRM13514_2762(nnaB)
ECOH : ECRM13516_2630(nnaB)
ECOI : ECOPMV1_03252(spsE)
ASI : ASU2_01185 ASU2_10545
ADP : NCTC12871_01316(spsE)
RPNE : NCTC8284_01156(spsE)
NMQ : NMBM04240196_0082(siaC)
NMZ : NMBNZ0533_0074(siaC)
NWE : SAMEA3174300_1366(siaC)
LAGG : B0E33_01050 B0E33_04290
HEBR : AEBR_0577 AEBR_2874
PSEL : GM415_02085 GM415_02270
LGZ : NCTC10812_01041(spsE)
MAUU : NCTC10437_01405(spsE)
SLE : sle_27930(sle_27930)
SLX : SLAV_09960(legI1) SLAV_15140(legI2)
SAST : CD934_06470 CD934_12310
SNK : CP967_05875 CP967_12450
AMAU : DSM26151_22300(legI)
PCLR : PC1C4_16490 PC1C4_23910
HYP : A0257_12515 A0257_22870
PRN : BW723_03025 BW723_09690
» show all
Taxonomy
Reference
Authors
BLACKLOW RS, WARREN L.
Title
Biosynthesis of sialic acids by Neisseria meningitidis.
Journal
J Biol Chem 237:3520-6 (1962)
Reference
Authors
Komaki E, Ohta Y, Tsukada Y.
Title
Purification and characterization of N-acetylneuraminate synthase from Escherichia coli K1-M12.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.56
ExPASy - ENZYME nomenclature database: 2.5.1.56