EC                Enzyme                                 

inositol-tetrakisphosphate 1-kinase;
1D-myo-inositol-tetrakisphosphate 1-kinase;
inositol-trisphosphate 6-kinase;
1D-myo-inositol-trisphosphate 6-kinase;
ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase;
inositol-trisphosphate 5-kinase;
1D-myo-inositol-trisphosphate 5-kinase;
ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate [RN:R03479]
ATP [CPD:C00002];
1D-myo-inositol 3,4,5,6-tetrakisphosphate [CPD:C04520]
ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:C01284]
This enzyme also phosphorylates Ins(1,3,4)P3 on O-5 and O-6. The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP. It can also catalyse an isomerization between Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP.
EC created 1990, (EC created 1989, incorporated 2002; EC created 1992, incorporated 2002), modified 2002
ec00562  Inositol phosphate metabolism
K00913  inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase
HSA: 3705(ITPK1)
PTR: 453121(ITPK1)
PPS: 100980755(ITPK1)
GGO: 101134664(ITPK1)
PON: 100448118(ITPK1)
NLE: 100590495(ITPK1)
MCC: 698756(ITPK1)
MCF: 102119398(ITPK1)
CSAB: 103229579(ITPK1)
RRO: 104679048(ITPK1)
RBB: 108519106(ITPK1)
CJC: 100396941(ITPK1)
SBQ: 101039869(ITPK1)
MMU: 217837(Itpk1)
RNO: 500709(Itpk1)
CGE: 100768438(Itpk1)
NGI: 103724593(Itpk1)
HGL: 101700462(Itpk1)
CCAN: 109693572(Itpk1)
OCU: 100345790(ITPK1)
TUP: 102479480(ITPK1)
CFA: 490591(ITPK1)
AML: 100484787(ITPK1)
UMR: 103673773(ITPK1)
ORO: 101385854(ITPK1)
FCA: 101087672(ITPK1)
PTG: 102951160(ITPK1)
AJU: 106980827(ITPK1)
BTA: 518488(ITPK1)
BOM: 102279411(ITPK1)
BIU: 109575578(ITPK1)
PHD: 102333268(ITPK1)
CHX: 102183460(ITPK1)
OAS: 101115161(ITPK1)
SSC: 100152339(ITPK1)
CFR: 102508931(ITPK1)
CDK: 105095826(ITPK1)
BACU: 103011955(ITPK1)
LVE: 103084508(ITPK1)
OOR: 101270326(ITPK1)
ECB: 100063828(ITPK1)
EPZ: 103556533(ITPK1)
EAI: 106825383(ITPK1)
MYB: 102246792(ITPK1)
MYD: 102764458(ITPK1) 102773325
HAI: 109376793(ITPK1)
RSS: 109442311 109454623(ITPK1)
PALE: 102877958(ITPK1)
LAV: 100668527(ITPK1)
TMU: 101341573
MDO: 100014342(ITPK1)
SHR: 100924957(ITPK1) 111719345
OAA: 100079832(ITPK1)
GGA: 423421(ITPK1)
MGP: 100541150(ITPK1)
CJO: 107315185(ITPK1)
APLA: 101801656(ITPK1)
ACYG: 106033487(ITPK1)
TGU: 100222999(ITPK1)
GFR: 102034047(ITPK1)
FAB: 101819235(ITPK1)
PHI: 102106037(ITPK1)
PMAJ: 107205493(ITPK1)
CCW: 104688688(ITPK1)
FPG: 101920131(ITPK1)
FCH: 102048369(ITPK1)
CLV: 102088692(ITPK1)
EGZ: 104135355(ITPK1)
AAM: 106483074(ITPK1)
ASN: 102373418(ITPK1)
AMJ: 102575334(ITPK1) 109280689
PSS: 102452019(ITPK1)
CMY: 102932685 102933310(ITPK1)
CPIC: 101948262(ITPK1) 101949054
ACS: 100566274(itpk1)
PVT: 110083634(ITPK1)
PBI: 103054635(ITPK1)
GJA: 107123858(ITPK1)
XLA: 108698651 108700483(itpk1.S) 379828(itpk1.L)
XTR: 100144987 549890(itpk1)
NPR: 108788675(ITPK1) 108804962
DRE: 100148744(itpk1b) 406290(itpk1a)
TRU: 101069194(itpk1) 101072928
NCC: 104941855(itpk1) 104945354
MZE: 101469029(itpk1) 101485309
OLA: 101157334(itpk1)
XMA: 102220593(itpk1)
PRET: 103458928(itpk1)
NFU: 107392041(itpk1)
CSEM: 103377198(itpk1) 103378259
HCQ: 109510866 109516026(itpk1)
BPEC: 110153603 110155270(itpk1)
ELS: 105015588(itpk1) 105017670
SFM: 108919611(itpk1)
LCM: 102351625(ITPK1) 102366649
CMK: 103174155 103185398(itpk1)
CIN: 100181853
SPU: 580408
APLC: 110977634
SKO: 102806915
AME: 551726(GB12674)
BIM: 100740014
BTER: 100647743
SOC: 105195554
AEC: 105150186
ACEP: 105618310
PBAR: 105426206
HST: 105181094
CFO: 105250081
LHU: 105673912
PGC: 109863770
NVI: 100117094
TCA: 660348
NVL: 108567762
BMOR: 101744563
PMAC: 106719950
PRAP: 110991381
API: 100159102
DNX: 107163234
ZNE: 110837839
FCD: 110844108
CRG: 105337850
MYI: 110440574
OBI: 106874910
EPA: 110247170
LJA: Lj1g3v2095610.1(Lj1g3v2095610.1) Lj2g3v1495070.1(Lj2g3v1495070.1) Lj4g3v1107900.1(Lj4g3v1107900.1) Lj4g3v1477230.1(Lj4g3v1477230.1) Lj5g3v2063140.1(Lj5g3v2063140.1) Lj5g3v2063140.2(Lj5g3v2063140.2)
DOSA: Os02t0466400-01(Os02g0466400) Os03t0230500-01(Os03g0230500) Os03t0726200-01(Os03g0726200) Os10t0103800-01(Os10g0103800) Os10t0576100-01(Os10g0576100)
ATS: 109732807(LOC109732807) 109748791(LOC109748791) 109751093(LOC109751093) 109759444(LOC109759444) 109773428(LOC109773428)
ZMA: 100194132 100282774 100282992(si618046c10b) 103627151 732818(lpa2)
APRO: F751_4717
DDI: DDB_G0269746(ITPK1)
DFA: DFA_02662(ITPK1)
EHI: EHI_042120(11.t00022) EHI_100310(151.t00008)
 » show all
1  [PMID:2829850]
Stephens LR, Hawkins PT, Morris AJ, Downes PC.
L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase.
Biochem J 249:283-92 (1988)
2  [PMID:3497156]
Balla T, Guillemette G, Baukal AJ, Catt KJ.
Metabolism of inositol 1,3,4-trisphosphate to a new tetrakisphosphate isomer in angiotensin-stimulated adrenal glomerulosa cells.
J Biol Chem 262:9952-5 (1987)
3  [PMID:2823793]
Shears SB, Parry JB, Tang EK, Irvine RF, Michell RH, Kirk CJ.
Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate.
Biochem J 246:139-47 (1987)
4  [PMID:2584198]
Shears SB.
The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase.
J Biol Chem 264:19879-86 (1989)
5  [PMID:11042108]
Yang X, Shears SB.
Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase.
Biochem J 351 Pt 3:551-5 (2000)
6  [PMID:11909533]
Ho MW, Yang X, Carew MA, Zhang T, Hua L, Kwon YU, Chung SK, Adelt S, Vogel G, Riley AM, Potter BV, Shears SB.
Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase.
Curr Biol 12:477-82 (2002)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 187175-98-0

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