EC                Enzyme                                 

inositol-tetrakisphosphate 1-kinase;
1D-myo-inositol-tetrakisphosphate 1-kinase;
inositol-trisphosphate 6-kinase;
1D-myo-inositol-trisphosphate 6-kinase;
ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase;
inositol-trisphosphate 5-kinase;
1D-myo-inositol-trisphosphate 5-kinase;
ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate [RN:R03479]
ATP [CPD:C00002];
1D-myo-inositol 3,4,5,6-tetrakisphosphate [CPD:C04520]
ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:C01284]
This enzyme also phosphorylates Ins(1,3,4)P3 on O-5 and O-6. The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP. It can also catalyse an isomerization between Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP. The enzymes from animals and plants also have the activity of EC, inositol-1,3,4-trisphosphate 5/6-kinase.
EC created 1990, (EC created 1989, incorporated 2002, EC created 1992, incorporated 2002), modified 2002
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
K00913  inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase
HSA: 3705(ITPK1)
PTR: 453121(ITPK1)
PPS: 100980755(ITPK1)
GGO: 101134664(ITPK1)
PON: 100448118(ITPK1)
NLE: 100590495(ITPK1)
MCC: 698756(ITPK1)
MCF: 102119398(ITPK1)
CSAB: 103229579(ITPK1)
CATY: 105596596(ITPK1)
RRO: 104679048(ITPK1)
RBB: 108519106(ITPK1)
TFN: 117071511(ITPK1)
CJC: 100396941(ITPK1)
SBQ: 101039869(ITPK1)
MMUR: 105856742(ITPK1)
MMU: 217837(Itpk1)
MCAL: 110307175(Itpk1)
MPAH: 110324479(Itpk1)
RNO: 500709(Itpk1)
MCOC: 116079633(Itpk1)
MUN: 110541472(Itpk1)
CGE: 100768438(Itpk1)
PLEU: 114706069(Itpk1)
NGI: 103724593(Itpk1)
HGL: 101700462(Itpk1)
CCAN: 109693572(Itpk1)
OCU: 100345790(ITPK1)
TUP: 102479480(ITPK1)
CFA: 490591(ITPK1)
VVP: 112909607(ITPK1)
AML: 100484787(ITPK1)
UMR: 103673773(ITPK1)
UAH: 113267338(ITPK1)
ORO: 101385854(ITPK1)
ELK: 111148744
MPUF: 101684430(ITPK1)
EJU: 114205219(ITPK1)
FCA: 101087672(ITPK1)
PTG: 102951160(ITPK1)
PPAD: 109274481(ITPK1)
AJU: 106980827(ITPK1)
BTA: 518488(ITPK1)
BOM: 102279411(ITPK1)
BIU: 109575578(ITPK1)
BBUB: 102415988(ITPK1)
CHX: 102183460(ITPK1)
OAS: 101115161(ITPK1)
SSC: 100152339(ITPK1)
CFR: 102508931(ITPK1)
CDK: 105095826(ITPK1)
BACU: 103011955(ITPK1)
LVE: 103084508(ITPK1)
OOR: 101270326(ITPK1)
DLE: 111176142(ITPK1)
PCAD: 102992293(ITPK1)
ECB: 100063828(ITPK1) 111770385
EPZ: 103556533(ITPK1)
EAI: 106825383(ITPK1)
MYB: 102246792(ITPK1)
MYD: 102764458(ITPK1)
MMYO: 118659788(ITPK1)
MNA: 107531577(ITPK1)
HAI: 109376793(ITPK1)
DRO: 112311350(ITPK1)
SHON: 118976637(ITPK1)
AJM: 119037888(ITPK1)
MMF: 118631619(ITPK1)
PALE: 102877958(ITPK1)
RAY: 107511245(ITPK1)
MJV: 108409820(ITPK1)
LAV: 100668527(ITPK1)
TMU: 101341573
MDO: 100014342(ITPK1)
SHR: 100924957(ITPK1)
PCW: 110217744(ITPK1)
OAA: 100079832(ITPK1)
GGA: 423421(ITPK1)
MGP: 100541150(ITPK1)
CJO: 107315185(ITPK1)
NMEL: 110402115(ITPK1)
APLA: 101801656(ITPK1)
ACYG: 106033487(ITPK1)
TGU: 100222999(ITPK1)
LSR: 110476414(ITPK1)
SCAN: 103826463(ITPK1)
GFR: 102034047(ITPK1)
FAB: 101819235(ITPK1)
PHI: 102106037(ITPK1)
PMAJ: 107205493(ITPK1)
CCAE: 111929864(ITPK1)
CCW: 104688688(ITPK1)
ETL: 114060630(ITPK1)
FPG: 101920131(ITPK1)
FCH: 102048369(ITPK1)
CLV: 102088692(ITPK1)
EGZ: 104135355(ITPK1)
NNI: 104022228(ITPK1)
ACUN: 113480449(ITPK1)
PADL: 103923943(ITPK1)
AAM: 106483074(ITPK1)
ASN: 102373418(ITPK1) 112548809
AMJ: 102575334(ITPK1) 109280689
PSS: 102452019(ITPK1)
CMY: 102932685 102933310(ITPK1)
CPIC: 101948262(ITPK1) 101949054
ACS: 100566274(itpk1)
PVT: 110083634(ITPK1)
PBI: 103054635(ITPK1)
PMUR: 107295460(ITPK1)
TSR: 106549451(ITPK1)
PMUA: 114590768(ITPK1)
GJA: 107123858(ITPK1)
XLA: 108698651(XB5961849.L) 108700483(itpk1.S) 379828(itpk1.L)
XTR: 100144987 549890(itpk1)
NPR: 108788675(ITPK1) 108804962
DRE: 100148744(itpk1b) 406290(itpk1a)
TRU: 101069194(itpk1) 101072928
LCO: 104927221 109142672(itpk1)
NCC: 104941855(itpk1) 104945354
MZE: 101469029(itpk1) 101485309
ONL: 100691819 100698428(itpk1)
OLA: 101157334(itpk1)
XMA: 102220593(itpk1)
XCO: 114133945(itpk1)
PRET: 103458928(itpk1)
CVG: 107099127(itpk1)
NFU: 107392041(itpk1)
KMR: 108237618(itpk1b)
ALIM: 106521176(itpk1)
AOCE: 111566021 111578952(itpk1)
CSEM: 103377198(itpk1) 103378259
SDU: 111225701(itpk1) 111232797
SLAL: 111654242 111659818(itpk1)
HCQ: 109510866 109516026(itpk1)
BPEC: 110153603 110155270(itpk1)
MALB: 109955064(itpk1)
SFM: 108919611(itpk1)
PKI: 111838846(itpk1) 111854941
LCM: 102351625(ITPK1) 102366649
CMK: 103185398(itpk1)
RTP: 109917182 109929038(itpk1)
CIN: 100181853
SPU: 580408
APLC: 110977634
SKO: 102806915
AME: 551726
BIM: 100740014
BTER: 100647743
CCAL: 108625595
OBB: 114880042
SOC: 105195554
MPHA: 105840617
AEC: 105150186
ACEP: 105618310
PBAR: 105426206
VEM: 105569711
HST: 105181094
DQU: 106743443
CFO: 105250081
LHU: 105673912
PGC: 109863770
OBO: 105280103
PCF: 106784291
NVI: 100117094
CSOL: 105361542
MDL: 103578390
TCA: 660348
DPA: 109544935
ATD: 109595277
NVL: 108567762
BMOR: 101744563
PMAC: 106719950
PRAP: 110991381
HAW: 110378751
TNL: 113495593
PXY: 105397344
API: 100159102
DNX: 107163234
AGS: 114125796
RMD: 113548798
BTAB: 109030649
CLEC: 106662859
ZNE: 110837839
FCD: 110844108
PVM: 113809605
DPTE: 113793158
CSCU: 111635823
PTEP: 107453142
PCAN: 112570001
CRG: 105337850
MYI: 110440574
OBI: 106874910
NVE: 5508018
EPA: 110247170
AMIL: 114966681
PDAM: 113668546
SPIS: 111319149
LJA: Lj1g3v2095610.1(Lj1g3v2095610.1) Lj2g3v1495070.1(Lj2g3v1495070.1) Lj4g3v1107900.1(Lj4g3v1107900.1) Lj4g3v1477230.1(Lj4g3v1477230.1) Lj5g3v2063140.2(Lj5g3v2063140.2)
DOSA: Os02t0466400-01(Os02g0466400) Os03t0230500-01(Os03g0230500) Os03t0726200-01(Os03g0726200) Os10t0103800-01(Os10g0103800) Os10t0576100-01(Os10g0576100)
ZMA: 100194132 100282774 100282992(si618046c10b) 103627151 732818(lpa2)
APRO: F751_4717
DDI: DDB_G0269746(ITPK1)
DFA: DFA_02662(ITPK1)
EHI: EHI_042120(11.t00022) EHI_100310(151.t00008)
 » show all
1  [PMID:2829850]
Stephens LR, Hawkins PT, Morris AJ, Downes PC.
L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase.
Biochem J 249:283-92 (1988)
2  [PMID:3497156]
Balla T, Guillemette G, Baukal AJ, Catt KJ.
Metabolism of inositol 1,3,4-trisphosphate to a new tetrakisphosphate isomer in angiotensin-stimulated adrenal glomerulosa cells.
J Biol Chem 262:9952-5 (1987)
3  [PMID:2823793]
Shears SB, Parry JB, Tang EK, Irvine RF, Michell RH, Kirk CJ.
Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate.
Biochem J 246:139-47 (1987)
4  [PMID:2584198]
Shears SB.
The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase.
J Biol Chem 264:19879-86 (1989)
5  [PMID:11042108]
Yang X, Shears SB.
Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase.
Biochem J 351 Pt 3:551-5 (2000)
6  [PMID:11909533]
Ho MW, Yang X, Carew MA, Zhang T, Hua L, Kwon YU, Chung SK, Adelt S, Vogel G, Riley AM, Potter BV, Shears SB.
Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase.
Curr Biol 12:477-82 (2002)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 187175-98-0

DBGET integrated database retrieval system