KEGG   ENZYME: 2.7.7.88Help
Entry
EC 2.7.7.88                 Enzyme                                 

Name
GDP polyribonucleotidyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
5'-triphospho-mRNA:GDP 5'-phosphopolyribonucleotidyltransferase [G(5')ppp-mRNA-forming]
Reaction(IUBMB)
5'-triphospho-mRNA + GDP = diphosphate + guanosine 5'-triphospho-mRNA [RN:R11203]
Reaction(KEGG)
Substrate
5'-triphospho-mRNA [CPD:C20864];
GDP [CPD:C00035]
Product
diphosphate [CPD:C00013];
guanosine 5'-triphospho-mRNA [CPD:C02031]
Comment
The enzyme from rhabdoviruses transfers 5'-monophosphorylated (p-)mRNA from 5'-triphosphorylated (ppp-)mRNA to GDP to form 5'-capped mRNA (GpppmRNA) in a viral mRNA-start sequence-dependent manner. The (p-)mRNA transfer reaction proceeds through a covalent enzyme-pmRNA intermediate.
History
EC 2.7.7.88 created 2015
Orthology
K21316  RNA-directed RNA polymerase
Reference
1  [PMID:21945214]
  Authors
Ogino T, Banerjee AK
  Title
An unconventional pathway of mRNA cap formation by vesiculoviruses.
  Journal
Virus Res 162:100-9 (2011)
DOI:10.1016/j.virusres.2011.09.012
  Sequence
[vg:1489835]
Reference
2  [PMID:20142503]
  Authors
Ogino T, Yadav SP, Banerjee AK
  Title
Histidine-mediated RNA transfer to GDP for unique mRNA capping by vesicular stomatitis virus RNA polymerase.
  Journal
Proc Natl Acad Sci U S A 107:3463-8 (2010)
DOI:10.1073/pnas.0913083107
Reference
3  [PMID:20107017]
  Authors
Ogino T, Banerjee AK
  Title
The HR motif in the RNA-dependent RNA polymerase L protein of Chandipura virus is required for unconventional mRNA-capping activity.
  Journal
J Gen Virol 91:1311-4 (2010)
DOI:10.1099/vir.0.019307-0
Reference
4  [PMID:18495767]
  Authors
Ogino T, Banerjee AK
  Title
Formation of guanosine(5')tetraphospho(5')adenosine cap structure by an unconventional mRNA capping enzyme of vesicular stomatitis virus.
  Journal
J Virol 82:7729-34 (2008)
DOI:10.1128/JVI.00326-08
Reference
5  [PMID:17218273]
  Authors
Ogino T, Banerjee AK
  Title
Unconventional mechanism of mRNA capping by the RNA-dependent RNA polymerase of vesicular stomatitis virus.
  Journal
Mol Cell 25:85-97 (2007)
DOI:10.1016/j.molcel.2006.11.013
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.88
IUBMB Enzyme Nomenclature: 2.7.7.88
ExPASy - ENZYME nomenclature database: 2.7.7.88
BRENDA, the Enzyme Database: 2.7.7.88

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