KEGG   ENZYME: 3.1.2.30
Entry
EC 3.1.2.30                 Enzyme                                 
Name
(3S)-malyl-CoA thioesterase;
mcl2 (gene name)
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
Sysname
(S)-malyl-CoA hydrolase
Reaction(IUBMB)
(S)-malyl-CoA + H2O = (S)-malate + CoA [RN:R10612]
Reaction(KEGG)
R10612
Substrate
(S)-malyl-CoA [CPD:C04348];
H2O [CPD:C00001]
Product
(S)-malate [CPD:C00149];
CoA [CPD:C00010]
Comment
Stimulated by Mg2+ or Mn2+. The enzyme has no activity with (2R,3S)-2-methylmalyl-CoA (cf. EC 4.1.3.24, malyl-CoA lyase) or other CoA esters.
History
EC 3.1.2.30 created 2014
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14451  (3S)-malyl-CoA thioesterase
K19282  bifunctional (S)-malyl-CoA lyase/thioesterase
Genes
BOJCBF45_15340
KGYEHF36_15360
RTEAHK414_20375
CPAFC6V80_02765
BRDJL11_15545
BRGA4249_01015
BVCCEP68_03750
BREVE7T10_13660
BVYNCTC9239_00695(mcl2)
AEXAstex_0375
SILSPO0352(citE)
SITTM1040_3520
RUAD1823_12170
RUTFIU92_01320(mcl1)
JANJann_0816
RDERD1_1620(citE)
RLIRLO149_c030880
RPONG3256_15365
DSHDshi_2874
PGAPGA1_c03680
PGLPGA2_c03240
PGDGal_03134
PHPPhaeoP97_02988
PPICPhaeoP14_00285
PHQD1820_14695
OATOAN307_c41520
OAROA238_c04250
OTMOSB_04760(mcl2)
OCTFTO60_02985
LMDMETH_03315
LEJETW24_04120
LAQUR2C4_13635
REDroselon_01727
CIDP73_3868
CMARIMCC12053_3020
CEHCEW89_10100
MALGMALG_02745
CONTQ29_02440
YPACCEW88_11165
YANAYJ57_04550
TPROGa0080559_TMP1136
PABYGa0080574_TMP3142
SUAMBOO69_13680
SULZC1J03_18190
SULIC1J05_18110
SULDB5M07_04980
SPOTG6548_04145
SMEDJNX03_18050
SINLDSM14862_02486(mcl2)
SPSESULPSESMR1_00394(mcl2)
TOMBWR18_01025
RMMROSMUCSMR3_02505(mcl2)
ROKRAK1035_0677
RIDRIdsm_04538(mcl2)
ROMEI983_02900
ROHFIU89_19180(mcl1)
AHTANTHELSMS3_02127(mcl2)
SAGUCDO87_04390
THAACFI11_04355
OCDFHY55_05855
MARUFIU81_04115(mcl1)
ROTFIV09_01380(mcl1)
MALUKU6B_41840(mcl2)
TGLHFZ77_08415
HATRC74_09365
RSPRSP_0970
RSHRsph17029_2630
RSQRsph17025_0082
RSKRSKD131_2362
CAZTLV780_00415
RCPRCAP_rcc00727(citE1)
RHPLPB142_03415
RBLB6K69_07625
PDEPden_0563
PAMIJCM7686_2574
PYEA6J80_13300
PCONB0A89_09550
PZHCX676_05535
PAROCUV01_17720
PAMNJCM7685_2545
PARSDRW48_09375
PARREOJ32_08540
PKDF8A10_02165
PPANESD82_12320
PLIAE4191_08475
PSANHGN31_04095
PMAUCP157_01939(mcl2)
PTPRCA23_c14020(citE)
RSUNHU_00724(citE)
RHMB5V46_04475
RHCRGUI_0622
RMBK529_020740
DAAAKL17_3637
DONBSK21_11440
THWBMG03_06670
TECAKL02_005525
LVSLOKVESSMR4R_02803(mcl2)
RBGBG454_13655
GEHHYN69_13115
GFUKM031_13965
TAWEI545_06975
SALOEF888_18565
SEDIEBB79_02250
HMLHmaOT1_03960
BOOE2K80_01990
PSEBEOK75_09400
LITFPZ52_01350
PPRUFDP22_03640
PAEDG5B38_15490
MONG8E03_14605
PAMOBAR1_14395
PSHQF3W81_20275
POZI0K15_13770
PALWPSAL_019030(mcl2)
PPAFI8N54_16895
CACTHZ995_03660
RBZB9057_02175
THASC6Y53_10240
HDHG5B40_16110
CMAGCBW24_13080
FAPGR316_00365
GCEKYE46_04235
FAQG5B39_05115
HYTHXX25_10655
SPHKSKP52_03440
SPHPLH20_16080
SMAGAN936_01440
SMAZLH19_01485
STERAOA14_02930
SGISGRAN_0950(mcl2)
SPHQBWQ93_11140
SPHOC3E99_01130
SPHXE5675_17240
SPHUSPPYR_0495(mcl)
SPHITS85_09155
SSANNX02_12375
SPLMBXU08_04065
SPHCCVN68_04030
SLANGV829_09535
SPAIFPZ24_11710
SARIH5J25_02820
SSUAFPZ54_04690
SJPSJA_C1-26890(citE)
SINBSIDU_01380
SCHSphch_1616
SSYSLG_14830
SYBTZ53_00395
SBDATN00_05850
SPMIK663_04105
SPHBEP837_00844(citE)
SPHRBSY17_744
SPHTK426_06735
SHYDCJD35_07870
SYAA6768_15560
SCLOSCLO_1015050
SPYGYGS_C1P0058
SUFLFIL70_12030
SBARH5V43_09595
SAMISAMIE_1022050
SPZRG5C33_12750
PALGHFP57_06190
SPHSETR14_23585
RPYY013_11815
RBYCEJ39_22715
RHQIM25_03505
GTABCM27_21690
BSOLFSW04_20430
DDRDeide_20020
DMRDeima_2864
DPTDeipr_2520
DGODGo_CA0363(citE)
DSWQR90_15895
DCHSY84_10370
DABAUC44_01395
DPUSU48_13230
DWUDVJ83_08830
DFCDFI_10115
DEINDAAJ005_03145
BLQL21SP5_01621(mcl2)
HDLHALDL1_15310
HHBHhub_3380(aceB)
HNOLT974_13710
HLULT972_01030
HSUHLASF_2007(aceB)
HSFHLASA_1993(aceB)
SALRFQU85_05715
HAADMW046_18245
HALXM0R89_21245
HMArrnAC1965(aceB)
HHIHAH_2476(aceB)
HHNHISP_12605
HABSG26_04910
HTABVU17_12045
HSINKDQ40_00995
NPHNP_4430A(aceB)
NMONmlp_2357(aceB)
NHOHWV23_13655
NSALHWV07_07395
HALIBV210_07645
HDOMUK72_12480
HWAHQ_1720A(aceB)
HWCHqrw_1842(aceB)
HVOHVO_1983(aceB1) HVO_B0200(aceB2)
HMEHFX_2078(aceB)
HGIABY42_09665 ABY42_16600
HALEG3A49_07690 G3A49_12900
HBOHbor_30530
HLMDV707_13970
SRUBC2R22_21540
HALGHUG10_03375
HALUHUG12_13540
HMPK6T50_01580
HREK6T36_01385
HRMK6T25_15035
HACBHbl1158_08495
HDFAArcSl_1031(aceB)
HTUHtur_4695
HSALJMJ58_24075
NMGNmag_3363(aceB)
NOUNatoc_4308
SAIMK0C01_12450
NAJB1756_06555
NBGDV706_17910
NASGCU68_18820
 » show all
Reference
1  [PMID:20047909]
  Authors
Erb TJ, Frerichs-Revermann L, Fuchs G, Alber BE
  Title
The apparent malate synthase activity of Rhodobacter sphaeroides is due to two paralogous enzymes, (3S)-Malyl-coenzyme A (CoA)/{beta}-methylmalyl-CoA lyase and (3S)- Malyl-CoA thioesterase.
  Journal
J Bacteriol 192:1249-58 (2010)
DOI:10.1128/JB.01267-09
  Sequence
[rsp:RSP_0970]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.30
IUBMB Enzyme Nomenclature: 3.1.2.30
ExPASy - ENZYME nomenclature database: 3.1.2.30
BRENDA, the Enzyme Database: 3.1.2.30

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