KEGG   ENZYME: 3.1.2.30Help
Entry
EC 3.1.2.30                 Enzyme                                 

Name
(3S)-malyl-CoA thioesterase;
mcl2 (gene name)
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
(S)-malyl-CoA hydrolase
Reaction(IUBMB)
(S)-malyl-CoA + H2O = (S)-malate + CoA [RN:R10612]
Reaction(KEGG)
Substrate
(S)-malyl-CoA [CPD:C04348];
H2O [CPD:C00001]
Product
(S)-malate [CPD:C00149];
CoA [CPD:C00010]
Comment
Stimulated by Mg2+ or Mn2+. The enzyme has no activity with (2R,3S)-2-methylmalyl-CoA (cf. EC 4.1.3.24, malyl-CoA lyase) or other CoA esters.
History
EC 3.1.2.30 created 2014
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14451  (3S)-malyl-CoA thioesterase
K19282  bifunctional (S)-malyl-CoA lyase/thioesterase
Genes
SIL: SPO0352(citE)
SIT: TM1040_3520
RUA: D1823_12170
RUT: FIU92_01320(mcl1)
RMB: K529_020740
RSP: RSP_0970
RSH: Rsph17029_2630
RSQ: Rsph17025_0082
RSK: RSKD131_2362
RCP: RCAP_rcc00727(citE1)
JAN: Jann_0816
RDE: RD1_1620(citE)
PDE: Pden_0563
DSH: Dshi_2874
PGD: Gal_03134
OTM: OSB_04760(mcl2)
LAQU: R2C4_13635
PTP: RCA23_c14020(citE)
CID: P73_3868
MALG: MALG_02745
RSU: NHU_00724(citE)
RHC: RGUI_0622
SPSE: SULPSESMR1_00394(mcl2)
RMM: ROSMUCSMR3_02505(mcl2)
RID: RIdsm_04538(mcl2)
LVS: LOKVESSMR4R_02803(mcl2)
AHT: ANTHELSMS3_02127(mcl2)
MARU: FIU81_04115(mcl1)
ROT: FIV09_01380(mcl1)
SPHP: LH20_16080
SMAZ: LH19_01485
SGI: SGRAN_0950(mcl2)
SPHU: SPPYR_0495(mcl)
DGO: DGo_CA0363(citE)
DFC: DFI_10115
HHB: Hhub_3380(aceB)
HSU: HLASF_2007(aceB)
HSF: HLASA_1993(aceB)
HMA: rrnAC1965(aceB)
HHI: HAH_2476(aceB)
NPH: NP_4430A(aceB)
NMO: Nmlp_2357(aceB)
HWA: HQ_1720A(aceB)
HWC: Hqrw_1842(aceB)
HVO: HVO_1983(aceB1) HVO_B0200(aceB2)
HME: HFX_2078(aceB)
HTU: Htur_4695
NMG: Nmag_3363(aceB)
 » show all
Taxonomy
Reference
1  [PMID:20047909]
  Authors
Erb TJ, Frerichs-Revermann L, Fuchs G, Alber BE
  Title
The apparent malate synthase activity of Rhodobacter sphaeroides is due to two paralogous enzymes, (3S)-Malyl-coenzyme A (CoA)/{beta}-methylmalyl-CoA lyase and  (3S)- Malyl-CoA thioesterase.
  Journal
J Bacteriol 192:1249-58 (2010)
DOI:10.1128/JB.01267-09
  Sequence
[rsp:RSP_0970]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.30
IUBMB Enzyme Nomenclature: 3.1.2.30
ExPASy - ENZYME nomenclature database: 3.1.2.30
BRENDA, the Enzyme Database: 3.1.2.30

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