EC                 Enzyme                                 

phosphatidylinositol-4,5-bisphosphate 4-phosphatase;
phosphatidylinositol-4,5-bisphosphate 4-phosphatase I;
phosphatidylinositol-4,5-bisphosphate 4-phosphatase II;
type I PtdIns-4,5-P2 4-Ptase;
type II PtdIns-4,5-P2 4-Ptase;
PtdIns-4,5-P2 4-phosphatase type I;
PtdIns-4,5-P2 4-phosphatase type II;
type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase;
type 1 4-phosphatase
Acting on ester bonds;
Phosphoric-monoester hydrolases
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate [RN:R08981]
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637];
H2O [CPD:C00001]
1-phosphatidyl-1D-myo-inositol 5-phosphate [CPD:C11557];
phosphate [CPD:C00009]
Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3].
EC created 2008
K13084  phosphatidylinositol-4,5-bisphosphate 4-phosphatase
K13085  phosphatidylinositol-4,5-bisphosphate 4-phosphatase
HSA: 55529(PIP4P2) 90809(PIP4P1)
PTR: 464281(PIP4P2) 465201(PIP4P1)
PPS: 100968374(TMEM55A) 100988983(TMEM55B)
GGO: 101129459(PIP4P2) 101132752(PIP4P1)
PON: 100451858(PIP4P2) 100454477(PIP4P1)
NLE: 100587627(PIP4P2) 100593745(PIP4P1)
MCC: 100428001(PIP4P1) 696779(PIP4P2)
MCF: 101866619(TMEM55B) 102115056(TMEM55A)
CSAB: 103231342 103231344 103237111(TMEM55A)
RRO: 104654642(PIP4P2) 104673120(PIP4P1)
RBB: 108527311(TMEM55B) 108528503(TMEM55A)
CJC: 100402264(TMEM55B) 100407390(TMEM55A)
SBQ: 101027468(TMEM55B) 101033445(TMEM55A)
MMU: 219024(Pip4p1) 72519(Pip4p2)
MCAL: 110292720(Tmem55a) 110309188(Tmem55b)
MPAH: 110325348(Tmem55b) 110338742(Tmem55a)
RNO: 362490(Tmem55a) 364298(Tmem55b)
MUN: 110549703(Tmem55b) 110557768(Tmem55a)
CGE: 100757444(Pip4p1) 100767770(Pip4p2)
NGI: 103729539(Tmem55a) 103733665(Tmem55b)
HGL: 101709122(Tmem55b) 101718072(Tmem55a)
CCAN: 109690515(Tmem55a) 109692126(Tmem55b)
OCU: 100349176(TMEM55B) 100353159(TMEM55A)
TUP: 102475472(TMEM55B) 102487160 102499548(TMEM55A)
CFA: 477939(PIP4P2) 482559(PIP4P1)
VVP: 112914985(PIP4P1) 112931637(PIP4P2)
AML: 100479476(PIP4P2) 100484149(PIP4P1)
UMR: 103656314(TMEM55B) 103661475(TMEM55A)
UAH: 113248962(PIP4P1) 113252947(PIP4P2)
ORO: 101372920(TMEM55B) 101382006(TMEM55A)
FCA: 101080798(PIP4P1) 101088301(PIP4P2)
PTG: 102952164(TMEM55A) 102956222(TMEM55B)
PPAD: 109255760(TMEM55B) 109269475(TMEM55A)
AJU: 106971402(PIP4P1) 106984681(PIP4P2)
BTA: 615077(PIP4P1) 616641(PIP4P2)
BOM: 102268358(TMEM55B) 102277826(TMEM55A)
BIU: 109564878(TMEM55B) 109568638(TMEM55A)
BBUB: 102392943(PIP4P2) 102415190(PIP4P1)
CHX: 102172557(TMEM55A) 102177240(TMEM55B)
OAS: 101111559(PIP4P2) 101117510(PIP4P1)
SSC: 100155939(TMEM55B) 100156639(TMEM55A)
CFR: 102505095(PIP4P2) 102507379(PIP4P1)
CDK: 105085724(PIP4P2) 105097644(PIP4P1)
BACU: 103007264(TMEM55A) 103012880(TMEM55B)
LVE: 103084248(TMEM55B) 103085248(TMEM55A)
OOR: 101273070(TMEM55A) 101273871(TMEM55B)
DLE: 111180432(PIP4P2) 111181805(PIP4P1)
PCAD: 102978742(PIP4P2) 102982773(PIP4P1)
ECB: 100050790(PIP4P2) 100058648(PIP4P1)
EPZ: 103559551(TMEM55B) 103564881(TMEM55A)
EAI: 106833288(TMEM55B) 106838979(TMEM55A)
MYB: 102241548(TMEM55A) 102252193(TMEM55B)
MYD: 102754867(TMEM55B) 102773968(TMEM55A)
MNA: 107526961(TMEM55B)
HAI: 109376449(TMEM55B)
DRO: 112310316(PIP4P2) 112311620(PIP4P1)
PALE: 102898229(PIP4P2) 102898278(PIP4P1)
RAY: 107507437(TMEM55A) 107521160(TMEM55B)
MJV: 108387665(TMEM55A) 108403281(TMEM55B)
LAV: 100660816(PIP4P1) 100664641(PIP4P2)
MDO: 100022045(TMEM55A) 100022893(TMEM55B)
SHR: 100916303(PIP4P2) 100924788(PIP4P1)
PCW: 110198547(TMEM55A) 110217864(TMEM55B)
OAA: 100086066(PIP4P1) 100092908(PIP4P2)
GGA: 420221(PIP4P2)
MGP: 100542892(PIP4P2)
CJO: 107307004(PIP4P1) 107310378(PIP4P2)
NMEL: 110393858(TMEM55A)
APLA: 101802244(PIP4P2)
ACYG: 106030630(TMEM55A)
TGU: 100226950(PIP4P2)
LSR: 110477429(PIP4P2) 110481133(PIP4P1)
SCAN: 103813442(PIP4P2) 115484135(PIP4P1)
GFR: 102040381(TMEM55A)
FAB: 101810791(TMEM55A)
PHI: 102099741(TMEM55A) 102101128(TMEM55B)
PMAJ: 107199089(TMEM55B) 107200089(TMEM55A)
CCAE: 111924560(PIP4P2)
CCW: 104692756(TMEM55A)
ETL: 114061739(PIP4P2)
FPG: 101922579(TMEM55A)
FCH: 102055459(PIP4P2)
CLV: 102090519(TMEM55A)
EGZ: 104125810(TMEM55A)
NNI: 104016500(TMEM55A)
ACUN: 113476160(PIP4P2)
PADL: 103917331(TMEM55A)
AAM: 106496195(TMEM55A)
ASN: 102373932(PIP4P2) 102374449(PIP4P1)
AMJ: 102562249(TMEM55B) 102570595(TMEM55A)
PSS: 102457479(PIP4P2)
CMY: 102938814 102941676(TMEM55B)
CPIC: 101937348(TMEM55A) 101946066(TMEM55B)
ACS: 100556773(tmem55a) 100567084(tmem55b)
PVT: 110089558(TMEM55B) 110090207(TMEM55A)
PBI: 103047975(PIP4P1) 103054248(PIP4P2)
PMUR: 107285754(PIP4P2) 107292313(PIP4P1)
TSR: 106545515(TMEM55A) 106549927(TMEM55B)
PMUA: 114581602(PIP4P1) 114600438(PIP4P2)
GJA: 107105993(TMEM55A) 107116165(TMEM55B)
XLA: 108695381(tmem55a.S) 108707045(tmem55b.S) 494834(tmem55b.L) 734343(tmem55a.L)
XTR: 100170610(pip4p1) 448483(pip4p2)
NPR: 108788678(TMEM55B) 108800143(TMEM55A)
DRE: 553253(pip4p1b) 556136(pip4p1a) 566642(pip4p2)
IPU: 108273350(tmem55a) 108274853 108280404(tmem55b)
PHYP: 113523871 113533535(pip4p1) 113543834(pip4p2)
AMEX: 103033991(pip4p1) 103040016(pip4p2) 103040625
EEE: 113574929 113580968(pip4p2) 113588959(pip4p1)
TRU: 101062738(pip4p1) 101068075(pip4p2) 101075194(pip4p1) 115251759
LCO: 104924562(pip4p2) 104926554(pip4p1) 104936244
NCC: 104947052(tmem55a) 104948613(tmem55b)
MZE: 101466447 101468284(pip4p2) 101479252(pip4p1)
ONL: 100693615(pip4p1) 100706272(pip4p2) 100710349
XMA: 102224770 102227240(pip4p2) 102234414(pip4p1)
XCO: 114145811(pip4p1) 114156427(pip4p2) 114157811
PRET: 103472397(tmem55a) 103479490(tmem55b) 103480619
CVG: 107092441(tmem55a) 107092674(tmem55b) 107095498
NFU: 107376897 107383456(tmem55b) 107394745(tmem55a)
KMR: 108232969(pip4p1) 108237806(pip4p2) 108248594
ALIM: 106515818(tmem55a) 106520802(tmem55b) 106523839
CSEM: 103388924 103394417(tmem55a) 103396783(tmem55b)
POV: 109631912(tmem55a) 109645994(tmem55b) 109647653
SDU: 111223251(pip4p2) 111233362 111239391(pip4p1)
SLAL: 111657891 111659343(pip4p2) 111668450(pip4p1)
HCQ: 109506970 109517989(tmem55a) 109529491(tmem55b)
BPEC: 110167447(tmem55a) 110170780 110175124(tmem55b)
MALB: 109952910(tmem55a) 109974206 109974507
SALP: 111974344 111979801(pip4p1) 112073639 112076069(pip4p2)
ELS: 105006704(pip4p2) 105024555(pip4p1) 105030639
LCM: 102348811(TMEM55A) 102357306(TMEM55B)
CMK: 103191060(tmem55a)
RTP: 109918341(tmem55b) 109938918(tmem55a)
CIN: 104266484
SPU: 588430
APLC: 110980124
SKO: 100368816
DME: Dmel_CG6707(CG6707)
DER: 6546082
DSE: 6605120
DSI: Dsimw501_GD12881(Dsim_GD12881)
DAN: 6506490
DSR: 110190635
DPE: 6600238
DMN: 108151830
DWI: 6638715
DAZ: 108613220
DNV: 108651252
DHE: 111598717
DVI: 6623987
MDE: 101893850
LCQ: 111682675
AAG: 5574542
AALB: 109428654
AME: 408301
BIM: 100749086
BTER: 100646549
CCAL: 108622913
OBB: 114874660
SOC: 105200883
MPHA: 105839704
AEC: 105143615
ACEP: 105620209
PBAR: 105430510
VEM: 105563835
HST: 105186717
DQU: 106748938
CFO: 105255380
LHU: 105674095
PGC: 109854987
OBO: 105282957
PCF: 106791075
NVI: 100120829
CSOL: 105359276
TCA: 655804
DPA: 109534456
NVL: 108563960
BMOR: 101741980
BMAN: 114247478
PMAC: 106719144
PRAP: 110992215
HAW: 110370045
TNL: 113501279
PXY: 105393931
API: 100164628
DNX: 107167499
AGS: 114121256
RMD: 113556156
BTAB: 109035975
CLEC: 106665999
ZNE: 110834071
FCD: 110849352
TUT: 107359622
DPTE: 113789342
PTEP: 107452055
CEL: CELE_Y71H2AM.2(Y71H2AM.2)
CBR: CBG00490
BMY: Bm1_18965
PCAN: 112576610
CRG: 105338362
MYI: 110464767
OBI: 106874795
LAK: 106178509
SHX: MS3_09652
NVE: 5521597
EPA: 110248578
ADF: 107342237
AMIL: 114977192
PDAM: 113677853
SPIS: 111332610
DGT: 114516540
HMG: 100208471
AQU: 100632025
STY: STY1121(sigD)
STT: t1828(sigD)
STM: STM1091(sopB)
SEO: STM14_1237(sopB)
SEY: SL1344_1030(sopB)
SEJ: STMUK_1060(sopB)
SEB: STM474_1083(sopB)
SEF: UMN798_1133(sigD)
SETC: CFSAN001921_11720(sopB)
SENR: STMDT2_10271(sigD)
SEND: DT104_10731(sopB)
SENI: CY43_05575(sopB)
SEEN: SE451236_11305(sopB)
SPT: SPA1759(sigD)
SEI: SPC_2659(sigD)
SEC: SCH_1043(sopB)
SHB: SU5_01724
SENH: CFSAN002069_03565(sopB)
SENS: Q786_04870(sopB)
SED: SeD_A1167
SEG: SG0980(sopB)
SEL: SPUL_1966(sopB)
SEGA: SPUCDC_1952(sopB)
SET: SEN0955(sopB)
SENA: AU38_04930(sopB)
SENO: AU37_04920(sopB)
SENV: AU39_04920(sopB)
SENQ: AU40_05535(sopB)
SENL: IY59_05020(sopB)
SEEC: CFSAN002050_11850(sopB)
SEEB: SEEB0189_014115(sopB)
SEEP: I137_08940(sopB)
SENE: IA1_05370(sopB)
SENC: SEET0819_12115(sopB)
SBG: SBG_0939(sopB)
SBZ: A464_1030
SBV: N643_04465(sopB)
SFL: CP0133(ipgD)
SFE: SFxv_4976(ipgD)
SSN: SSON_P095(ipgD)
SBC: SbBS512_A0166(ipgD)
SDY: SDY_P171(ipgD)
YAL: AT01_2850(sopB)
SGL: SG0550
SOD: Sant_3206(sigD) Sant_3209(sigD2)
PAY: PAU_01919
PSI: S70_12925
PSX: DR96_586(sopB)
ANS: ArsFIN_43100(sopB)
VAN: VAA_02157
PPNO: DA70_11385
PPNM: LV28_19660
PSF: PSE_2750(ipgD)
PCU: pc1256(ipgD)
PNL: PNK_0614(ipgD)
 » show all
1  [PMID:12356723]
Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology.
EMBO J 21:5069-78 (2002)
2  [PMID:16365287]
Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW
The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.
Proc Natl Acad Sci U S A 102:18854-9 (2005)
[hsa:55529 90809]
3  [PMID:17940011]
Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW
Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.
Proc Natl Acad Sci U S A 104:16834-9 (2007)
4  [PMID:17389247]
Mason D, Mallo GV, Terebiznik MR, Payrastre B, Finlay BB, Brumell JH, Rameh L, Grinstein S
Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase.
J Gen Physiol 129:267-83 (2007)
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