KEGG   ENZYME: 3.1.3.78
Entry
EC 3.1.3.78                 Enzyme                                 
Name
phosphatidylinositol-4,5-bisphosphate 4-phosphatase;
phosphatidylinositol-4,5-bisphosphate 4-phosphatase I;
phosphatidylinositol-4,5-bisphosphate 4-phosphatase II;
type I PtdIns-4,5-P2 4-Ptase;
type II PtdIns-4,5-P2 4-Ptase;
IpgD;
PtdIns-4,5-P2 4-phosphatase type I;
PtdIns-4,5-P2 4-phosphatase type II;
type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase;
type 1 4-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate [RN:R08981]
Reaction(KEGG)
R08981
Substrate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637];
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 5-phosphate [CPD:C11557];
phosphate [CPD:C00009]
Comment
Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3].
History
EC 3.1.3.78 created 2008
Orthology
K13084  phosphatidylinositol-4,5-bisphosphate 4-phosphatase
K13085  phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Genes
HSA55529(PIP4P2) 90809(PIP4P1)
PTR464281(PIP4P2) 465201(PIP4P1)
PPS100968374(PIP4P2) 100988983(PIP4P1)
GGO101129459(PIP4P2) 101132752(PIP4P1)
PON100451858(PIP4P2) 100454477(PIP4P1)
NLE100587627(PIP4P2) 100593745(PIP4P1)
HMH116484592(PIP4P1) 116813406(PIP4P2)
MCC100428001(PIP4P1) 696779(PIP4P2)
MCF101866619(PIP4P1) 102115056(PIP4P2)
MTHB126958302 126961846
MNI105497274(PIP4P2) 105499192(PIP4P1)
CSAB103231342 103231344 103237111(TMEM55A)
CATY105572859(TMEM55A) 105593939(TMEM55B)
PANU101001652(PIP4P1) 101009781(PIP4P2)
TGE112629452(PIP4P1) 112630711(PIP4P2)
MLEU105532033(TMEM55A) 105536724(TMEM55B)
RRO104654642(PIP4P2) 104673120(PIP4P1)
RBB108527311(TMEM55B) 108528503(TMEM55A)
TFN117070090(PIP4P1) 117079004(PIP4P2)
PTEH111522534(PIP4P1) 111549729(PIP4P2)
CANG105508233(TMEM55A) 105523149(TMEM55B)
CJC100402264(PIP4P1) 100407390(PIP4P2)
SBQ101027468(TMEM55B) 101033445(TMEM55A)
CIMI108310883(PIP4P2) 108311932(PIP4P1)
CSYR103250423(TMEM55B) 103271008(TMEM55A)
MMUR105864729(TMEM55B) 105869110(TMEM55A)
LCAT123621516(PIP4P1) 123644665(PIP4P2)
PCOQ105809733(TMEM55A) 105814398(TMEM55B)
OGA100951924(PIP4P2) 100962704(PIP4P1)
MMU219024(Pip4p1) 72519(Pip4p2)
MCAL110292720(Pip4p2) 110309188(Pip4p1)
MPAH110325348(Tmem55b) 110338742(Tmem55a)
RNO362490(Pip4p2) 364298(Pip4p1)
MCOC116084318(Pip4p1) 116088053(Pip4p2)
ANU117698715(Pip4p2) 117705197(Pip4p1)
MUN110549703(Pip4p1) 110557768(Pip4p2)
CGE100757444(Pip4p1) 100767770(Pip4p2)
MAUA101826945(Pip4p2) 101835221(Pip4p1)
PROB127216190(Pip4p1) 127232002(Pip4p2)
PLEU114694593(Pip4p2) 114696012(Pip4p1)
MORG121438588(Pip4p1) 121451254(Pip4p2)
MFOT126492851 126515920
AAMP119800363(Pip4p1) 119821440 119826590(Pip4p2)
NGI103729539(Tmem55a) 103733665(Tmem55b)
HGL101709122(Tmem55b) 101718072(Tmem55a)
CPOC100713718(Pip4p2) 100718609(Pip4p1)
CCAN109690515(Tmem55a) 109692126(Tmem55b)
DORD105982754(Tmem55a) 106000447(Tmem55b)
DSP122102382(Pip4p2) 122126588(Pip4p1)
PLOP125358523(Pip4p1) 125360907(Pip4p2)
NCAR124976820 124979632
MMMA107138264(Pip4p1) 107142308(Pip4p2)
OCU100338400 100349176(PIP4P1) 100353159(PIP4P2)
OPI101523968(PIP4P2) 101529039(PIP4P1)
TUP102475472(TMEM55B) 102487160 102499548(TMEM55A)
GVR103599363(TMEM55A) 103605041(TMEM55B)
CFA477939(PIP4P2) 482559(PIP4P1)
CLUD112650712(PIP4P2) 112654418(PIP4P1)
VVP112914985(PIP4P1) 112931637(PIP4P2)
VLG121481490(PIP4P1) 121499023(PIP4P2)
NPO129495774(PIP4P2) 129520681(PIP4P1)
AML100479476(PIP4P2) 100484149(PIP4P1)
UMR103656314(PIP4P1) 103661475(PIP4P2)
UAH113248962(PIP4P1) 113252947(PIP4P2)
UAR123783909(PIP4P1) 123797894(PIP4P2)
ELK111146677 111162295
LLV125098925 125103918
MPUF101672290(TMEM55A) 101692628(TMEM55B)
MNP131999591(PIP4P1) 132014151(PIP4P2)
MLK131826617(PIP4P2) 131836036(PIP4P1)
NVS122893351(PIP4P1) 122904450(PIP4P2)
ORO101372920(TMEM55B) 101382006(TMEM55A)
EJU114216080(PIP4P2) 114221365(PIP4P1)
ZCA113908838(PIP4P1) 113914498(PIP4P2)
MLX118002964(PIP4P1) 118015002(PIP4P2)
NSU110578689(PIP4P2) 110585483(PIP4P1)
LWW102725677(PIP4P1) 102740214(PIP4P2)
FCA101080798(PIP4P1) 101088301(PIP4P2)
PYU121031403(PIP4P1) 121042685(PIP4P2)
PCOO112856471(PIP4P1) 112859309(PIP4P2)
PBG122467674(PIP4P1) 122495586(PIP4P2)
LRUF124508753 124519060
PTG102952164(TMEM55A) 102956222(TMEM55B)
PPAD109255760(TMEM55B) 109269475(TMEM55A)
PUC125909747 125924809
AJU106971402(PIP4P1) 106984681(PIP4P2)
HHV120225955(PIP4P1) 120237341(PIP4P2) 120242017 120246391
BTA615077(PIP4P1) 616641(PIP4P2)
BOM102268358(TMEM55B) 102277826(TMEM55A)
BIU109564878(TMEM55B) 109568638(TMEM55A)
BBUB102392943(PIP4P2) 102415190(PIP4P1)
BBIS104988202(TMEM55B) 105004424(TMEM55A)
CHX102172557(TMEM55A) 102177240(TMEM55B)
OAS101111559(PIP4P2) 101117510(PIP4P1)
BTAX128053790(PIP4P1) 128059339(PIP4P2)
ODA120853335(PIP4P1) 120878509(PIP4P2)
CCAD122443317(PIP4P1) 122451301(PIP4P2)
MBEZ129560119(PIP4P2) 129563108(PIP4P1)
SSC100155939(TMEM55B) 100156639(TMEM55A)
CFR102505095(PIP4P2) 102507379(PIP4P1)
CBAI105064674(TMEM55B) 105079632(TMEM55A)
CDK105085724(PIP4P2) 105097644(PIP4P1)
VPC102541289(PIP4P1) 102541483(PIP4P2)
BACU103007264(TMEM55A) 103012880(TMEM55B)
LVE103084248(TMEM55B) 103085248(TMEM55A)
OOR101273070(PIP4P2) 101273871(PIP4P1)
DLE111180432(PIP4P2) 111181805(PIP4P1)
PCAD102978742(PIP4P2) 102982773(PIP4P1)
PSIU116742418(PIP4P2) 116749983(PIP4P1) 116763783
NASI112410017(PIP4P2) 112410622(PIP4P1)
ECB100050790(PIP4P2) 100058648(PIP4P1)
EPZ103559551(TMEM55B) 103564881(TMEM55A)
EAI106833288(PIP4P1) 106838979(PIP4P2)
MYB102241548(TMEM55A) 102252193(TMEM55B)
MYD102754867(TMEM55B) 102773968(TMEM55A)
MMYO118649171(PIP4P1) 118670481(PIP4P2)
MLF102422557(PIP4P1) 102436205(PIP4P2)
PKL118718475(PIP4P2) 118724275(PIP4P1)
EFUS103301857(PIP4P2) 103303503(PIP4P1)
MNA107526961(TMEM55B)
DRO112310316(PIP4P2) 112311620(PIP4P1)
SHON118982616(PIP4P1) 118989291(PIP4P2)
AJM119036603(PIP4P1) 119047622(PIP4P2)
PDIC114490301(PIP4P1) 114501670(PIP4P2)
PHAS123808166(PIP4P1) 123820957(PIP4P2)
MMF118631649(PIP4P2) 118641633(PIP4P1)
PPAM129064397(PIP4P1) 129088362(PIP4P2)
HAI109376449(TMEM55B)
RFQ117023446(PIP4P1) 117033621(PIP4P2)
PALE102898229(PIP4P2) 102898278(PIP4P1)
PGIG120608059(PIP4P1) 120614258(PIP4P2)
PVP105304152(PIP4P2) 105308945(PIP4P1)
RAY107507437(TMEM55A) 107521160(TMEM55B)
MJV108387665(PIP4P2) 108395116 108403281(PIP4P1)
TOD119238854(PIP4P1) 119239895(PIP4P2)
SARA101537201(TMEM55B) 101555869(TMEM55A)
LAV100660816(PIP4P1) 100664641(PIP4P2)
TMU101345599 101357101
ETF101650919(PIP4P1) 101656735(PIP4P2)
DNM101418300(PIP4P2) 101421442(PIP4P1)
MDO100022045(TMEM55A) 100022893(TMEM55B)
GAS123231880(PIP4P2) 123236082(PIP4P1)
SHR100916303(PIP4P2) 100924788(PIP4P1)
AFZ127544272 127549143
PCW110198547(TMEM55A) 110217864(TMEM55B)
OAA100086066(PIP4P1) 100092908(PIP4P2)
GGA420221(PIP4P2)
PCOC116227600(PIP4P2)
MGP100542892(PIP4P2)
CJO107307004(PIP4P1) 107310378(PIP4P2)
TPAI128090782(PIP4P2)
LMUT125690873(PIP4P2)
NMEL110393858(TMEM55A)
APLA101802244(PIP4P2)
ACYG106030630(PIP4P2)
CATA118247958(PIP4P2)
AFUL116486080(PIP4P2)
TGU100226950(PIP4P2)
LSR110477429(PIP4P2) 110481133(PIP4P1)
SCAN103813442(PIP4P2) 115484135(PIP4P1)
PMOA120500834(PIP4P2)
OTC121340325(PIP4P2) 121342965
PRUF121349816 121351993(PIP4P2)
GFR102040381(TMEM55A)
FAB101810791(TMEM55A)
OMA130249195(PIP4P2) 130262860(PIP4P1)
PHI102099741(TMEM55A) 102101128(TMEM55B)
PMAJ107199089(PIP4P1) 107200089(PIP4P2)
CCAE111924560(PIP4P2)
CCW104692756(PIP4P2)
CBRC103613447(TMEM55A)
ETL114061739(PIP4P2)
ZAB102062275(PIP4P2)
ACHL103806916(TMEM55A)
SVG106861992(TMEM55A) 106864465(TMEM55B)
MMEA130576023(PIP4P2) 130587493(PIP4P1)
HRT120748026(PIP4P1) 120760124(PIP4P2)
FPG101922579(TMEM55A)
FCH102055459(PIP4P2)
CLV102090519(TMEM55A)
EGZ104125810(TMEM55A)
NNI104016500(TMEM55A)
PCRI104033173(TMEM55A)
PLET104628197
EHS104511832(TMEM55A)
PCAO104052077
ACUN113476160(PIP4P2)
TALA104359578(PIP4P2)
PADL103917331(TMEM55A)
ACHC115340537(PIP4P2)
HALD104315809(TMEM55A)
HLE104828362(TMEM55A)
AGEN126036918 126050072
GCL127012969
CCRI104166516
CSTI104557491
CMAC104484755(TMEM55A)
MUI104546812(TMEM55A)
BREG104633898(TMEM55A)
FGA104082721
GSTE104256627
LDI104341576
MNB103774163(TMEM55A)
OHA104337584(TMEM55A)
SHAB115611265(PIP4P2)
DPUB104306048(TMEM55A)
PGUU104467747
ACAR104526135(PIP4P2)
CPEA104396643(TMEM55A)
AVIT104280036
CVF104292534(TMEM55A)
RTD128901846(PIP4P1) 128905701(PIP4P2)
CUCA104056790(TMEM55A)
TEO104380322
BRHI104490899(TMEM55A)
AAM106496195(TMEM55A)
AROW112964070(PIP4P2)
NPD112950677(PIP4P2)
TGT104571256(TMEM55A)
DNE112982968(PIP4P2)
SCAM104143960(TMEM55A)
ASN102373932(PIP4P2) 102374449(PIP4P1)
AMJ102562249(TMEM55B) 102570595(TMEM55A)
CPOO109320301(TMEM55A) 109320545(TMEM55B)
GGN109294681(TMEM55B) 109305031(TMEM55A)
PSS102457479(PIP4P2)
CMY102938814(PIP4P2) 102941676(PIP4P1)
CCAY125621966(PIP4P1) 125632651(PIP4P2)
DCC119842130(PIP4P1) 119852232(PIP4P2)
CPIC101937348(PIP4P2) 101946066(PIP4P1)
TST117871665(PIP4P2) 117885343(PIP4P1)
CABI116816452(PIP4P1) 116839386(PIP4P2)
MRV120380995(PIP4P1) 120396740(PIP4P2)
ACS100556773(tmem55a) 100567084(tmem55b)
ASAO132774975(PIP4P2) 132777717(PIP4P1)
PVT110089558(TMEM55B) 110090207(TMEM55A)
SUND121930003(PIP4P2) 121934894(PIP4P1)
PBI103047975(PIP4P1) 103054248(PIP4P2)
PMUR107285754(PIP4P2) 107292313(PIP4P1)
CTIG120311017(PIP4P1) 120312780(PIP4P2)
TSR106545515(TMEM55A) 106549927(TMEM55B)
PGUT117662190(PIP4P1) 117668494(PIP4P2)
APRI131195817(PIP4P2) 131197258(PIP4P1)
PTEX113439920(PIP4P2) 113449576(PIP4P1)
NSS113425318(PIP4P1) 113428459(PIP4P2)
VKO123019493(PIP4P1) 123020326(PIP4P2)
PMUA114581602(PIP4P1) 114600438(PIP4P2)
PRAF128401024(PIP4P1) 128417260(PIP4P2)
ZVI118090061(PIP4P2) 118095026(PIP4P1)
HCG128323362(PIP4P2) 128331662(PIP4P1)
GJA107105993(TMEM55A) 107116165(TMEM55B)
STOW125439088(PIP4P2) 125445234(PIP4P1)
EMC129333634(PIP4P2) 129338177(PIP4P1)
XLA108695381(pip4p2.S) 108707045(pip4p1.S) 494834(pip4p1.L) 734343(pip4p2.L)
XTR100170610(pip4p1) 448483(pip4p2)
NPR108788678(TMEM55B) 108800143(TMEM55A)
RTEM120940082(PIP4P1) 120941297(PIP4P2)
BBUF120988956(PIP4P1) 121001674(PIP4P2)
BGAR122933402(PIP4P1) 122939001(PIP4P2)
MUO115457762(PIP4P1) 115478800(PIP4P2)
GSH117350613(PIP4P1) 117355152(PIP4P2)
DRE553253(pip4p1b) 556136(pip4p1a) 566642(pip4p2)
SRX107709255 107721780 107723169 107724355 107749147
SANH107659916 107665981 107692688 107692894 107696196 107702130
SGH107555555(tmem55a) 107565103 107576828 107584351 107590777 107600071(tmem55b)
CCAR109045146 109053437 109065694 109075342 109077248 109088132 109090962 109109172
CAUA113044494 113045079 113070034 113075861 113091867 113109880 113114327 113119590(pip4p2)
CGIB127935004 127935703 127949376 127951672 127979451 127979938
PTET122323553(pip4p2) 122328751(pip4p1a) 122351954(pip4p1b)
LROH127169912(pip4p1b) 127177288(pip4p1a) 127182155(pip4p2)
OMC131525353(pip4p2) 131540332(pip4p1b) 131550884(pip4p1a)
PPRM120463074(pip4p1b) 120484999(pip4p2) 120495422(pip4p1a)
RKG130084677(pip4p2) 130092028(pip4p1a) 130096900(pip4p1b)
MAMB125251114(pip4p1a) 125272771(pip4p1b) 125274829(pip4p2)
CIDE127501452 127515689 127523736
MASI127421146 127425180 127440342 127442785 127444147 127445248
TROS130552951(pip4p1b) 130555054(pip4p1a) 130567312(pip4p2)
TDW130407090(pip4p1b) 130418517(pip4p1a)
MANU129443028(pip4p1a) 129444913(pip4p1b) 129455371(pip4p2)
IPU108273350(pip4p2) 108274853 108280404(pip4p1a)
IFU128615524(pip4p2) 128618376 128623998(pip4p1a)
PHYP113523871 113533535(pip4p1) 113543834(pip4p2)
SMEO124382184(pip4p2) 124403093(pip4p1a)
TFD113634755(pip4p2) 113640592(pip4p1a) 113648653 125145681
TVC132842794(pip4p2) 132847118(pip4p1a) 132857132 132857252
AMEX103033991(pip4p1) 103040016(pip4p2) 103040625
CMAO118796990(pip4p1a) 118798059(pip4p1b) 118805179 118805449(pip4p2)
EEE113574929 113580968(pip4p2) 113588959(pip4p1)
CHAR105904855 105905620(pip4p1a) 105907741(pip4p2) 122133737(pip4p1b)
TRU101062738(pip4p1) 101068075(pip4p2) 101075194(pip4p1) 115251759
TFS130518613(pip4p2) 130522552 130539028(pip4p1a)
TNGGSTEN00021192G001 GSTEN00033018G001
LCO104924562(pip4p2) 104926554(pip4p1) 104936244
NCC104947052(tmem55a) 104948613(tmem55b)
TBEN117477512(pip4p2) 117497656 117500341(pip4p1a)
CGOB115016250(pip4p2)
PGEO117443174 117455209(pip4p2) 117462430(pip4p1a)
GACU117538618(pip4p1a) 117561627 117563130(pip4p2)
EMAC134866542(pip4p1a) 134874803(pip4p2) 134876210
ELY117245953 117263899(pip4p2) 117271648(pip4p1a)
EFO125883529 125902623(pip4p1a) 125905002(pip4p2)
PLEP121951708(pip4p1a) 121958323(pip4p2) 121962432
SLUC116040589(pip4p1a) 116047453(pip4p2) 116053086
ECRA117935074 117953665(pip4p1a) 117957036(pip4p2)
ESP116669519 116698603(pip4p1) 116701796(pip4p2)
PFLV114545567 114565150(pip4p1) 114568780(pip4p2)
GAT120814228(pip4p1a) 120821340 120827077(pip4p2)
PPUG119207320(pip4p1a) 119219199(pip4p2) 119223022
AFB129088867(pip4p1a) 129093334 129097377(pip4p2)
CLUM117739500(pip4p2) 117746072(pip4p1a) 117747576
PSWI130190971(pip4p1a) 130195707(pip4p2) 130211903
MSAM119901556 119901743(pip4p1a) 119907514(pip4p2) 119913171
SCHU122863898(pip4p2) 122869707 122887462(pip4p1a)
CUD121504482 121520060(pip4p1a) 121523213(pip4p2)
ALAT119011575(pip4p1a) 119017362(pip4p2) 119027023
MZE101466447 101468284(pip4p2) 101479252(pip4p1)
ONL100693615(pip4p1) 100706272(pip4p2) 100710349
OAU116312075(pip4p2) 116332048 116332092(pip4p1a)
OLA101159467 101161334 101166147(pip4p2)
OML112150645(pip4p1a) 112155987 112160340(pip4p2)
CSAI133420551 133452506(pip4p1a) 133461503(pip4p2)
XMA102224770 102227240(pip4p2) 102234414(pip4p1)
XCO114145811(pip4p1) 114156427(pip4p2) 114157811
XHE116722183(pip4p1) 116731725(pip4p2) 116732542
PRET103472397(tmem55a) 103479490(tmem55b) 103480619
PFOR103135131(tmem55a) 103137995(tmem55b) 103138007 103149154
PLAI106944687 106946254(tmem55a) 106960164(tmem55b)
PMEI106903481 106910744(tmem55b) 106914598 106918621(tmem55a)
GAF122820284 122841343(pip4p1a) 122843283(pip4p2)
PPRL129355687(pip4p1a) 129375172(pip4p2) 129379932
CVG107092441(tmem55a) 107092674(tmem55b) 107095498
CTUL119779521(pip4p1a) 119784408 119795840(pip4p2)
GMU124870263(pip4p1a) 124879343(pip4p2) 124880396
NFU107376897 107383456(tmem55b) 107394745(tmem55a)
KMR108232969(pip4p1a) 108237806(pip4p2) 108248594
ALIM106515818(tmem55a) 106520802(tmem55b) 106523839
NWH119409972 119414799(pip4p1a) 119426013(pip4p2)
AOCE111563765(pip4p2) 111570900 111574634 111576584
MCEP125009150 125010257(pip4p1a) 125020005(pip4p2)
CSEM103388924 103394417(tmem55a) 103396783(tmem55b)
POV109631912(tmem55a) 109645994(tmem55b) 109647653
SSEN122759258(pip4p1a) 122766321 122786912(pip4p2)
HHIP117751911 117770135(pip4p2) 117777897(pip4p1a)
HSP118102936 118118156(pip4p1a) 118124848(pip4p2)
SMAU118285012 118292211(pip4p2) 118310349(pip4p1a)
LCF108873687 108884334(pip4p1a) 108898155(pip4p2)
SDU111223251(pip4p2) 111233362 111239391(pip4p1)
SLAL111657891 111659343(pip4p2) 111668450(pip4p1)
XGL120786092(pip4p2) 120797577 120799177(pip4p1a)
HCQ109506970 109517989(tmem55a) 109529491(tmem55b)
SSCV125985179 125985243 125987049
SBIA133501321(pip4p2) 133511299(pip4p1a)
PEE133395776(pip4p2) 133397577 133411993(pip4p1a)
PTAO133470661(pip4p2) 133472742 133488719(pip4p1a)
BPEC110167447(tmem55a) 110170780 110175124(tmem55b)
MALB109952910(tmem55a) 109974206 109974507
BSPL114844543(pip4p1a) 114851071 114865653(pip4p2)
SJO128369350(pip4p1a) 128373672(pip4p2) 128384248
SASA106569577 106570754 106589142(tmem55a) 106600488 106608438
STRU115157487 115169315 115174163 115176274(pip4p2)
OTW112226565 112229181 112236503(pip4p1a) 112239907 112241833
OMY110487822(pip4p2) 110504292 110508329(pip4p1a) 110512265 110530761
OGO123996760 124009576 124013190 124041636(pip4p1a) 124043125
ONE115102832 115115331 115125483 115128057
OKI109871533 109874839 109882695 109896536 109904365(pip4p2)
OKE118394935 118401771 127906637 127909116 127910048(pip4p2)
SALP111974344 111979801(pip4p1) 112073639 112076069(pip4p2)
SNH120020656 120027946 120041077(pip4p2) 120049537 120056169
CCLU121534682 121571070(pip4p1b) 121572226 121581288 121586848
ELS105006704(pip4p2) 105024555(pip4p1) 105030639
SFM108919216(pip4p2) 108926151 108937836
PKI111833149 111845350 111848239(pip4p2)
AANG118211335 118231305 118234635(pip4p2)
LOC102683795(tmem55b) 102691229(tmem55a)
PSPA121305330 121307399 121313200 121314988 121329256
ARUT117395030 117398263 117398906 117399698 117425668
PSEX120515573(pip4p2) 120522956(pip4p1a)
LCM102348811(TMEM55A) 102357306(TMEM55B)
CMK103191060(pip4p2)
RTP109918341(pip4p1)
CPLA122549003(pip4p2)
HOC132807696(pip4p1a) 132815462(pip4p2)
LERI129694918 129696126(pip4p2)
PMRN116956136(PIP4P2)
LRJ133357808 133357983
BFO118417220
BBEL109483241
CIN104266484
SPU588430
LPIC129254032 129278085
APLC110980124
AJC117118190
SKO100368816
DMEDmel_CG6707(CG6707)
DER6546082
DSE6605120
DSIDsimw501_GD12881(Dsim_GD12881)
DYADyak_GE20289
DAN6506490
DSR110190635
DPO4813276
DPE6600238
DMN108151830
DWI6638715
DGR6557366
DMODmoj_GI13013
DAZ108613220
DNV108651252
DHE111598717
DVI6623987
CCAT101458043
BOD106619668
BDR105231295
RZE108368047
AOQ129240984 129241589
TDA119667429
MDE101893850
SCAC106093469
LCQ111682675
LSQ119613382 119613667
GFS119631391
ECOE129946653
CLON129609136
HIS119647680
AGA1276903
ACOZ120951221
AARA120898884
AMER121591871
ASTE118509445
AFUN125771049
AMOU128303793
AALI118464008
AAG5574542
AALB109428654
CQUCpipJ_CPIJ009913
CPII120418667
CNS116347912
BCOO119073623
AME408301
ACER108001187
ALAB122710420
ADR102678254
AFLR100867798
BIM100749086
BBIF117205240
BVK117230173
BVAN117162943
BTER100646549
BAFF126923283
BPYO122571788
BPAS132908822
FVI122538927
CCAL108622913
OBB114874660
OLG117608715
MGEN117217459
NMEA116424096
CGIG122402714
SOC105200883
MPHA105839704
AEC105143615
ACEP105620209
PBAR105430510
VEM105563835
HST105186717
DQU106748938
CFO105255380
FEX115239704
LHU105674095
PGC109854987
OBO105282957
PCF106791075
PFUC122519801
VPS122630485
VCRB124424060
VVE124950554
NVI100120829
CSOL105359276
TPRE106649016
LHT122500596
LBD127279751
MDL103578153 106693532
CGLO123264322
FAS105270733
DAM107043087
AGIF122860638
CINS118072037
VCAN122417951
CCIN107264242
DSM124415005
NPT124223973
NLO107221332
AROA105691767
TCA655804
DPA109534456
SOY115877178
AGRG126739455
ATD109603339
CSET123318730
AGB108913856
LDC111504067
NVL108563960
APLN108735740
PPYR116174180
OTU111420505
BMOR101741980 119629095
BMAN114247478
MSEX115440024
DPLKGM_213618 KGM_213619
BANY112043167
MJU123868453
NIQ126774119
VCD124536201
MCIX123659859
PMAC106719144
PPOT106109686
PXU106121436
PRAP110992215
PBX123708002
PNAP125049331
ZCE119828288
CCRC123694651
LSIN126965102
HAW110370045
HZE124635448
TNL113501279
SLIU111358774
OFU114361656
PXY105393931
PGW126372376
CFEL113386632 113386871
CCRN123299341
API100164628
DNX107167499
AGS114121256
RMD113556156
ACOO126844334
DVT126897606
BTAB109035975
DCI103518847 103518848
CLEC106665999
HHAL106690513
NLU111043649
HVI124353714
MQU129002598 129004272
PHUPhum_PHUM358690 Phum_PHUM617960
FOC113203769
TPAL117651370
ZNE110834071
CSEC111869495
SGRE126354421
IEL124163472
FCD110849352
DPXDAPPUDRAFT_235760 DAPPUDRAFT_304652 DAPPUDRAFT_43581
DMK116915446 123469750
DPZ124329188 124337736 124337737
PVM113800971 113802341
PJA122250017
PCHN125030796
PMOO119576374
HAME121871871
PCLA123760636
CQD128702865
PTRU123506685
ESN126985961
HAZT108665058
EAF111709775
LSM121117358
TCF131885541
PPOI119099241
ISC8031937
DSV119432683 119465627
RSAN119374570 119377643
RMP119176165 119176407
VDE111244394 111245807
VJA111265977 111272307
TUT107359622
DPTE113789342
DFR124495003
CSCU111630924 111642355
PTEP107452055
ABRU129971650
UDV129221580
SDM118195297 118203607
LPOL106457221 106468378 106474695
PMEO129602651
CELCELE_Y71H2AM.2(pipp-4P)
CBRCBG_00490
CRQGCK72_010840
BMYBM_BM7065(Bm7065)
LOALOAG_02822
HROHELRODRAFT_187998
LGILOTGIDRAFT_133999
PVUL126814235 126814236
PCAN112576610
BGT106069844
GAE121389550
HRF124136840
HRJ124259351
CRG105338362
CVN111136180
CANU128189299
OED125667428
MYI110464767
PMAX117337259
MCAF127703050
MMER123548748
RPHI132725283
DPOL127874619
OBI106874795
OSN115220847
LAK106178509
SMMSmp_022540.1
SHXMS3_00002878(PIP4P2_1)
OVIT265_09562 T265_11868
EGLEGR_01135 EGR_09393
NVE5521597
EPA110248578
ATEN116304727
ADF107342237
AMIL114977192
PDAM113677853
SPIS111332610
DGT114516540
XEN124436983
HMG100208471
HSY130614016
AQU100632025
EMAC1192_24285
STYSTY1121(sigD)
STTt1828(sigD)
SEXSTBHUCCB_19440
SENTTY21A_09295
STMSTM1091(sopB)
SEOSTM14_1237(sopB)
SEVSTMMW_11031
SEYSL1344_1030(sopB)
SEMSTMDT12_C11120
SEJSTMUK_1060(sopB)
SEBSTM474_1083(sopB)
SEFUMN798_1133(sigD)
SETUSTU288_01790
SETCCFSAN001921_11720(sopB)
SENRSTMDT2_10271(sigD)
SENDDT104_10731(sopB)
SENICY43_05575(sopB)
SEENSE451236_11305(sopB)
SPTSPA1759(sigD)
SEKSSPA1634
SPQSPAB_02464
SEISPC_2659(sigD)
SECSCH_1043(sopB)
SEHSeHA_C1201
SHBSU5_01724
SENHCFSAN002069_03565(sopB)
SEEHSEEH1578_14685
SEESNSL254_A1187
SENNSN31241_21590
SEWSeSA_A1155
SEASeAg_B1050
SENSQ786_04870(sopB)
SEDSeD_A1167
SEGSG0980(sopB)
SELSPUL_1966(sopB)
SEGASPUCDC_1952(sopB)
SETSEN0955(sopB)
SENAAU38_04930(sopB)
SENOAU37_04920(sopB)
SENVAU39_04920(sopB)
SENQAU40_05535(sopB)
SENLIY59_05020(sopB)
SENJCFSAN001992_06185
SEECCFSAN002050_11850(sopB)
SEEBSEEB0189_014115(sopB)
SEEPI137_08940(sopB)
SENBBN855_10450
SENEIA1_05370(sopB)
SENCSEET0819_12115(sopB)
SESSARI_01910
SBGSBG_0939(sopB)
SBZA464_1030
SBVN643_04465(sopB)
SALZEOS98_14165
SFLCP0133(ipgD)
SFESFxv_4976(ipgD)
SSNSSON_P095(ipgD)
SBCSbBS512_A0166(ipgD)
SDYSDY_P171(ipgD)
SDZAsd1617_06366
SYMK6K13_10905
YALAT01_2850(sopB)
YEGPL78_07345
FSMCCS41_07775
RBADH2866_19305
SODSant_3206(sigD) Sant_3209(sigD2)
SLIGGTU79_05195
PAYPAU_01919
PSIS70_12925
PSXDR96_586(sopB)
PSTABGK56_15810
PTHAOI982_10265
PVCG3341_17095
ANSArsFIN_43100(sopB)
VANVAA_02157
LAGN175_09340
VAUVANGNB10_cI1105
EMPEZMO1_3388(ipgD)
CRZD1345_19490
CHAECH06BL_40220(sopB_sigD)
IFLC1H71_17665(sopB)
PBONQS306_09370
PPKU875_18870
PPNODA70_11385
PPNMLV28_19660
LIMNHKT17_05800
BGMCAL15_03515
CDNBN940_04026
PVACHC248_01669(ipgD)
COFFOZ74_09105
STARG3545_19400
HMCHYPMC_3453
PSFPSE_2750(ipgD)
DPGDESPIGER_2147
OXYHCG48_18215
PCUPC_RS06055
PNLPNK_0614(ipgD)
 » show all
Reference
1  [PMID:12356723]
  Authors
Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B
  Title
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology.
  Journal
EMBO J 21:5069-78 (2002)
DOI:10.1093/emboj/cdf522
  Sequence
[sfl:CP0133]
Reference
2  [PMID:16365287]
  Authors
Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW
  Title
The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.
  Journal
Proc Natl Acad Sci U S A 102:18854-9 (2005)
DOI:10.1073/pnas.0509740102
  Sequence
[hsa:55529 90809]
Reference
3  [PMID:17940011]
  Authors
Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW
  Title
Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.
  Journal
Proc Natl Acad Sci U S A 104:16834-9 (2007)
DOI:10.1073/pnas.0708189104
Reference
4  [PMID:17389247]
  Authors
Mason D, Mallo GV, Terebiznik MR, Payrastre B, Finlay BB, Brumell JH, Rameh L, Grinstein S
  Title
Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase.
  Journal
J Gen Physiol 129:267-83 (2007)
DOI:10.1085/jgp.200609656
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.78
IUBMB Enzyme Nomenclature: 3.1.3.78
ExPASy - ENZYME nomenclature database: 3.1.3.78
BRENDA, the Enzyme Database: 3.1.3.78

DBGET integrated database retrieval system