KEGG   ENZYME: 3.1.3.78
Entry
EC 3.1.3.78                 Enzyme                                 
Name
phosphatidylinositol-4,5-bisphosphate 4-phosphatase;
phosphatidylinositol-4,5-bisphosphate 4-phosphatase I;
phosphatidylinositol-4,5-bisphosphate 4-phosphatase II;
type I PtdIns-4,5-P2 4-Ptase;
type II PtdIns-4,5-P2 4-Ptase;
IpgD;
PtdIns-4,5-P2 4-phosphatase type I;
PtdIns-4,5-P2 4-phosphatase type II;
type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase;
type 1 4-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate [RN:R08981]
Reaction(KEGG)
R08981
Substrate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637];
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 5-phosphate [CPD:C11557];
phosphate [CPD:C00009]
Comment
Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3].
History
EC 3.1.3.78 created 2008
Orthology
K13084  phosphatidylinositol-4,5-bisphosphate 4-phosphatase
K13085  phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Genes
HSA55529(PIP4P2) 90809(PIP4P1)
PTR464281(PIP4P2) 465201(PIP4P1)
PPS100968374(PIP4P2) 100988983(PIP4P1)
GGO101129459(PIP4P2) 101132752(PIP4P1)
PON100451858(PIP4P2) 100454477(PIP4P1)
NLE100587627(PIP4P2) 100593745(PIP4P1)
MCC100428001(PIP4P1) 696779(PIP4P2)
MCF101866619(PIP4P1) 102115056(PIP4P2)
CSAB103231342 103231344 103237111(TMEM55A)
CATY105572859(TMEM55A) 105593939(TMEM55B)
PANU101001652(PIP4P1) 101009781(PIP4P2)
TGE112629452(PIP4P1) 112630711(PIP4P2)
RRO104654642(PIP4P2) 104673120(PIP4P1)
RBB108527311(TMEM55B) 108528503(TMEM55A)
TFN117070090(PIP4P1) 117079004(PIP4P2)
PTEH111522534(PIP4P1) 111549729(PIP4P2)
CJC100402264(TMEM55B) 100407390(TMEM55A)
SBQ101027468(TMEM55B) 101033445(TMEM55A)
CSYR103250423(TMEM55B) 103271008(TMEM55A)
MMUR105864729(TMEM55B) 105869110(TMEM55A)
OGA100951924(PIP4P2) 100962704(PIP4P1)
MMU219024(Pip4p1) 72519(Pip4p2)
MCAL110292720(Tmem55a) 110309188(Tmem55b)
MPAH110325348(Tmem55b) 110338742(Tmem55a)
RNO362490(Pip4p2) 364298(Pip4p1)
MCOC116084318(Pip4p1) 116088053(Pip4p2)
MUN110549703(Tmem55b) 110557768(Tmem55a)
CGE100757444(Pip4p1) 100767770(Pip4p2)
PLEU114694593(Pip4p2) 114696012(Pip4p1)
NGI103729539(Tmem55a) 103733665(Tmem55b)
HGL101709122(Tmem55b) 101718072(Tmem55a)
CPOC100713718(Pip4p2) 100718609(Pip4p1)
CCAN109690515(Tmem55a) 109692126(Tmem55b)
DORD105982754(Tmem55a) 106000447(Tmem55b)
DSP122102382(Pip4p2) 122126588(Pip4p1)
OCU100349176(TMEM55B) 100353159(TMEM55A)
OPI101523968(PIP4P2) 101529039(PIP4P1)
TUP102475472(TMEM55B) 102487160 102499548(TMEM55A)
CFA477939(PIP4P2) 482559(PIP4P1)
VVP112914985(PIP4P1) 112931637(PIP4P2)
VLG121481490(PIP4P1) 121499023(PIP4P2)
AML100479476(PIP4P2) 100484149(PIP4P1)
UMR103656314(TMEM55B) 103661475(TMEM55A)
UAH113248962(PIP4P1) 113252947(PIP4P2)
UAR123783909(PIP4P1) 123797894(PIP4P2)
ELK111146677 111162295
LLV125098925 125103918
MPUF101672290(TMEM55A) 101692628(TMEM55B)
ORO101372920(TMEM55B) 101382006(TMEM55A)
EJU114216080(PIP4P2) 114221365(PIP4P1)
ZCA113908838(PIP4P1) 113914498(PIP4P2)
MLX118002964(PIP4P1) 118015002(PIP4P2)
FCA101080798(PIP4P1) 101088301(PIP4P2)
PYU121031403(PIP4P1) 121042685(PIP4P2)
PBG122467674(PIP4P1) 122495586(PIP4P2)
PTG102952164(TMEM55A) 102956222(TMEM55B)
PPAD109255760(TMEM55B) 109269475(TMEM55A)
AJU106971402(PIP4P1) 106984681(PIP4P2)
HHV120225955(PIP4P1) 120237341(PIP4P2) 120242017 120246391
BTA615077(PIP4P1) 616641(PIP4P2)
BOM102268358(TMEM55B) 102277826(TMEM55A)
BIU109564878(TMEM55B) 109568638(TMEM55A)
BBUB102392943(PIP4P2) 102415190(PIP4P1)
CHX102172557(TMEM55A) 102177240(TMEM55B)
OAS101111559(PIP4P2) 101117510(PIP4P1)
ODA120853335(PIP4P1) 120878509(PIP4P2)
CCAD122443317(PIP4P1) 122451301(PIP4P2)
SSC100155939(TMEM55B) 100156639(TMEM55A)
CFR102505095(PIP4P2) 102507379(PIP4P1)
CBAI105064674(TMEM55B) 105079632(TMEM55A)
CDK105085724(PIP4P2) 105097644(PIP4P1)
VPC102541289(PIP4P1) 102541483(PIP4P2)
BACU103007264(TMEM55A) 103012880(TMEM55B)
LVE103084248(TMEM55B) 103085248(TMEM55A)
OOR101273070(TMEM55A) 101273871(TMEM55B)
DLE111180432(PIP4P2) 111181805(PIP4P1)
PCAD102978742(PIP4P2) 102982773(PIP4P1)
PSIU116742418(PIP4P2) 116749983(PIP4P1) 116763783
ECB100050790(PIP4P2) 100058648(PIP4P1)
EPZ103559551(TMEM55B) 103564881(TMEM55A)
EAI106833288(PIP4P1) 106838979(PIP4P2)
MYB102241548(TMEM55A) 102252193(TMEM55B)
MYD102754867(TMEM55B) 102773968(TMEM55A)
MMYO118649171(PIP4P1) 118670481(PIP4P2)
MLF102422557(PIP4P1) 102436205(PIP4P2)
MNA107526961(TMEM55B)
PKL118718475(PIP4P2) 118724275(PIP4P1)
HAI109376449(TMEM55B)
DRO112310316(PIP4P2) 112311620(PIP4P1)
SHON118982616(PIP4P1) 118989291(PIP4P2)
AJM119036603(PIP4P1) 119047622(PIP4P2)
PDIC114490301(PIP4P1) 114501670(PIP4P2)
PHAS123808166(PIP4P1) 123820957(PIP4P2)
MMF118631649(PIP4P2) 118641633(PIP4P1)
RFQ117023446(PIP4P1) 117033621(PIP4P2)
PALE102898229(PIP4P2) 102898278(PIP4P1)
PGIG120608059(PIP4P1) 120614258(PIP4P2)
PVP105304152(PIP4P2) 105308945(PIP4P1)
RAY107507437(TMEM55A) 107521160(TMEM55B)
MJV108387665(TMEM55A) 108403281(TMEM55B)
TOD119238854(PIP4P1) 119239895(PIP4P2)
SARA101537201(TMEM55B) 101555869(TMEM55A)
LAV100660816(PIP4P1) 100664641(PIP4P2)
TMU101345599 101357101
DNM101418300(PIP4P2) 101421442(PIP4P1)
MDO100022045(TMEM55A) 100022893(TMEM55B)
GAS123231880(PIP4P2) 123236082(PIP4P1)
SHR100916303(PIP4P2) 100924788(PIP4P1)
PCW110198547(TMEM55A) 110217864(TMEM55B)
OAA100086066(PIP4P1) 100092908(PIP4P2)
GGA420221(PIP4P2)
PCOC116227600(PIP4P2)
MGP100542892(PIP4P2)
CJO107307004(PIP4P1) 107310378(PIP4P2)
NMEL110393858(TMEM55A)
APLA101802244(PIP4P2)
ACYG106030630(TMEM55A)
AFUL116486080(PIP4P2)
TGU100226950(PIP4P2)
LSR110477429(PIP4P2) 110481133(PIP4P1)
SCAN103813442(PIP4P2) 115484135(PIP4P1)
PMOA120500834(PIP4P2)
OTC121340325(PIP4P2) 121342965
PRUF121349816 121351993(PIP4P2)
GFR102040381(TMEM55A)
FAB101810791(TMEM55A)
PHI102099741(TMEM55A) 102101128(TMEM55B)
PMAJ107199089(TMEM55B) 107200089(TMEM55A)
CCAE111924560(PIP4P2)
CCW104692756(PIP4P2)
ETL114061739(PIP4P2)
ZAB102062275(PIP4P2)
FPG101922579(TMEM55A)
FCH102055459(PIP4P2)
CLV102090519(TMEM55A)
EGZ104125810(TMEM55A)
NNI104016500(TMEM55A)
ACUN113476160(PIP4P2)
TALA104359578(PIP4P2)
PADL103917331(TMEM55A)
ACHC115340537(PIP4P2)
AAM106496195(TMEM55A)
AROW112964070(PIP4P2)
NPD112950677(PIP4P2)
DNE112982968(PIP4P2)
ASN102373932(PIP4P2) 102374449(PIP4P1)
AMJ102562249(TMEM55B) 102570595(TMEM55A)
CPOO109320301(TMEM55A) 109320545(TMEM55B)
GGN109294681(TMEM55B) 109305031(TMEM55A)
PSS102457479(PIP4P2)
CMY102938814(PIP4P2) 102941676(PIP4P1)
CPIC101937348(PIP4P2) 101946066(PIP4P1)
TST117871665(PIP4P2) 117885343(PIP4P1)
CABI116816452(PIP4P1) 116839386(PIP4P2)
MRV120380995(PIP4P1) 120396740(PIP4P2)
ACS100556773(tmem55a) 100567084(tmem55b)
PVT110089558(TMEM55B) 110090207(TMEM55A)
SUND121930003(PIP4P2) 121934894(PIP4P1)
PBI103047975(PIP4P1) 103054248(PIP4P2)
PMUR107285754(PIP4P2) 107292313(PIP4P1)
TSR106545515(TMEM55A) 106549927(TMEM55B)
PGUT117662190(PIP4P1) 117668494(PIP4P2)
VKO123019493(PIP4P1) 123020326(PIP4P2)
PMUA114581602(PIP4P1) 114600438(PIP4P2)
ZVI118090061(PIP4P2) 118095026(PIP4P1)
GJA107105993(TMEM55A) 107116165(TMEM55B)
XLA108695381(pip4p2.S) 108707045(pip4p1.S) 494834(pip4p1.L) 734343(pip4p2.L)
XTR100170610(pip4p1) 448483(pip4p2)
NPR108788678(TMEM55B) 108800143(TMEM55A)
RTEM120940082(PIP4P1) 120941297(PIP4P2)
BBUF120988956(PIP4P1) 121001674(PIP4P2)
BGAR122933402(PIP4P1) 122939001(PIP4P2)
DRE553253(pip4p1b) 556136(pip4p1a) 566642(pip4p2)
SRX107709255 107721780 107723169 107724355 107749147
SANH107659916 107665981 107692688 107692894 107696196 107702130
SGH107555555(tmem55a) 107565103 107576828 107584351 107590777 107600071(tmem55b)
CCAR109045146 109053437 109065694 109075342 109077248 109088132 109090962 109109172
CAUA113044494 113045079 113070034 113075861 113091867 113109880 113114327 113119590(pip4p2)
IPU108273350(pip4p2) 108274853 108280404(pip4p1a)
PHYP113523871 113533535(pip4p1) 113543834(pip4p2)
SMEO124382184(pip4p2) 124403093(pip4p1a)
AMEX103033991(pip4p1) 103040016(pip4p2) 103040625
EEE113574929 113580968(pip4p2) 113588959(pip4p1)
TRU101062738(pip4p1) 101068075(pip4p2) 101075194(pip4p1) 115251759
TNGGSTEN00021192G001 GSTEN00033018G001
LCO104924562(pip4p2) 104926554(pip4p1) 104936244
NCC104947052(tmem55a) 104948613(tmem55b)
CGOB115016250(pip4p2)
ELY117245953 117263899(pip4p2) 117271648(pip4p1a)
PLEP121951708(pip4p1a) 121958323(pip4p2) 121962432
SLUC116040589(pip4p1a) 116047453(pip4p2) 116053086
ECRA117935074 117953665(pip4p1a) 117957036(pip4p2)
PFLV114545567 114565150(pip4p1) 114568780(pip4p2)
GAT120814228(pip4p1a) 120821340 120827077(pip4p2)
PPUG119207320(pip4p1a) 119219199(pip4p2) 119223022
MSAM119901556 119901743(pip4p1a) 119907514(pip4p2) 119913171
CUD121504482 121520060(pip4p1a) 121523213(pip4p2)
MZE101466447 101468284(pip4p2) 101479252(pip4p1)
ONL100693615(pip4p1) 100706272(pip4p2) 100710349
OAU116312075(pip4p2) 116332048 116332092(pip4p1a)
OLA101159467 101161334 101166147(pip4p2)
OML112150645(pip4p1a) 112155987 112160340(pip4p2)
XMA102224770 102227240(pip4p2) 102234414(pip4p1)
XCO114145811(pip4p1) 114156427(pip4p2) 114157811
XHE116722183(pip4p1) 116731725(pip4p2) 116732542
PRET103472397(tmem55a) 103479490(tmem55b) 103480619
PFOR103135131(tmem55a) 103137995(tmem55b) 103138007 103149154
PLAI106944687 106946254(tmem55a) 106960164(tmem55b)
PMEI106903481 106910744(tmem55b) 106914598 106918621(tmem55a)
GAF122820284 122841343(pip4p1a) 122843283(pip4p2)
CVG107092441(tmem55a) 107092674(tmem55b) 107095498
CTUL119779521(pip4p1a) 119784408 119795840(pip4p2)
GMU124870263(pip4p1a) 124879343(pip4p2) 124880396
NFU107376897 107383456(tmem55b) 107394745(tmem55a)
KMR108232969(pip4p1a) 108237806(pip4p2) 108248594
ALIM106515818(tmem55a) 106520802(tmem55b) 106523839
NWH119409972 119414799(pip4p1a) 119426013(pip4p2)
AOCE111563765(pip4p2) 111570900 111574634 111576584
CSEM103388924 103394417(tmem55a) 103396783(tmem55b)
POV109631912(tmem55a) 109645994(tmem55b) 109647653
SSEN122759258(pip4p1a) 122766321 122786912(pip4p2)
HHIP117751911 117770135(pip4p2) 117777897(pip4p1a)
LCF108873687 108884334 108898155(tmem55a)
SDU111223251(pip4p2) 111233362 111239391(pip4p1)
SLAL111657891 111659343(pip4p2) 111668450(pip4p1)
XGL120786092(pip4p2) 120797577 120799177(pip4p1a)
HCQ109506970 109517989(tmem55a) 109529491(tmem55b)
BPEC110167447(tmem55a) 110170780 110175124(tmem55b)
MALB109952910(tmem55a) 109974206 109974507
SASA106569577 106570754 106589142(tmem55a) 106600488 106608438
OTW112226565 112229181 112236503(pip4p1a) 112239907 112241833
OMY110487822(pip4p2) 110504292 110508329(pip4p1a) 110512265 110530761
OGO123996760 124009576 124013190 124041636(pip4p1a) 124043125
ONE115102832 115115331 115125483 115128057
SALP111974344 111979801(pip4p1) 112073639 112076069(pip4p2)
SNH120020656 120027946 120041077(pip4p2) 120049537 120056169
ELS105006704(pip4p2) 105024555(pip4p1) 105030639
SFM108919216(pip4p2) 108926151 108937836
PKI111833149 111845350 111848239(pip4p2)
AANG118211335 118231305 118234635(pip4p2)
LOC102683795(tmem55b) 102691229(tmem55a)
PSPA121305330 121307399 121313200 121314988 121329256
ARUT117395030 117398263 117398906 117399698 117425668
LCM102348811(TMEM55A) 102357306(TMEM55B)
CMK103191060(pip4p2)
RTP109918341(tmem55b) 109938918(tmem55a)
BFO118417220
BBEL109483241
CIN104266484
SPU588430
APLC110980124
SKO100368816
DMEDmel_CG6707(CG6707)
DER6546082
DSE6605120
DSIDsimw501_GD12881(Dsim_GD12881)
DYADyak_GE20289
DAN6506490
DSR110190635
DPODpse_GA19800
DPE6600238
DMN108151830
DWI6638715
DGR6557366
DMODmoj_GI13013
DAZ108613220
DNV108651252
DHE111598717
DVI6623987
CCAT101458043
BOD106619668
MDE101893850
SCAC106093469
LCQ111682675
AGAAgaP_AGAP006243
ACOZ120951221
AARA120898884
AAG5574542
AALB109428654
CQUCpipJ_CPIJ009913
CPII120418667
CNS116347912
AME408301
ACER108001187
ALAB122710420
BIM100749086
BBIF117205240
BVK117230173
BVAN117162943
BTER100646549
BPYO122571788
CCAL108622913
OBB114874660
MGEN117217459
NMEA116424096
CGIG122402714
SOC105200883
MPHA105839704
AEC105143615
ACEP105620209
PBAR105430510
VEM105563835
HST105186717
DQU106748938
CFO105255380
FEX115239704
LHU105674095
PGC109854987
OBO105282957
PCF106791075
PFUC122519801
VPS122630485
NVI100120829
CSOL105359276
TPRE106649016
MDL103578153 106693532
CGLO123264322
FAS105270733
DAM107043087
AGIF122860638
CCIN107264242
TCA655804
DPA109534456
SOY115877178
ATD109603339 109605889
CSET123318730
AGB108913856
LDC111504067
NVL108563960
APLN108735740
PPYR116174180
OTU111420505
BMOR101741980 119629095
BMAN114247478
MSEX115440024
DPLKGM_213618 KGM_213619
BANY112043167
PMAC106719144
PPOT106109686
PXU106121436
PRAP110992215
ZCE119828288
HAW110370045
TNL113501279
OFU114361656
PXY105393931
API100164628
DNX107167499
AGS114121256
RMD113556156
BTAB109035975
DCI103518847 103518848
CLEC106665999
HHAL106690513
NLU111043649
PHUPhum_PHUM358690 Phum_PHUM617960
FOC113203769
ZNE110834071
CSEC111869495
FCD110849352
DPXDAPPUDRAFT_235760 DAPPUDRAFT_304652 DAPPUDRAFT_43581
DMK116915446 123469750
PVM113800971 113802341
PJA122250017
HAME121871871
PCLA123760636
PTRU123506685
HAZT108665058
EAF111709775
ISCIscW_ISCW008198
DSV119432683 119465627
RSAN119374570 119377643
RMP119176165 119176407
VDE111244394 111245807
VJA111265977 111272307
TUT107359622
DPTE113789342
DFR124495003
CSCU111630924 111642355
PTEP107452055
SDM118195297 118203607
CELCELE_Y71H2AM.2(Y71H2AM.2)
CBRCBG_00490
BMYBM_BM7065(Bm7065)
LOALOAG_02822
HROHELRODRAFT_187998
LGILOTGIDRAFT_133999
PCAN112576610
BGT106069844
GAE121389550
HRF124136840
HRJ124259351
CRG105338362
MYI110464767
PMAX117337259
MMER123548748
OBI106874795
OSN115220847
LAK106178509
SMMSmp_022540.1
SHXMS3_0017559
OVIT265_09562 T265_11868
EGLEGR_01135 EGR_09393
NVE5521597
EPA110248578
ATEN116304727
ADF107342237
AMIL114977192
PDAM113677853
SPIS111332610
DGT114516540
XEN124436983
HMG100208471
AQU100632025
EMAC1192_24285
STYSTY1121(sigD)
STTt1828(sigD)
SEXSTBHUCCB_19440
SENTTY21A_09295
STMSTM1091(sopB)
SEOSTM14_1237(sopB)
SEVSTMMW_11031
SEYSL1344_1030(sopB)
SEMSTMDT12_C11120
SEJSTMUK_1060(sopB)
SEBSTM474_1083(sopB)
SEFUMN798_1133(sigD)
SETUSTU288_01790
SETCCFSAN001921_11720(sopB)
SENRSTMDT2_10271(sigD)
SENDDT104_10731(sopB)
SENICY43_05575(sopB)
SEENSE451236_11305(sopB)
SPTSPA1759(sigD)
SEKSSPA1634
SPQSPAB_02464
SEISPC_2659(sigD)
SECSCH_1043(sopB)
SEHSeHA_C1201
SHBSU5_01724
SENHCFSAN002069_03565(sopB)
SEEHSEEH1578_14685
SEESNSL254_A1187
SENNSN31241_21590
SEWSeSA_A1155
SEASeAg_B1050
SENSQ786_04870(sopB)
SEDSeD_A1167
SEGSG0980(sopB)
SELSPUL_1966(sopB)
SEGASPUCDC_1952(sopB)
SETSEN0955(sopB)
SENAAU38_04930(sopB)
SENOAU37_04920(sopB)
SENVAU39_04920(sopB)
SENQAU40_05535(sopB)
SENLIY59_05020(sopB)
SENJCFSAN001992_06185
SEECCFSAN002050_11850(sopB)
SEEBSEEB0189_014115(sopB)
SEEPI137_08940(sopB)
SENBBN855_10450
SENEIA1_05370(sopB)
SENCSEET0819_12115(sopB)
SESSARI_01910
SBGSBG_0939(sopB)
SBZA464_1030
SBVN643_04465(sopB)
SALZEOS98_14165
SFLCP0133(ipgD)
SFESFxv_4976(ipgD)
SSNSSON_P095(ipgD)
SBCSbBS512_A0166(ipgD)
SDYSDY_P171(ipgD)
SDZAsd1617_06366
SYMK6K13_10905
YALAT01_2850(sopB)
FSMCCS41_07775
RBADH2866_19305
SODSant_3206(sigD) Sant_3209(sigD2)
PAYPAU_01919
PSIS70_12925
PSXDR96_586(sopB)
PSTABGK56_15810
PVCG3341_17095
ANSArsFIN_43100(sopB)
VANVAA_02157
LAGN175_09340
VAUVANGNB10_cI1105
CRZD1345_19490
CHAECH06BL_40220(sopB_sigD)
IFLC1H71_17665(sopB)
PPKU875_18870
PPNODA70_11385
PPNMLV28_19660
LIMNHKT17_05800
BGMCAL15_03515
CDNBN940_04026
PVACHC248_01669(ipgD)
COFFOZ74_09105
DPGDESPIGER_2147
STARG3545_19400
HMCHYPMC_3453
PSFPSE_2750(ipgD)
OXYHCG48_18215
PCUPC_RS06055
PNLPNK_0614(ipgD)
 » show all
Reference
1  [PMID:12356723]
  Authors
Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B
  Title
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology.
  Journal
EMBO J 21:5069-78 (2002)
DOI:10.1093/emboj/cdf522
  Sequence
[sfl:CP0133]
Reference
2  [PMID:16365287]
  Authors
Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW
  Title
The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.
  Journal
Proc Natl Acad Sci U S A 102:18854-9 (2005)
DOI:10.1073/pnas.0509740102
  Sequence
[hsa:55529 90809]
Reference
3  [PMID:17940011]
  Authors
Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW
  Title
Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.
  Journal
Proc Natl Acad Sci U S A 104:16834-9 (2007)
DOI:10.1073/pnas.0708189104
Reference
4  [PMID:17389247]
  Authors
Mason D, Mallo GV, Terebiznik MR, Payrastre B, Finlay BB, Brumell JH, Rameh L, Grinstein S
  Title
Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase.
  Journal
J Gen Physiol 129:267-83 (2007)
DOI:10.1085/jgp.200609656
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.78
IUBMB Enzyme Nomenclature: 3.1.3.78
ExPASy - ENZYME nomenclature database: 3.1.3.78
BRENDA, the Enzyme Database: 3.1.3.78

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