KEGG   ENZYME: 3.13.1.9
Entry
EC 3.13.1.9                 Enzyme                                 
Name
S-inosyl-L-homocysteine hydrolase;
SIHH
Class
Hydrolases;
Acting on carbon-sulfur bonds;
Acting on carbon-sulfur bonds
Sysname
S-inosyl-L-homocysteine hydrolase (inosine-forming)
Reaction(IUBMB)
S-inosyl-L-homocysteine + H2O = inosine + L-homocysteine [RN:R12588]
Reaction(KEGG)
R12588
Substrate
S-inosyl-L-homocysteine [CPD:C03431];
H2O [CPD:C00001]
Product
inosine [CPD:C00294];
L-homocysteine [CPD:C00155]
Comment
The enzyme, characterized from the methanogenic archaeon Methanocaldococcus jannaschii, binds an NAD+ cofactor. It participates in an alternative pathway for the regeneration of S-adenosyl-L-methionine from S-adenosyl-L-homocysteine that involves the deamination of the latter to S-inosyl-L-homocysteine.
History
EC 3.13.1.9 created 2020
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K01566  S-inosyl-L-homocysteine hydrolase
Genes
CDANSOJ16_000882
SFPQUY26_28970
TTGP8625_11875
MJAMJ_1388
MFEMefer_0890
MVUMetvu_1483
MFSMFS40622_0464
MIFMetin_0659
MJHJH146_0148
MESGMLAUSG7_1343
MESAMLASG1_0952
MIGMetig_0396
MMPMMP0920(ahcY)
MMQMmarC5_0727
MMXMmarC6_1735
MMZMmarC7_0167
MMDGYY_05320
MMAKMMKA1_10180(ahcY)
MMAOMMOS7_09960(ahcY)
MMADMMJJ_00710(ahcY)
MAEMaeo_0674
MVNMevan_0213
MVOMvol_0942
MOKMetok_1428
METFCFE53_02135
MTHMTH_1636
MMGMTBMA_c02210(ahcY)
MWOMWSIV6_0182(sahH)
MTEEMTTB_13860
METCMTCT_1495
METEtca_01586(ahcY)
METZMETMT2_1475
METKFVF72_03445
MTHMFZP57_00800
METJFZP68_05810
MSTMsp_1085(ahcY)
METBAW729_03875 AW729_10400
MEISPXD04_02185
MRUmru_0380(ahcY)
MSIMsm_0727
MEBAbm4_0172(ahcY)
MMILsm9_1954(ahcY1) sm9_2165(ahcY2)
MEYETL18_01045
MOLYLM1_0051
MAROMarbSA_13760
METVK4897_04180
MELMetbo_2065
MEWMSWAN_0575
METHMBMB1_0284(ahcY)
MFCBRM9_1991(ahcY)
MFIDSM1535_0183(ahcY)
MCUBMCBB_0574(ahcY)
MSUBBK009_11585
METNBK008_07160
METTCIT01_06865
METOCIT02_05465
MEMEHYG87_07585
MFEGGCM10025860_11440
MFVMfer_0970
MKAMK0368
MBAMbar_A3251
MBYMSBRM_2086
MBWMSBRW_1480
MBARMSBR2_0325
MBAKMSBR3_0051
MACMA_1275(ahcY2)
MMAMM_2278
MMAZMmTuc01_2334
MMJMSMAS_2417
MMACMSMAC_2031
MVCMSVAZ_1592
MEKMSKOL_1523
MLSMSLAZ_0771
METMMSMTP_0824
MEFMSWH1_2236
MEQMSWHS_2837
MSJMSSAC_1063
MSZMSSIH_0923
MSWMSSIT_0956
MTHRMSTHT_0993
MTHEMSTHC_2314
MHORMSHOH_1046
MFZAOB57_011500
MBUMbur_1181(ahcY)
MMETMCMEM_1649
MELOJ7W08_07105
MMHMmah_0527
MHAZBHR79_00785
MEVMetev_0785 Metev_0802
MZHMzhil_0500
MPYMpsy_1004
MZIHWN40_03470
MMAVRE476_06715
MSEBRE474_03030
MHZMetho_1915
MEHFMmiHf6_01790(ahcY)
MEESMmiEs2_08060(ahcY)
MEFWF1737_00500
MESBL1S32_07305
 » show all
Reference
1  [PMID:25917907]
  Authors
Miller D, Xu H, White RH
  Title
S-Inosyl-L-Homocysteine Hydrolase, a Novel Enzyme Involved in S-Adenosyl-L-Methionine Recycling.
  Journal
J Bacteriol 197:2284-91 (2015)
DOI:10.1128/JB.00080-15
  Sequence
[mja:MJ_1388]
Other DBs
ExplorEnz - The Enzyme Database: 3.13.1.9
IUBMB Enzyme Nomenclature: 3.13.1.9
ExPASy - ENZYME nomenclature database: 3.13.1.9
BRENDA, the Enzyme Database: 3.13.1.9

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