KEGG   ENZYME: 3.13.1.9
Entry
EC 3.13.1.9                 Enzyme                                 

Name
S-inosyl-L-homocysteine hydrolase;
SIHH
Class
Hydrolases;
Acting on carbon-sulfur bonds;
Acting on carbon-sulfur bonds (only sub-subclass identified to date)
Sysname
S-inosyl-L-homocysteine hydrolase (inosine-forming)
Reaction(IUBMB)
S-inosyl-L-homocysteine + H2O = inosine + L-homocysteine [RN:R12588]
Reaction(KEGG)
R12588
Substrate
S-inosyl-L-homocysteine [CPD:C03431];
H2O [CPD:C00001]
Product
inosine [CPD:C00294];
L-homocysteine [CPD:C00155]
Comment
The enzyme, characterized from the methanogenic archaeon Methanocaldococcus jannaschii, binds an NAD+ cofactor. It participates in an alternative pathway for the regeneration of S-adenosyl-L-methionine from S-adenosyl-L-homocysteine that involves the deamination of the latter to S-inosyl-L-homocysteine.
History
EC 3.13.1.9 created 2020
Reference
1  [PMID:25917907]
  Authors
Miller D, Xu H, White RH
  Title
S-Inosyl-L-Homocysteine Hydrolase, a Novel Enzyme Involved in S-Adenosyl-L-Methionine Recycling.
  Journal
J Bacteriol 197:2284-91 (2015)
DOI:10.1128/JB.00080-15
  Sequence
[mja:MJ_1388]
Other DBs
ExplorEnz - The Enzyme Database: 3.13.1.9
IUBMB Enzyme Nomenclature: 3.13.1.9
ExPASy - ENZYME nomenclature database: 3.13.1.9
BRENDA, the Enzyme Database: 3.13.1.9

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