| Entry |
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| Name |
glycosylceramidase;
phlorizin hydrolase;
phloretin-glucosidase;
glycosyl ceramide glycosylhydrolase;
cerebrosidase;
phloridzin beta-glucosidase;
lactase-phlorizin hydrolase;
phloridzin glucosidase
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| Class |
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
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| Sysname |
glycosyl-N-acylsphingosine glycohydrolase
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| Reaction(IUBMB) |
a glycosyl-N-acylsphingosine + H2O = a ceramide + a sugar [RN: R01501]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Broad specificity [cf. EC 3.2.1.45 (glucosylceramidase) and EC 3.2.1.46 (galactosylceramidase)]. Also hydrolyses phlorizin to phloretin and glucose. The intestinal enzyme is a complex that also catalyses the reaction of EC 3.2.1.108 lactase.
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| History |
EC 3.2.1.62 created 1972, modified 1976
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| Orthology |
| K01229 | lactase-phlorizin hydrolase |
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| Genes |
» show all
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| Reference |
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| Authors |
Leese HJ, Semenza G. |
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| Title |
On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase. |
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| Journal |
J Biol Chem 248:8170-3 (1973) |
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| Reference |
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| Authors |
Lorenz-Meyer H, Blum AL, Haemmerli HP, Semenza G. |
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| Title |
A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase. |
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| Journal |
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| Reference |
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| Authors |
Malathi P, Crane RK. |
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| Title |
Phlorizin hydrolase: a beta-glucosidase of hamster intestinal brush border membrane. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.2.1.62 |
| ExPASy - ENZYME nomenclature database: | 3.2.1.62 |
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