EC                 Enzyme                                 

interstitial collagenase;
vertebrate collagenase;
matrix metalloproteinase 1
Acting on peptide bonds (peptidases);
Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775!Ile in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue
The enzyme takes its name from substrates of the interstitial collagen group - types I, II and III, all of which are cleaved in the helical domain. However, alpha-macroglobulins are cleaved much more rapidly. The enzyme is widely distributed in vertebrate animals. Type example of peptidase family M10
EC created 1978
K01388  matrix metalloproteinase-1 (interstitial collagenase)
HSA: 4312(MMP1)
PTR: 451510(MMP1)
PPS: 100995251(MMP1)
GGO: 101131051(MMP1)
PON: 100459931(MMP1)
NLE: 100582292(MMP1)
MCC: 703653(MMP1)
MCF: 102142258(MMP1)
CSAB: 103248335(MMP1)
CATY: 105588779(MMP1)
PANU: 101000222(MMP1)
RRO: 104674665(MMP1)
RBB: 108514074(MMP1)
TFN: 117081260(MMP1)
PTEH: 111540071(MMP1)
CJC: 100400727(MMP1)
SBQ: 101051246(MMP1)
MMU: 83995(Mmp1a) 83996(Mmp1b)
MPAH: 110327208
RNO: 300338(Mmp1b) 300339(Mmp1)
CGE: 100754854
PLEU: 114708012(Mmp1)
HGL: 101697620(Mmp1)
CCAN: 109689286(Mmp1)
OCU: 100009110(MMP1)
TUP: 102489479(MMP1) 102490608
CFA: 489428(MMP1)
VVP: 112925907
VLG: 121500184(MMP1)
AML: 100478167(MMP1) 100481181
UMR: 103662453(MMP1) 103662455
MPUF: 101688986(MMP1) 101689258
EJU: 114211360
MLX: 118013155
FCA: 101083957 101084217(MMP1)
PTG: 102951453 102970572(MMP1)
BTA: 112441463 281308(MMP1)
BOM: 102264402(MMP1)
CHX: 102170620(MMP1)
OAS: 101120355(MMP1)
ODA: 120876148(MMP1)
SSC: 397320(MMP1)
CFR: 102517049(MMP1)
CBAI: 105067595(MMP1)
CDK: 105087169(MMP1)
BACU: 103009752(MMP1)
LVE: 103089047(MMP1)
OOR: 101270980(MMP1)
DLE: 111167568(MMP1)
PCAD: 102996438(MMP1)
ECB: 100033896(MMP1)
EPZ: 103552636(MMP1)
EAI: 106843117(MMP1)
MYB: 102253167(MMP1)
MYD: 102770236(MMP1)
MMYO: 118664460(MMP1)
MNA: 107532387(MMP1)
HAI: 109376363
DRO: 112317543(MMP1)
SHON: 118975722(MMP1)
AJM: 119054054(MMP1)
MMF: 118627979(MMP1)
PALE: 102893881(MMP1)
RAY: 107504633(MMP1)
MJV: 108385449(MMP1)
TOD: 119240913(MMP1)
LAV: 100656422(MMP1)
TMU: 101341516
MDO: 100012472(MMP1)
SHR: 100915062(MMP1)
PCW: 110215019
OAA: 100078975
GGA: 418982(MMP1)
PCOC: 116230604
MGP: 100543241
CJO: 107308399
NMEL: 110389878
APLA: 101798298
ACYG: 106034204
TGU: 100218575
LSR: 110470054
SCAN: 103827284
PMOA: 120506634
GFR: 102045551(MMP1)
FAB: 101811360(MMP1)
PHI: 102110938(MMP1)
PMAJ: 107213683
CCAE: 111924335
CCW: 104690063
ETL: 114067040
FPG: 101924590(MMP1)
FCH: 102051111
CLV: 102089808
EGZ: 104128912
NNI: 104023069
ACUN: 113477011
PADL: 103915454
AAM: 106495498
NPD: 112943713
AMJ: 102563438(MMP8) 102563684(MMP1) 109281824
PSS: 102448178
CMY: 114018917
CABI: 116814901
ACS: 100552848
PVT: 110089072
TSR: 106552779
PGUT: 117660852
PMUA: 114595663
ZVI: 118084936
GJA: 107119159
XLA: 108708733(mmp1.L) 495287(mmp1.S)
XTR: 594916(mmp1)
NPR: 108795960
BBEL: 109462004
VEM: 105565628
 » show all
1  [PMID:3009463]
Goldberg GI, Wilhelm SM, Kronberger A, Bauer EA, Grant GA, Eisen AZ.
Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.
J Biol Chem 261:6600-5 (1986)
2  [PMID:3041177]
Birkedal-Hansen H.
Catabolism and turnover of collagens: collagenases.
Methods Enzymol 144:140-71 (1987)
3  [PMID:3032960]
Fields GB, Van Wart HE, Birkedal-Hansen H.
Sequence specificity of human skin fibroblast collagenase. Evidence for the role of collagen structure in determining the collagenase cleavage site.
J Biol Chem 262:6221-6 (1987)
4  [PMID:2462561]
Sottrup-Jensen L, Birkedal-Hansen H.
Human fibroblast collagenase-alpha-macroglobulin interactions. Localization of cleavage sites in the bait regions of five mammalian alpha-macroglobulins.
J Biol Chem 264:393-401 (1989)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 9001-12-1

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