KEGG   ENZYME: 3.5.1.123Help
Entry
EC 3.5.1.123                Enzyme                                 

Name
gamma-glutamylanilide hydrolase;
atdA2 (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
N5-phenyl-L-glutamine amidohydrolase
Reaction(IUBMB)
N5-phenyl-L-glutamine + H2O = L-glutamate + aniline [RN:R11561]
Reaction(KEGG)
Substrate
N5-phenyl-L-glutamine [CPD:C20843];
H2O [CPD:C00001]
Product
L-glutamate [CPD:C00025];
aniline [CPD:C00292]
Comment
The enzyme, characterized from the bacterium Acinetobacter sp. YAA, catalyses the opposite reaction from that cayalysed by EC 6.3.1.18, gamma-glutamylanilide synthase, which is part of an aniline degradation pathway. Its purpose is likely to maintain a low concentration of N5-phenyl-L-glutamine, which is potentially toxic.
History
EC 3.5.1.123 created 2016
Orthology
K21287  gamma-glutamylanilide hydrolase
Reference
1  [PMID:23893114]
  Authors
Takeo M, Ohara A, Sakae S, Okamoto Y, Kitamura C, Kato D, Negoro S
  Title
Function of a glutamine synthetase-like protein in bacterial aniline oxidation via gamma-glutamylanilide.
  Journal
J Bacteriol 195:4406-14 (2013)
DOI:10.1128/JB.00397-13
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.123
IUBMB Enzyme Nomenclature: 3.5.1.123
ExPASy - ENZYME nomenclature database: 3.5.1.123
BRENDA, the Enzyme Database: 3.5.1.123

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