TYRDC-2 (gene name)
L-tyrosine carboxy-lyase (oxidative-deaminating)
L-tyrosine + O2 + H2O = (4-hydroxyphenyl)acetaldehyde + CO2 + NH3 + H2O2 [RN:
A pyridoxal 5'-phosphate protein. The enzyme, isolated from the the plant Petroselinum crispum (parsley), catalyses the production of 4-hydroxyphenylacetaldehyde directly from L-tyrosine. Tyramine is not formed as an intermediate. The enzyme has a low activity with L-dopa (cf. EC
, 3,4-dihydroxyphenylacetaldehyde synthase).
EC 22.214.171.124 created 2017
ec00950 Isoquinoline alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
K22327 4-hydroxyphenylacetaldehyde synthase
Torrens-Spence MP, Gillaspy G, Zhao B, Harich K, White RH, Li J
Biochemical evaluation of a parsley tyrosine decarboxylase results in a novel 4-hydroxyphenylacetaldehyde synthase enzyme.
Torrens-Spence MP, Liu P, Ding H, Harich K, Gillaspy G, Li J
Biochemical evaluation of the decarboxylation and decarboxylation-deamination activities of plant aromatic amino acid decarboxylases.
ExPASy - ENZYME nomenclature database: 126.96.36.199