KEGG   ENZYME: 4.1.1.84
Entry
EC 4.1.1.84                 Enzyme                                 

Name
D-dopachrome decarboxylase;
phenylpyruvate tautomerase II;
D-tautomerase;
D-dopachrome tautomerase;
D-dopachrome carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming)
Reaction(IUBMB)
D-dopachrome = 5,6-dihydroxyindole + CO2 [RN:R07313]
Reaction(KEGG)
R07313
Substrate
D-dopachrome [CPD:C15566]
Product
5,6-dihydroxyindole [CPD:C05578];
CO2 [CPD:C00011]
Comment
This enzyme is specific for D-dopachrome as substrate and belongs to the MIF (macrophage migration inhibitory factor) family of proteins. L-Dopachrome, L- or D-alpha-methyldopachrome and dopaminochrome do not act as substrates (see also EC 5.3.3.12, L-dopachrome isomerase)
History
EC 4.1.1.84 created 2005
Orthology
K10028  D-dopachrome decarboxylase
Genes
HSA: 100037417(DDTL) 1652(DDT) 391322
PTR: 112206708 747265(DDT) 747294
PPS: 100983429 100991346(DDT) 100992828 100994211 100995427
GGO: 101147498 109024612 115931951(DDTL)
PON: 100439570 100446092(DDT)
NLE: 100590066(DDT)
MCC: 699933(DDT)
MCF: 102140262(DDT)
CSAB: 103217148 103223037(DDT)
CATY: 105599380(DDT)
PANU: 101016817
RBB: 108513786 108524064(DDT)
TFN: 117083678
PTEH: 111522014(DDT)
CJC: 100389231(DDT)
SBQ: 101039109(DDT)
MMUR: 105862792
MMU: 13202(Ddt)
MCAL: 110303554
MPAH: 110326959
RNO: 29318(Ddt)
MCOC: 116075259
MUN: 110558689
CGE: 100765163
PLEU: 114696493
NGI: 103738065(Ddt)
HGL: 101717732(Ddt)
OCU: 100337941 100359341(DDT)
TUP: 102483953(DDT)
CFA: 100856501(DDT)
VVP: 112907517
VLG: 121475224
AML: 100476910(DDT)
UMR: 103669207(DDT)
UAH: 113247090
ORO: 101378457(DDT)
ELK: 111142557
MPUF: 101683606
EJU: 114201478(DDT)
MLX: 117999845(DDT)
FCA: 101082852
PTG: 102959720(DDT)
PPAD: 109277452
AJU: 106979699(DDT)
HHV: 120225644
BTA: 101907022 615999(DDT)
BIU: 109571323
CHX: 102181889(DDT)
OAS: 101111911
ODA: 120871297
SSC: 100155535(DDT)
CFR: 102504827
CBAI: 105069336(DDT)
CDK: 105095200
BACU: 103004027
LVE: 103073649
OOR: 101276351(DDT)
DLE: 111163030
PCAD: 102978088(DDT)
ECB: 100053419
EPZ: 103561727(DDT)
EAI: 106847118
MMYO: 118655536
MNA: 107530479(DDT)
HAI: 109394876
DRO: 112310862
SHON: 119001786
AJM: 119059194(DDT)
MMF: 118639981
PALE: 102883548(DDT)
PGIG: 120590074(DDT)
RAY: 107500677(DDT)
MJV: 108387169
TOD: 119233518(DDT)
LAV: 100655770
TMU: 101349989
MDO: 103106482(DDT)
PCW: 110201788(DDT)
OAA: 100092476(DDT)
GGA: 416937(DDT)
PCOC: 116228482(DDT)
CJO: 107321319(DDT)
NMEL: 110406242(DDT)
APLA: 101797488(DDT)
TGU: 100190700(DDT)
LSR: 110481323
SCAN: 103818241
PMOA: 120510335
FAB: 101807708(DDT)
PHI: 102103009(DDT)
PMAJ: 107211467
CCAE: 111936645(DDT)
CCW: 104688585
ETL: 114061510
FCH: 102050365(DDT)
ASN: 102382950
AMJ: 102572983(DDT)
CPOO: 109312822(DDT)
GGN: 109290401(DDT)
PSS: 102445420
CMY: 102941960
CPIC: 101935886
TST: 117888284
CABI: 116837114(DDT)
ACS: 100555560
PMUR: 107291843(DDT)
TSR: 106549266(DDT)
PGUT: 117677954(DDT)
PMUA: 114586956(DDT)
ZVI: 118076001(DDT)
GJA: 107108548(GekBS149P)
XLA: 447275(ddt.S) 494727(ddt.L)
XTR: 550015(ddt)
NPR: 108794802
DRE: 415237(ddt)
SGH: 107576985
IPU: 108279157
PHYP: 113535583
AMEX: 103025217(ddt)
EEE: 113590036
TRU: 101067398
LCO: 104931754
CGOB: 115014246
ELY: 117254806(ddt)
PLEP: 121937693(ddt)
SLUC: 116060581(ddt)
ECRA: 117961472(ddt)
PFLV: 114566813
CUD: 121508261(ddt)
MZE: 101482690
ONL: 100703572
OAU: 116328955(ddt)
OLA: 101166691
OML: 112137411(ddt)
XCO: 114147658
XHE: 116723000
PRET: 103461849(ddt)
CVG: 107104399(ddt)
CTUL: 119795869(ddt)
NFU: 107397169
KMR: 108247357(ddt)
ALIM: 106530573(ddt)
AOCE: 111571199
CSEM: 103384276
POV: 109627283
LCF: 108873416
SDU: 111239861
SLAL: 111647596
XGL: 120799672(ddt)
HCQ: 109521711
BPEC: 110167612(ddt)
MALB: 109972590
SASA: 106562836(DOPD) 106570496(DOPD)
SNH: 120026314(ddt)
ELS: 105030824
SFM: 108933907
PKI: 111842064
AANG: 118212797(ddt)
LOC: 102695813
PSPA: 121296874(ddt)
LCM: 102345613(DDT)
CMK: 103189632(ddt)
RTP: 109915873(ddt)
PVM: 113815342
EAF: 111700826
DSV: 119445799
RMP: 119160004
VDE: 111243803
VJA: 111263797
PCAN: 112561345
GAE: 121374239
 » show all
Reference
1  [PMID:8267597]
  Authors
Odh G, Hindemith A, Rosengren AM, Rosengren E, Rorsman H.
  Title
Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole.
  Journal
Biochem Biophys Res Commun 197:619-24 (1993)
DOI:10.1006/bbrc.1993.2524
  Sequence
[rno:29318]
Reference
2  [PMID:9285056]
  Authors
Yoshida H, Nishihira J, Suzuki M, Hikichi K.
  Title
NMR characterization of physicochemical properties of rat D-dopachrome tautomerase.
  Journal
Biochem Mol Biol Int 42:891-9 (1997)
DOI:10.1080/15216549700203331
  Sequence
[rno:29318]
Reference
3  [PMID:10079069]
  Authors
Sugimoto H, Taniguchi M, Nakagawa A, Tanaka I, Suzuki M, Nishihira J.
  Title
Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution.
  Journal
Biochemistry 38:3268-79 (1999)
DOI:10.1021/bi982184o
  Sequence
[hsa:1652]
Reference
4  [PMID:9480844]
  Authors
Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M.
  Title
Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation.
  Journal
Biochem Biophys Res Commun 243:538-44 (1998)
DOI:10.1006/bbrc.1998.8123
  Sequence
[hsa:1652]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.84
IUBMB Enzyme Nomenclature: 4.1.1.84
ExPASy - ENZYME nomenclature database: 4.1.1.84
BRENDA, the Enzyme Database: 4.1.1.84
CAS: 184111-06-6

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