KEGG   ENZYME: 4.1.1.84
Entry
EC 4.1.1.84                 Enzyme                                 
Name
D-dopachrome decarboxylase;
phenylpyruvate tautomerase II;
D-tautomerase;
D-dopachrome tautomerase;
D-dopachrome carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming)
Reaction(IUBMB)
D-dopachrome = 5,6-dihydroxyindole + CO2 [RN:R07313]
Reaction(KEGG)
R07313
Substrate
D-dopachrome [CPD:C15566]
Product
5,6-dihydroxyindole [CPD:C05578];
CO2 [CPD:C00011]
Comment
This enzyme is specific for D-dopachrome as substrate and belongs to the MIF (macrophage migration inhibitory factor) family of proteins. L-Dopachrome, L- or D-alpha-methyldopachrome and dopaminochrome do not act as substrates (see also EC 5.3.3.12, L-dopachrome isomerase)
History
EC 4.1.1.84 created 2005
Orthology
K10028  D-dopachrome decarboxylase
Genes
HSA100037417(DDTL) 1652(DDT) 391322
PTR112206708 747265(DDT) 747294
PPS100983429(DDTL) 100992828 100995427
GGO101147498 109024612 115931951(DDTL)
PON100439570 100446092(DDT)
NLE100590066(DDT)
MCC699933(DDT)
MCF102140262(DDT)
CSAB103217148 103223037(DDT)
CATY105599380(DDT)
PANU101016817
TGE112632388(DDTL) 112632542(DDT)
RRO104667410 104668729
RBB108513786 108524064(DDT)
TFN117083678
PTEH111522014(DDT)
CJC100389231(DDT)
SBQ101039109(DDT)
CSYR103265544
MMUR105862792
LCAT123625601 123625714(DDT)
OGA100958360
MMU13202(Ddt)
MCAL110303554
MPAH110326959
RNO29318(Ddt)
MCOC116075259
MUN110558689
CGE100765163
MAUA101844189
PLEU114696493
MORG121445618
AAMP119822640
NGI103738065(Ddt)
HGL101717732(Ddt)
CPOC100726700(Ddt)
CCAN109690502 109690503 109690514 109699628 109699632
DORD105984129(Ddt)
DSP122095931
NCAR124991563 124991664
OCU100337941 100359341(DDT)
OPI101531751 101531986
TUP102483953(DDT)
CFA100856501(DDT)
CLUD112676927(DDT)
VVP112907517
VLG121475224
AML100476910(DDT)
UMR103669207(DDT)
UAH113247090
UAR123795619
ELK111142557
LLV125081631
MPUF101683606
ORO101378457(DDT)
EJU114201478(DDT)
ZCA113912686
MLX117999845(DDT)
FCA101082852
PYU121010167
PBG122470368
PTG102959720(DDT)
PPAD109277452
AJU106979699(DDT)
HHV120225644
BTA101907022 615999(DDT)
BOM102276387 102279028
BIU109571323
BBUB102398269 102401890(DDT)
CHX102181889
OAS101111911
ODA120871297
CCAD122419897
SSC100155535(DDT)
CFR102504827
CBAI105069336(DDT)
CDK105095200
VPC102539091 102539339 102541006
BACU103004027
LVE103073649
OOR101276351(DDT)
DLE111163030
PCAD102978088(DDT)
PSIU116764927
ECB100053419
EPZ103561727(DDT)
EAI106847118
MMYO118655536
MNA107530479(DDT)
PKL118710425(DDT)
HAI109394876
DRO112310862
SHON119001786
AJM119059194(DDT)
PDIC114509736
PHAS123806601(DDT)
MMF118639981
RFQ117017222
PALE102883548(DDT)
PGIG120590074(DDT)
PVP105289346
RAY107500677(DDT)
MJV108387169
TOD119233518(DDT)
SARA101543214(DDT)
LAV100655770
TMU101349989
DNM101440189
MDO103106482(DDT)
PCW110201788(DDT)
OAA100092476(DDT)
GGA416937(DDT)
PCOC116228482(DDT)
CJO107321319(DDT)
NMEL110406242(DDT)
APLA101797488(DDT)
AFUL116496311
TGU100190700(DDT)
LSR110481323
SCAN103818241
PMOA120510335
OTC121344501
PRUF121365059
FAB101807708(DDT)
PHI102103009(DDT)
PMAJ107211467
CCAE111936645(DDT)
CCW104688585
ETL114061510
FCH102050365(DDT)
TALA116963778(DDT)
ACHC115345811(DDT)
AROW112970652(DDT)
DNE112992802(DDT)
ASN102382950
AMJ102572983(DDT)
CPOO109312822(DDT)
GGN109290401(DDT)
PSS102445420
CMY102941960(DDT)
CPIC101935886
TST117888284
CABI116837114(DDT)
MRV120386507(DDT)
ACS100555560
SUND121917042
PMUR107291843(DDT)
TSR106549266(DDT)
PGUT117677954(DDT)
VKO123030293
PMUA114586956(DDT)
ZVI118076001(DDT)
GJA107108548(GekBS149P)
STOW125443129(DDT)
XLA447275(ddt.S) 494727(ddt.L)
XTR550015(ddt)
NPR108794802
RTEM120936657 120936662
BBUF120991427(DDT)
BGAR122934274
DRE415237(ddt)
SRX107736937 107737884
SANH107662822 107692330
SGH107576985
CCAR109046036 109046039 109081447
CAUA113038774 113064102
PPRM120490718(ddt)
MAMB125252253(ddt)
IPU108279157(ddt)
PHYP113535583
SMEO124398461(ddt)
TFD113663527(ddt)
AMEX103025217(ddt)
EEE113590036
TRU101067398
TNGGSTEN00026322G001
LCO104931754
CGOB115014246
ELY117254806(ddt)
EFO125886076(ddt)
PLEP121937693(ddt)
SLUC116060581(ddt)
ECRA117961472(ddt)
PFLV114566813
MSAM119914363 119914429
CUD121508261(ddt)
ALAT119027426(ddt)
MZE101482690
ONL100703572
OAU116328955(ddt)
OLA101166691
OML112137411(ddt)
XCO114147658
XHE116723000
PRET103461849(ddt)
PFOR103138118 103138121
PLAI106939669 106944044
PMEI106907686
GAF122839998(ddt)
CVG107104399(ddt)
CTUL119795869(ddt)
GMU124871705(ddt)
NFU107397169
KMR108247357(ddt)
ALIM106530573(ddt)
NWH119419508(ddt)
AOCE111571199
MCEP125003782(ddt)
CSEM103384276
POV109627283
SSEN122761488 122770463(ddt)
HHIP117776222(ddt)
HSP118119061(ddt)
LCF108873416
SDU111239861
SLAL111647596
XGL120799672(ddt)
HCQ109521711
BPEC110167612(ddt)
MALB109972590
BSPL114852234(ddt)
SASA106562836(DOPD) 106570496(DOPD)
OTW112220074(ddt) 112230750
OMY110509492 110523258
OGO123989405(ddt)
ONE115119181
SALP111963780 112080605
SNH120026314(ddt)
CCLU121541101 121582066
ELS105030824
SFM108933907
PKI111842064
AANG118212797(ddt)
LOC102695813
PSPA121296874(ddt)
ARUT117428481 117973390
LCM102345613(DDT)
CMK103189632(ddt)
RTP109915873(ddt)
BFO118425834 118426334
BBEL109462381 109466923 109475256
SPU754012 764606
DPXDAPPUDRAFT_93282
DMK123470747
PVM113815342
PJA122256282
PCHN125033492
PTRU123512799
EAF111700826
DSV119445799
RSAN119389069 119390191
RMP119160004
VDE111243803
VJA111263797
PCAN112561345
BGT106058022 106061999 106079212
GAE121374239
HRF124120281 124120282 124120291
HRJ124259651 124259658 124259668 124259672 124267371 124267372 124267373 124275669
PMAX117333385 117333386
MMER123533903 123534640 123559017
OSN115224448
 » show all
Reference
1  [PMID:8267597]
  Authors
Odh G, Hindemith A, Rosengren AM, Rosengren E, Rorsman H.
  Title
Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole.
  Journal
Biochem Biophys Res Commun 197:619-24 (1993)
DOI:10.1006/bbrc.1993.2524
  Sequence
[rno:29318]
Reference
2  [PMID:9285056]
  Authors
Yoshida H, Nishihira J, Suzuki M, Hikichi K.
  Title
NMR characterization of physicochemical properties of rat D-dopachrome tautomerase.
  Journal
Biochem Mol Biol Int 42:891-9 (1997)
DOI:10.1080/15216549700203331
  Sequence
[rno:29318]
Reference
3  [PMID:10079069]
  Authors
Sugimoto H, Taniguchi M, Nakagawa A, Tanaka I, Suzuki M, Nishihira J.
  Title
Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution.
  Journal
Biochemistry 38:3268-79 (1999)
DOI:10.1021/bi982184o
  Sequence
[hsa:1652]
Reference
4  [PMID:9480844]
  Authors
Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M.
  Title
Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation.
  Journal
Biochem Biophys Res Commun 243:538-44 (1998)
DOI:10.1006/bbrc.1998.8123
  Sequence
[hsa:1652]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.84
IUBMB Enzyme Nomenclature: 4.1.1.84
ExPASy - ENZYME nomenclature database: 4.1.1.84
BRENDA, the Enzyme Database: 4.1.1.84
CAS: 184111-06-6

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