KEGG   ENZYME: 4.1.3.16
Entry
EC 4.1.3.16                 Enzyme                                 
Name
4-hydroxy-2-oxoglutarate aldolase;
2-oxo-4-hydroxyglutarate aldolase;
hydroxyketoglutaric aldolase;
4-hydroxy-2-ketoglutaric aldolase;
2-keto-4-hydroxyglutaric aldolase;
4-hydroxy-2-ketoglutarate aldolase;
2-keto-4-hydroxyglutarate aldolase;
2-oxo-4-hydroxyglutaric aldolase;
DL-4-hydroxy-2-ketoglutarate aldolase;
hydroxyketoglutarate aldolase;
2-keto-4-hydroxybutyrate aldolase;
4-hydroxy-2-oxoglutarate glyoxylate-lyase;
KHGA
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
Sysname
4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
Reaction(IUBMB)
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate [RN:R00470]
Reaction(KEGG)
R00470 > R00471 R10283
Substrate
4-hydroxy-2-oxoglutarate [CPD:C01127]
Product
pyruvate [CPD:C00022];
glyoxylate [CPD:C00048]
Comment
The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. cf. EC 4.1.3.42, (4S)-4-hydroxy-2-oxoglutarate aldolase.
History
EC 4.1.3.16 created 1972 (EC 4.1.2.1 created 1961, incorporated 1972, EC 4.1.2.31 created 1978, incorporated 1982)
Pathway
ec00330  Arginine and proline metabolism
ec00630  Glyoxylate and dicarboxylate metabolism
ec01100  Metabolic pathways
Orthology
K18123  4-hydroxy-2-oxoglutarate aldolase
Genes
HSA112817(HOGA1)
PTR742884(HOGA1)
PPS103782784(HOGA1)
GGO101154009(HOGA1)
PON100171598(HOGA1)
NLE100589206(HOGA1)
MCC706661(HOGA1)
MCF102126728(HOGA1)
MTHB126962086
CSAB103216345(HOGA1)
CATY105581795(HOGA1)
PANU101014787(HOGA1)
TGE112631561(HOGA1)
RRO104682808(HOGA1)
RBB108534698(HOGA1)
TFN117068959(HOGA1)
PTEH111538766(HOGA1)
CJC103796777(HOGA1)
SBQ104650492(HOGA1)
CSYR103264836(HOGA1)
MMUR105873085(HOGA1)
LCAT123650168(HOGA1)
OGA100958797(HOGA1)
MMU67432(Hoga1)
MCAL110285310(Hoga1)
MPAH110333903(Hoga1)
RNO293949(Hoga1)
MCOC116103842(Hoga1)
MUN110564114(Hoga1)
CGE100759109(Hoga1)
MAUA101824115(Hoga1)
PLEU114706886(Hoga1)
MORG121454497(Hoga1)
MFOT126504665
AAMP119822156(Hoga1)
NGI103733196(Hoga1)
HGL101700602(Hoga1)
CPOC100720763(Hoga1)
CCAN109695304(Hoga1)
DORD105986751(Hoga1)
DSP122115913(Hoga1)
NCAR124984723
OCU100344505(HOGA1)
OPI101517296(HOGA1)
TUP102486364(HOGA1)
CFA608755(HOGA1)
CLUD112672141(HOGA1)
VVP112914409(HOGA1)
VLG121483974(HOGA1)
AML100478059(HOGA1)
UMR103674087(HOGA1)
UAH113251791(HOGA1)
UAR123783886(HOGA1)
ELK111145298
LLV125084924
MPUF101693912(HOGA1)
ORO101385318(HOGA1)
EJU114205383(HOGA1)
ZCA113919122(HOGA1)
MLX118024504(HOGA1)
NSU110589086(HOGA1)
FCA101101417(HOGA1)
PYU121037065(HOGA1)
PBG122493090(HOGA1)
LRUF124506708
PTG102965487(HOGA1)
PPAD109272717(HOGA1)
AJU106966929(HOGA1)
HHV120230623(HOGA1)
BTA506001(HOGA1)
BOM102265621(HOGA1)
BIU109552999(HOGA1)
BBUB102398601(HOGA1)
CHX102173994(HOGA1)
OAS101114573(HOGA1)
ODA120873942(HOGA1)
CCAD122446094(HOGA1)
SSC100153961(HOGA1)
CFR102512614(HOGA1)
CBAI105081776(HOGA1)
CDK105084288(HOGA1)
VPC102541568(HOGA1)
BACU103004258(HOGA1)
LVE103077167 103089444(HOGA1)
OOR101271753(HOGA1)
DLE111172427(HOGA1)
PCAD102979032(HOGA1)
PSIU116741875(HOGA1)
ECB100070689(HOGA1)
EPZ103558701(HOGA1)
EAI106844960(HOGA1)
MYB102246939(HOGA1)
MYD102768587(HOGA1)
MMYO118669893(HOGA1)
MLF102427524(HOGA1)
MNA107542604(HOGA1)
PKL118719357(HOGA1)
HAI109379716(HOGA1)
DRO112307109(HOGA1)
SHON118990274(HOGA1)
AJM119044532(HOGA1)
PDIC114495945(HOGA1)
PHAS123828952(HOGA1)
MMF118632358(HOGA1)
RFQ117036234(HOGA1)
PALE102884382(HOGA1)
PGIG120609240(HOGA1)
PVP105301380(HOGA1)
RAY107520438(HOGA1)
MJV108399750(HOGA1)
TOD119233797(HOGA1)
LAV100670230(HOGA1)
TMU101355404
DNM101419181(HOGA1)
MDO100021876(HOGA1)
GAS123238246(HOGA1)
SHR100929176(HOGA1)
PCW110215427(HOGA1)
OAA100088274(HOGA1)
GGA770036(HOGA1)
PCOC116231725(HOGA1)
MGP100548398(HOGA1)
CJO107316003(HOGA1)
NMEL110400352(HOGA1)
ACYG106036839(HOGA1)
AFUL116491080(HOGA1)
TGU100231472(HOGA1)
LSR110473597(HOGA1)
SCAN103813888(HOGA1)
PMOA120502206(HOGA1)
OTC121341648(HOGA1)
PRUF121350021(HOGA1)
GFR102042170(HOGA1)
FAB101806953(HOGA1)
PHI102112987(HOGA1)
PMAJ107206698(HOGA1)
CCAE111931229(HOGA1)
CCW104695887(HOGA1)
CBRC103624537(HOGA1)
ETL114070777(HOGA1)
ZAB102062750(HOGA1)
ACHL103807138(HOGA1)
FPG101920952(HOGA1)
FCH102052298(HOGA1)
CLV102097409(HOGA1)
EGZ104132255(HOGA1)
NNI104012772(HOGA1)
PLET104621767(HOGA1)
ACUN113481407(HOGA1)
TALA116962067(HOGA1)
PADL103916280(HOGA1)
AFOR103897686(HOGA1)
ACHC115348491(HOGA1)
CCRI104160613(HOGA1)
CSTI104558098(HOGA1)
EHS104511181(HOGA1)
CMAC104486380(HOGA1)
MUI104544738(HOGA1)
LDI104355014(HOGA1)
MNB103775287(HOGA1)
OHA104332280(HOGA1)
NNT104401870(HOGA1)
DPUB104307074(HOGA1)
PGUU104471445(HOGA1)
ACAR104531510(HOGA1)
AVIT104274804(HOGA1)
CVF104288806(HOGA1)
AROW112968046(HOGA1)
NPD112957175(HOGA1)
DNE112984791(HOGA1)
ASN102382587(HOGA1)
AMJ102563093(HOGA1)
CPOO109324348(HOGA1)
GGN109287532(HOGA1)
CMY114018236(HOGA1)
CPIC103307603(HOGA1)
TST117880415(HOGA1)
CABI116822802(HOGA1)
ACS100566929(hoga1)
PVT110089167(HOGA1)
SUND121926128(HOGA1)
PBI103053263(HOGA1)
PMUR107295219(HOGA1)
CTIG120302535(HOGA1)
TSR106549035(HOGA1)
PGUT117678595(HOGA1)
VKO123026676(HOGA1)
PMUA114597588(HOGA1)
ZVI118093538(HOGA1)
GJA107114457(HOGA1)
STOW125438115(HOGA1)
XLA495193(hoga1.L)
XTR496669(hoga1)
NPR108792933(HOGA1)
RTEM120946635(HOGA1)
BBUF121004610(HOGA1)
BGAR122941075 122942538
DRE405806(hoga1)
SRX107706114
SANH107663482(hoga1)
SGH107551368 107588470(hoga1)
CCAR109069442
CAUA113039744(hoga1)
PPRM120468726 120468763(hoga1)
MAMB125254424(hoga1)
IPU108259603(hoga1)
PHYP113546731(hoga1)
SMEO124379684(hoga1)
TFD113656985(hoga1)
AMEX103023796(hoga1)
EEE113577699(hoga1)
TRU101061435(hoga1)
TNGGSTEN00009068G001
LCO104930035(hoga1)
NCC104953008(hoga1)
ELY117255225(hoga1)
EFO125885368(hoga1)
SLUC116049892(hoga1)
ECRA117962147(hoga1)
PFLV114570716(hoga1)
GAT120813082(hoga1)
PPUG119218010(hoga1)
MSAM119898305(hoga1)
CUD121508633(hoga1)
ALAT119019204(hoga1)
MZE101479315(hoga1)
ONL100690946(hoga1)
OAU116315581(hoga1)
OLA101161460(hoga1)
OML112156927(hoga1)
XMA102230783(hoga1)
XCO114145238(hoga1)
XHE116720256(hoga1)
PRET103470116(hoga1)
PFOR103154489(hoga1)
PLAI106948744(hoga1)
PMEI106927085(hoga1)
GAF122830294(hoga1)
CVG107081958(hoga1)
CTUL119798502(hoga1)
GMU124869120(hoga1)
NFU107382406(hoga1)
KMR108247450(hoga1)
ALIM106537034(hoga1)
NWH119422511 119423198
AOCE111580411(hoga1)
MCEP125002125(hoga1)
CSEM103383203(hoga1)
POV109645371
SSEN122771614(hoga1)
HHIP117760502(hoga1)
HSP118099088(hoga1)
LCF108880833
SDU111235845(hoga1)
SLAL111665639(hoga1)
XGL120800280(hoga1)
HCQ109511381(hoga1)
BPEC110155940(hoga1)
MALB109952000(hoga1)
BSPL114861357(hoga1)
SASA106591168(hoga1) 106591313
STRU115178813(hoga1)
OTW112230192(hoga1)
OMY110485610 110487262
OGO124018276(hoga1)
ONE115127679(hoga1)
SALP112079381(hoga1)
SNH120032829(hoga1) 120032838
CCLU121533209(hoga1)
ELS105006876(hoga1)
SFM108924852(hoga1)
PKI111848362(hoga1)
AANG118219744(hoga1)
LOC102687344(hoga1)
PSPA121321919(hoga1)
ARUT117415418(hoga1)
LCM102362318(HOGA1)
CMK103172525(hoga1)
RTP109921722(hoga1)
BFO118413704 118414415
BBEL109485298
CIN100181036
SCLV120331743
SPU579934
APLC110981286
SKO100372772
BCOO119068060
API100570569
DNX107163989
AGS114132054
RMD113549091
BTAB109031207 109033146 109037695
DCI103507739 103520261
CLEC106664885 106665585
HHAL106681743
NLU111064155
ZNE110831450
CSEC111864684
FCD110856855
DPXDAPPUDRAFT_52277
DMK116921690
PVM113818492
PJA122267255
PCHN125038676
HAME121871046
PCLA123774790
PTRU123517476
HAZT108672513
EAF111698923
PPOI119112206
DSV119442461
RSAN119388374
RMP119159482
CSCU111618478
PTEP107438884
SDM118202582
HROHELRODRAFT_157064
LGILOTGIDRAFT_211287
PCAN112565420
BGT106072266
GAE121383851
HRF124138672
HRJ124264316
CRG105328725
MYI110455405
PMAX117339557
MMER123547812
OBI106884306
OSN115232061
LAK106170963
NVE5520994
EPA110231654
ATEN116307006
ADF107337820
AMIL114962597
PDAM113686876
SPIS111324439
DGT114515751
XEN124444846
HMG100199549
QSU111991330
NCRNCU04744 NCU05977
NTENEUTE1DRAFT148948(NEUTE1DRAFT_148948) NEUTE1DRAFT48910(NEUTE1DRAFT_48910)
SMPSMAC_03823 SMAC_07903
PANPODANSg09878 PODANSg3113 PODANSg3131
TTTTHITE_2041371 THITE_2110019 THITE_2122366
MTMMYCTH_82456
CTHRCTHT_0040680 CTHT_0055950
MGRMGG_05159 MGG_07933 MGG_08615 MGG_16966
PPEIPpBr36_03531 PpBr36_03838 PpBr36_03851
TMNUCRPA7_1105 UCRPA7_1858 UCRPA7_4535 UCRPA7_6686 UCRPA7_7278 UCRPA7_729 UCRPA7_7973
SSCKSPSK_00143 SPSK_01848 SPSK_03433 SPSK_03475 SPSK_07785
FGRFGSG_01813 FGSG_02063 FGSG_03069 FGSG_03647 FGSG_05048 FGSG_09521
FPUFPSE_01888 FPSE_02157 FPSE_03347 FPSE_04939 FPSE_05154 FPSE_11340
FVRFVEG_04070 FVEG_06008 FVEG_07522 FVEG_07725 FVEG_08807 FVEG_10721
FOXFOXG_04402 FOXG_04587 FOXG_06217 FOXG_08665 FOXG_09663 FOXG_12147
NHENECHADRAFT_103547 NECHADRAFT_41228 NECHADRAFT_51004 NECHADRAFT_53351 NECHADRAFT_73269 NECHADRAFT_75207 NECHADRAFT_82289 NECHADRAFT_99111
TRETRIREDRAFT_122582 TRIREDRAFT_2036 TRIREDRAFT_3717 TRIREDRAFT_53123
TRRM419DRAFT_129606 M419DRAFT_131928 M419DRAFT_141790 M419DRAFT_88777
MAWMAC_01236 MAC_04491 MAC_09455
MAJMAA_00627 MAA_07813 MAA_09251
CMTCCM_05289 CCM_07759 CCM_07861
PLJVFPFJ_01790 VFPFJ_02536 VFPFJ_03142 VFPFJ_07463 VFPFJ_09031
VALVDBG_01853 VDBG_03325 VDBG_05072 VDBG_08158 VDBG_09109 VDBG_09557
VDAVDAG_01702 VDAG_02228 VDAG_04788 VDAG_07257 VDAG_10050 VDAG_10512
CFJCFIO01_04102 CFIO01_04988 CFIO01_05142 CFIO01_05423 CFIO01_08392 CFIO01_08695 CFIO01_12712 CFIO01_13735
CLUPCLUP02_01428 CLUP02_02715 CLUP02_15676 CLUP02_16425 CLUP02_16731
CHIGCH63R_02055 CH63R_05135 CH63R_06511 CH63R_10333 CH63R_10575 CH63R_11316 CH63R_14095
ELAUCREL1_1 UCREL1_10034 UCREL1_3023 UCREL1_4493 UCREL1_7875 UCREL1_8344 UCREL1_9767
PFYPFICI_02155 PFICI_06710 PFICI_10660 PFICI_11183 PFICI_13580 PFICI_14195
SSLSS1G_02917 SS1G_04053
BFUBCIN_01g06600 BCIN_06g05360
MBEMBM_05778
PSCOLY89DRAFT_58302 LY89DRAFT_587194 LY89DRAFT_685858 LY89DRAFT_694995 LY89DRAFT_705574
GLZGLAREA_07669
ANIAN1503.2
AFMAFUA_2G01230 AFUA_4G08690 AFUA_8G05040
ACTACLA_048040 ACLA_058440 ACLA_072950 ACLA_094540
NFINFIA_033530 NFIA_089760 NFIA_097850 NFIA_107490
AORAO090005000638 AO090701000399
ANGANI_1_1446134(An15g04230) ANI_1_1986144(An16g07700) ANI_1_26174(An10g00330)
AFVAFLA_003449 AFLA_004914
ALUCAKAW2_50024S AKAW2_70609S AKAW2_71046S
ACHEACHE_40068S ACHE_60607S
APUUAPUU_11117S APUU_21711S APUU_40056A APUU_60006S APUU_60054S
PCSPc20g10350(dap) Pc21g12190 Pc22g00130 Pc22g00220
PDPPDIP_02670 PDIP_46650
TMFPMAA_009780 PMAA_021640 PMAA_039050 PMAA_084040 PMAA_099590 PMAA_100580
TRGTRUGW13939_01370 TRUGW13939_02223 TRUGW13939_02289 TRUGW13939_03930 TRUGW13939_04239 TRUGW13939_07477 TRUGW13939_08086 TRUGW13939_08229 TRUGW13939_08539 TRUGW13939_09259 TRUGW13939_10146
CIMCIMG_00151 CIMG_06885
CPWCPC735_032800 CPC735_059910
UREUREG_00255 UREG_03604
PBLPAAG_03143 PAAG_03793
PBNPADG_03024 PADG_03296
ABEARB_01658 ARB_05761
TVETRV_00049 TRV_04481
AJEHCAG_01713 HCAG_07219
BGHBDBG_00749 BDBG_02384 BDBG_03560
PNOSNOG_03839 SNOG_04544 SNOG_15818
PTEPTT_08311 PTT_12228 PTT_17993
BZECOCCADRAFT_109610 COCCADRAFT_37284 COCCADRAFT_9535
BSCCOCSADRAFT_271752 COCSADRAFT_33387 COCSADRAFT_335849
BORCOCMIDRAFT_23190 COCMIDRAFT_26603 COCMIDRAFT_8673
AALTCC77DRAFT_1017551 CC77DRAFT_1040104 CC77DRAFT_840448
ZTRMYCGRDRAFT_66153
PFJMYCFIDRAFT_29231
FFUCLAFUR5_02034 CLAFUR5_09491
BCOMBAUCODRAFT_150164 BAUCODRAFT_558779 BAUCODRAFT_573577 BAUCODRAFT_68239
NPAUCRNP2_1393 UCRNP2_68 UCRNP2_7892 UCRNP2_894
TMLGSTUM_00008462001
CNECNC03990
CNBCNBC3190
CNGCNAG_02781
CGICGB_C6100W CGB_G2440W
TMSTREMEDRAFT_70222
TASAA1Q1_07016
TVSTRAVEDRAFT_145691 TRAVEDRAFT_29711 TRAVEDRAFT_62801
DSQDICSQDRAFT_129292 DICSQDRAFT_152921
PCOPHACADRAFT_166860 PHACADRAFT_252672 PHACADRAFT_255535 PHACADRAFT_257602
SHSSTEHIDRAFT_119341 STEHIDRAFT_49383
HIRHETIRDRAFT_157267 HETIRDRAFT_412119 HETIRDRAFT_448998
PSQPUNSTDRAFT_52021 PUNSTDRAFT_70957
ADLAURDEDRAFT_110014 AURDEDRAFT_148009
FMEFOMMEDRAFT_131642
GTRGLOTRDRAFT_116882
LBCLACBIDRAFT_189233
CCICC1G_04219 CC1G_06285
ABPAGABI1DRAFT111212(AGABI1DRAFT_111212) AGABI1DRAFT114952(AGABI1DRAFT_114952)
ABVAGABI2DRAFT190432(AGABI2DRAFT_190432) AGABI2DRAFT191181(AGABI2DRAFT_191181)
PCUBJR316_0006081
MRRMoror_14079 Moror_4689 Moror_8005
MOREE1B28_006317 E1B28_007270 E1B28_008904
SCMSCHCO_02605035(SCHCODRAFT_02605035)
CPUTCONPUDRAFT_129595 CONPUDRAFT_51541
SLASERLADRAFT_361556 SERLADRAFT_454235
WSEWALSEDRAFT_29927 WALSEDRAFT_61673
WICJ056_003032
UMAUMAG_04667
LIPLI0108(dapA)
LIRLAW_00107(dapA_1)
DHDDhaf_1978
DDLDesdi_0801
DORDesor_3029
TFRBR63_09785(dapA)
TMRTmar_1165
THEFE1B22_09485
THEPDYI95_005800
IBUIB211_03323c
TEXTeth514_1917
THXThet_1017
TITThit_1575
TWIThewi_1732
TTOThethe_02138
MASMahau_1310
KMEH0A61_00412(dapA_2)
STISthe_0488
KBSEPA93_24885
TRATrad_0621
TTLTtJL18_1311
TSCTSC_c08910(dapA1)
THCTCCBUS3UF1_14710
TOSTheos_1413
MRBMrub_2327
MREK649_10895
MSVMesil_2236
LCREPla8534_42110(dapA_3)
BHCJFL75_14300
ABAAcid345_2666
ACAACP_0327
ACMAciX9_1581
GMAAciX8_1331
GRWFTO74_12010
TRSTerro_1985 Terro_2351
TALBFTW19_14730
ABASACPOL_6664
EDAGWR55_03525
SUSAcid_1067
PFERIRI77_34435
ABACLuPra_06084(dapA_3)
ACOAmico_1829
TLITlie_1310
AMOAnamo_0048
GAUGAU_0904
GPHGEMMAAP_05215
GBAJ421_2804
HLOJ0X27_13620
 » show all
Reference
1  [PMID:14089442]
  Authors
KURATOMI K, FUKUNAGA K.
  Title
THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT LIVER. I. ENZYMIC SYNTHESIS OF GAMMA-HYDROXY-ALPHA-KETOGLUTARATE FROM PYRUVATE AND GLYOXYLATE.
  Journal
Biochim Biophys Acta 78:617-28 (1963)
DOI:10.1016/0006-3002(63)91027-8
Reference
2  [PMID:5780845]
  Authors
Kobes RD, Dekker EE
  Title
2-Keto-4-hydroxyglutarate aldolase of bovine liver. Purification, criteria of purity, and general properties.
  Journal
J Biol Chem 244:1919-25 (1969)
Reference
3  [PMID:5580656]
  Authors
Lane RS, Shapley A, Dekker EE.
  Title
2-keto-4-hydroxybutyrate aldolase. Identification as 2-keto-4-hydroxyglutarate aldolase, catalytic properties, and role in the mammalian metabolism of L-homoserine.
  Journal
Biochemistry 10:1353-64 (1971)
DOI:10.1021/bi00784a013
Reference
4  [PMID:3942759]
  Authors
Scholtz JM, Schuster SM
  Title
Regulation of rat liver 4-hydroxy-2-ketoglutarate aldolase.
  Journal
Biochim Biophys Acta 869:192-6 (1986)
DOI:10.1016/0167-4838(86)90294-3
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.16
IUBMB Enzyme Nomenclature: 4.1.3.16
ExPASy - ENZYME nomenclature database: 4.1.3.16
BRENDA, the Enzyme Database: 4.1.3.16
CAS: 9030-81-3

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