baiE (gene name);
7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming);
BA7 alpha dehydratase
7alpha,12alpha-dihydroxy-3-oxochol-4-enoyl-CoA hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoyl-CoA-forming)
7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O [RN:
This enzyme, characterized from the gut bacterium Clostridium scindens (previously known as Eubacterium sp. strain VPI 12708), participates in the 7-dehydroxylation process associated with bile acid degradation.
EC 22.214.171.124 created 2005, modified 2016
ec00121 Secondary bile acid biosynthesis
K15872 bile-acid 7alpha-dehydratase
Mallonee DH, White WB, Hylemon PB
Cloning and sequencing of a bile acid-inducible operon from Eubacterium sp. strain VPI 12708.
Dawson JA, Mallonee DH, Bjorkhem I, Hylemon PB
Expression and characterization of a C24 bile acid 7 alpha-dehydratase from Eubacterium sp. strain VPI 12708 in Escherichia coli.
J Lipid Res 37:1258-67 (1996)
Bhowmik S, Chiu HP, Jones DH, Chiu HJ, Miller MD, Xu Q, Farr CL, Ridlon JM, Wells JE, Elsliger MA, Wilson IA, Hylemon PB, Lesley SA
Structure and functional characterization of a bile acid 7alpha dehydratase BaiE in secondary bile acid synthesis.
ExPASy - ENZYME nomenclature database: 126.96.36.199