KEGG   ENZYME: 4.2.1.158
Entry
EC 4.2.1.158                Enzyme                                 
Name
galactarate dehydratase (D-threo-forming)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
galactarate hydro-lyase (3-deoxy-D-threo-hex-2-ulosarate-forming)
Reaction(IUBMB)
galactarate = (2S,3R)-2,3-dihydroxy-5-oxohexanedioate + H2O [RN:R11077]
Reaction(KEGG)
R11077
Substrate
galactarate [CPD:C00879]
Product
(2S,3R)-2,3-dihydroxy-5-oxohexanedioate [CPD:C21091];
H2O [CPD:C00001]
Comment
The enzyme has been characterized from the bacterium Oceanobacillus iheyensis. cf. EC 4.2.1.42, galactarate dehydratase.
History
EC 4.2.1.158 created 2015
Orthology
K20022  galactarate dehydratase (D-threo-forming)
Genes
MHAR: L1P08_01550
BCL: ABC3013
OIH: OB2843
PMS: KNP414_06295
PMQ: PM3016_5909
PMW: B2K_30050
PNP: IJ22_08470
ACUR: JZ785_07290
RHAL: LQF10_17540
RSUA: LQF12_15070
Reference
1  [PMID:19883118]
  Authors
Rakus JF, Kalyanaraman C, Fedorov AA, Fedorov EV, Mills-Groninger FP, Toro R, Bonanno J, Bain K, Sauder JM, Burley SK, Almo SC, Jacobson MP, Gerlt JA
  Title
Computation-facilitated assignment of the function in the enolase superfamily: a regiochemically distinct galactarate dehydratase from Oceanobacillus iheyensis .
  Journal
Biochemistry 48:11546-58 (2009)
DOI:10.1021/bi901731c
  Sequence
[oih:OB2843]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.158
IUBMB Enzyme Nomenclature: 4.2.1.158
ExPASy - ENZYME nomenclature database: 4.2.1.158
BRENDA, the Enzyme Database: 4.2.1.158

  All links  
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (10)   
Protein sequence (3)   
   UniProt (2)   
   SWISS-PROT (1)   
Protein domain (7)   
   InterPro (7)   
All databases (26)   

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