Entry
Name
galactarate dehydratase;
D-galactarate hydro-lyase;
D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming);
talrD (gene name)/galrD (gene name);
galactarate dehydratase (L-threo-forming)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)
Reaction(IUBMB)
galactarate = (2R,3S)-2,3-dihydroxy-5-oxohexanedioate + H2O [RN:
R05608 ]
Reaction(KEGG)
Substrate
Product
(2R,3S)-2,3-dihydroxy-5-oxohexanedioate [CPD:
C00679 ];
H2O [CPD:
C00001 ]
Comment
The enzyme from the bacterium Escherichia coli is specific for galactarate [2], while the enzyme from Salmonella typhimurium also has activity with L-talarate (cf. EC
4.2.1.156 , L-talarate dehydratase) [3]. cf. EC
4.2.1.158 , galactarate dehydratase (D-threo-forming).
History
EC 4.2.1.42 created 1972, modified 2015
Pathway
ec00053 Ascorbate and aldarate metabolism
Orthology
K01708 galactarate dehydratase
K20023 L-talarate/galactarate dehydratase
Genes
ECOO : ECRM13514_4089(yhaG)
ECOH : ECRM13516_3893(yhaG)
ECW : EcE24377A_3608(garD)
EDJ : ECDH1ME8569_3019(garD)
ECOI : ECOPMV1_03439(garD_5)
EFE : EFER_1473 EFER_4365(garD)
STY : STY3432(garD) STY4099
SEX : STBHUCCB_33530 STBHUCCB_40340
SENT : TY21A_16065 TY21A_19420
STM : STM3250(garD) STM3697
SEO : STM14_3935(garD) STM14_4457
SEV : STMMW_32501 STMMW_36851
SEY : SL1344_3223(garD) SL1344_3662
SEM : STMDT12_C33070 STMDT12_C37540
SEJ : STMUK_3238(garD) STMUK_3683
SEB : STM474_3407(garD) STM474_3870
SEF : UMN798_3538(garD) UMN798_4016
SETU : STU288_16455(garD) STU288_18680
SETC : CFSAN001921_00760(garD) CFSAN001921_21960
SENR : STMDT2_31431(garD) STMDT2_35811
SEEN : SE451236_02435 SE451236_22375(garD)
SPQ : SPAB_04058 SPAB_04594
SEH : SeHA_C3550(garD) SeHA_C4022
SENH : CFSAN002069_13555 CFSAN002069_15890(garD)
SEEH : SEEH1578_02395(garD) SEEH1578_04570
SEE : SNSL254_A3513(garD) SNSL254_A3977
SENN : SN31241_1830 SN31241_43800
SEA : SeAg_B3442(garD) SeAg_B3915
SENS : Q786_15855(garD) Q786_18075
SEL : SPUL_3264(garD) SPUL_3867
SEGA : SPUCDC_3250(garD) SPUCDC_3853
SET : SEN3090(garD) SEN3519
SENA : AU38_15735(garD) AU38_17975
SENO : AU37_15935(garD) AU37_18165
SENV : AU39_15930(garD) AU39_18170
SENQ : AU40_17740(garD) AU40_20245
SENL : IY59_16335(garD) IY59_18610
SENJ : CFSAN001992_17285(garD)
SEEC : CFSAN002050_23240(garD) CFSAN002050_25455
SEEB : SEEB0189_001380 SEEB0189_003620(garD)
SEEP : I137_15565(garD) I137_18555
SENB : BN855_33310(garD) BN855_37920
SENE : IA1_15725(garD) IA1_17970
SENC : SEET0819_02245 SEET0819_23255(garD)
SES : SARI_03944 SARI_04366
SALZ : EOS98_00750 EOS98_03005(garD)
ENR : H650_02680 H650_12210(garD)
ENF : AKI40_0630 AKI40_3173
KPE : KPK_0570(garD) KPK_2460
KPK : A593_07960(garD) A593_24325
KVD : KR75_05230 KR75_22265
KVQ : SP68_03000 SP68_11850
KOY : J415_06285(garD) J415_17725
KOM : HR38_02040(garD) HR38_18235
KOK : KONIH1_13975 KONIH1_26000(garD)
KOC : AB185_10320(garD) AB185_22085
KQV : B8P98_03090(garD) B8P98_13040
KLL : BJF97_14135 BJF97_25655
KLW : DA718_03515(garD) DA718_13910
KAR : LGL98_02940(garD) LGL98_11520
KGR : JJJ10_03140(garD) JJJ10_14785
KPAS : LUW96_03380(garD) LUW96_20430
KLC : K7H21_03135(garD) K7H21_13640
KLM : BWI76_13570 BWI76_24840
REE : electrica_00550(garD)
RON : TE10_13620 TE10_24680(garD)
RPLN : B1209_02945 B1209_14000
RTG : NCTC13098_00755(garD_2) NCTC13098_03845(rhmD_2)
CRO : ROD_42111 ROD_47521(garD)
CBRA : A6J81_04480 A6J81_20255(garD)
CWE : CO701_00830(garD) CO701_10195
CYO : CD187_02915(garD) CD187_11675
CPOT : FOB25_14270(garD) FOB25_23225
CFQ : C2U38_11960 C2U38_22600(garD)
CAMA : F384_07290 F384_17190(garD)
CIF : AL515_12340 AL515_20525(garD)
CFAR : CI104_03115(garD) CI104_13290
CPAR : CUC49_08055 CUC49_16265(garD)
CTEL : GBC03_17215 GBC03_27765(garD)
CARS : E1B03_13505 E1B03_23130(garD)
CIB : HF677_002735(garD) HF677_011720
CLAP : NCTC11466_04590(garD_2)
KSA : C813_03310 C813_18435
KOR : AWR26_02880(garD) AWR26_12660
KRD : A3780_11390 A3780_21840(garD)
KPSE : IP581_11405 IP581_20305(garD)
KOO : O9K67_03110(garD) O9K67_12340
KOU : C0557_12245 C0557_23235(garD)
KIE : NCTC12125_04504(garD_1)
BAGE : BADSM9389_36270(garD)
SYM : K6K13_04780 K6K13_17075(garD)
ASUB : NLZ15_06270 NLZ15_19380(garD)
KIN : AB182_12420 AB182_28640(garD)
PDZ : HHA33_05385(garD) HHA33_15045
METY : MRY16398_06320(garD) MRY16398_29200
PSGC : G163CM_11410 G163CM_41820(garD)
SUPE : P0H77_10915 P0H77_19700(garD)
TOE : QMG90_02440 QMG90_18885(garD)
EBC : C2U52_11560(garD) C2U52_23330
SFJ : SAMEA4384070_0815(garD_1)
SOF : NCTC11214_00734(garD_1)
SERA : Ser39006_007210(garD)
ECA : ECA0998 ECA3578(garD)
PATR : EV46_05095 EV46_17755(garD)
PATO : GZ59_10330(lfeW) GZ59_36020(garD)
PCC : PCC21_009410 PCC21_034020
PWA : Pecwa_3386 Pecwa_3558
PPAR : A8F97_00840 A8F97_01720
PWS : A7983_02890 A7983_13740
PPOA : BJK05_11995 BJK05_21625
PBRA : B5S52_04680 B5S52_16950
PPUJ : E2566_05250 E2566_17110(garD)
PARI : I2D83_04840(garD) I2D83_17385
PAQU : DMB82_0004445(garD)
PVZ : OA04_10500(talD) OA04_36670(garD)
PPAV : LOZ86_04880(garD) LOZ86_17050
PCAC : OI450_13865(garD) OI450_16390
PACB : M9782_07155 M9782_19395(garD)
PARL : PEC302110_08910 PEC302110_31650(garD)
PPEU : DUT67_04325(garD) DUT67_17235
DDD : Dda3937_00185(garD) Dda3937_02647(lfeW)
DZE : Dd1591_0806 Dd1591_3561
DDC : Dd586_0512 Dd586_3337
DZC : W909_02680 W909_16030(garD)
DSO : A4U42_04610(garD) A4U42_11735
CED : LH89_09595 LH89_17020(garD)
DFN : CVE23_02720 CVE23_17805(garD)
DIC : Dpoa569_000776(garD)
DDA : Dd703_0840 Dd703_2476
SOD : Sant_2144 Sant_3271(garD)
PAM : PANA_1262(mdlA) PANA_3087(garD)
PLF : PANA5342_0946(garD) PANA5342_3023(mdlA1)
PAJ : PAJ_0583(mdlA) PAJ_2361(garD)
PAQ : PAGR_g0948 PAGR_g2896
PAO : Pat9b_3104 Pat9b_5240
PPHO : CTZ24_12960(garD) CTZ24_20280
LRI : NCTC12151_02560(garD_2)
XFU : XFF4834R_chr12580(garD)
VOS : KNV97_00145(garD) KNV97_05945(garD)
PFV : Psefu_0996 Psefu_1619
POR : APT59_05475 APT59_21025(garD)
PVD : CFBP1590__4628(garD)
PFE : PSF113_0914 PSF113_5900
PZA : HU749_000770 HU749_005410(garD)
PCG : AXG94_15245 AXG94_19690(garD)
PMUD : NCTC8068_04450(garD)
PFW : PF1751_v1c08220(garD)
PPUU : PputUW4_00755(garD)
PSES : PSCI_1981 PSCI_2638(garD)
PALL : UYA_05665 UYA_05710
PPSH : G5J76_15315 G5J76_23810(garD)
PSEJ : HNQ25_18420(garD) HNQ25_18460 HNQ25_18470
PVK : EPZ47_04365(garD) EPZ47_29775
PEZ : HWQ56_10270 HWQ56_24375(garD)
PKH : JLK41_06330 JLK41_06340 JLK41_06380(garD)
PTY : JWV26_16575 JWV26_16625(garD)
PMAO : PMYSY11_1234 PMYSY11_1254(garD)
PVW : HU752_019425(garD) HU752_021755
PTRT : HU722_0005500(garD)
PXA : KSS93_15770 KSS93_19110(garD)
PPRG : HU725_011800(garD) HU725_022740
PFAK : KSS94_11635 KSS94_12435 KSS94_14775(garD)
PALV : KSS97_05360(garD) KSS97_25235
PCAS : LOY40_04295(garD) LOY40_25120
PTAE : NCTC10697_03876(garD_3)
PCHE : QYM18_13685 QYM18_13730(garD)
PPAO : K3169_16065 K3169_25595(garD)
PRHZ : CRX69_08325(garD) CRX69_23470
PSLP : BHQ29_16320 BHQ29_16365
PBEJ : PSH84_09035(garD) PSH84_28615
PSR : PSTAA_3995 PSTAA_4005
PSC : A458_01930 A458_01970(garD)
PSH : Psest_0369 Psest_0377
PSTT : CH92_11115 CH92_11165(garD)
PSED : DM292_21105 DM292_21145(garD)
PCHL : LLJ08_01890 LLJ08_01930(garD)
PKG : LW136_01895 LW136_01935(garD)
PZD : KQ248_15755 KQ248_15795(garD)
HAAH : HALA3H3_50014(garD)
RPJ : N234_26230 N234_26270
REH : H16_B0965(h16_B0965)
REU : Reut_B3690 Reut_B4643
CBW : RR42_s0382 RR42_s1732
CGD : CR3_3080(garD) CR3_3082
CPAU : EHF44_25590(garD) EHF44_26465
COX : E0W60_09115 E0W60_10190(garD)
CCAM : M5D45_07670 M5D45_24240(garD)
CCAX : KZ686_20545(garD) KZ686_20555
BCEP : APZ15_23125(garD) APZ15_38170(garD)
BARI : NLX30_24535(garD) NLX30_28525(garD)
BGO : BM43_2754 BM43_4175(garD)
BUE : BRPE67_DCDS11390 BRPE67_FCDS01940
BGP : BGL_2c04650(garD1) BGL_2c12620
BPLA : bpln_2g05200 bpln_2g13430
PCAF : DSC91_001114 DSC91_001734 DSC91_007322
PDIO : PDMSB3_1260.1(garD)
PLG : NCTC10937_00398(mdlA_1) NCTC10937_04573(garD)
CABA : SBC2_17980 SBC2_79380(garD_5)
CABK : NK8_54240(garD) NK8_55770
BGM : CAL15_01490 CAL15_04940 CAL15_19280
AXX : ERS451415_02951(garD_2)
ACHB : DVB37_14045(garD) DVB37_23635
ACHO : H4P35_13665(garD) H4P35_21850
AMUI : PE062_10375(garD) PE062_18460
ASEL : RAS12_03600 RAS12_07870(garD)
PACR : FXN63_06065(garD) FXN63_20655
PARK : LSG25_00600 LSG25_05460(garD)
RHY : RD110_20190 RD110_21720
PVAC : HC248_01350(garD_1)
ACIO : EAG14_03880(garD) EAG14_06870
DEL : DelCs14_0259 DelCs14_2561
DTS : BI380_07215 BI380_23030
DHK : BO996_01685 BO996_19130
DLA : I6G47_02915 I6G47_22990(garD)
CENP : M9799_12575(garD) M9799_18600
LIM : L103DPR2_02529(garD_2)
LIH : L63ED372_02032(mdlA_1) L63ED372_02034(garD_1)
KIA : G8A07_05130(garD) G8A07_05140
MIU : ABE85_11800 ABE85_12655(garD)
SMIO : CATMQ487_42480(garD)
RGU : A4W93_05245 A4W93_28700(garD)
HFR : G5S34_16850(garD) G5S34_19205
MASW : AM586_05720 AM586_23215(garD)
MFY : HH212_21780 HH212_21795(garD)
XYK : GT347_00410 GT347_22830(garD)
XYG : R9X41_05735(garD) R9X41_10995
UPL : DSM104440_01948(garD_2)
BRC : BCCGELA001_25025(garD)
BGQ : X265_14315(garD) X265_38085
BGZ : XH91_12085(garD) XH91_37285
BSEP : HAP48_0007445(garD)
BCAN : BcanWSM471_26085(garD)
BRAY : ML401_22600(garD) ML401_36755
MAQU : Maq22A_c21660(uxaA)
MMES : MMSR116_02235 MMSR116_22195 MMSR116_22960(garD)
MTAD : M6G65_04075 M6G65_06210(garD)
RAP : RHOA_2737(garD) RHOA_3354
AZL : AZL_a04710(garD) AZL_b02810(garD) AZL_c03560
BSON : S101395_04743(garD)
CGEL : psyc5s11_09910(garD)
CBAR : PATL70BA_2263(garD)
PAUS : NCTC13651_01417(mdlA_1)
NOA : BKM31_27070 BKM31_27075
NOW : GBF35_19210 GBF35_19215
NGN : LCN96_19505 LCN96_19510
NFS : OIE67_26855 OIE67_26860
SGP : SpiGrapes_0542 SpiGrapes_1714
» show all
Taxonomy
Reference
1
Authors
Blumenthal HJ, Jepson T.
Title
Galactarate dehydrase.
Journal
Methods Enzymol 9:665-669 (1966)
Reference
Authors
Hubbard BK, Koch M, Palmer DR, Babbitt PC, Gerlt JA
Title
Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli.
Journal
Reference
Authors
Yew WS, Fedorov AA, Fedorov EV, Almo SC, Gerlt JA
Title
Evolution of enzymatic activities in the enolase superfamily: L-talarate/galactarate dehydratase from Salmonella typhimurium LT2.
Journal
Sequence
Reference
Authors
Rakus JF, Kalyanaraman C, Fedorov AA, Fedorov EV, Mills-Groninger FP, Toro R, Bonanno J, Bain K, Sauder JM, Burley SK, Almo SC, Jacobson MP, Gerlt JA
Title
Computation-facilitated assignment of the function in the enolase superfamily: a regiochemically distinct galactarate dehydratase from Oceanobacillus iheyensis .
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.42
ExPASy - ENZYME nomenclature database: 4.2.1.42