KEGG   ENZYME: 4.2.3.156
Entry
EC 4.2.3.156                Enzyme                                 

Name
hydroxysqualene synthase;
hpnC (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
presqualene diphosphate diphosphate-lyase (adding water; hydroxyasqualene-forming)
Reaction(IUBMB)
presqualene diphosphate + H2O = hydroxysqualene + diphosphate [RN:R11410]
Reaction(KEGG)
R11410
Substrate
presqualene diphosphate [CPD:C03428];
H2O [CPD:C00001]
Product
hydroxysqualene [CPD:C21116];
diphosphate [CPD:C00013]
Comment
This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103, presqualene diphosphate synthase, and EC 1.17.8.1, hydroxysqualene dehydroxylase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC 2.5.1.21, squalene synthase.
History
EC 4.2.3.156 created 2016
Orthology
K21679  hydroxysqualene synthase
Genes
MEJ: Q7A_951(hpnC)
MEC: Q7C_988
HHC: M911_10410
EBS: ECTOBSL9_3058
TGR: Tgr7_1525
TKM: TK90_1510
TNI: TVNIR_1520
APRS: BI364_06325
TTC: FOKN1_2196
REV: HUE57_10345(hpnC)
RHG: EXZ61_07460(hpnC)
POS: DT070_19910(hpnC)
POO: F7R28_10650(hpnC)
AJS: Ajs_1205
ACRA: BSY15_67(hpnC)
ACIO: EAG14_07725(hpnC)
AMON: H9L24_00435(hpnC)
AANT: HUK68_06680(hpnC)
DAC: Daci_2573
DLA: I6G47_11335(hpnC)
VBO: CKY39_15560(hpnC)
VAM: C4F17_07375(hpnC)
CTES: O987_06870
COF: FOZ74_15310(hpnC)
LIM: L103DPR2_02181(crtB_2)
HYR: BSY239_1397(hpnC)
HYB: Q5W_23335
HPSE: HPF_15100(crtB1)
HYN: F9K07_17405(hpnC)
DIH: G7047_03060(hpnC)
DAER: H9K75_19365(hpnC)
DRG: H9K76_16410(hpnC)
CBAA: SRAA_0599
CBAB: SMCB_1449
LCH: Lcho_2548
RGE: RGE_27980
ABRE: pbN1_35070(hpnC)
APET: ToN1_08500(hpnC)
KMN: HW532_17980(hpnC)
BJA: blr3001(blr3001)
BRA: BRADO2627
BBT: BBta_2966
BRS: S23_49960(sqs)
AOL: S58_49920
BRAD: BF49_1691
BRK: CWS35_18210(hpnC)
BOT: CIT37_38590(hpnC)
BRQ: CIT40_09505(hpnC)
BGQ: X265_25995(hpnC)
BGZ: XH91_24135(hpnC)
BSYM: CIT39_08625(hpnC)
BBET: F8237_05040(hpnC)
BARH: WN72_16435(hpnC)
BDG: LPJ38_18005(hpnC)
RPA: RPA3743
RPB: RPB_1723
RPC: RPC_1717
RPD: RPD_3576
RPE: RPE_1811
RPT: Rpal_4264
RBK: E0H22_09825(hpnC)
NWI: Nwi_2272
NHA: Nham_2685
OCA: OCAR_6674(hpnC)
VGO: GJW-30_1_02139(crtB_1)
TRB: HB776_13770(hpnC)
STAR: G3545_15495(hpnC)
MDI: METDI2702
MEX: Mext_1941
MCH: Mchl_2217
MPO: Mpop_1832
MET: M446_6350
MNO: Mnod_7143
MOR: MOC_5998(hpnC)
META: Y590_09025
MAQU: Maq22A_c25240(erg9)
MEE: DA075_06160(hpnC)
METD: C0214_10780(hpnC)
METS: DK389_19270(hpnC)
METI: DK427_24620(hpnC)
MMES: MMSR116_24440(hpnC)
MTEA: DK419_24995(hpnC)
MIND: mvi_55640
BID: Bind_3153
MSL: Msil_3240
MLG: CWB41_01830(hpnC)
BBAR: RHAL1_00131(hpnC)
HDN: Hden_0474
RVA: Rvan_3020
MSC: BN69_1681
MROS: EHO51_00865(hpnC)
MHEY: H2LOC_015890(hpnC)
MPAR: F7D14_11080(hpnC)
MTW: CQW49_11740(hpnC)
TSO: IZ6_27220
RBM: TEF_04825
LIZ: LGH83_10460(hpnC)
CAUL: KCG34_23160(hpnC)
PALW: PSAL_001920(hpnC)
ZMO: ZMO0869
ZMN: Za10_0423
ZMM: Zmob_0428
ZMB: ZZ6_0426
ZMI: ZCP4_0442
NOR: FA702_05050(hpnC)
SPHM: G432_09195
SPHA: D3Y57_13880(hpnC)
SARI: H5J25_10655(hpnC)
POQ: KZX46_17590(hpnC)
GOX: GOX2255
GOH: B932_2747
GOY: GLS_c23980(hpnC)
GTI: FXF46_13800(hpnC)
GSP: IGS75_12740(hpnC)
ACR: Acry_0119
GDI: GDI1623
GDJ: Gdia_1828
GXY: GLX_17360
GXL: H845_3226
KSC: CD178_01162(crtB_2)
KRE: GWK63_14330(hpnC)
KHA: IFJ82_01370(hpnC)
ASZ: ASN_2211
APOM: CPF11_06310(hpnC)
ATO: CIW82_01575(hpnC)
ACET: DS739_01130(hpnC)
AOY: EOV40_001055(hpnC)
ABG: Asbog_02599(hpnC)
ROS: CTJ15_07705(hpnC)
RMUC: FOB66_09730(hpnC)
NEH: E3E11_07650(hpnC)
SSAM: E3D00_09650(hpnC)
SWF: E3E12_06915(hpnC)
BOB: GN304_03805(hpnC)
BOMB: GT348_03330(hpnC)
EBLA: JGUZn3_04120(hpnC)
LCK: HN018_00155(hpnC)
SHUM: STHU_32410
SKT: IGS68_10430(hpnC)
SROE: JL101_015655(hpnC)
RRU: Rru_A0065
RRF: F11_00330
RCE: RC1_1044
MAG: amb2509
MGRY: MSR1_10410(crtB_2)
MAGX: XM1_3269
MAGN: WV31_06945
DVN: HQ394_07745(hpnC)
MAGQ: MGMAQ_1490
LFC: LFE_1960
 » show all
Reference
1  [PMID:26258173]
  Authors
Pan JJ, Solbiati JO, Ramamoorthy G, Hillerich BS, Seidel RD, Cronan JE, Almo SC, Poulter CD
  Title
Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes.
  Journal
ACS Cent Sci 1:77-82 (2015)
DOI:10.1021/acscentsci.5b00115
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.156
IUBMB Enzyme Nomenclature: 4.2.3.156
ExPASy - ENZYME nomenclature database: 4.2.3.156
BRENDA, the Enzyme Database: 4.2.3.156

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