KEGG   ENZYME: 4.2.3.183
Entry
EC 4.2.3.183                Enzyme                                 

Name
nezukol synthase;
TPS2
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(+)-copalyl-diphosphate diphosphate-lyase (cyclizing, nezukol-forming)
Reaction(IUBMB)
(+)-copalyl diphosphate + H2O = nezukol + diphosphate [RN:R11848]
Reaction(KEGG)
R11848
Substrate
(+)-copalyl diphosphate [CPD:C11901];
H2O [CPD:C00001]
Product
nezukol [CPD:C21709];
diphosphate [CPD:C00013]
Comment
Isolated from the plant Isodon rubescens.
History
EC 4.2.3.183 created 2017
Pathway
ec00904  Diterpenoid biosynthesis
Orthology
K22945  nezukol synthase
Reference
1  [PMID:28445526]
  Authors
Pelot KA, Hagelthorn DM, Addison JB, Zerbe P
  Title
Biosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases.
  Journal
PLoS One 12:e0176507 (2017)
DOI:10.1371/journal.pone.0176507
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.183
IUBMB Enzyme Nomenclature: 4.2.3.183
ExPASy - ENZYME nomenclature database: 4.2.3.183
BRENDA, the Enzyme Database: 4.2.3.183

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