KEGG   ENZYME: 4.2.3.195
Entry
EC 4.2.3.195                Enzyme                                 

Name
rhizathalene A synthase;
TPS08 (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranygeranyl-diphosphate diphosphate-lyase (rhizathalene A-forming)
Reaction(IUBMB)
geranylgeranyl diphosphate = rhizathalene A + diphosphate [RN:R11920]
Reaction(KEGG)
R11920
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
rhizathalene A [CPD:C21765];
diphosphate [CPD:C00013]
Comment
The enzyme was identified in the roots of the plant Arabidopsis thaliana (thale cress). The product is a semivolatile diterpene that acts as a local antifeedant in belowground direct defense against root-feeding insects.
History
EC 4.2.3.195 created 2017
Orthology
K22467  rhizathalene A synthase
Genes
ATH: AT4G20210
CSAT: 104733459
Reference
1  [PMID:23512856]
  Authors
Vaughan MM, Wang Q, Webster FX, Kiemle D, Hong YJ, Tantillo DJ, Coates RM, Wray AT, Askew W, O'Donnell C, Tokuhisa JG, Tholl D
  Title
Formation of the unusual semivolatile diterpene rhizathalene by the Arabidopsis class I terpene synthase TPS08 in the root stele is involved in defense against belowground herbivory.
  Journal
Plant Cell 25:1108-25 (2013)
DOI:10.1105/tpc.112.100057
  Sequence
[ath:AT4G20210]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.195
IUBMB Enzyme Nomenclature: 4.2.3.195
ExPASy - ENZYME nomenclature database: 4.2.3.195
BRENDA, the Enzyme Database: 4.2.3.195

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