KEGG   ENZYME: 4.2.3.201
Entry
EC 4.2.3.201                Enzyme                                 

Name
hydropyrene synthase;
HpS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, hydropyrene-forming)
Reaction(IUBMB)
geranylgeranyl diphosphate = hydropyrene + diphosphate [RN:R12363]
Reaction(KEGG)
R12363
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
hydropyrene [CPD:C22108];
diphosphate [CPD:C00013]
Comment
Isolated from the bacterium Streptomyces clavuligerus. The 1-proR hydrogen atom of geranylgeranyl diphosphate is lost in the reaction. The enzyme also produces hydropyrenol, isoelisabethatriene and traces of other diterpenoids. cf. EC 4.2.3.202, hydropyrenol synthase, and EC 4.2.3.203, isoelisabethatriene synthase.
History
EC 4.2.3.201 created 2019
Orthology
K23530  hydropyrene/hydropyrenol/isoelisabethatriene synthase
Genes
SCLF: BB341_28045
Reference
1  [PMID:28696553]
  Authors
Rinkel J, Rabe P, Chen X, Kollner TG, Chen F, Dickschat JS
  Title
Mechanisms of the Diterpene Cyclases beta-Pinacene Synthase from Dictyostelium discoideum and Hydropyrene Synthase from Streptomyces clavuligerus.
  Journal
Chemistry 23:10501-10505 (2017)
DOI:10.1002/chem.201702704
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.201
IUBMB Enzyme Nomenclature: 4.2.3.201
ExPASy - ENZYME nomenclature database: 4.2.3.201
BRENDA, the Enzyme Database: 4.2.3.201

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