KEGG   ENZYME: 4.2.3.203
Entry
EC 4.2.3.203                Enzyme                                 

Name
isoelisabethatriene synthase;
HpS (ambiguous)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, isoelisabethatriene-forming)
Reaction(IUBMB)
geranylgeranyl diphosphate = isoelisabethatriene + diphosphate [RN:R12365]
Reaction(KEGG)
R12365
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
isoelisabethatriene [CPD:C22110];
diphosphate [CPD:C00013]
Comment
Isolated from the bacterium Streptomyces clavuligerus. The 1-proR hydrogen atom of geranylgeranyl diphosphate is involved in a 1,3-hydride shift to the side-chain. The enzyme also produces hydropyrene, hydropyrenol, and traces of other diterpenoids. cf. EC 4.2.3.201, hydropyrene synthase, and EC 4.2.3.202, hydropyrenol synthase.
History
EC 4.2.3.203 created 2019
Orthology
K23530  hydropyrene/hydropyrenol/isoelisabethatriene synthase
Genes
SCLF: BB341_28045
Reference
1  [PMID:28696553]
  Authors
Rinkel J, Rabe P, Chen X, Kollner TG, Chen F, Dickschat JS
  Title
Mechanisms of the Diterpene Cyclases beta-Pinacene Synthase from Dictyostelium discoideum and Hydropyrene Synthase from Streptomyces clavuligerus.
  Journal
Chemistry 23:10501-10505 (2017)
DOI:10.1002/chem.201702704
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.203
IUBMB Enzyme Nomenclature: 4.2.3.203
ExPASy - ENZYME nomenclature database: 4.2.3.203
BRENDA, the Enzyme Database: 4.2.3.203

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