KEGG ENZYME: 4.2.3.55

ENZYME: 4.2.3.55

Entry

EC 4.2.3.55                 Enzyme

Name

(S)-beta-bisabolene synthase

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(S)-beta-bisabolene-forming]

Reaction(IUBMB)

(2E,6E)-farnesyl diphosphate = (S)-beta-bisabolene + diphosphate [RN:R09623]

Reaction(KEGG)

R09623

Substrate

(2E,6E)-farnesyl diphosphate [CPD:C00448]

Product

(S)-beta-bisabolene [CPD:C16775];
diphosphate [CPD:C00013]

Comment

The synthesis of (S)-beta-macrocarpene from (2E,6E)-farnesyl diphosphate proceeds in two steps. The first step is the cyclization to (S)-beta-bisabolene. The second step is the isomerization to (S)-beta-macrocarpene (cf. EC 5.5.1.17, (S)-beta-macrocarpene synthase). The enzyme requires Mg2+ or Mn2+ for activity.

History

EC 4.2.3.55 created 2011

Pathway

ec00909

Sesquiterpenoid and triterpenoid biosynthesis

Orthology

K15794

(S)-beta-bisabolene synthase

Genes

MUS:

103975051

ZOF:	121969623 121969625 121969628 121969629 121973171 121974758 121974759 121974761 121974762 121974764 121974765 121977409 121977410 121978125 122049060

Reference

1 [PMID:20229191]

Authors

Fujisawa M, Harada H, Kenmoku H, Mizutani S, Misawa N

Title

Cloning and characterization of a novel gene that encodes (S)-beta-bisabolene synthase from ginger, Zingiber officinale.

Journal

Planta 232:121-30 (2010)
DOI:10.1007/s00425-010-1137-6

Sequence

[ag:BAI67934]

Other DBs

ExplorEnz - The Enzyme Database: