KEGG   ENZYME: 4.2.99.23Help
Entry
EC 4.2.99.23                Enzyme                                 

Name
tuliposide B-converting enzyme
Class
Lyases;
Carbon-oxygen lyases;
Other carbon-oxygen lyases
BRITE hierarchy
Sysname
6-tuliposide B D-glucose-lyase (tulipalin B-forming)
Reaction(IUBMB)
6-tuliposide B = tulipalin B + D-glucose [RN:R11215]
Reaction(KEGG)
Substrate
6-tuliposide B [CPD:C21186]
Product
tulipalin B [CPD:C21187];
D-glucose [CPD:C00031]
Comment
The enzyme, characterized from pollen of the plant Tulipa gesneriana (tulip), catalyses the intramolecular transesterification of 6-tuliposide B to form the antibiotic aglycon tulipalin B as a sole product. It does not catalyse the hydrolysis of 6-tuliposide B to form a hydroxy acid. The enzyme has marginal activity with 6-tuliposide A. cf. EC 4.2.99.22, tuliposide A-converting enzyme.
History
EC 4.2.99.23 created 2016
Orthology
K20507  tuliposide B-converting enzyme
Reference
1  [PMID:25997073]
  Authors
Nomura T, Murase T, Ogita S, Kato Y
  Title
Molecular identification of tuliposide B-converting enzyme: a lactone-forming carboxylesterase from the pollen of tulip.
  Journal
Plant J 83:252-62 (2015)
DOI:10.1111/tpj.12883
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.99.23
IUBMB Enzyme Nomenclature: 4.2.99.23
ExPASy - ENZYME nomenclature database: 4.2.99.23
BRENDA, the Enzyme Database: 4.2.99.23

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