KEGG   ENZYME: 4.6.1.22
Entry
EC 4.6.1.22                 Enzyme                                 

Name
Bacillus subtilis ribonuclease;
Proteus mirabilis RNase;
ribonucleate nucleotido-2'-transferase (cyclizing);
bacterial RNA lyase;
Bacillus subtilis intracellular ribonuclease
Class
Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)
Sysname
[RNA] 5'-hydroxy-ribonucleotide-3'-[RNA fragment]-lyase (cyclicizing; [RNA fragment]-3'- nucleoside -2',3'-cyclophosphate-forming)
Reaction(IUBMB)
RNA = a 5'-hydroxy-ribonucleotide + n nucleoside-2',3'-cyclophosphates
Substrate
RNA [CPD:C00046]
Product
5'-hydroxy-ribonucleotide;
nucleoside-2',3'-cyclophosphates
Comment
This enzyme catalyses endonucleolytic cleavage to 2',3'-cyclic nucleotides. The cyclic products may be hydrolysed to the corresponding 3'-phosphates by 2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16). The enzyme from B. subtilis is inhibited by ATP.
History
EC 4.6.1.22 created 1978 as EC 3.1.27.2, transferred 2028 to EC 4.6.1.22
Reference
1  [PMID:13854124]
  Authors
NISHIMURA S, MARUO B.
  Title
Intracellular ribonuclease from Bacillus subtilis.
  Journal
Biochim Biophys Acta 40:355-7 (1960)
DOI:10.1016/0006-3002(60)91364-0
Reference
2  [PMID:4962137]
  Authors
Yamasaki M, Arima K.
  Title
Regulation of intracellular ribonuclease of Bacillus subtilis by ATP and ADP.
  Journal
Biochim Biophys Acta 139:202-4 (1967)
DOI:10.1016/0005-2744(67)90135-0
Reference
3  [PMID:4981632]
  Authors
Yamasaki M, Arima K.
  Title
Intracellular ribonuclease of Bacillus subtilis; specific inhibition by ATP and dATP.
  Journal
Biochem Biophys Res Commun 37:430-6 (1969)
DOI:10.1016/0006-291X(69)90933-4
Reference
4  [PMID:4296400]
  Authors
Center MS, Behal FJ
  Title
Studies on the ribonuclease activity of Proteus mirabilis.
  Journal
Biochim Biophys Acta 151:698-9 (1968)
DOI:10.1016/0005-2744(68)90022-3
Other DBs
ExplorEnz - The Enzyme Database: 4.6.1.22
IUBMB Enzyme Nomenclature: 4.6.1.22
ExPASy - ENZYME nomenclature database: 4.6.1.22
BRENDA, the Enzyme Database: 4.6.1.22

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