KEGG   ENZYME: 5.3.2.3
Entry
EC 5.3.2.3                  Enzyme                                 
Name
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming);
dTDP-6-deoxy-hex-4-ulose isomerase;
TDP-6-deoxy-hex-4-ulose isomerase;
FdtA
Class
Isomerases;
Intramolecular oxidoreductases;
Interconverting keto- and enol-groups
Sysname
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose isomerase
Reaction(IUBMB)
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose = dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose [RN:R09904]
Reaction(KEGG)
R09904
Substrate
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose [CPD:C11907]
Product
dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose [CPD:C19960]
Comment
The enzyme is involved in the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose. Four moieties of alpha-D-rhamnose and two moities of 3-acetamido-3,6-dideoxy-alpha-D-galactose form the repeating unit of the glycan chain in the S-layer of the bacterium Aneurinibacillus thermoaerophilus.
History
EC 5.3.2.3 created 2011
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec00541  Biosynthesis of various nucleotide sugars
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20679  TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase
Reference
1  [PMID:12740380]
  Authors
Pfoestl A, Hofinger A, Kosma P, Messner P
  Title
Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose in Aneurinibacillus thermoaerophilus L420-91T.
  Journal
J Biol Chem 278:26410-7 (2003)
DOI:10.1074/jbc.M300858200
  Sequence
[ag:AAS55720]
Reference
2  [PMID:17459872]
  Authors
Davis ML, Thoden JB, Holden HM
  Title
The x-ray structure of dTDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase.
  Journal
J Biol Chem 282:19227-36 (2007)
DOI:10.1074/jbc.M702529200
  Sequence
[ag:AAS55720]
Other DBs
ExplorEnz - The Enzyme Database: 5.3.2.3
IUBMB Enzyme Nomenclature: 5.3.2.3
ExPASy - ENZYME nomenclature database: 5.3.2.3
BRENDA, the Enzyme Database: 5.3.2.3

  All links  
Protein sequence (196)   
   UniProt (194)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (315)   
   RefSeq(nuc) (1)   
   GenBank (159)   
   EMBL (155)   
Protein domain (3)   
   InterPro (3)   
All databases (514)   

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