KEGG   ENZYME: 5.4.99.65Help
Entry
EC 5.4.99.65                Enzyme                                 

Name
pre-alpha-onocerin synthase;
LCC
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene mutase (cyclizing, pre-alpha-onocerin-forming)
Reaction(IUBMB)
(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene = pre-alpha-onocerin [RN:R11867]
Reaction(KEGG)
Substrate
(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene [CPD:C21732]
Product
pre-alpha-onocerin [CPD:C21733]
Comment
Isolated from the plant Lycopodium clavatum. The enzyme does not act on (3S)-2,3-epoxy-2,3-dihydrosqualene and does not form any alpha-onocerin.
History
EC 5.4.99.65 created 2017
Orthology
K22964  pre-alpha-onocerin synthase
Reference
1  [PMID:26663356]
  Authors
Araki T, Saga Y, Marugami M, Otaka J, Araya H, Saito K, Yamazaki M, Suzuki H, Kushiro T
  Title
Onocerin Biosynthesis Requires Two Highly Dedicated Triterpene Cyclases in a Fern Lycopodium clavatum.
  Journal
Chembiochem 17:288-90 (2016)
DOI:10.1002/cbic.201500663
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.65
IUBMB Enzyme Nomenclature: 5.4.99.65
ExPASy - ENZYME nomenclature database: 5.4.99.65
BRENDA, the Enzyme Database: 5.4.99.65

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