KEGG   ENZYME: 6.3.1.14
Entry
EC 6.3.1.14                 Enzyme                                 
Name
diphthine---ammonia ligase;
diphthamide synthase;
diphthamide synthetase;
DPH6 (gene name);
ATPBD4 (gene name);
diphthine:ammonia ligase (AMP-forming)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)
Sysname
diphthine-[translation elongation factor 2]:ammonia ligase (AMP-forming)
Reaction(IUBMB)
ATP + diphthine-[translation elongation factor 2] + NH3 = AMP + diphosphate + diphthamide-[translation elongation factor 2] [RN:R03613]
Reaction(KEGG)
R03613
Substrate
ATP [CPD:C00002];
diphthine-[translation elongation factor 2] [CPD:C01573];
NH3 [CPD:C00014]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
diphthamide-[translation elongation factor 2]
Comment
This amidase catalyses the last step in the conversion of an L-histidine residue in the translation elongation factor EF2 to diphthamide. This factor is found in all archaea and eukaryota, but not in eubacteria, and is the target of bacterial toxins such as the diphtheria toxin and the Pseudomonas exotoxin A (see EC 2.4.2.36, NAD+---diphthamide ADP-ribosyltransferase). The substrate of the enzyme, diphthine, is produced by EC 2.1.1.98, diphthine synthase.
History
EC 6.3.1.14 created 1990 as EC 6.3.2.22, transferred 2010 to EC 6.3.1.14, modified 2013
Orthology
K06927  diphthine-ammonia ligase
Genes
HSA89978(DPH6)
PTR735941(DPH6)
PPS100988692(DPH6)
GGO101153919(DPH6)
PON100445767(DPH6)
NLE100606699(DPH6)
MCC701401(DPH6)
MCF102141727(DPH6)
CSAB103245888(DPH6)
CATY105574132(DPH6)
PANU101023519(DPH6)
TGE112627646(DPH6)
RRO104665652(DPH6)
RBB108543693(DPH6)
TFN117070908(DPH6)
PTEH111554588(DPH6)
CJC100394882(DPH6)
SBQ101036126(DPH6)
CSYR103268341(DPH6)
MMUR105872397(DPH6)
OGA100958185(DPH6) 100958823
MMU66632(Dph6)
MCAL110290024(Dph6)
MPAH110319199(Dph6)
RNO362191(Dph6)
MCOC116090666(Dph6)
CGE100765802(Dph6)
PLEU114697511(Dph6)
HGL101724973(Dph6)
CPOC100726776(Dph6)
CCAN109686902
DORD105981205(Dph6)
DSP122114521(Dph6)
OCU100339838(DPH6)
OPI101523653(DPH6)
TUP102488589(DPH6)
CFA487480(DPH6)
VVP112919924(DPH6)
VLG121482008(DPH6)
AML100464985(DPH6)
UMR103673486
UAH113242065(DPH6)
UAR123804020(DPH6)
ELK111162261
LLV125104984
MPUF101687016(DPH6)
ORO101384735(DPH6)
EJU114221435(DPH6)
ZCA113909753(DPH6)
MLX118003334(DPH6)
FCA101094855(DPH6)
PYU121041463(DPH6)
PBG122468811(DPH6)
PTG102962514(DPH6)
PPAD109263198(DPH6)
AJU106969797(DPH6)
HHV120224227 120241885(DPH6)
BTA767944(DPH6)
BOM102266159(DPH6)
BIU109564906(DPH6)
BBUB102400200(DPH6)
CHX102168266(DPH6)
OAS101103817(DPH6)
ODA120853241(DPH6)
CCAD122443351(DPH6)
SSC102166599(DPH6)
CFR102515310(DPH6)
CBAI105076877(DPH6)
CDK105089991(DPH6)
VPC102536797(DPH6)
BACU102999917
LVE103073700(DPH6)
OOR101286626(DPH6)
DLE111181579(DPH6)
PCAD102986799(DPH6)
PSIU116749259(DPH6)
ECB100071713(DPH6)
EPZ103549169
EAI106835154(DPH6)
MYB102242552(DPH6)
MYD102762328(DPH6)
MMYO118649499(DPH6)
MLF102436543(DPH6)
MNA107543010(DPH6)
PKL118723897(DPH6)
HAI109386232(DPH6) 109386235
DRO112311983(DPH6)
SHON118993625(DPH6) 118993721
AJM119040266(DPH6)
PDIC114493310(DPH6)
PHAS123808718(DPH6)
MMF118633085(DPH6)
RFQ117022880(DPH6)
PALE102879441(DPH6)
PGIG120587215(DPH6)
PVP105288610(DPH6)
RAY107508077(DPH6)
MJV108395481(DPH6)
TOD119238455(DPH6)
SARA101546897(DPH6)
LAV100665153(DPH6)
TMU101341843
MDO100031655(DPH6)
SHR111718835(DPH6)
PCW110213387(DPH6)
OAA100092006(DPH6)
GGA423294(DPH6)
PCOC116229327(DPH6)
MGP100545423
CJO107314989(DPH6)
NMEL110401071(DPH6)
APLA101791384(DPH6)
ACYG106031715(DPH6)
AFUL116490097(DPH6)
TGU100228635(DPH6)
LSR110475282(DPH6)
SCAN103826577(DPH6)
PMOA120500486(DPH6)
OTC121332427(DPH6)
PRUF121349582(DPH6)
GFR102038484(DPH6)
FAB101807633(DPH6)
PHI102100472(DPH6)
PMAJ107205831(DPH6)
CCAE111930341(DPH6)
CCW104684337(DPH6)
ETL114055308(DPH6)
ZAB102068424(DPH6)
FPG101914569(DPH6)
FCH102050705(DPH6)
CLV102092941(DPH6)
EGZ104126473(DPH6)
NNI104015898(DPH6)
ACUN113480775(DPH6)
TALA104358011(DPH6)
PADL103914362(DPH6)
ACHC115335627(DPH6)
AAM106482814(DPH6)
AROW112973443(DPH6)
NPD112957972(DPH6)
DNE112979605(DPH6)
ASN102371902(DPH6)
AMJ102576788(DPH6)
CPOO109321378(DPH6)
GGN109298704(DPH6)
PSS102459890(DPH6)
CMY102940116(DPH6)
CPIC101943027(DPH6)
TST117876661(DPH6)
CABI116821647(DPH6)
MRV120402830(DPH6)
ACS100562724(dph6)
PVT110076865(DPH6)
SUND121918378(DPH6)
PBI103051724(DPH6)
PMUR107285394(DPH6)
TSR106553933(DPH6)
PGUT117665721(DPH6)
VKO123026554(DPH6)
PMUA114593272(DPH6)
ZVI118082617(DPH6)
GJA107111519(DPH6)
XLA444081(dph6.L)
XTR100497052(dph6)
NPR108799324(DPH6)
RTEM120920863(DPH6)
BBUF120982110(DPH6)
BGAR122922141(DPH6)
DRE503603(dph6)
SRX107724237 107749548
SANH107665515(dph6)
SGH107554776(dph6)
CCAR109054609
CAUA113060441(dph6)
IPU108269848(dph6)
PHYP113538748(dph6)
SMEO124389881(dph6)
TFD113659299(dph6)
AMEX103047424(dph6)
EEE113572703 113591790(dph6)
TRU101077017(dph6)
TNGGSTEN00032006G001
LCO104922411(dph6)
NCC104942349(dph6)
CGOB115027816(dph6)
ELY117266649(dph6)
PLEP121954034(dph6)
SLUC116057571(dph6)
ECRA117935898(dph6)
PFLV114546786(dph6)
GAT120832507(dph6)
PPUG119227353(dph6)
MSAM119900178 119910319(dph6)
CUD121525939(dph6)
MZE101482267(dph6)
ONL100710751(dph6)
OAU116326108(dph6)
OLA105356906(dph6)
OML112149443(dph6)
XMA102222678(dph6)
XCO114134749(dph6)
XHE116709553(dph6)
PRET103458761(dph6)
PFOR103154794(dph6)
PLAI106961434
PMEI106906415(dph6)
GAF122846436(dph6)
CVG107094430(dph6)
CTUL119774954(dph6)
GMU124856045(dph6)
NFU107392174(dph6)
KMR108232843(dph6)
ALIM106518433(dph6)
NWH119427664(dph6)
AOCE111573295(dph6)
CSEM103379697(dph6)
POV109636226(dph6)
SSEN122783274(dph6)
HHIP117756108(dph6)
LCF108875040(dph6)
SDU111225729(dph6)
SLAL111660122(dph6)
XGL120795386(dph6)
HCQ109517449(dph6)
BPEC110161158(dph6) 110173883
MALB109968060(dph6)
SASA106601537(dph6)
OTW112261621(dph6)
OMY110498341(dph6)
OGO124001840(dph6)
ONE115146080(dph6)
SALP111968581(dph6)
SNH120060398(dph6)
ELS105015517(dph6)
SFM108919340(dph6)
PKI111843588(dph6)
AANG118234034(dph6)
LOC102685393(dph6)
PSPA121324652(dph6)
ARUT117416705 117421836
LCM102351051(DPH6)
CMK103175186(dph6)
RTP109927511(dph6)
BFO118414575
BBEL109479114
CIN100180152
SCLV120326470
SPU576024
APLC110986338
SKO100368513
DMEDmel_CG1578(CG1578)
DER6551260
DSE6619914
DSIDsimw501_GD15968(Dsim_GD15968)
DYADyak_GE17596
DAN6502958
DSR110179611
DPODpse_GA13952
DPE6598352
DMN108152890
DWI6652914
DGR6564883
DMODmoj_GI14716
DAZ108619156
DNV108656815
DHE111605301
DVI6633410
CCAT101456184
BOD106624054
MDE101887741
SCAC106084117
LCQ111678657 111689493 111689730
AGAAgaP_AGAP001943
ACOZ120952292
AARA120901380
AAG110680828 5571896
AALB109426358 115258087 115266292
CQUCpipJ_CPIJ008398 CpipJ_CPIJ008400
CPII120414328
CNS116342317
AME411591
ACER107993124
ALAB122711830
BIM100744165
BBIF117214313
BVK117232220
BVAN117156145
BTER100646351
BPYO122571911
CCAL108632135
OBB114877338
MGEN117220250
NMEA116428379
CGIG122403287
SOC105201757
MPHA105828132
AEC105151494
ACEP105625480
PBAR105425226
VEM105566286
HST105187241
DQU106741259
CFO105252780
FEX115238924
LHU105678440
PGC109857928
OBO105287527
PCF106790755
PFUC122517881
VPS122627039
NVI100116698
CSOL105361579
TPRE106658338
MDL103578395
CGLO123274789
FAS105265348
DAM107043128
AGIF122860682
TCA663632
DPA109540798
SOY115891753
ATD109598175
CSET123309241
AGB108906113
LDC111503164
NVL108567777
APLN108735055
PPYR116169659
OTU111416928
BMOR101741069
BMAN114246347
MSEX115441919
DPLKGM_211338
BANY112054202
PMAC106719804
PPOT106101588
PXU106113286 106113825
PRAP110992933
ZCE119832770
HAW110379789
TNL113496068
OFU114351542
PXY105381769
API100162183
DNX107171861 107173869
AGS114129070
RMD113551725
BTAB109032974
CLEC106661200
HHAL106686730
NLU111058949
PHUPhum_PHUM169970
FOC113217960
ZNE110828110
CSEC111873257
FCD110843893
DPXDAPPUDRAFT_198635
PVM113812445
PJA122248421
PCHN125029465
HAME121859316 121866220
PCLA123768967
PTRU123502715
HAZT108671978
EAF111696303
ISCIscW_ISCW015534
DSV119464153
RSAN119401706
RMP119164291
VDE111250872
VJA111258689
TUT107360450
DPTE113788661 113794700
DFR124490914
CSCU111627398
PTEP107442365
CELCELE_E01A2.5(E01A2.5)
CBRCBG_12063
BMYBM_BM3081(Bm3081)
LOALOAG_01813
NAINECAME_03449
HROHELRODRAFT_192994
LGILOTGIDRAFT_138598
PCAN112571353
BGT106069187
GAE121372355
HRF124131874 124131877
HRJ124270921
CRG105333362
MYI110459198
PMAX117323566
OBI106869672
OSN115211892
LAK106171049
OVIT265_12963
EGLEGR_02475
NVE5521664
EPA110232352
ATEN116295777
ADF107332439
AMIL114968054
PDAM113686951
SPIS111336499
DGT114525724 114541825
XEN124453165
HMG100205848
TADTRIADDRAFT_49818
AQU100639417
ATHAT3G04480
ALY9320511
CRB17893221
CSAT104701366 104744552 104764074
EUSEUTSA_v10020155mg
BRP103848915 103859035
BNA106349636 106438981 106447631
BOE106334011 106343263
RSZ108805154 108863209
THJ104827285
CPAP110825988
CIT102624743
CICCICLE_v10019185mg
PVY116136417
MINC123209262
TCC18600065
GRA105804621
GHI107892726 107926823
GAB108474237
DZI111277117 111296659 111296660
EGR104432545 104432791
GMX100807009
GSJ114400147
PVUPHAVU_001G114900g
VRA106753982
VAR108329395
VUN114194713
CCAJ109796664
APRC113861687
MTRMTR_7g111650
CAM101493811
LJALj1g3v3976130.1(Lj1g3v3976130.1) Lj1g3v3977140.1(Lj1g3v3977140.1)
ADU107494379
AIP107604801 107647222
AHF112696922 112696923 112754787 112757437
LANG109331641
FVE101294087 101294869
RCN112195267
PPER18775339
PMUM103318703
PAVI110754347
PDUL117632448
MDM103434213
PXB103935688
ZJU107412319
MNT21407235
CSV101206966
CMO103485878
BHJ120079428
MCHA111018223
CMAX111465391
CMOS111444237
CPEP111799056
RCU8258634
JCU105647750
HBR110643260 110643264
MESC110621217
POP7487187 7487708
PEU105133876
PALZ118036487 118050649
JRE108991516
QSU112002671 112003069 112011407
QLO115953010
TWL119999948
VVI100244247
VRI117930727
SLY101245449
SPEN107018291
SOT102584229
CANN107870276
NTA107810033 107831427
NSY104218637
NTO104105323
NAU109238642
INI109187093
ITR116019893
SIND105163797
OEU111397972 111403848
EGT105977780
SSPL121749653 121792384
HAN110904437
ECAD122605943
LSV111916346
CCAV112508050
DCR108204789
CSIN114268316
BVG104903997
SOE110786502
CQI110718941 110739892
NNU104602820
MING122091109
TSS122638863
PSOM113319064 113349896
NCOL116252959
OSA9270287
DOSAOs02t0810450-01(Os02g0810450)
OBR102713720
BDI100838496
ATS109758520
TDC119318444 119324053
TAES123128904 123139472 123146059
SBI110434488
ZMA103627881
SITA101785566
SVS117841490
PVIR120645796 120657557
PHAI112877438
PDA103721763
EGU105055708
MUS103999817
DCT110095883
PEQ110031426
AOF109827995
ATR18447174
SMOSELMODRAFT_130429 SELMODRAFT_134094
PPP112288731
VCNVOLCADRAFT_32944
MNGMNEG_14629
CSLCOCSUDRAFT_37397
CVRCHLNCDRAFT_35997
APROF751_6486
OLUOSTLU_6853
OTAOT_ostta09g03340
BPGBathy10g01150
MISMICPUN_63974
MPPMICPUCDRAFT_56170
CMECYME_CMS447C
GSLGasu_59960
CCPCHC_T00005667001
SCEYLR143W(DPH6)
AGOAGOS_AGL164W
ERCEcym_4223
KLAKLLA0_D16984g
KMXKLMA_50514
LTHKLTH0G11594g
VPOKpol_1036p86
ZROZYRO0F14014g
CGRCAGL0M04521g
NDINDAI_0G02460(NDAI0G02460)
TPFTPHA_0C00650(TPHA0C00650)
TBLTBLA_0A04110(TBLA0A04110)
TDLTDEL_0F04730(TDEL0F04730)
TGBHG536_0C01070
KAFKAFR_0H02150(KAFR0H02150)
ZMKHG535_0F03930
PPAPAS_chr4_0132
DHADEHA2B04884g
PICPICST_43636
PGUPGUG_03693
SPAASPAPADRAFT_60556 SPAPADRAFT_60558
LELLELG_01257
CALCAALFM_C203830WA(CaO19.839)
CTPCTRG_01289
COTCORT_0A10540
CDUCD36_18500
CTENCANTEDRAFT_92694
YLIYALI0F14553g
CLUCLUG_05377
CLUSA9F13_23g00088
CAURCJI97_000205
SLBAWJ20_1830(DPH6)
PKZC5L36_0B07880
BNNFOA43_002193
BBRXBRETT_003796
NCRNCU02670
NTENEUTE1DRAFT73167(NEUTE1DRAFT_73167)
SMPSMAC_04330
PANPODANSg2029 PODANSg2030
TTTTHITE_2112245
MTMMYCTH_2296812
CTHRCTHT_0009350
MGRMGG_00500
TMNUCRPA7_4792
SSCKSPSK_02236
FGRFGSG_06870
FPUFPSE_11795
FVRFVEG_05116
FOXFOXG_01956
NHENECHADRAFT_38099
TRETRIREDRAFT_58363
TRRM419DRAFT_33976
MAWMAC_01007
MAJMAA_05725
PLJVFPFJ_05380
VALVDBG_04681 VDBG_04682
VDAVDAG_04223
CFJCFIO01_03038
ELAUCREL1_1438
PFYPFICI_01826
SSLSS1G_04410
BFUBCIN_01g05150(Bcdph6)
MBEMBM_08301
PSCOLY89DRAFT_607075
GLZGLAREA_04499
AFMAFUA_4G09070
ACTACLA_048430
NFINFIA_107100
AORAO090023000649
ANGANI_1_1794184(An04g03970)
ALUCAKAW2_51411A
ACHEACHE_10631S
PCSPc18g03510
TMFPMAA_056380
TRGTRUGW13939_00698
CIMCIMG_08216
CPWCPC735_022280
UREUREG_02463
PBLPAAG_03286
PBNPADG_03156
ABEARB_00365
TVETRV_04205
AJEHCAG_07093
BGHBDBG_00570
PNOSNOG_03779
PTEPTT_06876
BZECOCCADRAFT_21958
BSCCOCSADRAFT_95267
BORCOCMIDRAFT_30308
AALTCC77DRAFT_1019761
ZTRMYCGRDRAFT_73868
PFJMYCFIDRAFT_31828
BCOMBAUCODRAFT_80130
NPAUCRNP2_2687
TMLGSTUM_00009914001
SPOSPBC577.12(mug71)
CNECNJ02960
CNBCNBJ0560
CGICGB_J0485W CGB_J0500W
TMSTREMEDRAFT_40163
TASAA1Q1_07026
PPLPOSPLDRAFT_96100
TVSTRAVEDRAFT_70252
PCOPHACADRAFT_86977
SHSSTEHIDRAFT_54099
HIRHETIRDRAFT_472254
PSQPUNSTDRAFT_22799
ADLAURDEDRAFT_156956
FMEFOMMEDRAFT_142052
GTRGLOTRDRAFT_125792
LBCLACBIDRAFT_245647
MPRMPER_07596
MRRMoror_7461
CCICC1G_00411
SCMSCHCODRAFT_47155
ABPAGABI1DRAFT38553(AGABI1DRAFT_38553)
ABVAGABI2DRAFT67613(AGABI2DRAFT_67613)
SLASERLADRAFT_360402
WSEWALSEDRAFT_61134
WICJ056_003599
UMAUMAG_11559
PFPPFL1_01618
MRTMRET_0007
MSYMMSY001_2154
PGRPGTG_04940
MLRMELLADRAFT_28793
EINEint_081790
EHEEHEL_081780
EROEROM_081810
NCENCER_100049
MBRMONBRDRAFT_14389
SREPTSG_01523
DDIDDB_G0278373
DPPDICPUDRAFT_30664
DFADFA_01168
EDIEDI_078790
EIVEIN_224420
ACANACA1_166560 ACA1_379050
PFAPF3D7_1222500
PFHPFHG_01614
PYOPY17X_1439900
PCBPCHAS_143940(PC000462.04.0)
PBEPBANKA_1437400
PVVPVVCY_1403950
PKNPKNH_1441600
PVXPVX_123755
PCYPCYB_144820
TANTA13205
TPVTP02_0444
TOTTOT_020000430
BEQBEWA_021790
BBOBBOV_III005100(17.m07455)
BMICBmR1_04g07195
BBIGBBBOND_0309560
CPVcgd4_610
CHOChro.40077
TETTTHERM_00191860
PTMGSPATT00008350001 GSPATT00013073001 GSPATT00015871001
SMINv1.2.008547.t1(symbB.v1.2.008547.t1)
FCYFRACYDRAFT_160918
NGDNGA_0485810
AAFAURANDRAFT_22120
PIFPITG_00939
PSOJPHYSODRAFT_553661
SPARSPRG_14835
GTTGUITHDRAFT_107532
TCR503917.14
NGRNAEGRDRAFT_31983
ABBABBFA_00895
ABXABK1_2872
ABZABZJ_03002
ABRABTJ_00896
ABDABTW07_2992
ABHM3Q_3052
ABADABD1_25290
ABJBJAB07104_02908
ABABBJAB0715_02948
ABAJBJAB0868_02788
ABAZP795_4250
ABKLX00_13835
ABAUIX87_09380
ABAAIX88_15910
ABWBL01_06105
ABALABLAC_09280
ACCBDGL_002011
ANORR32_04915
ALCOTEC02_04670
ACALBUM88_14875
ASEII8T81_04850
ATTAMQ28_03045
AJORZ95_10820
ACWA0J50_04490
AHLAHTJS_04785
AJNBVL33_06980
AWUBEN71_13390
AGUAS4_31640
ADSFPL17_08215
ABERBSR55_15200
ATNFM020_04575
AHYAHML_08245
AHDAI20_11770
AHRV428_08475
AHPV429_08480
AHJV469_15015
AHHRY45_08085
AHIVU14_15145
AAJBOQ57_07165
AEOO23A_p2090
AVRB565_2704
AVOAMS64_16290
AMEDB224_3712
ASRWL1483_1904
ADHCK627_18680
ACAVVI35_06330
AEAC2U39_06970
ARVC7N77_18430
AESC2U30_06605
AELNCTC12917_01344
AALLI6G90_01760
AJDI6H43_03560
NBACUN60_00620
CVCBKX93_02505
CHROCXB49_10065
CHRIDK842_19260
CHRBDK843_02190
CRZD1345_11715
CHRMFYK34_07245
CHAECH06BL_24010
JEUBJP62_12060
HYFDTO96_101842
DDZDSYM_12620
DEOCAY53_01725
DAVDESACE_08850
SBFJCM31447_16940
BIFN288_10915
BMETBMMGA3_06810
GSTHW35_01855
BACOOXB_0552
BFDNCTC4823_00924
BDAFSZ17_10570
BONA361_11735
BKOCKF48_22710
LFUHR49_12400
LYSLBYS11_11060
LYBC3943_16735
LYGC1N55_07390
LPAKGDS87_12360
LAGRFJQ98_13230
VIRX953_08240
VHLBME96_07150
VNECFK40_17985
LAOAOX59_09890
FPNABE65_005875
BSJUP17_20870
BMURABE28_000920
PBUTDTO10_06340
NMKCHR53_16555
MSEMGMB29_10310
BVQFHE72_16150
BVJI5776_01850
BOUI5818_02020
PIHUB51_16150
PLENEIM92_05165
PLUTEI981_03195
PALBEJC50_03320
PRZGZH47_11140
TCOTheco_0382
COHEAV92_17890
SIVSSIL_2313
SSILSOLI23_06825 SOLI23_07065
SOBCSE16_17195 CSE16_17545
PLNPlano_0332
PKUAUO94_14925
PRTAUC31_08155
PLLI858_005705
PANABBH88_00755
PDGBCM40_14070
PHCBBI08_14640
PMARB0X71_02100
PPLABBI15_13870
PFAEAJGP001_02175
PLXCW734_03220
PMATBBI11_02990
PDECH1Q58_02135
PGQFK545_09640
KURASO14_149
KZONCTC404_00967
SPSYAZE41_02190
SPORSporoP33_10495
SPOPSporoP37_10910
SURESporoP32a_10900
SPOSDV702_15075
SPAEE2C16_14725
PANCE2636_01675
PLAYDNR44_001355
VIJJNUCC6_06205
WCFC6P13_06935
EFLEF62_2702
EFIOG1RF_11913
EFDEFD32_2100
EFSEFS1_2008
EFNDENG_02463
EFQDR75_1231
VCPH9L18_12740
CMLBN424_3138
CBZCbs_1271
CBEILF65_01403
CSRCspa_c14700
CSBCLSA_c31970
CLTCM240_1160
CBVU729_2763
CTAEBGI42_11170
CCHVBTM20_09805
CARGRSJ17_17660
CSEPCP523_12995
CDYF3K33_06805
CGASJ1C67_15570
SARJHH195_00185
CCLClocl_3522
CEWEKH84_19435
BPROPMF13cell1_03785
PDCCDIF630_01578
PDFCD630DERM_14170
PSORRSJ16_06885
ROCHF520_08075
PHXKGNDJEFE_01729
DDHDesde_1506
AMIJEQM06_04130
AMICAmi3637_15720
ABUTAmi103574_12455
TPZTph_c22540
CADCuri_c21470
TSGHLK68_07670
ACITHPK19_07920 HPK19_20370
ORNDV701_10375
NBEBack2_01780
DEVDhcVS_1335(rdhH) DhcVS_95(rdhH)
DMCbtf_1444
DMDdcmb_243 dcmb_92
DMGGY50_0083 GY50_0092 GY50_0238 GY50_0243 GY50_1406
DMXX792_00420 X792_00505 X792_00530 X792_07360 X792_07530
DMYX793_01105 X793_01240
DMZX794_00985 X794_06575 X794_06790
DUCUCH007_09910(rdhH) UCH007_13590(rdhH) UCH007_13800(rdhH)
DEWDGWBC_1744
DFODform_01992 Dform_02039
DWUDVJ83_11860
DEINDAAJ005_16400
BIPBint_0289
PCAGNCTC12856_00608
PETPEIBARAKI_5414
RBCBN938_2401
ASXCDL62_10690
CHITFW415_16135
FLASY85_22985
RHOZGXP67_32655
FCOFCOL_05065
FINKQS_04600
FCMBIW12_12310
FEKC1H87_19810
TAJC1A40_01200
AQBD1818_23475
AQAD1815_08745
FBUUJ101_00006
TTATheth_1733
THPBG95_04815
THERY592_04885
FIANA23_08535
OCYOSSY52_18110
ASACATHSA_1270
MJAMJ_0570
MFEMefer_0771
MVUMetvu_0750
MFSMFS40622_1547
MIFMetin_0265
MJHJH146_0786
MESGMLAUSG7_0091
MESAMLASG1_1277
MIGMetig_1371
MMPMMP0343
MMQMmarC5_1331
MMXMmarC6_0609
MMZMmarC7_1344
MMDGYY_01760
MMAKMMKA1_03510
MMAOMMOS7_03770
MMADMMJJ_07130
MAEMaeo_1253
MVNMevan_1353
MVOMvol_1678
MOKMetok_1456
METFCFE53_01860
MTHMTH_432
MMGMTBMA_c08270
METCMTCT_0372
MWOMWSIV6_0816
METEtca_00397
METZMETMT2_0553
METKFVF72_00255
MTHMFZP57_03905
METJFZP68_08950
MTEEMTTB_07580
MSTMsp_0563
METBAW729_04185
MRUmru_1231
MSIMsm_0142
MEBAbm4_0818
MMILsm9_0907
MEYETL18_05745
MOLYLM1_0669
MAROMarbSA_01690
MELMetbo_1158
MEWMSWAN_1046
METHMBMB1_1181
MFCBRM9_1386
MFIDSM1535_2085
MCUBMCBB_1084
MSUBBK009_02375
METNBK008_10040
METTCIT01_00560 CIT01_00955
METOCIT02_02770
MEMEHYG87_01210
MFVMfer_0659
MKAMK0644
AFUAF_1666
AFGAFULGI_00008000 AFULGI_00019150
APOArcpr_0678
AVEArcve_0936
ASTAsulf_01658 Asulf_02236
FPLFerp_1978
GACGACE_1487
GAHGAH_01683
PFUPF0828
PFIPFC_03325
PHOPH1257(PH1257)
PABPAB0759
PYNPNA2_0144 PNA2_1836
PYAPYCH_00170
PYSPy04_0449 Py04_1196
PYCTQ32_01380 TQ32_10715
TKOTK2280
TONTON_1247
TGATGAM_1854
TSITSIB_1787
TBATERMP_01129
THEGQS_09435
THATAM4_39
THMCL1_1476
TLTOCC_09299 OCC_11964
THSTES1_0975 TES1_1180
TNUBD01_1627
TEUTEU_00195 TEU_09235
TGYX802_01995 X802_07610
THVADU37_CDS15740 ADU37_CDS19070
TCHCHITON_0543 CHITON_1512
TPEPA0127_03965
TPIEA7C91_01670
TGGA3K92_01910
TCEA3L02_03940 A3L02_05680
TBSA3L01_06845
THHCDI07_06815
TSLA3L11_01115
TTDA3L14_09235
TPRFA3L09_03250 A3L09_09485
TRLA3L10_06290
TPAFA3L08_00130 A3L08_05910
THYA3L12_02075 A3L12_04905
TICFH039_10345
TCQTIRI35C_1678
THEMFPV09_11270
PPACPAP_02520 PAP_03190
MBAMbar_A2904
MBYMSBRM_1435 MSBRM_2503
MBWMSBRW_1834
MBARMSBR2_0970 MSBR2_2481
MBAKMSBR3_0267
MACMA_1374
MMAMM_2359
MMAZMmTuc01_2410 MmTuc01_2873
MMJMSMAS_1914 MSMAS_2340
MMACMSMAC_1212 MSMAC_2105
MVCMSVAZ_1776 MSVAZ_2553
MEKMSKOL_1752 MSKOL_2561
MLSMSLAZ_0959
METMMSMTP_2170
MEFMSWH1_2303
MEQMSWHS_2772
MSJMSSAC_1382
MSZMSSIH_1576
MSWMSSIT_1670
MTHRMSTHT_0845
MTHEMSTHC_2426
MHORMSHOH_2962
MFZAOB57_012270
MBUMbur_0466
MMETMCMEM_0897
MELOJ7W08_02725
MMHMmah_0924
MHAZBHR79_08960
MEVMetev_1538
MZHMzhil_0704
MPYMpsy_0422
MZIHWN40_05455
MHZMetho_1047
MTPMthe_1352
MCJMCON_2225 MCON_2598
MHIMhar_0713 Mhar_1290
MHUMhun_1584
MRTJKHC33_06135
MLAMlab_0933
MEMMemar_1634
MBGBN140_2003
MEMAMMAB1_2595
MCHKMchiMG62_17800
MPIMpet_1270
MBNMboo_0992
MFOMetfor_2416
MPLMpal_1086
MPDMCP_2153
MEZMtc_2164
RCIRRC12
HALVNG_0391C
HSLOE_1579R(dph6)
HDLHALDL1_06100
HHBHhub_1552(dph6)
HAGSJT689_02940
HABOJRZ79_01440
HNOLT974_02945
HLULT972_10855
HANRLJ422_01660
HJEHacjB3_12690
HALHHTSR_1390
HHSRHSR6_1462
HSUHLASF_0680
HSFHLASA_0676
SALRFQU85_01800
HALREFA46_006650
HARAAArcS_2353(dph6)
HAADMW046_08475
HALXM0R89_10785
HMArrnAC0632
HHIHAH_1290
HHNHISP_06610
HABSG26_14470
HTABVU17_06295
HALJG9465_08340
HSINKDQ40_07015
NPHNP_0382A(dph6)
NMONmlp_1424(dph6)
NHOHWV23_13310
NSALHWV07_05505
HUTHuta_2709
HTIHTIA_2451
HALAHrd1104_07500
HMUHmuk_2825
HALZE5139_01400
HALLLC1Hm_2172(dph6)
HAZPGBQ70_01400
HALIBV210_03915
HSNDV733_14310
HDSHSR122_2731(dph6)
HRRHZS55_01325
HPELHZS54_07880
HLTI7X12_13715
HARCHARCEL1_02100
HDOMUK72_12625
HWAHQ_1669A(dph6)
HWCHqrw_1786(dph6)
HVOHVO_1077(dph6)
HMEHFX_1082
HGIABY42_05245
HALEG3A49_08615
HBOHbor_22660
HAQDU484_11535
HAJDU500_11810
HAERDU502_09175
HRAEI982_04430
HLMDV707_12185
HALMFCF25_11820
HLAHlac_0801
HALPDOS48_04185
HALBEKH57_06790
HEZZEO776_05675
HALQHrr1229_000675
HSAIHPS36_01335
HAZZKI388_03125
SRUBC2R22_06950
HAEhalTADL_1774
HALNB4589_000685
HALGHUG10_02230
HALUHUG12_14810
HMPK6T50_00420
HREK6T36_00435
HRMK6T25_00740
HACBHbl1158_07685
HDFAArcSl_0908
HAHHalar_0789
HTUHtur_1353
HDABB347_02330
HJTDVR14_06480
HALYHYG82_17120
HSALJMJ58_01980
HLOJ0X27_10685
HAKZJ0X25_13635
NMGNmag_2610(dph6)
HXAHalxa_3910
NATNJ7G_4097
NPENatpe_3273
NVRFEJ81_15675
NPLFGF80_14470
NAYHYG81_13205
NGENatgr_0658
HRUHalru_1211
NOUNatoc_0679 Natoc_4175
SALIL593_03460
SAIMK0C01_07805
HLRHALLA_07185
HLCCHINAEXTREME00490
NAJB1756_04835
NAGAArcMg_0664
NANAArc1_2927
NBGDV706_01080 DV706_16190
NASGCU68_12650
NACAQV86_05470
MELUMTLP_08060
MEAMMU439_05565
FACFACI_IFERC01G0266
FAIFAD_1184
CDIVCPM_0882
TARTALC_00308
MAXMMALV_02810
MERMMINT_05540
MEARMpt1_c10770
MARCAR505_1512
ABIAboo_1093
ACFAciM339_1405
APEAPE_0421
ACJACAM_0304
SMRSmar_1167
SHCShell_1304
IHOIgni_0787
IISEYM_00155
DKADKAM_0999
DFDDesfe_1117
DMUDesmu_0079
THGTCELL_0584
HBUHbut_1070
PFMPyrfu_1060
PDLPyrde_0963
STOSTK_20480
SOHD1869_11230
SSOSSO0678
SOLSsol_1736
SSOASULA_1762
SSOLSULB_1763
SSOFSULC_1761
SSHIJ5U23_02732
SCASSACC_03050
SAISaci_0103
SACNSacN8_00485
SACRSacRon12I_00485
SACSSUSAZ_00495
SISLS215_1568
SIAM1425_1460
SIMM1627_1575
SIDM164_1457
SIYYG5714_1464
SINYN1551_1372
SIILD85_1667
SIHSiH_1418
SIRSiRe_1336
SICSiL_1338
SULABFU36_02675
SULEGFS03_08370
SULOGFS33_00140
SULLEWF20_12390
MSEMsed_2025
MCNMcup_0263
MPRUDFR88_08045
MTENGWK48_03920
MJNMjAS7_0326
AHOAhos_0557
AMANB6F84_06465
ABRIDFR85_09040
ASULDFR86_05520
AAMBD1866_10485
ACIHHS5_19220
SACDHS1genome_0116
SAZOD1868_09710
CSTYKN1_04720
STEPIC006_1395
SAHSHS7_08400
PAIPAE2672
PISPisl_1875
PCLPcal_0164
PASPars_1010
PYRP186_2602
POGPogu_1278 Pogu_1310
TNETneu_1245
PYWPYWP30_00404 PYWP30_01304
CMACmaq_1530
TTNTTX_0088 TTX_0299
TUZTUZN_0170 TUZN_1236
VDIVdis_1754
VMOVMUT_0201
TPETpen_1107
THBN186_06395
TCBTCARB_0347
THELIG193_02715
ASCASAC_0411
ACIASE86_00240 SE86_02920
CLGCalag_0969 Calag_1396
FFOFFONT_0024 FFONT_0041 FFONT_1384
NMRNmar_0530
NIRNSED_02670
NKRNKOR_02740
NIDNPIRD3C_1746
NINNADRNF5_1654
NIWNisw_02225
NCLC5F47_02715
NOXC5F49_02900
NUEC5F50_04005
NIPNsoK4_05705
NCTNMSP_1144
NICDSQ20_02950
CSYCENSYa_0420
NGANgar_c26930
NVNNVIE_016140
NEVNTE_00775
TAANMY3_02348
NFNNFRAN_3124
NCVNCAV_1332
CSUCSUB_C1038
NBVT478_0392
TAHSU86_003435
NIUDSQ19_02715
NDVNDEV_0520
CCAINAS2_1008 NAS2_1478
BARCAOA65_1520
BARBAOA66_1229
NAANps_03125
MARHMia14_0811
FLTSv326_1297
MIYMicr_00966
NCONLC1Nh_0884(asnB)
PSYTDSAG12_00331 DSAG12_03850
AGWQT03_C0001G0076
ARGQT11_C0001G0581
 » show all
Reference
1
  Authors
Moehring, T.J. and Moehring, J.M.
  Title
Mutant cultured cells used to study the synthesis of diphthamide.
  Journal
UCLA Symp Mol Cell Biol New Ser 45:53-63 (1987)
Reference
2  [PMID:3346227]
  Authors
Moehring JM, Moehring TJ.
  Title
The post-translational trimethylation of diphthamide studied in vitro.
  Journal
J Biol Chem 263:3840-4 (1988)
Reference
3  [PMID:23169644]
  Authors
Su X, Lin Z, Chen W, Jiang H, Zhang S, Lin H
  Title
Chemogenomic approach identified yeast YLR143W as diphthamide synthetase.
  Journal
Proc Natl Acad Sci U S A 109:19983-7 (2012)
DOI:10.1073/pnas.1214346109
  Sequence
[sce:YLR143W]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.1.14
IUBMB Enzyme Nomenclature: 6.3.1.14
ExPASy - ENZYME nomenclature database: 6.3.1.14
BRENDA, the Enzyme Database: 6.3.1.14
CAS: 114514-33-9

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