Entry
Name
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase;
MurE synthetase [ambiguous];
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming);
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase;
UDP-N-acetylmuramoylalanyl-D-glutamate---2,6-diaminopimelate ligase;
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate:meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)
Reaction(IUBMB)
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate [RN:
R02788 ]
Reaction(KEGG)
Substrate
ATP [CPD:
C00002 ];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate [CPD:
C00692 ];
meso-2,6-diaminoheptanedioate [CPD:
C00680 ]
Product
ADP [CPD:
C00008 ];
phosphate [CPD:
C00009 ];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate [CPD:
C04877 ]
Comment
Involved in the synthesis of a cell-wall peptide in bacteria. This enzyme adds diaminopimelate in Gram-negative organisms and in some Gram-positive organisms; in others EC
6.3.2.7 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase) adds lysine instead. It is the amino group of the L-centre of the diaminopimelate that is acylated.
History
EC 6.3.2.13 created 1972, modified 2002, modified 2010
Pathway
Orthology
K01928 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
K15792 MurE/MurF fusion protein
Genes
ECOH : ECRM13516_0092(murE)
ELR : ECO55CA74_00420(murE)
ECW : EcE24377A_0087(murE)
ECOA : APECO78_03875(murE)
EDJ : ECDH1ME8569_0082(murE)
ECOI : ECOPMV1_00088(murE)
SEM : STMDT12_C01230(murE)
SETC : CFSAN001921_16805(murE)
SEEN : SE451236_06630(murE)
SENH : CFSAN002069_08610(murE)
SEEH : SEEH1578_09645(murE)
SENJ : CFSAN001992_10390(murE)
SEEC : CFSAN002050_07060(murE)
SEEB : SEEB0189_018770(murE)
SENC : SEET0819_07495(murE)
REE : electrica_04248(murE)
RTG : NCTC13098_06210(murE)
CLAP : NCTC11466_03838(murE)
KIE : NCTC12125_02951(murE)
AHN : NCTC12129_04171(murE)
METY : MRY16398_47330(murE)
PTF : PROFFT_A_01700(murE)
PSHI : SAMEA2665130_0383(murE)
MPHG : MPHASIOC01_004520(murE)
YPG : YpAngola_A2923(murE)
YPI : YpsIP31758_3392(murE)
SMW : SMWW4_v1c07420(murE)
SERS : SERRSCBI_03410(murE)
SFJ : SAMEA4384070_0780(murE)
SOF : NCTC11214_00770(murE)
SSAR : SSARUM_000685(murE)
PAQU : DMB82_0017190(murE)
PARL : PEC302110_33520(murE)
EHD : ERCIPSTX3056_380(murE)
BAPF : BUMPF009_CDS00373(mure)
BAPG : BUMPG002_CDS00374(mure)
BAPU : BUMPUSDA_CDS00373(mure)
BAPW : BUMPW106_CDS00373(mure)
TPTY : NCTC11468_03100(murE)
PHEI : NCTC12003_01241(murE)
PRJ : NCTC6933_02768(murE)
LRI : NCTC12151_02617(murE)
HIC : NTHIC486_01609(murE)
HPIT : NCTC13334_01194(murE)
HHZ : NCTC10839_01086(murE)
HAEG : NCTC8502_01257(murE)
PDAG : 4362423_00237(murE)
ADP : NCTC12871_01083(murE)
ALIG : NCTC10568_00015(murE)
ASEG : NCTC10977_00972(murE)
AVT : NCTC3438_00975(murE)
RPNE : NCTC8284_03154(murE_3)
PAET : NCTC13378_01319(murE)
XFU : XFF4834R_chr07790(murE)
XPH : XppCFBP6546_07560(XppCFBP6546P_07560)
XHD : LMG31886_35570(murE)
LLZ : LYB30171_02237(murE)
VNI : VIBNI_A0224(murE) VIBNI_B0312
VAU : VANGNB10_cI2174c(murE)
VCY : IX92_12325(murE) IX92_23310
VCT : JV59_02030(murE) JV59_16240
VGI : MID13_02310(murE) MID13_22365
VPL : SA104470976_00420(murE)
VCRA : IS519_08090(murE) IS519_24405
VIB : VspSTUT11_25510(murE)
VIS : VspSTUT16_26560(murE)
PGB : H744_1c0649 H744_2c0698
PGH : FH974_01825(murE) FH974_21255
GKD : K6Q96_01905(murE) K6Q96_16925
PAEB : NCGM1900_2247(murE)
PAEU : BN889_04911(murE_1)
PVD : CFBP1590__1168(murE)
PPRC : PFLCHA0_c50410(murE)
PMUD : NCTC8068_04360(murE)
PFW : PF1751_v1c09020(murE)
PPUU : PputUW4_04508(murE)
PTW : TUM18999_13360(murE)
PTAE : NCTC10697_00856(murE)
MSHE : MAALD49_08910(murE)
PSYC : DABAL43B_2679(murE)
MCAT : MC25239_01689(murE)
MCUN : NCTC10297_00637(murE)
SCAA : TUM17387_03590(murE)
SALH : HMF8227_02475(murE)
CBS : COXBURSA331_A0213(murE)
LLG : 44548918_00814(murE)
LJR : NCTC11533_00944(murE)
LCJ : NCTC11976_01653(murE)
LWA : SAMEA4504053_1249(murE)
LSS : NCTC12082_00965(murE)
LADL : NCTC12735_01465(murE)
LANT : TUM19329_22880(murE)
MISZ : MishRS11D_06410(murE)
TSE : THMIRHAS_19300(murE)
TZO : THMIRHAT_06520(murE)
THIM : KFB96_07490 KFB96_13725(murE)
TBOG : LT988_03215 LT988_09270(murE)
TFRI : Thiofri_04400(murE)
TNI : TVNIR_2609(murE_[H])
AFY : BW247_00835 BW247_02695
GAI : IMCC3135_29205(murE)
THIC : TspCOW1_31430(murE)
HAAH : HALA3H3_950056(murE)
AEL : NCTC12917_03787(murE)
CHJ : NCTC10426_02284(murE)
CDIZ : CEDIAZO_03164(murE)
NMQ : NMBM04240196_0422(murE)
NMZ : NMBNZ0533_1835(murE)
NMX : NMA510612_2338(murE)
NWE : SAMEA3174300_1595(murE)
NZO : SAMEA4504057_0369(murE)
NCI : NCTC10296_00551(murE)
NCZ : NCTC10294_01274(murE)
NANI : NCTC12227_02072(murE)
ECOR : SAMEA4412678_0485(murE)
BMV : BMASAVP1_A0477(murE)
BPM : BURPS1710b_3550(murE)
BPL : BURPS1106A_3555(murE)
POLT : TUM22923_01590(murE)
PLG : NCTC10937_01072(murE)
LMIR : NCTC12852_00827(murE)
BUO : BRPE64_ACDS24220(murE)
BUE : BRPE67_ACDS23700(murE)
VTR : MYVALT_F_00030(murE)
BTRM : SAMEA390648700553(murE)
AXX : ERS451415_00801(murE)
LIM : L103DPR2_02757(murE)
LIH : L63ED372_02323(murE)
SMIO : CATMQ487_11950(murE)
CFU : CFU_3307(murE) CFU_3947(murE2)
URU : DSM104443_00673(murE)
UPL : DSM104440_00638(murE)
THAG : CKCBHOJB_00768(murE)
FPHO : SHINM1_017290(murE)
RTT : RTTH1527_02820(murE)
RTB : RTB9991CWPP_02820(murE)
PACA : ID47_03365 ID47_07605
RBS : RHODOSMS8_01901(murE)
SMEL : SM2011_c01861(murE)
SFD : USDA257_c45050(murE)
SAME : SAMCFNEI73_Ch2467(murE)
AGR : AGROH133_07455(murE)
AVV : RvVAT039_03570(murE)
AVF : RvVAR031_24250(murE)
REC : RHECIAT_CH0003003(murE)
REL : REMIM1_CH02900(murE)
REP : IE4803_CH03077(murE)
REI : IE4771_CH03115(murE)
RGA : RGR602_CH02501(murE)
RPHA : AMC79_CH03015(murE)
NEN : NCHU2750_14790(murE)
LAS : CLIBASIA_05020(murE)
VGO : GJW-30_1_01839(murE)
BHS : BM1374165_01169(murE)
BBK : BARBAKC583_0952(murE)
BTX : BM1374166_01523(murE)
BEZ : NCTC12898_01035(murE)
MAQU : Maq22A_c02210(murE)
MTUN : MTUNDRAET4_1818(murE)
FIL : BN1229_v1_3981(murE)
FIY : BN1229_v1_3968(murE)
BVY : NCTC9239_00710(murE)
TSV : DSM104635_02832(murE)
RLI : RLO149_c025770(murE)
PHP : PhaeoP97_00919(murE)
PPIC : PhaeoP14_00872(murE)
SINL : DSM14862_01092(murE)
SPSE : SULPSESMR1_01949(murE)
RMM : ROSMUCSMR3_03658(murE)
LALG : LentiSH36_00845(murE)
LVS : LOKVESSMR4R_00995(murE)
SBIN : SBA_ch1_35060(murE)
SPAG : sphantq_01062(murE)
SFLA : SPHFLASMR4Y_00084(murC)
HPO : HMPREF4655_20092(murE)
HPX : HMPREF0462_1477(murE)
HPYA : HPAKL117_07180(murE)
HPYK : HPAKL86_00465(murE)
HTY : BN2458_PEG1001 BN2458_PEG1009 BN2458_PEG1017
HCL : NCTC13205_01255(murE)
HSH : NHP194022_11240(murE)
HPUL : NCTC13154_00319(murE)
CJV : MTVDSCj20_1602(murE)
CFV : CFVI03293_0063(murE)
CAMP : CFT03427_0064(murE)
CCOC : CCON33237_1720(murE)
CLR : UPTC16701_0119(murE)
CLM : UPTC16712_0120(murE)
CAMR : CAQ16704_0112(murE)
CHV : CHELV3228_0282(murE)
CPIN : CPIN18020_0951(murE)
CAMZ : CVIC12175_0079(murE)
GBN : GEOBRER4_04840(murE)
PPOR : JCM14722_12380(murE)
ECOM : QTN59_08190 QTN59_13600
EAJ : Q3M24_05410 Q3M24_21475
ELAX : KKHLCK_01145 KKHLCK_11650
PAUU : E8A73_002645(murE) E8A73_005885
MRM : A7982_00371 A7982_03229 A7982_04801
CTJT : CTJTET1_01395(murE)
CTFS : CTRC342_01425(murE)
CTHF : CTRC852_01425(murE)
CTCJ : CTRC943_01380(murE)
CTHJ : CTRC953_01380(murE)
CTMJ : CTRC966_01395(murE)
CTTJ : CTRC971_01380(murE)
CTJS : CTRC122_01405(murE)
OBG : Verru16b_03522(murE)
ABIW : Abiwalacus_07580(murE)
BAFH : BafHLJ01_0210(murE)
BTHO : Btheta7330_04843(murE)
BCEL : BcellWH2_02378(murE)
PCRE : NCTC12858_00548(murE)
PCAG : NCTC12856_01149(murE)
PSOE : CE91St14_01960(murE)
COPR : Cop2CBH44_24830(murE)
PMZ : HMPREF0659_A5214(murE)
PDN : HMPREF9137_0790(murE)
PHER : prwr041_13810(murE)
POC : NCTC13071_02624(murE)
ACOU : A5CBH24_13100(murE)
ADA : A5CPEGH6_11440(murE)
SMIZ : 4412673_03098(murE)
SDJ : NCTC13534_04389(murE_1)
STHA : NCTC11429_02675(murE)
PSEZ : HME7025_00481(murE)
FOK : KK2020170_02390(murE)