KEGG   ENZYME: 6.3.2.51
Entry
EC 6.3.2.51                 Enzyme                                 
Name
phosphopantothenate---cysteine ligase (ATP);
phosphopantothenoylcysteine synthetase (ambiguous);
PPCS (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
(R)-4'-phosphopantothenate:L-cysteine ligase (ATP-utilizing)
Reaction(IUBMB)
ATP + (R)-4'-phosphopantothenate + L-cysteine = AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine [RN:R04230]
Reaction(KEGG)
R04230
Substrate
ATP [CPD:C00002];
(R)-4'-phosphopantothenate [CPD:C03492];
L-cysteine [CPD:C00097]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
N-[(R)-4'-phosphopantothenoyl]-L-cysteine [CPD:C04352]
Comment
A key enzyme in the production of coenzyme A. The eukaryotic enzyme requires ATP, in contrast to the bacterial enzyme, EC 6.3.2.5, phosphopantothenate---cysteine ligase, which requires CTP.
History
EC 6.3.2.51 created 2017
Pathway
ec00770  Pantothenate and CoA biosynthesis
Orthology
K01922  phosphopantothenate---cysteine ligase (ATP)
Genes
HSA79717(PPCS)
PTR747056(PPCS)
PPS100969367(PPCS)
GGO101138135(PPCS)
PON100457154(PPCS)
NLE100591238(PPCS)
MCC697064(PPCS)
MCF102127325(PPCS)
CATY105594665(PPCS)
PANU101019902(PPCS)
TGE112622795(PPCS)
RRO104668997(PPCS)
RBB108530371(PPCS)
TFN117092763(PPCS)
PTEH111548701(PPCS)
CJC100414413(PPCS)
SBQ101027483(PPCS)
CSYR103269616(PPCS)
MMUR105862279(PPCS) 105866347
LCAT123634281(PPCS)
OGA100962200(PPCS)
MMU106564(Ppcs)
MCAL110293510(Ppcs)
MPAH110323533(Ppcs)
RNO298490(Ppcs)
MCOC116096540(Ppcs)
MUN110547469(Ppcs)
CGE100768962(Ppcs)
MAUA101825463(Ppcs)
PLEU114704935(Ppcs)
MORG121447904(Ppcs)
AAMP119816771(Ppcs)
NGI103741896(Ppcs)
HGL101722213(Ppcs)
CPOC100713605(Ppcs)
CCAN109691199(Ppcs)
DORD105986203(Ppcs)
DSP122108961(Ppcs)
NCAR124990562
OCU100357911(PPCS)
OPI101535629(PPCS)
TUP102492271(PPCS)
CFA475309(PPCS)
VVP112908230(PPCS)
VLG121481620(PPCS)
AML100472297(PPCS)
UAH113254811(PPCS)
UAR123793825(PPCS)
ELK111143172
LLV125098361
MPUF101685440(PPCS)
ORO101367565(PPCS)
EJU114224214(PPCS)
ZCA113910250(PPCS)
MLX118019546(PPCS)
FCA101093376(PPCS)
PYU121026954(PPCS)
PBG122480353(PPCS)
PTG102952696(PPCS)
PPAD109254895(PPCS)
AJU106970199(PPCS)
HHV120236102(PPCS)
BTA539294(PPCS)
BOM102286433(PPCS)
BIU109556430(PPCS)
BBUB102407720(PPCS)
OAS100145879(PPCS)
ODA120856318(PPCS)
CCAD122437134(PPCS) 122446657
SSC100523850(PPCS)
CBAI105072741(PPCS)
CDK105101636(PPCS)
VPC102544832(PPCS)
BACU103017104(PPCS)
LVE103082840(PPCS)
OOR101275156(PPCS)
DLE111175676(PPCS)
PCAD102982388(PPCS)
PSIU116742038(PPCS)
ECB100067429(PPCS)
EPZ103557318(PPCS)
EAI106847804(PPCS)
MYB102263608(PPCS)
MYD102754989
MMYO118675940(PPCS)
MLF102429882(PPCS)
MNA107531163(PPCS)
PKL118722913(PPCS)
HAI109383329(PPCS)
DRO112299406(PPCS)
SHON118977579(PPCS)
AJM119052414(PPCS)
PDIC114496621(PPCS)
PHAS123832023(PPCS)
MMF118626463(PPCS)
PALE102883263(PPCS)
PGIG120607196(PPCS)
PVP105304027(PPCS)
RAY107508300(PPCS)
MJV108399394(PPCS)
TOD119237174(PPCS)
SARA101546571(PPCS)
LAV100675395(PPCS)
TMU101359260
DNM101420657(PPCS)
GAS123243216(PPCS)
PCW110206225(PPCS)
OAA100074041
GGA100859789(PPCS)
PCOC116238364(PPCS)
MGP100548772(PPCS)
CJO107323493(PPCS)
NMEL110408744(PPCS)
APLA101794666(PPCS)
TGU100190089(PPCS)
LSR110474448(PPCS)
SCAN103820860(PPCS)
PMOA120496749(PPCS)
OTC121343922(PPCS)
PRUF121351424(PPCS)
FAB101809422(PPCS)
PHI102105519(PPCS)
PMAJ107213781(PPCS)
CCW104698568(PPCS)
ETL114070822(PPCS)
CLV102092507(PPCS)
TALA104364123(PPCS)
ACHC115342427(PPCS)
NPD112959614(PPCS)
ASN102384769(PPCS)
AMJ102563930(PPCS)
CPOO109314290(PPCS)
GGN109293871(PPCS)
PSS102461376(PPCS)
CMY102947115(PPCS)
CPIC101937310(PPCS)
TST117867946(PPCS)
MRV120387953(PPCS)
PMUR107291366(PPCS)
PGUT117669661(PPCS)
PMUA114602330(PPCS)
ZVI118085890(PPCS)
GJA107121306(PPCS)
STOW125445623(PPCS)
XLA444166(ppcs.L)
XTR780088(ppcs)
NPR108783951(PPCS)
RTEM120915611(PPCS)
BBUF120998188(PPCS)
BGAR122928881(PPCS)
DRE561272(ppcs)
SRX107749447
SANH107685733 107691385
SGH107551114 107565714
CCAR109090824 109098837(ppcs)
CAUA113095929 113111127
PPRM120480647(ppcs)
MAMB125256668(ppcs)
IPU100528440(ppcs)
PHYP113538003(ppcs)
SMEO124402487(ppcs)
TFD113641328(ppcs)
AMEX103033972(ppcs)
EEE113589351(ppcs)
TRU101077805(ppcs)
TNGGSTEN00027553G001
LCO104919367(ppcs)
NCC104951534(ppcs)
CGOB115008749(ppcs)
ELY117257560(ppcs)
PLEP121959361(ppcs)
SLUC116051408(ppcs)
ECRA117943155(ppcs)
PFLV114554799(ppcs)
GAT120835171(ppcs)
PPUG119193878(ppcs)
MSAM119886795(ppcs)
CUD121528040(ppcs)
ALAT119021143(ppcs)
MZE101472115(ppcs)
ONL100697161(ppcs)
OAU116334212(ppcs)
OLA101171657(ppcs)
OML112144767(ppcs)
XMA102225955(ppcs)
XCO114135978(ppcs)
XHE116711076(ppcs)
PRET103464482(ppcs)
PFOR103136679(ppcs)
PLAI106945819(ppcs)
PMEI106924799(ppcs)
GAF122833637(ppcs)
CVG107087511(ppcs)
CTUL119772753(ppcs)
GMU124857178(ppcs)
NFU107385253(ppcs)
KMR108231112(ppcs)
ALIM106513855(ppcs)
NWH119412391(ppcs)
AOCE111588014(ppcs)
CSEM103385673(ppcs)
POV109638627(ppcs)
SSEN122768415(ppcs)
HHIP117761739(ppcs)
HSP118105201(ppcs)
LCF108899884(ppcs)
SDU111224029(ppcs)
SLAL111658270(ppcs)
XGL120783214(ppcs)
HCQ109529187(ppcs)
BPEC110168650(ppcs)
MALB109959069(ppcs)
BSPL114856135(ppcs)
SASA100195917(ppcs)
OTW112254313(ppcs)
OMY110527825(ppcs)
OGO124020870(ppcs)
ONE115145423(ppcs)
SALP111969807(ppcs)
SNH120065629(ppcs)
ELS105017418(ppcs)
SFM108918354(ppcs)
PKI111857030(ppcs)
AANG118211730(ppcs)
LOC102690568(ppcs)
PSPA121329062 121329290
ARUT117425455(ppcs)
LCM102354936(PPCS)
CMK103190078(ppcs)
RTP109914734(ppcs)
BFO118432735
BBEL109475808
CIN100187386
SCLV120330713 120330890
SPU115930015 763180
APLC110986600
DMEDmel_CG5629(Ppcs)
DER6553807
DSE6619106
DSIDsimw501_GD20133(Dsim_GD20133)
DYADyak_GE25151
DAN6501707
DSR110188289
DPODpse_GA19016
DPE6588107
DMN108156647
DWI6650618
DGR6563511
DMODmoj_GI24057
DAZ108621442
DNV108656764
DHE111601755
DVI6629969
CCAT101460214
BOD106622346
MDE101896548
SCAC106086952
LCQ111677515 111679505
LSQ119614449
HIS119653039
AGAAgaP_AGAP004311
ACOZ120948848
AARA120898799
ASTE118504678 118517182
AAG5566454
AALB109411495 109414891
CQUCpipJ_CPIJ005389
CPII120414284
CNS116338520
BCOO119067862
AME411581
ACER108001779
ALAB122719780
BIM100740383
BBIF117207594
BVK117232053
BVAN117156768
BTER100650397
BPYO122566620
CCAL108628133
OBB114872026
MGEN117221565
NMEA116432467
CGIG122397541
SOC105205708
MPHA105840145
AEC105147096
ACEP105623733
PBAR105431579
VEM105560163
HST105192129
DQU106741223
CFO105248320
FEX115245119
LHU105677782
PGC109858729
OBO105285709
PCF106786200
PFUC122525447
VPS122633337
NVI100118134
CSOL105364493 105364496 105367020
TPRE106655062
MDL103578853
CGLO123269391
FAS105268192
DAM107046331
AGIF122854346
CCIN107265267
TCA660081
DPA109535479 109545974
SOY115891324
ATD109609696
CSET123319160
AGB108916466
LDC111502572
NVL108556490
APLN108743595
PPYR116163642 116164075
OTU111428402
BMOR101744316
BMAN114239951
MSEX115451570 119192357 119192399
DPLKGM_210635
BANY112047925
PMAC106711815
PXU106117897
PRAP110992047
ZCE119838778
HAW110383582 110383624
TNL113493400
SLIU111355954
OFU114353399
PXY105384516 105396574
API100163022
DNX107167285
AGS114129052
RMD113553848
BTAB109030283
DCI103512227
CLEC106674302
HHAL106690778
NLU111047123
PHUPhum_PHUM259630
FOC113206610 113217260
ZNE110839972
CSEC111871309
FCD110863257
DPXDAPPUDRAFT_45011
DMK116926312
PVM113820687
PJA122256060
PCHN125045588
HAME121867384
PCLA123762714
PTRU123520495
HAZT108667766
EAF111710008
LSM121122823
PPOI119113865 119114389
ISCIscW_ISCW019157
DSV119456296
RSAN119378203 119393578
RMP119171884
VDE111243660
VJA111268829
TUT107366377
DPTE113799837
DFR124490719
CSCU111625717
PTEP107457055
SDM118195775
CELCELE_Y71H2AM.6(Y71H2AM.6)
CBRCBG_09817
BMYBM_BM13973(Bm13973)
LOALOAG_01280
TSPTsp_10032
HROHELRODRAFT_142989
LGILOTGIDRAFT_110784
PCAN112557722
BGT106067959
GAE121373726
HRF124134668
HRJ124288547
CRG105342890
MYI110451916
PMAX117322545
MMER123561537
OBI106869582
OSN115220681 115228358
LAK106158648 106158669
SMMSmp_131090
OVIT265_00160 T265_00164
NVE5499071 5516124
EPA110238329
ADF107338862
AMIL114964741
PDAM113680872
SPIS111333219
DGT114534012
TADTRIADDRAFT_21703
AQU100632677
ATHAT1G12350(COAB) AT5G02080
ALY9309105 9325992
CRB17896814
CSAT104708941 104734212 104739885 104755502 104771278
EUSEUTSA_v10014147mg
BRP103847479 103850438
BNA106370708 106423951 106432532 106433523 106433563 111212128
BOE106313101 106326761
RSZ108816965 108834747 108839977
THJ104813137
CPAP110815197
CIT102609359
CICCICLE_v10005436mg
PVY116126091 116131539
MINC123230153
TCC18592236
GRA105786143
GHI107922382 107925904
GAB108460574
DZI111299830 111311261 111315600
EGR104450967
GMX100777777 100808811
GSJ114410474 114415359
PVUPHAVU_009G026700g
VRA106760923
VAR108330018
VUN114195895
CCAJ109798121
APRC113871860
MTRMTR_3g073550 MTR_4g112080
CAM101497791 105851170
LJALj1g3v0726950.1(Lj1g3v0726950.1) Lj1g3v0726950.2(Lj1g3v0726950.2)
ADU107460811 107473380
AIP107606108 107624942 107630330
AHF112706133 112726903 112736967 112738152 112766648
LANG109326059 109328582
FVE101302311
RCN112180118 112195869 112195879
PPER18791206
PMUM103332954
PAVI110754094
PDUL117615804
MDM103416203 103421294
PXB103936128 103942766 103957001
ZJU107422696
MNT21404361
CSV101214416
CMO103488424
BHJ120075282
MCHA111004651
CMAX111496541
CMOS111454754
CPEP111798026
RCU8263001
JCU105638860
HBR110634554
MESC110604814
POP7463190 7469116
PEU105112743 105127879
PALZ118029181 118041721
JRE109012450 109021340
QSU112023230 112033206
QLO115972384
TWL120010048
VVI100264408
VRI117906383
SLY101254283 101259538 109121235 112940037
SPEN107006035 107017006
SOT102588919 102590816
CANN107867573 124889802
NTA107794222 107797793 107799632 107821980
NSY104229704 104238619
NTO104086248 104107836
NAU109216702 109236957
INI109151330
ITR116018721
SIND105165946
OEU111396735 111408904
EGT105950980 105951009
SSPL121765894 121792871
HAN110942323 110942448 110942460
ECAD122578790
LSV111908051 111920701
CCAV112511116 112514381
DCR108199462 108199557
CSIN114260205 114324090
BVG104895245
SOE110801139
CQI110706674 110709720
NNU104589311
MING122082922
TSS122661913
PSOM113331737 113347465
NCOL116258821
OSA4329749 4344795
DOSAOs02t0575200-01(Os02g0575200) Os08t0176100-01(Os08g0176100)
OBR102705934 102710850
BDI100821221 100835250
ATS109761447 109768359
TDC119324230 119330438 119339879
TAES123134136 123144636 123149575 123159825 123167176
TUA125522025
SBI8072624 8080899
ZMA100193520 100283870
SITA101763961 101772064
SVS117833591 117859536
PVIR120656183 120679321 120706162 120711563
PHAI112897670 112900265
PDA103715234
EGU105060911
MUS103973933
DCT110111014
PEQ110031606
AOF109832648
ATR18422188
SMOSELMODRAFT_172589 SELMODRAFT_417301 SELMODRAFT_57639 SELMODRAFT_96458
PPP112288417
CRECHLRE_01g048050v5
MNGMNEG_0529
CSLCOCSUDRAFT_37270
APROF751_5622
OLUOSTLU_6578
OTAOT_ostta01g00390
BPGBathy01g00300
MISMICPUN_71596
MPPMICPUCDRAFT_5184
CMECYME_CMQ096C
GSLGasu_28840
SCEYIL083C(CAB2)
SPAOSPAR_I00840
AGOAGOS_AGR391W
ERCEcym_3343
KLAKLLA0_E08757g
KMXKLMA_80113(CAB2)
LTHKLTH0G10846g
VPOKpol_1003p52
ZROZYRO0A02332g
CGRCAGL0M06721g
NCSNCAS_0B06150(NCAS0B06150)
NDINDAI_0B03450(NDAI0B03450)
TPFTPHA_0G00840(TPHA0G00840)
TBLTBLA_0B06070(TBLA0B06070)
TDLTDEL_0G02350(TDEL0G02350)
TGBHG536_0A02130
KAFKAFR_0H03260(KAFR0H03260)
KNGKNAG_0A05310(KNAG0A05310) KNAG_0H01950(KNAG0H01950)
ZMKHG535_0D01850
PPAPAS_chr2-2_0204
DHADEHA2A09922g
PICPICST_54534
PGUPGUG_02000
SPAASPAPADRAFT_140523
LELLELG_02786
CALCAALFM_C305760WA(CaO19.7357)
CTPCTRG_02452
COTCORT_0C02080
CDUCD36_85700
CTENCANTEDRAFT_114328
YLIYALI0C06996g
CLUCLUG_04761
CLUSA9F13_11g00330
CAURCJI97_002289
PKZC5L36_0A10970
BNNFOA43_004190
BBRXBRETT_001965
OPAHPODL_01352
SLUDSCDLUD_002734
NCRNCU09090
NTENEUTE1DRAFT70340(NEUTE1DRAFT_70340)
SMPSMAC_05243
PANPODANSg4220
TTTTHITE_2111714
MTMMYCTH_2085895
CTHRCTHT_0012610
MGRMGG_17982
PPEIPpBr36_09703
TMNUCRPA7_5693
SSCKSPSK_03373
FGRFGSG_08803
FPUFPSE_11970
FVRFVEG_01841
FOXFOXG_02990
NHENECHADRAFT_67579
TRETRIREDRAFT_3350
TRRM419DRAFT_76070
MAWMAC_00950
MAJMAA_03810
PLJVFPFJ_00465
VALVDBG_01738
VDAVDAG_01811
CFJCFIO01_12807
CHIGCH63R_07523
ELAUCREL1_8778
PFYPFICI_10569
SSLSS1G_09394
BFUBCIN_06g04980(Bccab2)
MBEMBM_07184
PSCOLY89DRAFT_589644
GLZGLAREA_11509
ANIAN4830.2
AFMAFUA_3G07230
ACTACLA_035170
NFINFIA_070020
AORAO090020000202
ANGANI_1_1854024(An02g13510)
AFVAFLA_010461
ALUCAKAW2_11133S
ACHEACHE_70344S
APUUAPUU_31049S
PCSPc20g02180
PDPPDIP_09730
TMFPMAA_002180
TRGTRUGW13939_10993
CIMCIMG_00337
CPWCPC735_058580
UREUREG_00402
PBLPAAG_03857
PBNPADG_11590(PADG_03355)
ABEARB_07380
TVETRV_00221
AJEHCAG_07269
BGHBDBG_00825
PNOSNOG_00223
PTEPTT_16312
BZECOCCADRAFT_82201
BSCCOCSADRAFT_306199
BORCOCMIDRAFT_89442
AALTCC77DRAFT_62378
ZTRMYCGRDRAFT_88465
PFJMYCFIDRAFT_65188
FFUCLAFUR5_14063
BCOMBAUCODRAFT_66284
NPAUCRNP2_9487
TMLGSTUM_00009271001
SPOSPCC4B3.18
CNECNE03180
CNBCNBE3190
CNGCNAG_02222
CGICGB_E4190C
TMSTREMEDRAFT_44607
TASAA1Q1_04608
TVSTRAVEDRAFT_39401
DSQDICSQDRAFT_88872
PCOPHACADRAFT_116598
SHSSTEHIDRAFT_75605
HIRHETIRDRAFT_67218
PSQPUNSTDRAFT_103147
ADLAURDEDRAFT_116159
FMEFOMMEDRAFT_113269
GTRGLOTRDRAFT_80252
LBCLACBIDRAFT_185029
MRRMoror_7689
MOREE1B28_005680
CCICC1G_07662
SCMSCHCODRAFT_70696
ABPAGABI1DRAFT115287(AGABI1DRAFT_115287)
ABVAGABI2DRAFT194249(AGABI2DRAFT_194249)
PCUBJR316_0008795
CPUTCONPUDRAFT_60642
SLASERLADRAFT_457523
WSEWALSEDRAFT_9733
UMAUMAG_03699
PFPPFL1_04969
MGLMGL_0113
MRTMRET_1206
MSYMMSY001_0501
PGRPGTG_11375 PGTG_11417
MLRMELLADRAFT_38628
MBRMONBRDRAFT_30065
SREPTSG_08107
DDIDDB_G0282611
DPPDICPUDRAFT_159223
DFADFA_11657
ACANACA1_230520
PYOPY17X_0616300
PCBPCHAS_061530(PC000395.01.0)
PBEPBANKA_0613600
PKNPKNH_0310500
PVXPVX_000630
PCYPCYB_031970
TANTA12810
TOTTOT_020000364
BEQBEWA_021100
BBOBBOV_III006270(17.m07557)
BBIGBBBOND_0308500
CPVcgd4_2250
CHOChro.40256
TGOTGME49_318600
TETTTHERM_01309090
PTMGSPATT00015070001
FCYFRACYDRAFT_162082
TPSTHAPSDRAFT_15545
AAFAURANDRAFT_54169
PIFPITG_16385
PSOJPHYSODRAFT_506618
SPARSPRG_05012
EHXEMIHUDRAFT_229510 EMIHUDRAFT_55007 EMIHUDRAFT_55011
GTTGUITHDRAFT_69144
TBRTb927.3.1970
TBGTbgDal_III1890
TCR504045.80
LMALMJF_25_1900
LIFLINJ_25_1980
LDOLDBPK_251980
LMILMXM_25_1900
LBZLBRM_25_1460
LPANLPMP_251980
 » show all
Reference
1  [PMID:11923312]
  Authors
Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, de Crecy-Lagard V, Osterman A
  Title
Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics.
  Journal
J Biol Chem 277:21431-9 (2002)
DOI:10.1074/jbc.M201708200
  Sequence
[hsa:79717]
Reference
2  [PMID:12906824]
  Authors
Manoj N, Strauss E, Begley TP, Ealick SE.
  Title
Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution.
  Journal
Structure 11:927-36 (2003)
DOI:10.1016/S0969-2126(03)00146-1
  Sequence
[hsa:79717]
Reference
3  [PMID:12860978]
  Authors
Kupke T, Hernandez-Acosta P, Culianez-Macia FA
  Title
4'-phosphopantetheine and coenzyme A biosynthesis in plants.
  Journal
J Biol Chem 278:38229-37 (2003)
DOI:10.1074/jbc.M306321200
  Sequence
[ath:AT1G12350]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.51
IUBMB Enzyme Nomenclature: 6.3.2.51
ExPASy - ENZYME nomenclature database: 6.3.2.51
BRENDA, the Enzyme Database: 6.3.2.51
CAS: 9023-50-1

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