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Entry
EC 6.3.2.51                 Enzyme                                 

Name
phosphopantothenate---cysteine ligase (ATP);
phosphopantothenoylcysteine synthetase (ambiguous);
PPCS (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
(R)-4'-phosphopantothenate:L-cysteine ligase (ATP-utilizing)
Reaction(IUBMB)
ATP + (R)-4'-phosphopantothenate + L-cysteine = AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine [RN:R04230]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
(R)-4'-phosphopantothenate [CPD:C03492];
L-cysteine [CPD:C00097]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
N-[(R)-4'-phosphopantothenoyl]-L-cysteine [CPD:C04352]
Comment
A key enzyme in the production of coenzyme A. The eukaryotic enzyme requires ATP, in contrast to the bacterial enzyme, EC 6.3.2.5, phosphopantothenate---cysteine ligase, which requires CTP.
History
EC 6.3.2.51 created 2017
Pathway
ec00770  Pantothenate and CoA biosynthesis
Orthology
K01922  phosphopantothenate---cysteine ligase (ATP)
Genes
HSA: 79717(PPCS)
PTR: 747056(PPCS)
PPS: 100969367(PPCS)
GGO: 101138135(PPCS)
PON: 100457154(PPCS)
NLE: 100591238(PPCS)
MCC: 697064(PPCS)
MCF: 102127325(PPCS)
RRO: 104668997(PPCS)
RBB: 108530371(PPCS)
CJC: 100414413(PPCS)
SBQ: 101027483(PPCS)
MMU: 106564(Ppcs)
RNO: 298490(Ppcs)
CGE: 100768962(Ppcs)
NGI: 103741896(Ppcs)
HGL: 101722213(Ppcs)
CCAN: 109691199(Ppcs)
OCU: 100357911(PPCS)
TUP: 102492271(PPCS)
CFA: 475309(PPCS)
AML: 100472297(PPCS)
UMR: 103670831(PPCS)
ORO: 101367565(PPCS)
FCA: 101093376(PPCS)
PTG: 102952696(PPCS)
AJU: 106970199(PPCS)
BTA: 539294(PPCS)
BOM: 102286433(PPCS)
BIU: 109556430(PPCS)
PHD: 102330726(PPCS)
OAS: 100145879(PPCS)
SSC: 100523850(PPCS)
CFR: 102503946(PPCS) 106730820
CDK: 105101636(PPCS)
BACU: 103017104(PPCS)
LVE: 103082840(PPCS)
OOR: 101275156(PPCS)
ECB: 100067429(PPCS)
EPZ: 103557318(PPCS)
EAI: 106847804(PPCS)
MYB: 102263608(PPCS) 106726059
HAI: 109383329(PPCS)
PALE: 102883263(PPCS)
LAV: 100675395(PPCS)
TMU: 101359260
SHR: 100913772(PPCS)
OAA: 100073962(PPCS)
GGA: 100859789(PPCS)
MGP: 100548772(PPCS)
CJO: 107323493(PPCS)
APLA: 101794666(PPCS)
ACYG: 106049734(PPCS)
TGU: 100190089(PPCS)
GFR: 102044927(PPCS)
FAB: 101809422(PPCS)
PHI: 102105519(PPCS)
PMAJ: 107213781(PPCS)
CCW: 104698568(PPCS)
FPG: 101918627(PPCS)
FCH: 102055252(PPCS)
CLV: 102092507(PPCS)
EGZ: 104134708(PPCS)
ASN: 102384769(PPCS)
AMJ: 102563930(PPCS)
PSS: 102461376(PPCS)
CMY: 102947115(PPCS)
CPIC: 101937310(PPCS)
PVT: 110072633(PPCS)
PBI: 103056662(PPCS)
GJA: 107121306(PPCS)
XLA: 444166(ppcs.L)
XTR: 780088(ppcs)
NPR: 108783951(PPCS)
DRE: 561272(ppcs)
SRX: 107749447
CCAR: 109090824 109098837(ppcs)
IPU: 100528440(ppcs)
AMEX: 103033972(ppcs)
TRU: 101077805(ppcs)
LCO: 104919365(ppcs) 104919367
NCC: 104951534(ppcs)
MZE: 101472115(ppcs)
OLA: 101171657(ppcs)
XMA: 102225955(ppcs)
PRET: 103464482(ppcs)
NFU: 107385253(ppcs)
CSEM: 103385673(ppcs)
LCF: 108899884(ppcs)
HCQ: 109529187(ppcs)
BPEC: 110168650(ppcs)
SASA: 100195917(ppcs)
ELS: 105017418(ppcs)
SFM: 108918354(ppcs)
LCM: 102354936(PPCS)
CMK: 103190078(ppcs)
CIN: 100187386
SPU: 763180
APLC: 110986600
DME: Dmel_CG5629(Ppcs)
DSI: Dsimw501_GD20133(Dsim_GD20133)
MDE: 101896548
AAG: 5566454
AME: 411581(Ppcs)
BIM: 100740383
BTER: 100650397
SOC: 105205708
AEC: 105147096
ACEP: 105623733
PBAR: 105431579
HST: 105192129
CFO: 105248320
LHU: 105677782
PGC: 109858729
NVI: 100118134
TCA: 660081
NVL: 108556490
PRAP: 110992047
API: 100163022
DNX: 107167285
ZNE: 110839972
FCD: 110863257
TUT: 107366377
CEL: CELE_Y71H2AM.6(Y71H2AM.6)
CBR: CBG09817
BMY: Bm1_45070
TSP: Tsp_10032
CRG: 105342890
MYI: 110451916
OBI: 106869582
EPA: 110238329
ADF: 107338862
AQU: 100632677
ATH: AT1G12350(COAB) AT5G02080
CRB: 17896814
THJ: 104813137
CPAP: 110815197
CIT: 102609359
TCC: 18592236
GRA: 105786143
EGR: 104450967
VRA: 106760923
VAR: 108330018
CCAJ: 109798121
LJA: Lj1g3v0726950.1(Lj1g3v0726950.1) Lj1g3v0726950.2(Lj1g3v0726950.2)
FVE: 101302311
PPER: 18791206
PMUM: 103332954
PAVI: 110754094
ZJU: 107422696
CSV: 101214416
CMO: 103488424
MCHA: 111004651
CMAX: 111496541
CMOS: 111454754
CPEP: 111798026
RCU: 8263001
JCU: 105638860
HBR: 110634554
VVI: 100264408
CANN: 107867573
INI: 109151330
SIND: 105165946
BVG: 104895245
SOE: 110801139
NNU: 104589311
DOSA: Os02t0575200-01(Os02g0575200) Os08t0176100-01(Os08g0176100)
ATS: 109761447(LOC109761447) 109768359(LOC109768359)
PDA: 103715234
EGU: 105060911
MUS: 103973933
DCT: 110111014
AOF: 109832648
ATR: 18422188
PPP: 112288417
MNG: MNEG_0529
APRO: F751_5622
SCE: YIL083C(CAB2)
ERC: Ecym_3343
KMX: KLMA_80113(CAB2)
NCS: NCAS_0B06150(NCAS0B06150)
NDI: NDAI_0B03450(NDAI0B03450)
TPF: TPHA_0G00840(TPHA0G00840)
TBL: TBLA_0B06070(TBLA0B06070)
TDL: TDEL_0G02350(TDEL0G02350)
KAF: KAFR_0H03260(KAFR0H03260)
CAL: CAALFM_C305760WA(CaO19.7357)
CAUR: QG37_00342
SLB: AWJ20_4923(CAB2)
NCR: NCU09090
NTE: NEUTE1DRAFT70340(NEUTE1DRAFT_70340)
MGR: MGG_17982
MAW: MAC_00950
MAJ: MAA_03810
BFU: BCIN_06g04980(Bccab2)
MBE: MBM_07184
ANI: AN4830.2
ANG: ANI_1_1854024(An02g13510)
PBN: PADG_11590(PADG_03355)
ABE: ARB_07380
TVE: TRV_00221
PTE: PTT_16312
CNE: CNE03180
CNB: CNBE3190
ABP: AGABI1DRAFT115287(AGABI1DRAFT_115287)
ABV: AGABI2DRAFT194249(AGABI2DRAFT_194249)
MGL: MGL_0113
DFA: DFA_11657
PYO: PY17X_0616300(PY05326)
PCB: PCHAS_061530(PC000395.01.0)
SMIN: v1.2.019703.t1(symbB.v1.2.019703.t1)
TCR: 504045.80
 » show all
Taxonomy
Reference
1  [PMID:11923312]
  Authors
Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, de Crecy-Lagard V, Osterman A
  Title
Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics.
  Journal
J Biol Chem 277:21431-9 (2002)
DOI:10.1074/jbc.M201708200
  Sequence
[hsa:79717]
Reference
2  [PMID:12906824]
  Authors
Manoj N, Strauss E, Begley TP, Ealick SE.
  Title
Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution.
  Journal
Structure 11:927-36 (2003)
DOI:10.1016/S0969-2126(03)00146-1
  Sequence
[hsa:79717]
Reference
3  [PMID:12860978]
  Authors
Kupke T, Hernandez-Acosta P, Culianez-Macia FA
  Title
4'-phosphopantetheine and coenzyme A biosynthesis in plants.
  Journal
J Biol Chem 278:38229-37 (2003)
DOI:10.1074/jbc.M306321200
  Sequence
[ath:AT1G12350]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.51
IUBMB Enzyme Nomenclature: 6.3.2.51
ExPASy - ENZYME nomenclature database: 6.3.2.51
BRENDA, the Enzyme Database: 6.3.2.51
CAS: 9023-50-1

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