KEGG   ENZYME: 7.2.2.19
Entry
EC 7.2.2.19                 Enzyme                                 
Name
H+/K+-exchanging ATPase;
H+-K+-ATPase;
H,K-ATPase;
(K+ + H+)-ATPase
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate
Sysname
ATP phosphohydrolase (P-type,H+/K+-exchanging)
Reaction(IUBMB)
ATP + H2O + H+[side 1] + K+[side 2] = ADP + phosphate + H+[side 2] + K+[side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
H+[side 1];
K+[side 2]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
H+[side 2];
K+[side 1]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A gastric mucosal enzyme that catalyses the efflux of one H+ and the influx of one K+ per ATP hydrolysed.
History
EC 7.2.2.19 created 1984 as EC 3.6.1.36, transferred 2000 to EC 3.6.3.10, transferred 2018 to EC 7.2.2.19
Pathway
ec00190  Oxidative phosphorylation
ec01100  Metabolic pathways
Orthology
K01542  H+/K+-exchanging ATPase subunit alpha
K01543  H+/K+-exchanging ATPase subunit beta
K01544  non-gastric H+/K+-exchanging ATPase
Genes
HSA479(ATP12A) 495(ATP4A) 496(ATP4B)
PTR452489(ATP12A) 738405(ATP4B) 747915(ATP4A)
PPS100979788(ATP12A) 100980523(ATP4A) 100991047(ATP4B)
GGO101138827(ATP4A) 101141471(ATP4B) 101142592(ATP12A)
PON100435235(ATP4A) 100435325(ATP12A) 100459814(ATP4B)
NLE100582869(ATP12A) 100593416(ATP4A) 100603851(ATP4B)
MCC100426215(ATP4A) 698222(ATP4B) 721488(ATP12A)
MCF102119167(ATP12A) 102124568(ATP4A) 102131451(ATP4B)
MTHB126940838 126940867 126941882
CSAB103214853(ATP4B) 103234521(ATP4A) 103249015(ATP12A)
CATY105578179(ATP4A) 105584959(ATP4B) 105591901
PANU100998598(ATP4B) 101008375(ATP4A) 101018431
TGE112610847(ATP12A) 112610870(ATP4B) 112613167(ATP4A)
RRO104659972(ATP12A) 104667094(ATP4A) 104671368(ATP4B)
RBB108512346(ATP4A) 108515377(ATP12A) 108521834(ATP4B)
TFN117063465(ATP4B) 117092362(ATP4A) 117098305(ATP12A)
PTEH111525000(ATP12A) 111529928(ATP4A) 111546384(ATP4B)
CJC100400287(ATP12A) 100405348(ATP4A) 100414695(ATP4B)
SBQ101047397(ATP12A) 101047734(ATP4A) 101051285(ATP4B)
CSYR103254666 103268157(ATP12A) 103271326(ATP4B) 103273562(ATP4A)
MMUR105871943(ATP4B) 105876924(ATP4A) 105878841(ATP12A)
LCAT123624471(ATP4A) 123648826(ATP4B) 123649506(ATP12A)
OGA100940453(ATP4B) 100941378(ATP4A) 100958415(ATP12A)
MMU11944(Atp4a) 11945(Atp4b) 192113(Atp12a)
MCAL110297674(Atp4a) 110300103(Atp4b) 110309153(Atp12a)
MPAH110316696(Atp4a) 110325315(Atp12a) 110336832(Atp4b)
RNO171028(Atp12a) 24216(Atp4a) 24217(Atp4b)
MCOC116071161(Atp4b) 116085109(Atp12a) 116101990(Atp4a)
MUN110551638(Atp4a) 110558227 110558241 110559568(Atp12a)
CGE100750430(Atp4b) 100765522(Atp12a) 100767384(Atp4a)
MAUA101834043(Atp4a) 101840044(Atp4b) 101844033(Atp12a)
PLEU114681649(Atp4a) 114683800(Atp12a) 114701215(Atp4b)
MORG121434991(Atp12a) 121449422(Atp4a) 121462110(Atp4b)
MFOT126486695 126492615 126498731
AAMP119800127(Atp12a) 119813512(Atp4b) 119821880(Atp4a)
NGI103726773(Atp12a) 103729925(Atp4a) 103746296(Atp4b)
HGL101697924(Atp4b) 101711071(Atp12a) 101724247(Atp4a)
CPOC100135482(Atp12a) 100731685(Atp4b) 100732743(Atp4a)
CCAN109674869(Atp12a) 109686917(Atp4b) 109689140(Atp4a)
DORD105990414(Atp4b) 105992620(Atp12a) 105993074(Atp4a)
DSP122097466(Atp4a) 122112681(Atp12a) 122122856(Atp4b)
NCAR124966338 124984830 124985869
OCU100008669(ATP12A) 100009125(ATP4B) 100009279(ATP4A)
OPI101519902(ATP12A) 101526616(ATP4B) 101532969(ATP4A)
TUP102472050(ATP4B) 102475043(ATP12A) 102480463(ATP4A)
GVR103590632(ATP4B) 103601451(ATP4A) 103607310(ATP12A)
CFA403820(ATP12A) 404020(ATP4B) 431686(ATP4A)
CLUD112643525(ATP4A) 112656012(ATP4B) 112669581(ATP12A)
VVP112918512(ATP12A) 112927436(ATP4B) 112928326(ATP4A)
VLG121477139(ATP4B) 121479246(ATP4A) 121497686(ATP12A)
AML100465081(ATP4A) 100465461(ATP12A) 100477747(ATP4B)
UMR103657517(ATP4B) 103664389(ATP12A) 103682508(ATP4A)
UAH113244763(ATP4A) 113247563(ATP4B) 113251156(ATP12A)
UAR123776756(ATP4B) 123792000(ATP12A) 123793887(ATP4A)
ELK111147139 111159902 111161471
LLV125088370 125094869 125096136
MPUF101689957(ATP4B) 101692909(ATP12A) 106003277(ATP4A)
ORO101367449(ATP12A) 101368519(ATP4A) 101369365(ATP4B)
EJU114196614(ATP4B) 114204018 114210997(ATP12A) 114224363(ATP4A)
ZCA113920154(ATP4B) 113920413(ATP12A) 113935424(ATP4A)
MLX118009110(ATP4B) 118022790(ATP4A) 118026855
NSU110570195(ATP12A) 110585884(ATP4B) 110590090(ATP4A)
LWW102728557(ATP4A) 102732485(ATP4B) 102734201(ATP12A)
FCA101091583(ATP12A) 101092078(ATP4B) 101100771(ATP4A)
PYU121022550(ATP12A) 121037674(ATP4B)
PBG122480267(ATP12A) 122485157(ATP4B) 122495067(ATP4A)
LRUF124502271 124511813 124514002
PTG102957326(ATP12A) 102964110(ATP4A) 102971257(ATP4B)
PPAD109251505(ATP4A) 109259125(ATP12A) 109264027(ATP4B)
AJU106974749(ATP4A) 106979787(ATP12A) 106986712(ATP4B)
HHV120223456(ATP4B) 120243462(ATP4A) 120248570(ATP12A)
BTA521163(ATP4A) 530703(ATP12A) 614308(ATP4B)
BOM102273487(ATP4A) 102275089(ATP12A) 102276541(ATP4B)
BIU109567033(ATP4B) 109567056(ATP12A) 109571697(ATP4A)
BBUB102404508(ATP4B) 102412846(ATP12A) 102415959(ATP4A)
BBIS104982120(ATP4B) 104982884(ATP12A) 104995244(ATP4A)
CHX102172639(ATP12A) 102180792(ATP4A) 102185581(ATP4B)
OAS101116166(ATP4A) 101120253(ATP12A) 114116709(ATP4B)
ODA120873301(ATP4A) 120883224(ATP12A) 120883388(ATP4B)
CCAD122421382(ATP4A) 122447536(ATP12A) 122447558(ATP4B)
SSC100521921(ATP12A) 397131(ATP4B) 397552(ATP4A)
CFR102505116(ATP4A) 102505590(ATP12A) 102520241(ATP4B)
CBAI105065041(ATP4A) 105066291(ATP12A) 105066876(ATP4B)
CDK105088096(ATP4A) 105091347(ATP4B) 105096383(ATP12A)
VPC102526679(ATP4B) 102530856(ATP4A)
BACU103000639(ATP4B) 103012701(ATP4A) 103013174(ATP12A)
LVE103071695(ATP4B) 103071724(ATP4A) 103091328(ATP12A)
OOR101270907(ATP12A) 101275692(ATP4B) 101276734(ATP4A)
DLE111175101 111176321(ATP4B) 111181140(ATP4A)
PCAD102992690(ATP4B) 102994540(ATP12A) 102994597(ATP4A)
PSIU116743261(ATP4B) 116743292(ATP12A) 116744556(ATP4A)
ECB100052912(ATP12A) 100069135(ATP4B) 100147108(ATP4A)
EPZ103540402(ATP12A) 103549650(ATP4B) 103560041(ATP4A)
EAI106827635(ATP12A) 106829240(ATP4A) 106848204(ATP4B)
MYB102246595(ATP12A) 102249396(ATP4A) 102259435(ATP4B)
MYD102753224(ATP4A) 102760948(ATP4B) 102774686(ATP12A)
MMYO118651209(ATP12A) 118659640(ATP4B) 118674738(ATP4A)
MLF102427161(ATP4A) 102430275(ATP12A) 102433406(ATP4B)
MNA107529938(ATP12A) 107536947(ATP4B) 107543398(ATP4A)
PKL118720628(ATP4A) 118728745(ATP12A) 118729705(ATP4B)
HAI109372015(ATP4A) 109383950(ATP4B) 109387998(ATP12A)
DRO112320122(ATP4A) 112321536(ATP4B) 112323160(ATP12A)
SHON118980541(ATP12A) 118982540(ATP4A) 118984262(ATP4B)
AJM119034612(ATP4B) 119041295(ATP12A) 119044216(ATP4A)
PDIC114508905(ATP4B) 114511655(ATP4A) 114514025(ATP12A)
PHAS123807486(ATP4B) 123822694(ATP12A) 123823744(ATP4A)
MMF118622394(ATP4B) 118624296(ATP12A) 118638589(ATP4A)
RFQ117021725(ATP4B) 117021768(ATP12A) 117035341(ATP4A)
PALE102881469(ATP12A) 102881537(ATP4B) 102882245(ATP4A)
PGIG120592418(ATP4A) 120610690(ATP12A) 120615612(ATP4B)
PVP105305088(ATP4B) 105306638(ATP4A)
RAY107497657(ATP4A) 107502956(ATP12A) 107514348(ATP4B)
MJV108394994(ATP12A) 108398957(ATP4A) 108399961(ATP4B)
TOD119248621(ATP4A) 119258939(ATP12A) 119259642(ATP4B)
SARA101545017(ATP4B) 101550748(ATP12A) 101559007(ATP4A)
LAV100657258 100657835 100663989(ATP4B) 100670470(ATP4A)
TMU101348997 101350003 101351027 101351289 101351555
ETF101645840(ATP4B) 101656652(ATP4A) 101662203 101663158 101664088
DNM101419560(ATP4B) 101422745(ATP12A) 101442103(ATP4A)
MDO100013166(ATP4A) 100016220(ATP4B) 100022970(ATP12A) 100022999 100023029
GAS123238898 123238900 123238901 123239805(ATP4B) 123243026(ATP4A)
SHR100914456 100914716 100914816(ATP4B) 100926385(ATP4A)
PCW110193383(ATP4B) 110195855 110195856 110195881 110195885 110201386(ATP4A)
OAA100092554 107547886(ATP4B)
GGA386581(ATP4B) 419743(ATP12A)
PCOC116233002(ATP12A) 116242796(ATP4B)
MGP100548075(ATP4B) 100550873(ATP12A)
CJO107307398 107307930(ATP4B) 107324177(ATP12A)
NMEL110387724(ATP12A) 110407217(ATP4B)
APLA101793299(ATP4B) 101800708(ATP12A)
ACYG106029490(ATP4A) 106040569(ATP12A) 106046430(ATP4B)
AFUL116497802(ATP12A) 116501745(ATP4A) 116502387(ATP4B)
TGU100230086(ATP12A) 100230444(ATP4B) 115492958(ATP4A)
LSR110468196(ATP12A) 110478747(ATP4B) 110483038
SCAN103812391(ATP4B) 103823636(ATP12A)
PMOA120504701(ATP4B) 120508470(ATP12A) 120510986
OTC121340772(ATP12A) 121343216(ATP4B)
PRUF121352629(ATP4B) 121360596(ATP12A)
GFR102031709(ATP4B) 102044487(ATP12A)
FAB101805703(ATP4B) 101807408(ATP12A)
PHI102099301(ATP4A) 102107731(ATP12A) 102110942(ATP4B)
PMAJ107200428(ATP4B) 107214473(ATP12A)
CCAE111922763(ATP4B) 111939335(ATP12A)
CCW104686103(ATP4B) 104692117(ATP12A)
CBRC103617551(ATP4B) 103618483(ATP12A)
ETL114057871(ATP4B) 114059527(ATP12A)
ZAB102067076(ATP4B) 102071800(ATP12A)
ACHL103797643(ATP4B) 103800232(ATP12A)
FPG101911437(ATP4A) 101912680(ATP12A) 101923846(ATP4B)
FCH102051647(ATP4B) 102055866(ATP4A) 102056385(ATP12A)
CLV102093855(ATP4B) 102096447(ATP12A)
EGZ104126355(ATP4B) 104129213(ATP12A)
NNI104011769 104016631(ATP12A) 104019363(ATP4B)
PLET104619478(ATP12A) 104620876(ATP4B)
PCRI104025066(ATP4B) 104038866(ATP12A)
PCAO104047644(ATP12A) 104049714(ATP4B)
ACUN113483761(ATP4B) 113488438
TALA104367185(ATP12A) 104368768(ATP4B)
PADL103918852(ATP4B) 103924807(ATP12A)
AFOR103896267(ATP4B) 103900590(ATP12A) 103901363
ACHC115334614(ATP4B) 115345206(ATP12A)
HALD104314953(ATP4B) 104318330(ATP12A)
HLE104836597 104836891(ATP4B) 104840466(ATP12A)
AGEN126035147 126038380 126052848
GCL127025766 127029482
CCRI104154888(ATP4B) 104161098(ATP12A)
CSTI104562132(ATP12A) 104563826(ATP4B)
EHS104502662(ATP4B) 104508395(ATP12A)
CMAC104477570(ATP12A) 104487016(ATP4B)
MUI104541132(ATP4B) 104546756(ATP12A)
FGA104075212(ATP4B) 104082600(ATP12A)
GSTE104254118(ATP12A) 104260403(ATP4B)
LDI104344343(ATP12A)
MNB103770271(ATP12A) 103775206(ATP4B)
OHA104331863(ATP4B) 104336398(ATP12A)
NNT104401099(ATP4B) 104403833(ATP12A)
DPUB104298633(ATP4B) 104301005(ATP12A)
PGUU104457839(ATP4B) 104461546(ATP12A)
ACAR104525867(ATP4B) 104531729(ATP12A)
CPEA104388968(ATP4B) 104393392(ATP12A)
AVIT104267173(ATP4B) 104278430(ATP12A)
CVF104291541(ATP12A) 104292711(ATP4B) 104294498
CUCA104056296(ATP12A) 104056622(ATP4B)
TEO104373628(ATP12A) 104375187(ATP4B)
BRHI104490829(ATP4B) 104499986(ATP12A)
AAM106490229(ATP12A) 106493946(ATP4B)
AROW112960870(ATP4B) 112963221 112968934(ATP12A)
NPD112946322(ATP12A) 112953183(ATP4B) 112957892(ATP4A)
TGT104567366(ATP4B) 104575248(ATP12A)
DNE112981390(ATP4B) 112982673(ATP12A) 112996443
SCAM104138053(ATP4B) 104143518(ATP12A)
ASN102374285(ATP4B) 102387741(ATP4A) 102388005(ATP12A)
AMJ102561484(ATP12A) 102575926(ATP4B) 109283416
CPOO109306290(ATP4B) 109318032(ATP12A)
GGN109292371(ATP12A) 109303472(ATP4B)
PSS102450978(ATP4A) 102452724(ATP12A) 102457968(ATP4B)
CMY102933065(ATP12A) 102936245(ATP4A) 102942318(ATP4B)
CPIC101946000(ATP4A) 101947527(ATP12A) 101951389(ATP4B)
TST117868663(ATP12A) 117869762(ATP4A) 117870769(ATP4B)
CABI116823339(ATP4B) 116833676(ATP4A) 116837728(ATP12A)
MRV120375453(ATP12A) 120390272(ATP4A) 120395477(ATP4B)
ACS100560046(atp4b) 100563430 100563553(atp4a)
PVT110074103(ATP4B) 110079317(ATP12A) 110089078(ATP4A)
SUND121915588(ATP4A) 121927015(ATP4B) 121933066(ATP12A)
PBI103053937(ATP12A) 103054731(ATP4A) 103064507
PMUR107286485(ATP12A) 107290450(ATP4B) 107292625(ATP4A)
CTIG120300069(ATP4A) 120310589(ATP4B) 120319550(ATP12A)
TSR106539185(ATP4B) 106548299 106552003
PGUT117666518(ATP4B) 117668233(ATP12A) 117669240(ATP4A)
VKO123019395(ATP4A) 123022672(ATP4B) 123028028(ATP12A)
PMUA114585731(ATP12A) 114596444(ATP4B) 114602396(ATP4A)
ZVI118084839(ATP4B) 118087382(ATP4A) 118096947(ATP12A)
GJA107110926(ATP4B) 107116203(ATP4A) 107120678(ATP12A)
STOW125431344(ATP4B) 125434809(ATP4A) 125441940(ATP12A)
XLA108696872 108716413 379283(atp12a.L) 379459(atp4b.S) 380512(atp12a.S) 447127(atp4b.L) 733327(atp4a.S)
XTR100488221(atp4a) 448282(atp4b) 594945(atp12a-like)
NPR108790589(ATP12A) 108790966 108790973 108791690(ATP4B) 108797188(ATP4A)
RTEM120915674(ATP12A) 120916253(ATP4A) 120916471 120926395(ATP4B)
BBUF120986820(ATP4A) 120993481(ATP4B) 121000065(ATP12A) 121002743
BGAR122926670 122928793(ATP12A) 122933327(ATP4B)
IPU108256310 108259063
PHYP113532853(atp4a) 113537621(atp4b)
SMEO124375394 124378676
TFD113648878 113649694
AMEX103023943(atp4b) 103024000(atp4a)
EEE113571928(atp4a) 113577520(atp4b)
LCO104919947(atp4b) 104940311(atp4a)
NCC104957693(atp4a) 104958804(atp4b)
CGOB115006065(atp4b) 115021320(atp4a)
ELY117260771 117265754
EFO125892646 125903207
PLEP121942309 121946001
SLUC116049457 116067660
ECRA117946445 117949401
ESP116691811 116699051(atp4b)
PFLV114556886(atp4a) 114561383(atp4b)
GAT120809652 120810035
PPUG119197524 119229020
MSAM119897685 119908241
ALAT119005673 119017714
MZE101464178(atp4a) 101482966(atp4b) 112434842
ONL100690043(atp4a) 100698050(atp4b)
OAU116312210 116331347
AOCE111565500(atp4b) 111573133(atp4a)
MCEP125005523 125016364
POV109624948(atp4b) 109633020(atp4a)
SSEN122772736 122774091
HHIP117757682 117776339
HSP118114115 118125016
LCF108888014 108892214
SDU111236799(atp4a) 111238420(atp4b)
SLAL111652775(atp4a) 111668322(atp4b)
XGL120784338 120795460
BPEC110171389(atp4a) 110173092(atp4b)
MALB109964254(atp4b) 109967366(atp4a)
BSPL114842534 114852357
SASA106574844 106577750 106594464(atp4b) 106605632
STRU115176661 115179540(atp4b) 115179541 115182575
OTW112227190 112242012 112245864
OMY100136301 110519329 110519929 118936670
OGO123997984 124005106 124024975
ONE115102130 115140890
SALP111959186 111964878 112077546(atp4b)
SNH120031708 120039469 120039484 120048543
CCLU121543053 121556072 121556764 123485649
ELS105019136(atp4a) 105020060(atp4b)
SFM108919133(atp4a) 108931953(atp4b)
PKI111841121(atp4a) 111845443
AANG118211254 118223461
LOC102687313(atp4a) 102692102(atp4b)
PSPA121299114 121320884 121327874
ARUT117406220 117407214 117434009 117968514
PSEX120517152 120524415 120535954 120541731
LCM102352096(ATP4A) 102355665(ATP4B)
RTP109913661(atp12a)
 » show all
Reference
1  [PMID:5682852]
  Authors
Sachs G, Collier RH, Shoemaker RL, Hirschowitz BI.
  Title
The energy source for gastric H+ secretion.
  Journal
Biochim Biophys Acta 162:210-9 (1968)
DOI:10.1016/0005-2728(68)90103-5
Reference
2  [PMID:2552824]
  Authors
Hersey SJ, Perez A, Matheravidathu S, Sachs G.
  Title
Gastric H+-K+-ATPase in situ: evidence for compartmentalization.
  Journal
Am J Physiol 257:G539-47 (1989)
DOI:10.1152/ajpgi.1989.257.4.G539
Reference
3  [PMID:2158765]
  Authors
Rabon EC, Reuben MA.
  Title
The mechanism and structure of the gastric H,K-ATPase.
  Journal
Annu Rev Physiol 52:321-44 (1990)
DOI:10.1146/annurev.ph.52.030190.001541
Other DBs
ExplorEnz - The Enzyme Database: 7.2.2.19
IUBMB Enzyme Nomenclature: 7.2.2.19
ExPASy - ENZYME nomenclature database: 7.2.2.19
BRENDA, the Enzyme Database: 7.2.2.19

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